Periodontology and Dental Implantology最新文献

Chemically Modified Tetracyclines 化学修饰四环素

Periodontology and Dental Implantology Pub Date : 2019-01-23 DOI: 10.5772/INTECHOPEN.79724

Anshul Sawhney

{"title":"Chemically Modified Tetracyclines","authors":"Anshul Sawhney","doi":"10.5772/INTECHOPEN.79724","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79724","url":null,"abstract":"The use of chemotherapeutic agents or drugs specifically designed to treat periodontal diseases is emerging to aid in this risk assessment and reduction strategy. They include locally applied and systemically delivered antimicrobials and host modulatory thera - pies. Tetracyclines are a group of antibiotics produced naturally from certain species of Streptomyces or derived semisynthetically. Their advantages were broad-spectrum activ ity, better tolerated, and less toxic to some individuals. Further modifications of these natural products by means of synthetic reactions and reagents led to the production of the clinically used antibiotic tetracycline compounds—minocycline, doxycycline, and methacycline. Tetracyclines are now recognized to have non-antimicrobial properties that may also be therapeutically advantageous. They have anti-inflammatory properties, particularly in the treatment of certain skin diseases. One important aspect is their abil ity to inhibit host collagenolytic enzymes, an effect that inhibits the connective tissue degradation and thus preventing bone resorption. To identify the site of the anticollage nase property, Golub and co-workers in 1991 synthesized 10 different analogs of tetra - cyclines known as chemically modified tetracyclines (CMTs 1-10). All 10 analogs lacked antimicrobial efficacy and inhibited collagenase activity, but only 1 did not. Though not approved for human use by the FDA, preliminary studies using CMT-3 are being inves tigated on humans with cancer.","PeriodicalId":310586,"journal":{"name":"Periodontology and Dental Implantology","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124932874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aggressive Periodontitis 积极的牙周炎

Periodontology and Dental Implantology Pub Date : 2019-01-23 DOI: 10.1002/9781119312093.ch1

A. Lektemur Alpan

引用次数: 36

Platelet-Rich Fibrin: Utilization in the Treatment of Periodontitis 富血小板纤维蛋白在牙周炎治疗中的应用

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78561

A. Goel, L. Windsor, S. Blanchard

引用次数: 0

Immediate Dentoalveolar Restoration in Compromised Sockets: Technique and Bone Biology 受损牙槽骨即刻修复:技术与骨生物学

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78619

J. Rosa

引用次数: 0

Immunomodulatory Properties of Dental-Derived Mesenchymal Stem Cells 牙源性间充质干细胞的免疫调节特性

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78049

O. Andrukhov, C. Behm, A. Blufstein, X. Rausch-Fan

{"title":"Immunomodulatory Properties of Dental-Derived Mesenchymal Stem Cells","authors":"O. Andrukhov, C. Behm, A. Blufstein, X. Rausch-Fan","doi":"10.5772/INTECHOPEN.78049","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78049","url":null,"abstract":"Mesenchymal stem cells are considered as an attractive tool for tissue regeneration. Almost all dental tissues contain a population of MSC-like cells, which were extensively studied within the last few years. Besides their ability to differentiate into different cell types, dental MSCs also possess strong immunomodulatory properties. Dental MSCs modulate both innate and adaptive immune response and influence the activity of almost all components of the immune system. The interaction between dental MSCs and the immune system is reciprocal because immunomodulatory activity of MSCs is strongly regulated by cytokines produced by immune cells. MSCs isolated from inflamed tissues might exhibit impaired immunomodulatory capacity, suggesting a potential role of these cells in inflammatory diseases and particularly periodontitis. Recent studies suggest that immunomodulatory properties of MSCs can also play an important role in their tissue regenerative capacity. The therapeutic effects of MSCs, including their immunomodulatory capacity, are largely explained by their tropic activity, including production of immunomodulatory proteins and growth factors. Summarizing, dental MSCs play an important role in tissue homeostasis under healthy and diseased conditions.","PeriodicalId":310586,"journal":{"name":"Periodontology and Dental Implantology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125583629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Post-Operative Pain Following Non-Surgical and Surgical Periodontal Procedures 非手术和手术牙周手术后疼痛

