Infarma Pharmaceutical Sciences最新文献_第6页

The Effect of Aqueous-Alcoholic Extract of Toothbrush Tree (Salvadora persica) on the Healing of Second-degree Skin Burns in BALB/c Mice 牙刷树水醇提取物对BALB/c小鼠皮肤二度烧伤愈合的影响

Infarma Pharmaceutical Sciences Pub Date : 2022-04-21 DOI: 10.34172/ps.2022.19

M. Afshar, Hamed Lotfi, Mohammad Mehdi Hassanzadeh Taheri, M. Zardast

{"title":"The Effect of Aqueous-Alcoholic Extract of Toothbrush Tree (Salvadora persica) on the Healing of Second-degree Skin Burns in BALB/c Mice","authors":"M. Afshar, Hamed Lotfi, Mohammad Mehdi Hassanzadeh Taheri, M. Zardast","doi":"10.34172/ps.2022.19","DOIUrl":"https://doi.org/10.34172/ps.2022.19","url":null,"abstract":"Background: Researchers have mentioned many beneficial effects for the compounds in the toothbrush tree (Miswak)(Salvadora persica: SP), such as anti-inflammatory, antioxidant and antimicrobial activities. The present study aimed to evaluate the effect of aqueous-alcoholic extract of toothbrush tree on the wound healing of second-degree skin burns in BALB/c mice. Methods: In this study, 60 mature mice (8 weeks) were used. Mice were divided into 5 groups of twelve. Groups 1 and 2 were treated with concentrations of 5% and 10% of the aqueous-alcoholic extract of the toothbrush, respectively, group3 was treated with silver sulfadiazine ointment (positive control), group4 with cream base (negative control), and group5 (sham) received no treatment. A second-degree circular burn wound with a diameter of 1cm was created on the back of the animal. The first to fourth groups were dressed twice a day. On days 4,7,10 and 14 after anaesthasia, sampling was performed from the wound site and wound healing was evaluated histopathologically. Results: Inflammation and infiltration of neutrophils and lymphocytes were significantly reduced in the group treated with 10%SP extract compared to the negative and sham control groups (P<0.01). On the other hand, the number of fibroblasts, followed by collagen production, epithelialization and the formation of new hair follicles in the wound margins on days10 and14 in the group treated with 10 and 5% SP extracts significantly increased compared to the negative control and sham group (P<0.05). The number of fibroblasts and collagen fiber density in the group treated with 10% SP extract showed a significant increase compared to the 5% extract group and silver sulfadiazine (P<0.05). Conclusion: Our findings showed that using extract of toothbrush accelerates the burn wound healing process. So it can be a suitable, cost-effective substitute for available commercial products.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82876356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Professor Jalil Afshar; the Founding Editor of Pharmaceutical Sciences Jalil Afshar 教授；《制药科学》创刊编辑

Infarma Pharmaceutical Sciences Pub Date : 2022-04-17 DOI: 10.34172/ps.2022.18

A. Jouyban, A. Shayanfar

引用次数: 0

Designing a Topical Nanoliposomal Formulation of Ruxolitinib Phosphate 磷酸鲁索利替尼外用纳米脂质体制剂的设计

Infarma Pharmaceutical Sciences Pub Date : 2022-04-08 DOI: 10.34172/ps.2022.17

Atefeh Naeimifar, S. Ahmad Nasrollahi, H. Akbari Javar, Mansoor Nassiri Kashani, A. Firooz, M. Rouini

{"title":"Designing a Topical Nanoliposomal Formulation of Ruxolitinib Phosphate","authors":"Atefeh Naeimifar, S. Ahmad Nasrollahi, H. Akbari Javar, Mansoor Nassiri Kashani, A. Firooz, M. Rouini","doi":"10.34172/ps.2022.17","DOIUrl":"https://doi.org/10.34172/ps.2022.17","url":null,"abstract":"Background: The JAK-STAT pathway has been revealed to play a crucial role in the dysregulation of immune responses in autoimmune skin disorders. Ruxolitinib, a selective inhibitor of JAK1 and JAK2, potently suppresses cytokine signaling. Methods: A topical emulgel containing ruxolitinib nanoliposome (RuxoLip) was prepared by thin film hydration method. Then, its physicochemical characteristics were evaluated at 25±2 ̊C/60±5% RH for 12 months. RuxoLip was assessed based on particle characteristics, Scanning Electron Microscopy (SEM), entrapment efficiency (EE), drug loading (DL), and Differential Scanning Calorimetry (DSC). The pH, density, viscosity, microbial assessment, in vitro drug release, and in vivo tape stripping test were evaluated on the emulgel of RuxoLip. Validating the analysis method was performed by UV spectroscopy. Results: Nanoliposomal preparation was successfully formulated with a good particle size (218±2 nm), an EE of 67% and a DL of 8%. The formulation was stable in a long-term condition. SEM showed that liposomes had a regular spherical surface. Moreover, in vitro drug release and the in vivo tape stripping test revealed good absorption and permeation, respectively. Conclusion: The liposome dosage form is anticipated to be a perfect carrier for the topical drug delivery system of ruxolitinib in autoimmune skin disorders.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72561758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phytochemical and antiplasmodial evaluation of five Colombian plants with ethnopharmacological background of antimalarial use 五种具有抗疟民族药理学背景的哥伦比亚植物的植物化学和抗疟原虫评价

