Journal of Food and Pharmaceutical Sciences最新文献

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet 一水肌酸替代剂型的开发：漂浮片剂

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.8284

Arifatu Nur Hidayah, Anas Ardiana Wati, Nunung Yuniarti, M. Laksitorini

{"title":"The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet","authors":"Arifatu Nur Hidayah, Anas Ardiana Wati, Nunung Yuniarti, M. Laksitorini","doi":"10.22146/jfps.8284","DOIUrl":"https://doi.org/10.22146/jfps.8284","url":null,"abstract":"Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"76 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Real-time PCR with Mitochondrial D-Loop Specific Primers for Halal Authentication: Identifying Bovine Adulteration in Meatball Products 应用线粒体 D 环特异性引物进行实时 PCR 检测清真食品真伪：识别肉丸产品中的牛掺假行为

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.8930

Rien Larasati Arini, Abdul Rohman, Rumiyati

{"title":"Application of Real-time PCR with Mitochondrial D-Loop Specific Primers for Halal Authentication: Identifying Bovine Adulteration in Meatball Products","authors":"Rien Larasati Arini, Abdul Rohman, Rumiyati","doi":"10.22146/jfps.8930","DOIUrl":"https://doi.org/10.22146/jfps.8930","url":null,"abstract":"This study aimed to develop an analytical method using Real-time PCR and a specific primer to analyze bovine DNA in meatballs, addressing the issue of non-halal meat being used in halal meatballs. Real-time PCR enables rapid, specific, and sensitive detection, allowing for qualitative and quantitative identification of species in processed products. The research involved designing specific primers for bovine DNA using IDT software, followed by DNA isolation and testing for various parameters such as specifications, linearity, limit of detection, efficiency, and repeatability. The results demonstrated that the primer D-Loop 922 (forward: 5-ATTACCATGCCGCGTGAA-3', Reverse: 5'-GATGAGATGGCCCTGAAGAAA-3'), designed and tested in silico using Primer-BLAST software from NCBI, effectively identified bovine DNA in both fresh meat and meatballs at an optimum annealing temperature of 59.5°C. The real-time PCR method utilizing the D-loop 922 primer successfully amplified bovine DNA in both bovine samples and bovine meatballs at a minimum concentration of 1 ng, with coefficients of variation (CV) of 0.20% for bovine DNA and 0.22% for bovine meatballs. Consequently, the D-loop 922 primer met the testing criteria and can be utilized to authenticate the halal status of meatball products, supporting the implementation of Law No. 33 of 2014 regarding halal certification.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"354 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139170570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique 以碳酸氢铵和柠檬酸为模板剂，利用喷雾干燥技术优化高多孔甘露醇制备工艺

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.10062

Nindya Kusumorini, Adhyatmika

{"title":"Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique","authors":"Nindya Kusumorini, Adhyatmika","doi":"10.22146/jfps.10062","DOIUrl":"https://doi.org/10.22146/jfps.10062","url":null,"abstract":"This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of FTIR Spectroscopy Combined Chemometrics for Analysis of Keting Fish Oil in Binary Mixture with Patin Fish Oil and Palm Oil 应用傅立叶变换红外光谱结合化学计量学分析 Keting 鱼油与 Patin 鱼油和棕榈油的二元混合物

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.7955

Nadia Miftahul Jannah, Abdul Rohman, Lily Arsanti Lestari

引用次数: 0

Analysis of Total Flavonoid and Antioxidant Activity of Black Turmeric (Curcuma caesia) using ABTS (2,2-azinobis-3-Ethylbenzothiazoline-6-Sulfonic Acid) Method 用 ABTS（2,2-偶氮二-3-乙基苯并噻唑啉-6-磺酸）法分析黑姜黄（莪术）的总类黄酮和抗氧化活性

