Journal of Clinical and Preventive Cardiology最新文献

{"title":"Relationship between blood pressure variables (Systolic Blood Pressure, Diastolic Blood Pressure, Pulse Pressure, and Mean Arterial Pressure) and left atrial measurements among hypertensive subjects in a Tertiary Hospital in South-South Nigeria","authors":"A. Henry, E. Umuerri, Aisosa Ogbomo, J. Osarenkhoe, A. Obasohan","doi":"10.4103/jcpc.jcpc_16_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_16_22","url":null,"abstract":"Background: Hypertension is known to impact significant changes on the heart causing left ventricle diastolic dysfunction which precedes a sequel of anatomical and functional changes in the left atrium. Since hypertension remains the leading cause of diastolic dysfunction in the heart, it is expedient to determine how changes in the blood pressure of patients relate to measures of left atrial (LA) indices. Aims and Objectives: to determine how changes in blood pressure parameters relate to measures in LA indices. Materials and Methods: The study was a descriptive cross-sectional appraisal of 200 hypertensive patients and 100 normotensive controls (matched for age and sex in a 2:1 ratio) using electrocardiography and echocardiography. Participants were recruited from the cardiology clinics in Delta State University Teaching Hospital (DELSUTH), Oghara. Results: The mean age of the study population was 58.7 ± 13.96 (58.42 ± 13.29 for hypertensives and 59.26 ± 15.27 for controls) years, while the median age was 59 years. The female-to-male ratio was 1.06 among cases and 1.27 among the controls. The LA size (volumes and linear diameter) was significantly larger in the hypertensive group compared to the control arm. LA maximum volume correlated significantly with average systolic blood pressure, pulse pressure, and mean arterial pressure. LA pre A wave volume and LA minimum volume correlated significantly with average systolic blood pressure and pulse pressures. Conclusion: Hypertensive patients have larger LA volumes than normotensive controls. The size of the left atrium relates positively with blood pressure variables.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"64 - 68"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48354313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced liver injury: A primer for cardiologists","authors":"N. Choudhary, N. Saraf, Vinod Kumar, M. Bansal, R. Kasliwal","doi":"10.4103/jcpc.jcpc_8_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_8_22","url":null,"abstract":"Although drug-induced liver injury (DILI) is an uncommon diagnosis, it is an important cause of morbidity and mortality in hepatology practice. A timely diagnosis of DILI is important to stop causative drugs and keeping a high index of suspicion is important. There is no gold standard single test to diagnosed DILI, causality scores help in establishing a diagnosis. DILI presenting as acute liver failure is associated with poor prognosis in natural course. The association of nonalcoholic fatty liver disease with cardiac disease makes it more important to think of DILI in a patient with liver dysfunction. We discuss various aspects of DILI in cardiology context in the current review.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"79 - 82"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46564897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of serum cholinesterase in acute myocardial infarction","authors":"Krishna Reddy Parvathareddy, Raghava Balla, Praveen Nagula, Srinivas Ravi, S. Maale, Monica Rayapu","doi":"10.4103/jcpc.jcpc_18_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_18_22","url":null,"abstract":"Background: Autonomic dysfunction has a prognostic significance in various cardiovascular (CV) disorders, particularly atherosclerotic coronary artery disease (CAD). Previous studies are few, regarding the association of parasympathetic dysfunction with increased complications in patients with the acute coronary syndrome, a subset of CAD. We aimed to study the correlation of trends in the serum cholinesterase (sChE) levels, the marker of parasympathetic activity, with the occurrence of major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients. Methodology: We prospectively observed the levels of sChE in patients with STEMI on the day of admission, day 3, and day 5 along with routine biochemical profile, electrocardiogram, echocardiography, and coronary angiography. The patients were monitored during the hospital stay and were followed up at 1 month for the occurrence of any MACE. The MACE monitored was cardiac death, complete heart block, arrhythmias, and heart failure. The sChE levels are laboratory dependent and a value between 4000 and 14000 IU/L was considered normal in our laboratory. A value <4000 IU/L is noted as a low sChE level. The receiver operating characteristic curve was plotted for the cut off value of the sChE levels to predict the outcomes of patients. Results: Of the 100 STEMI patients studied, the sChE levels were persistently lower in patients who had MACE compared to those without MACE during the hospital stay and at month follow-up, which was statistically significant. A sChE <3745 IU/l on day 5 predicted an increased MACE with a sensitivity of 93.55% and specificity of 92.11%. Conclusion: A persistently low sChE levels from the day of admission can predict MACE in STEMI patients. Larger studies with prolonged follow-up are required for the causal association in the future.