Jiao-Jiao Zhang, Xin Shen, Yong-Ming Yan, Yan Wang, Yong‐Xian Cheng
{"title":"Discovery of anti-SARS-CoV-2 agents from commercially available flavor via docking screening","authors":"Jiao-Jiao Zhang, Xin Shen, Yong-Ming Yan, Yan Wang, Yong‐Xian Cheng","doi":"10.31219/osf.io/vjch2","DOIUrl":"https://doi.org/10.31219/osf.io/vjch2","url":null,"abstract":"Flavor and spice is largely consumed in food, cosmetics, and pharmaceutical industries. A novel coronavirus, recently named the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was first identified in humans in Wuhan China in 2019. This study is to examine whether the flavor components can prevent human from SARS-CoV-2 infection. Given that the druggable antiviral target ACE2 receptor and viral main protease were reported, 169 compounds were screened against these two targets by using autodock vina. According to our docking screening, 10 antiviral components, including glycyrrhizic acid, theaflavin 3,3'-digallate, agnuside, fenflumizole, angelicide, sageone, oleanic acid, benzyl (3-fluoro-4-morpholine-4-yl phenyl) carbamate, glycerol ester of rosin, and endere S can directly bind to both host cell target ACE2 receptor and viral target main protease, indicating their potential for SARS-CoV-2 treatment.","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"24 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133011572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew L. Tomlinson, Man Zhao, Elaine J. Barclay, Jie Li, Haixiu Li, J. Felix, L. Hill, G. Saalbach, M. Rejžek, Dongfeng Yang, Qing Zhao, Paul Kroon, Wei Wang, Y. Bao, M. Howes, E. Tatsis, Cathie Martin
{"title":"Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis","authors":"Matthew L. Tomlinson, Man Zhao, Elaine J. Barclay, Jie Li, Haixiu Li, J. Felix, L. Hill, G. Saalbach, M. Rejžek, Dongfeng Yang, Qing Zhao, Paul Kroon, Wei Wang, Y. Bao, M. Howes, E. Tatsis, Cathie Martin","doi":"10.48130/mpb-2022-0003","DOIUrl":"https://doi.org/10.48130/mpb-2022-0003","url":null,"abstract":"","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133281047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yueli Tang, Li-en Xiang, Fangyuan Zhang, K. Tang, Z. Liao
{"title":"Metabolic regulation and engineering of artemisinin biosynthesis in A. annua","authors":"Yueli Tang, Li-en Xiang, Fangyuan Zhang, K. Tang, Z. Liao","doi":"10.48130/mpb-2023-0004","DOIUrl":"https://doi.org/10.48130/mpb-2023-0004","url":null,"abstract":"","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131897391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrated analysis of transcriptome, small RNA, and phytohormonal content changes between Artemisia annua Linn. and Nicotiana benthamiana Domin in heterogeneous grafting","authors":"Boran Dong, Shunuo Li, Xingxing Wang, Shi-yuan Fang, Jinxing Li, Zongyou Lv, Wansheng Chen","doi":"10.48130/mpb-2023-0002","DOIUrl":"https://doi.org/10.48130/mpb-2023-0002","url":null,"abstract":"Grafting, one of the artificial propagation methods used in plants, is now widely used in flower breeding, vegetable cultivation and stress response research. In order to discover the reason for success of heterograft and information exchange mechanisms, we used Artemisia annua (Aa) as scion and Nicotiana benthamiana (Nb) as rootstock to build a grafting model. After grafting 30 days co-growth, 7,794 DEGs (different expression genes) and 8,214 DEGs were identified in Aa scion and Nb rootstock, respectively. Most of the DEGs belong to defense response and signal transduction in scion and substance metabolism in rootstock, which indicate that the diverging response mechansim of grafted parts. Fifty Nb genes and 20 Aa genes were detected in Aa scion and Nb rootstock, which were regarded as potentially active genes during the grafting process. The most abundant miRNAs are miR159 and miR166 , which may be closely related to their conservation and physiological functions. Besides, miR159 and miR166 could quickly respond to internal change, therefore the two miRNAs should be considered as biomarkers of successful grafting models. And then, as simultaneously screened miRNAs, miR396 and miR6149 could be potential biomarker in Aa and Nb, respectively . Through the analysis of the miRNA-target gene network in differentially expressed miRNAs, transcription factor R2R3-MYB, bHLH , GRAS , GAMYB , SBP-box , MADS-box , IIS in","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129493695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan-qing Ma, Licheng Guo, W. Hou, Jinsheng Zhuo, Min Zhao, Yang-Yun Liu