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.9325

Molesy Fransina Tanesib, Kholif Sholehah Indra Kurniasih, Andre Toga Nugraha

{"title":"Analysis of Total Flavonoid and Antioxidant Activity of Black Turmeric (Curcuma caesia) using ABTS (2,2-azinobis-3-Ethylbenzothiazoline-6-Sulfonic Acid) Method","authors":"Molesy Fransina Tanesib, Kholif Sholehah Indra Kurniasih, Andre Toga Nugraha","doi":"10.22146/jfps.9325","DOIUrl":"https://doi.org/10.22146/jfps.9325","url":null,"abstract":"Black turmeric (Curcuma caesia) has a higher concentration of phytochemical compounds compared to other turmeric species. This means it's an incredibly potent natural antioxidant. Experts believe that black turmeric could have some amazing health benefits, such as protecting against oxidative stress and reducing inflammation. Black turmeric was extracted using the maceration method with a methanol solvent. After extracting black turmeric using the maceration method and methanol solvent, the resulting extracts were tested qualitatively for flavonoids, phenolics, and tannins. Then proceed with the quantitative test to determine the total levels of flavonoids and test the antioxidant activity using the ABTS method. The results of this study obtained a yield of 13.26%, positive qualitative test results for flavonoids, phenolics, and tannins, and total flavonoid levels of 10.326 ± 0.074 mgEQ/g extract with an IC50 of 88.581 ± 3.376 ppm. Based on the results of the antioxidant activity, black turmeric methanol extract has strong antioxidant activity. \u0000 ","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"67 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138957161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black Pepper’s Anti-Aging and Chemo-preventive Properties: A Review 黑胡椒的抗衰老和化疗预防特性：综述

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.7100

Endah

{"title":"Black Pepper’s Anti-Aging and Chemo-preventive Properties: A Review","authors":"Endah","doi":"10.22146/jfps.7100","DOIUrl":"https://doi.org/10.22146/jfps.7100","url":null,"abstract":"The possible uses of black pepper, a common spice used for cooking, have been expanded. Despite countless studies on its advantageous biological effects, it would be difficult to determine its effectiveness as an anti-aging and chemo-preventive medication. Piperine, chavicine, caryophyllene, and sabinene are a few examples of black pepper components that exhibit pharmacological characteristics. This article reviews black pepper's main ingredients and discusses how effective it is at preventing aging and cancer. Using Google Scholar, PubMed, and Medline for our electronic research, we screened pertinent papers from scientific journals. To help with the explanation in the narrative, all the data was compiled and summarized into tables and graphs. Overall, the anti-aging properties of black pepper and its constituents are exhibited through several pathways, including senescence prevention, antioxidant protection, control of ROS levels, and the inhibition of aging-related enzymes. Additionally, cell cycle regulation, antiangiogenic and anti-metastatic action, apoptosis induction, and the suppression of carcinogenesis are some of the mechanisms utilized in cancer prevention activities. It has been shown to have synergistic effects on several cancer cells when combined with doxorubicin. According to these studies, black pepper could be considered for development as an anti-aging and chemo-preventive agent.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"52 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138955422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DPPH Scavenging Activity, Reducing Power, and Metal Chelating Capacity of Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone 化合物 1-(2,5-二羟基苯基)-3-吡啶-2-基丙烯酮的 DPPH 清除活性、还原力和金属螯合能力

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-20 DOI: 10.22146/jfps.7317

Andy Eko Wibowo, Navista Sri Octa Ujiantari, R. A. Susidarti

{"title":"DPPH Scavenging Activity, Reducing Power, and Metal Chelating Capacity of Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone","authors":"Andy Eko Wibowo, Navista Sri Octa Ujiantari, R. A. Susidarti","doi":"10.22146/jfps.7317","DOIUrl":"https://doi.org/10.22146/jfps.7317","url":null,"abstract":"Background: The excessive free radicals in the body could stimulate oxidative stress which has been implicated in several diseases such as cancer, inflammation, aging, and cardiovascular diseases. The presence of antioxidants can diminish the reactivity of free radicals. The antioxidant defense system in the body may be insufficient thus intake of dietary antioxidants is recommended. Natural flavonoid such as chalcone has been known to exert several biological activities, especially antioxidant activity. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone was successfully synthesized using microwave radiation and several studies reported its biological activities such as antiinflammation, anticancer, and antibacterial activities. Those activities are thought to be related to antioxidant mechanisms. Therefore, this study aimed to evaluate its antioxidant activity. Methods: The antioxidant activities were performed with three different methods: DPPH scavenging activity, ferric reducing power, and metal chelating capacity. Results: 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone showed DPPH scavenging activity, ferric reducing power, and metal chelating capacity with IC50S values of 4,471 ± 0,052 μg/mL; 156.56 ± 4.42μg/mL; and 6,273 ± 0,025 μg/mL, respectively. Conclusions: Our results found that 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone had quite potent antioxidant activity.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"64 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Study of Caffeic Acid as Acetylcholinesterase Inhibitor 咖啡酸作为乙酰胆碱酯酶抑制剂的分子对接研究