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"69 - 73"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42148320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Page July 2022","authors":"R. Kasliwal","doi":"10.4103/2250-3528.361696","DOIUrl":"https://doi.org/10.4103/2250-3528.361696","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"63 - 63"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47046651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest pain as presentation of monkeypox: A note","authors":"R. Mungmunpuntipantip, V. Wiwanitkit","doi":"10.4103/jcpc.jcpc_19_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_19_22","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"83 - 83"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49458599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac surgery-associated acute kidney injury: The core of etiology, treatment, and prognosis","authors":"D. Karathanasis, Christos-Rafail Karathanasis, Androula Karaolia","doi":"10.4103/jcpc.jcpc_5_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_5_22","url":null,"abstract":"Cardiac surgery-associated acute kidney injury (CS-AKI) is a very serious and common complication after heart surgery. Standard knowledge of the etiology, treatment, and prognosis is a prerequisite for effective therapy. The etiology includes a set of predisposing pre-, intra-, and postoperative factors with varying incidence and severity. Although not specified yet, the treatment involves standard and modern modalities based on medication, nutrition, and dialysis as well as on alleviative measures. CS-AKI enhances the incidence of infections and hospitalization leading to increased morbidity and overall mortality. Early diagnosis and treatment reduce the risk of transition to a more severe stage of AKI or chronic kidney disease.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"74 - 78"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46418223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 pandemic induced lockdown on management of myocardial infarction: An Indian survey report from the experiences by 1083 cardiologists","authors":"C. Ponde, Dharmendra Jain, Manjula Suresh, S. Gunasekaran, Sundeep Mishra, T. Alexander, T. Nair","doi":"10.4103/jcpc.jcpc_55_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_55_21","url":null,"abstract":"Background: COVID-19 has induced a change in the management of myocardial infarction (MI). Methods: We developed a customized technological virtual response system for mapping exercise, during August 14–28, 2020, to understand the management of MI. Prior telephonic consent was obtained, and the weblink of the questionnaire was provided on individual WhatsApp. Anonymized data were statistically analyzed by GraphPad software version 8.4.3. Results: The mean year of experience in active clinical practice was 12 years (standard deviation 10, 95% confidence interval 12–13). There were 41% (n = 445) participants who reported reduction by 25%–29% of MI patients, reporting to hospital, followed by 27.8% (n = 302) participants, reporting that <25% patients with MI approached the hospital. Sixty percent reported as the most important reason for a decrease in cases of MI patient's fear of contracting COVID-19 (n = 648), followed by limited transportation by 20.49% (n = 222) participants. There were health-care-driven reasons for a decrease in MI primary percutaneous coronary intervention activations. These included cardiologist's reluctance to do primary percutaneous cardiovascular interventions (PCI) due to COVID-19 and patients presenting late beyond the optimal window for PCI/thrombolysis by 34.71% (n = 376) and 31% (n = 341) of participants, respectively. There were 68.5% (n = 742) of respondents that were of opinion that the time component of MI care that has increased most was time between symptom onset to first medical contact, followed by time between medical contact to catheterization laboratory arrival, as opined by 20% (n = 217) of the participants. It was reported that patients undergoing no reperfusion due to delayed treatment were increased to less than 25%, as reported by 43.4% (n = 471), respondents. This was followed by 32.5% (n = 352), respondents reporting that there was 26%–50% increase in the number of patients undergoing no reperfusion due to delayed treatment. Immediate thrombolysis was preferred by 28% (n = 304) of participants from the teaching institutions. There were 75.1% (n = 814) of the participants, that tested patients for COVID-19 before shifting to the catheterization laboratory. Conclusion: This is one of the largest perception mapping exercises, limited with the absence of actual patient data, which is a cohesive reflection in line with global evidence for a remarkable decrease in cases and interventions for the management of MI. The lessons from the experiences entail that there is a need to encourage patients with symptoms suspected of MI to promptly contact emergency services to enable timely diagnosis and enable reperfusion therapy. Impact on the MI management appears to be substantial, which calls for action for change in infrastructure and policy framework to improvise MI care.