{"title":"Phytochemistry, bioactivities, and future prospects of Callicarpa nudiflora: A review","authors":"Yan-qing Ma, Licheng Guo, W. Hou, Jinsheng Zhuo, Min Zhao, Yang-Yun Liu","doi":"10.48130/mpb-2022-0005","DOIUrl":"https://doi.org/10.48130/mpb-2022-0005","url":null,"abstract":"","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114626774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Establishment of a convenient ChIP-seq protocol for identification of the histone modification regions in the medicinal plant Andrographis paniculata","authors":"Ling Zhang, Wai-Shing Yung, Yufang Hu, Liping Wang, Wei Sun, Mingkun Huang","doi":"10.48130/mpb-2023-0006","DOIUrl":"https://doi.org/10.48130/mpb-2023-0006","url":null,"abstract":"","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117295199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharpkate Shaker, Zhimin Hu, Z. Wang, G. Ye, Jin-Chen Long, Xin Zhai, X. Qiao, M. Ye
{"title":"Functional characterization of a UDP-xylose-preferring C-glycosyltransferase from Lemna aequinoctialis","authors":"Sharpkate Shaker, Zhimin Hu, Z. Wang, G. Ye, Jin-Chen Long, Xin Zhai, X. Qiao, M. Ye","doi":"10.48130/mpb-2022-0002","DOIUrl":"https://doi.org/10.48130/mpb-2022-0002","url":null,"abstract":"","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133266338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing Huang, Xiaojie Yan, Rongjun Liao, Kao-hua Liu, L. Qin, B. Zhu
{"title":"Lindera aggregata (Sims) Kosterm: A Systematic Review of its Traditional Applications, Phytochemical and Pharmacological Properties, and Quality Control","authors":"Qing Huang, Xiaojie Yan, Rongjun Liao, Kao-hua Liu, L. Qin, B. Zhu","doi":"10.48130/mpb-2023-0011","DOIUrl":"https://doi.org/10.48130/mpb-2023-0011","url":null,"abstract":"Lindera aggregata (Sims) Kosterm (LA), a traditional medicinal herb, has been used since long as a regulator of \"Qi\" (vital energy) in China, for treating chest and abdominal pain, bladder deficiency, hernia, bladder cold, dysmenorrhea, and frequent enuresis and urination. This article describes a systematic review of botanical characteristics; traditional applications; and phytochemical, pharmacological, pharmacokinetic, and toxicological properties of LA through the collation and discussion of literatures from several databases, namely Elsevier, Web of Science, SciFinder, PubMed, CNKI, ScienceDirect, and Google Scholar, as well as Master's theses and Doctoral dissertations. Thus far, over 166 chemical components have been isolated from LA, including alkaloids, sesquiterpenoids, flavonoids, cyclopentanedione derivatives and enantiomers of ketone derivatives, disesquiterpenoid-geranylbenzofuranone conjugates, benzenoids, and benzenoid glycosides. Crude extracts of LA and its purified compounds are used for treating inflammation, tumor, hyperlipidemia, alcoholic liver disease, diarrhea, abdominal pain, and antibiotics; thes3be extracts and compounds possess broad pharmacological properties with anti-inflammatory activity, liver protection effect, antitumor effect, lipid lowering effect, antibacterial and analgesic effects, and kidney protection activity. Additional studies are needed to confirm the relationship between the traditional effects of LA and modern pharmacological research. Hence, we suggest that future investigations on LA should emphasize on modern pharmacological research to confirm or support its traditional application.","PeriodicalId":310067,"journal":{"name":"Medicinal Plant Biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116448066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}