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-12-18 DOI: 10.22146/jfps.7665

Stephanus Satria Wira Waskitha, Enade P Istyastono, Florentinus Dika Octa Riswanto

{"title":"Molecular Docking Study of Caffeic Acid as Acetylcholinesterase Inhibitor","authors":"Stephanus Satria Wira Waskitha, Enade P Istyastono, Florentinus Dika Octa Riswanto","doi":"10.22146/jfps.7665","DOIUrl":"https://doi.org/10.22146/jfps.7665","url":null,"abstract":"Abstract: Acetylcholinesterase (AChE) receptor is a receptor that has been widely used as a potential drug target for Alzheimer's disease. Caffeic acid is a phenolic compound that had been experimentally proven to be an inhibitor of AChE. In this study, 100 molecular docking simulations were performed to study the interaction of caffeic acid in inhibiting AChE. The molecular docking simulations were performed using YASARA software with an in-house developed plug-in. Redocking results showed that there were 99 out of 100 docking poses had an RMSD value of ≤ 2.000 Å, which indicated that the molecular docking procedure could be used for further processes. The molecular docking of caffeic acid showed that all docking poses had an RMSD value of ≤ 2.000 Å relative to the best pose of the first simulation, revealing that there was only one dominant docking pose in the AChE active site. Caffeic acid interacted favorably in the AChE active site with binding energy of about -8.022 kcal/mol. Its interactions were stabilized by hydrophobic and pi-anion interactions, in which some of the interactions resemble the same interaction of the native ligand. Keywords: Acetylcholinesterase, Alzheimer's disease, caffeic acid, molecular docking","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"198 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Characterization and Fatty Acid Profiles of Catfish Oil (Clarias gariepinus) 鲶鱼油的理化特征和脂肪酸谱图

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-07-16 DOI: 10.22146/jfps.7418

Karina Primatyas Ningrum, A. Rohman, Ronny Martien

引用次数: 0

Comparison of Xenograft and Alloplast Bone Grafts for Infrabony Bone Defect: Literature Review Xenograft 和 Alloplast 骨移植治疗骨缺损的比较：文献综述

Journal of Food and Pharmaceutical Sciences Pub Date : 2023-07-11 DOI: 10.22146/jfps.6962

Hesty Nurcahyanti, Martina Amalia

{"title":"Comparison of Xenograft and Alloplast Bone Grafts for Infrabony Bone Defect: Literature Review","authors":"Hesty Nurcahyanti, Martina Amalia","doi":"10.22146/jfps.6962","DOIUrl":"https://doi.org/10.22146/jfps.6962","url":null,"abstract":"Restoring supporting tissues to a healthy state is a critical area that provides a much more appealing beside prevention, initial therapy, and corrective procedure. Infrabony defects can be found in the interalveolar and marginal bone caused by periodontal disease as a result of local factors. Nowadays, various surgical therapies are available for treating infrabony defects such as bone graft. However, many considerations in selecting the best option of bone graft materials. To compare the effectiveness of Xenograft and Alloplast bonegraft in infrabony defect therapy. The allograft presented a significantly higher amount of newly formed bone than the xenograft. There were no differences in the percentage of newly formed bone between the allograft and the alloplastic graft, and between the alloplastic graft and the xenograft. Between the three types of grafts, there were no discernible changes in the percentage of remaining particles. All bone substitute materials shown favorable properties for use in bone regeneration treatments. Local factors such as oral hygiene and controlled chronic disease are the main point of successful bone graft therapy. The present study concludes that both Alloplast and Xenograft have equal potential in infrabony bone defect therapy.","PeriodicalId":314392,"journal":{"name":"Journal of Food and Pharmaceutical Sciences","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139360512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0