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"30 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46609496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial myxoma in a patient with hypertrophic obstructive cardiomyopathy","authors":"Jayaprasad Narayanapillai, Suresh Madhavan","doi":"10.4103/jcpc.jcpc_12_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_12_22","url":null,"abstract":"Hypertrophic cardiomyopathy and left atrial myxoma are important cardiac causes of syncope. We present an extremely rare combination of these two diseases in a middle-aged man with syncope. Transthoracic echocardiographic images show the typical features of both conditions. There were no features of progressive cardiomyopathic lentiginosis (LEOPARD syndrome) which is known to be associated with both the conditions.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"60 - 62"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48331699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical and biochemical parameters of trinidadian patients with coronary artery disease for predicting the revascularization strategy","authors":"T. Monplaisir, B. Nayak, Geetha Bhaktha, R. Ali, S. Mohan, J. Ambrose","doi":"10.4103/jcpc.jcpc_46_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_46_21","url":null,"abstract":"Background: In recent times, optimal revascularization approaches have been used for treating multi-vessel obstructive coronary artery disease (CAD) patients. Based on the disease severity, making the decision to perform a suitable revascularization intervention in the patients is of paramount importance. Aim: This study aimed to evaluate the biochemical parameters of patients with suspected CAD in Trinidad and assess their clinical significance for predicting revascularization strategy. Materials and Methods: One hundred and twenty-four patients referred for angiography were recruited for the study. Biochemical parameters such as fasting blood sugar (FBS), lipid profile, cardiac enzymes, creatinine, uric acid, N-terminal probrain natriuretic peptide (NT-proBNP), soluble ST2, interleukin 6, and hemoglobin A1C (HbA1c) were explored. Similarly, we examined clinical parameters such as age, the presence of chronic conditions, and ethnicity. Results: With respect to revascularization strategies, FBS, NT-proBNP, HbA1c, and soluble ST2 correlated moderately with coronary artery bypass grafting (CABG) by Point-Biserial correlations: FBS-r = 0.196, P = 0.029, NT-proBNP-r = 0.208, P = 0.020, soluble ST2-r = 0.178, P = 0.048, and HbA1c-r = 0.282, P = 0.001. The presence of Type 2 diabetes (T2D) at baseline and ethnicity also formed statistically significant associations with CABG-ethnicity (χ2 (1) =7.267, P = 0.007) and T2D at baseline (χ2 (1) =12.858, P < 0.001). Conclusion: Ethnicity and presence of T2D were also significantly associated with both CAD severity and revascularization decision-making and should be taken into consideration for further study. Further investigation of these parameters might prove to be useful to predict the revascularization strategy required for treating CAD patients.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"50 - 55"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47363662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of coronary artery calcium score for excluding obstructive coronary artery disease","authors":"M. Bansal, Devender Kumar Sharma, R. Kasliwal","doi":"10.4103/jcpc.jcpc_1_22","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_1_22","url":null,"abstract":"Background: Studies in western populations have shown that zero coronary artery calcium score (CACS) is associated with a very low prevalence of obstructive coronary artery disease (CAD), even in patients presenting with chest pain. However, no data are available about the relationship between CACS and coronary artery plaques among Indian subjects. Methods: A total of 380 subjects undergoing comprehensive health check, including computed tomography coronary angiography (CTCA), at a tertiary care center in North India were included. The distribution of CACS was correlated with the coronary plaque burden and with the clinical and laboratory investigation findings. Results: The mean age of the subjects was 52.8 ± 10.0 years, and 71.8% were men. The median CACS value in the study population was 0 (interquartile range 0–4.3). Two-third of all the subjects had zero CACS and 91 (23.9%) had CACS between 1 and 99. Nonobstructive and obstructive (>50% stenosis) plaques were found in 106 (27.9%) and 24 (6.3%) subjects, respectively. Only 5.9% of the subjects with zero CACS had any coronary plaque and only 1.2% had obstructive plaques, yielding zero CACS 98.8% negative predictive value for excluding obstructive disease. Conclusion: This study shows that similar to the western populations, in Indian subjects also, zero CACS is associated with a very low prevalence of obstructive CAD and has excellent negative predictive value for ruling it out. Further large studies in diverse patient subgroups, including those with stable or unstable chest pain, are required to validate these findings.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"11 1","pages":"44 - 49"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43464772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}