Journal of Clinical and Preventive Cardiology最新文献

{"title":"Atrial myxoma with malignant appearance and dual arterial supply","authors":"S. Nandal, A. Castles, O. Narayan","doi":"10.4103/JCPC.JCPC_18_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_18_20","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"123 - 124"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42175110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ebstein's anomaly with rheumatic mitral valve disease: A rare case report","authors":"K. Jena, J. Arul","doi":"10.4103/JCPC.JCPC_21_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_21_20","url":null,"abstract":"Ebstein's anomaly (EA) is a rare congenital heart disease characterized by the apical displacement of the septal and posterior leaflets of the tricuspid valve, leading to an atrialized right ventricle. The clinical presentation is varied, depending on the severity and associated cardiac anomalies. Here, we discuss a case of a 16-year-old young girl with EA and Wolff-Parkinson-White syndrome with rheumatic mitral valve stenosis.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"118 - 120"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45823645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commemorating James Lind: The man who gave us the concept of controlled clinical trials","authors":"S. Upadhyayula, R. Kasliwal","doi":"10.4103/JCPC.JCPC_40_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_40_20","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"92 - 93"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45213751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Page July 2020","authors":"R. Kasliwal","doi":"10.4103/2250-3528.296188","DOIUrl":"https://doi.org/10.4103/2250-3528.296188","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"91 - 91"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47496396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma high-density lipoprotein cholesterol responses to endurance exercise training: A meta-analysis of randomized controlled trials","authors":"M. Choudhary, Sun Runlu, Shivir Dahal, Robin Bhattarai, Rajesh Nepal, Yuling Zhang","doi":"10.4103/JCPC.JCPC_9_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_9_20","url":null,"abstract":"Background: Endurance exercise improves lipid and lipoproteins levels, while low high-density lipoprotein cholesterol (HDL-C) levels are risk factors for cardiovascular disease. There is a lack of evidence for the exercise characteristics in increasing lipids level, irrespective of the fact that endurance exercise increases lipids and lipoproteins level. The aim of this study was to clarify the effect and characteristics of endurance exercise in increasing HDL-C in randomized controlled trials. Methods: A search was performed for published studies between 1999 and 2014. Studies that assessed endurance exercise for ≥8 weeks and also reported the HDL-C levels pre- and post-training were included. The random effects model was used to measure the association between exercise and net change of HDL-C. Univariate regression analyses investigated the correlation of exercise characteristics. Subgroup and sensitivity analyses were performed to explore the sources of heterogeneity and the effect of potential confounders. The influence of pre-exercise lipid profile was assessed by meta-regression. Data were analyzed using Stata SE (12.0). Results: Fourteen studies with a total of 777 subjects were included. The mean HDL-C was reported to be increased and was statistically significant (weighted mean difference: 4.41 mg/dL; 95% confidence interval [CI]: 2.16–6.66 mg/dL, P < 0.001; I2 = 87.4%, P < 0.001). Univariate analysis indicated that exercise length was significantly associated with a net change of HDL-C (r = 0.56, P = 0.01). Nevertheless, there was no significant association between exercise frequency, duration, and total minutes. By subgroup analysis, exercise increased HDL-C level in Asia, Europe, and Africa and among all body mass index groups (P < 0.05). None of the studies omitted, in turn, seemed to substantially influence the effect of exercise on HDL-C by sensitivity analysis. Meta-regression showed that pre-exercise total cholesterol (TC) negatively correlated with net change of HDL-C (95% CI: 0.127, −0.018, r = −0073, P = 0.012). However, pre-exercise triglycerides, low-density lipoprotein cholesterol, and HDL-C did not correlate with a net change of HDL-C. Conclusions: Regular endurance exercise increases HDL-C level in any weight population. Exercise length of more than 8 weeks was the most important element of an exercise prescription. Among all lipid profiles, only the initial lower TC level responded better to exercise training and was more effective in increasing HDL-C level.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"107 - 117"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48820913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Hospital and 1 year outcomes of octogenarian Indian patients with heart disease: Results from the elder heart registry","authors":"S. Ahmad, C. Koshy, G. Koshy, K. Jacob, K. Venugopal","doi":"10.4103/JCPC.JCPC_22_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_22_20","url":null,"abstract":"Aim: The Elder Heart Registry aims to study the demographics, clinical profile, in-hospital, and 1 year outcomes of octogenarian patients (≥80 years) with acute cardiovascular disease. Materials and Methods: This is a prospective observational, longitudinal cohort, single-center registry of octogenarian cardiac patients admitted to the cardiology intensive care unit (CICU) at a tertiary care teaching hospital in Kerala, India for 2 years. Data analysis was performed using SPSS version 20 software. Results: From a total of 4199 patients admitted to the CICU, the Registry enrolled 406 patients aged ≥80 years, which constituted 9.6% of the total admissions (mean age 84.24 ± 3.67 years, male-to-female ratio of 1.15:1, mean follow-up of 1.2 years). Acute coronary syndromes (ACS) constituted 42.1% of admissions, with ST-elevation myocardial infarction in 22.2%, non-ST elevation myocardial infarction in 64.3%, and unstable angina in 13.4%. Presentation with heart failure (HF) was seen in 36.4% of patients, with HF with preserved ejection fraction (HFpEF) in 51.7%. The rates of in-hospital mortality, mortality on follow-up and rehospitalization were 14.0%, 9.3%, and 21% in the ACS group, and 9.4%, 8.1% and 18.9% in the HF group, respectively (12.1%, 8.6%, and 15.5% in the HF with reduced ejection fraction subset and 10%, 8.3%, and 20% in the HFpEF subset). Atrial fibrillation was the most common arrhythmia (16.5%). Apart from systemic hypertension (77.3%) and diabetes mellitus (53.9%), co-morbidities noted were chronic kidney disease (16.7%), obstructive airway disease (8%), thyroid disorders (4%), significant anemia (3%), depression (2.5%), and malignancy (2%). Conclusions: Octogenarians constitute almost 10% of all admissions to the CICU. ACS and HF are the major cardiac causes for hospitalization among these very elderly patients. The Elder Heart Registry is currently the largest series of octogenarian cardiac patients from India.