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78728

D. Gillam, D. Chatzopoulou

引用次数: 2

Optical Diagnostics to Improve Periodontal Diagnosis and Treatment 光学诊断改善牙周诊断和治疗

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.76888

F. Shakibaie, L. Walsh

{"title":"Optical Diagnostics to Improve Periodontal Diagnosis and Treatment","authors":"F. Shakibaie, L. Walsh","doi":"10.5772/INTECHOPEN.76888","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76888","url":null,"abstract":"The performance of clinicians undertaking periodontal assessment or periodontal therapy can be improved by using optical methods as adjuncts to visual inspection and periodontal probing. Subtle changes that occur over time in periodontal tissues that are below the detection limit of visual examination or periodontal probing can be found and tracked accurately over time using 3D imaging, fluorescence spectroscopy, and optical coherence tomography. During debridement of teeth and dental implants, the effective removal of subgingival microbial biofilms and dental calculus deposits can be enhanced using magnifying loupes and operating microscopes and by novel methods based on the interactions of light with bacterial deposits, such as differential reflectometry and light-induced fluorescence. While such techniques can also be used using initial case assessment, their primary purpose is for checking debridement procedures, since the point when bacterial deposits are no longer present represents an endpoint for treatment. The concept of real-time feedback has been developed, using fluorescence readings to control the removal of deposits. Overall, optical methods can support traditional periodontal diagnosis and improve treatment planning and clinical periodontal care.","PeriodicalId":310586,"journal":{"name":"Periodontology and Dental Implantology","volume":"314 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114048482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Supportive Periodontal Therapy for Dental Implant Patients 种植牙患者的支持牙周治疗

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.77950

Krishna Kripal, Kavita Chandrasekaran

引用次数: 0

Clinical Application of Enamel Matrix Derivative for Periodontal Regeneration and Treatment of Peri-Implantitis 牙釉质基质衍生物在牙周再生及种植周炎治疗中的临床应用

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78595

Jun-Beom Park

{"title":"Clinical Application of Enamel Matrix Derivative for Periodontal Regeneration and Treatment of Peri-Implantitis","authors":"Jun-Beom Park","doi":"10.5772/INTECHOPEN.78595","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78595","url":null,"abstract":"One of the goals of periodontal therapy is to regenerate lost supporting structures that have been destroyed by periodontal disease. Treatment procedures including various bone grafts, guided tissue regeneration, use of enamel matrix derivative, or combina- tions of the aforementioned have been suggested as regenerative periodontal therapies to achieve this goal. Enamel matrix derivative is composed of a number of proteins, 90% of which are amelogenins, and these proteins are thought to induce the formation of periodontal attachment during tooth formation. Previous reports have shown that enamel matrix derivative was able to improve clinical attachment level and reduce probing depth. The results of previous controlled clinical trials have shown that using enamel matrix derivative in combination with bovine porous bone mineral may enhance the regenerative outcome with regard to the clinical attachment level gain compared with using the enamel matrix derivative alone. In this chapter, an extensive review of the role of enamel matrix derivate will be performed using in vitro and in vivo studies. Clinical implications of the enamel matrix derivative will also be discussed.","PeriodicalId":310586,"journal":{"name":"Periodontology and Dental Implantology","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132940003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Periodontal Diseases in Patients with Special Health Care Needs 有特殊保健需要的病人的牙周病

Periodontology and Dental Implantology Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78348

M. Gomes, Andrea Carvalho De Marco, L. Giannasi, M. C. Salgado

{"title":"Periodontal Diseases in Patients with Special Health Care Needs","authors":"M. Gomes, Andrea Carvalho De Marco, L. Giannasi, M. C. Salgado","doi":"10.5772/INTECHOPEN.78348","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78348","url":null,"abstract":"A wide variation of people with an impairment or disability requires a “special care den- tistry” once their general manifestations directly act in the oral cavity. This target public is inserted into the following categories: neuromotor disability, sensory disability, mental disorder, infecto-contagious diseases, chronic systemic diseases, and systemic conditions. Among the several oral illnesses found in these groups, periodontal diseases have been the most frequent, becoming a major challenge for the dental practitioners. Thus, we described the microbiological, histopathological, and clinical features of periodontal diseases in each “special health care needs” group. Advances in “Omic” technologies have suggested the application of molecular biology methods to assess the genomics (genes), proteomics (proteins), transcriptomics (mRNA), and metabolomics (metabolites) aspects of periodontal diseases. These researches aim to promote a better understanding of the mechanisms involved in the pathogenesis and in the identification of new bio markers of periodontal diseases that help in diagnosis of periodontal diseases and in tis- sue responses after treatments of gingivitis and periodontitis. As an alternative therapy, some bioactive materials and photobiomodulation may be indicated once they strongly stimulate the periodontal tissue regeneration, attenuate the inflammatory processes, and/ or promote the reconstruction of the microstructure of the periodontium.","PeriodicalId":310586,"journal":{"name":"Periodontology and Dental Implantology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123000040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1