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"94 - 101"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45607462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotension in cath lab, a rare cause…","authors":"V. Guleria, Prafull Sharma","doi":"10.4103/JCPC.JCPC_19_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_19_20","url":null,"abstract":"Sudden onset of hypotension during a procedure makes interventionalist perturbed. In cath lab, hypotension is a red flag sign, and the causes are diverse, ranging from vasovagal, cardiac tamponade, or a significant bleed somewhere, keeping the operators on their toes. We had a similar ordeal recently when a patient developed prolonged hypotension requiring inotrope and vasopressor support after local anesthesia. This case will act as a sensitizer to practitioners and make them more vigilant for the symptoms of toxicity after local anesthetic administration.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"121 - 122"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45182002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Page April 2020","authors":"R. Kasliwal","doi":"10.4103/JCPC.JCPC_39_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_39_20","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"39 - 39"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47281497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year clinical outcomes of drug-eluting stents versus bare-metal stents in large coronary arteries","authors":"Roopesh R. Singhal, J. Prajapati, I. Patel, C. Patel, S. Sahoo","doi":"10.4103/JCPC.JCPC_56_19","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_56_19","url":null,"abstract":"Background: Drug-eluting stents (DESs) have been shown to reduce the risk of restenosis and other adverse cardiac events after percutaneous coronary intervention (PCI) as compared with bare-metal stents (BMSs). However, the superiority of DES over BMS has been questioned in large vessels. We evaluated the risks and benefits of the use of DES versus BMS in patients who undergo stenting of large coronary arteries (≥3.5 mm) up to 1-year follow-up. Materials and Methods: This was a prospective study carried out in all-comer patients enrolled between January 2015 and December 2015. The patients with the variable indication for PCI, multivessel involvement, prior revascularization, and adjuvant drugs such as GP IIb–IIIa inhibitors were included in the study. However, patients who did not provide written informed consent and received both DES and BMS were excluded from the study. The clinical outcomes were evaluated at 1 year. Results: A total of 266 lesions (240 patients) in the large coronary arteries were stented, of which 130 lesions were treated with BMS and 136 lesions were treated with DES. At 1-year follow-up, target lesion revascularization/target vessel revascularization (P = 0.6492) and all-cause death (P = 0.7098) did not differ significantly between the two groups. In addition, no significant difference was found in patients requiring medical management (P = 0.3937) as well as number of asymptomatic patients (P = 0.2027). Conclusions: At 1-year follow-up, BMSs and DESs showed similar clinical outcomes in large coronary arteries. Hence, the use of BMS in large coronary arteries (≥3.5 mm) should not be discouraged unless clinically indicated.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"56 - 60"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48344410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of neutrophil-to-lymphocyte ratio, triglycerides, and high-density lipoprotein cholesterol in assessing the severity of coronary artery disease","authors":"S. Mangalesh, Paras Yadav, S. Dudani, N. Mahesh","doi":"10.4103/JCPC.JCPC_7_20","DOIUrl":"https://doi.org/10.4103/JCPC.JCPC_7_20","url":null,"abstract":"Context: Coronary artery disease (CAD) occurs as a consequence of dyslipidemia and chronic inflammation. Cardiovascular disease mortality is on the rise in India. Aims: Explore the utility of simple markers such as neutrophil-to-lymphocyte ratio (NLR) and triglyceride/high-density lipoprotein cholesterol (TG/HDLc) ratio, to study the extent of coronary lesions as seen on angiography. Settings and Design: Observational study in a tertiary-care hospital in North-India. Methodology: Coronary angiograms of 126 outpatients were graded as per Friesinger Index. Lipid profile was analyzed for each patient, along with complete blood count parameters, including total leukocyte count (TLC), absolute neutrophil, and lymphocyte counts and mean platelet volume (MPV). Statistical Analysis Used:Comparison of groups was done using a Mann–Whitney U test, of continuous variables using a correlation coefficient, and of categorical variables using a Chi-square test, and odds ratios were estimated. Receiver operator characteristic curves were constructed, and cutoffs were obtained. Results: TG/HDLc-ratio was associated with severe coronary lesions (Friesinger-Index ≥5) [odds ratio (OR): 3.46; 95% confidence interval (CI): 1.32–9.10], which was stronger than the association of TG [OR: 3.15; 95%CI: 1.33–7.42] or HDLc [OR: 1.86; 95%CI: 0.81–3.82] alone. No association existed for total or low-density lipoprotein cholesterol. NLR was significantly higher among patients with severe lesions. NLR and MPV were significantly correlated with TG/HDLc ratio. Area under curve for TG/HDLc ratio and NLR was 73.7 and 60.8. Cutoff values were 2.53 (Sensitivity (SN) = 83.1%, Specificity (SP) = 56.7%) and 1.84 (SN = 61.0%, SP = 49.3%), respectively. Conclusions: TG/HDLc ratio and NLR are associated with CAD severity, more so than TG or HDLc alone, or TLC. They are easily accessible and inexpensive markers that may be utilized in identifying patients at risk for heart disease.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"9 1","pages":"51 - 55"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41489215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}