Infarma Pharmaceutical Sciences Pub Date : 2022-04-06 DOI: 10.34172/ps.2022.16

Jorge Enrique Hernández-Carvajal, María Helena Arias-Marciales, Josefina Garcia, Y. Hata-Uribe, Giovanny Garavito-Cárdenas, Pilar Ester Luengas Caicedo

{"title":"Phytochemical and antiplasmodial evaluation of five Colombian plants with ethnopharmacological background of antimalarial use","authors":"Jorge Enrique Hernández-Carvajal, María Helena Arias-Marciales, Josefina Garcia, Y. Hata-Uribe, Giovanny Garavito-Cárdenas, Pilar Ester Luengas Caicedo","doi":"10.34172/ps.2022.16","DOIUrl":"https://doi.org/10.34172/ps.2022.16","url":null,"abstract":"Background: The study of medicinal plants has made it possible to develop products and drugs for the treatment of different diseases. Several plants in Colombia have a history of popular use for the treatment of malaria. The objective of this work was to provide information on the antiplasmodic and phytochemical activity of five neotropical native plants with a folk use for the treatment of malarial.Methods: The ethanolic extract of each species was obtained by percolation method and characterized by TLC, HPLC, and 1H-NMR. The in vitro antiplasmodial activity was evaluated against Plasmodium falciparum (strain FCR-3, chloroquine-resistant).Results: Ethanolic extracts of Ambelania duckey, Cecropia metensis, Cecropia membranacea, and Verbena littoralis showed no activity. However, Curarea toxicofera extract exhibited an IC50 of 7.6 ± 3.9 μg/mL and was classified as moderately active. Furthermore, hemolytic activity was assayed, none of the extracts were tested positive. A preliminary phytochemical study was carried out using tube analysis, thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), and hydrogen nuclear magnetic resonance (1H-NMR). Steroids or triterpenes, and phenolic compounds were detected by TLC in all extracts. These findings were confirmed by characteristic aliphatic and aromatic signals in 1H-NMR spectra, corresponding to triterpenes and phenolics, respectively. Additionally, alkaloids were extracted from C. toxicofera and detected by aromatic signals in 1H-NMR spectra.Conclusion: ethanolic extract of C. toxicofera showed antiplasmodial activity (IC50 of 7.6 ± 3.9 μg/mL); this activity may be due to the bisbenzylisoquinoline alkaloids. The ethanol extracts of A. duckey, C. membranacea, C. metensis, and V. littoralis did not present antiplasmodial activity.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91046685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ester prodrugs of levofloxacin to prevent chelate formation in presence of aluminium ion 左氧氟沙星酯前药在铝离子存在下防止螯合物的形成

Infarma Pharmaceutical Sciences Pub Date : 2022-04-03 DOI: 10.34172/ps.2022.15

Y. Maeda, Yuka Takahashi, Yuki Naika, Takato Maeda, Y. Otsuka, Yumi Saeki, Saki Otani, Kunihiko Kohama, Yuhzo Hieda, Takeshi Goromaru, S. Eto, T. Murakami

{"title":"Ester prodrugs of levofloxacin to prevent chelate formation in presence of aluminium ion","authors":"Y. Maeda, Yuka Takahashi, Yuki Naika, Takato Maeda, Y. Otsuka, Yumi Saeki, Saki Otani, Kunihiko Kohama, Yuhzo Hieda, Takeshi Goromaru, S. Eto, T. Murakami","doi":"10.34172/ps.2022.15","DOIUrl":"https://doi.org/10.34172/ps.2022.15","url":null,"abstract":"Abstract Background: Intestinal absorption of levofloxacin (LFX) is decreased by the concomitant administration of antacids due to the formation of insoluble chelate complexes with various metal cations. Methods: The following four ester prodrugs of LFX—cilexetil ester (LFX-CLX), medoxomil ester (LFX-MDX), ethoxycarbonyl 1-ethyl hemiacetal ester (LFX-EHE) and pivaloyloxymethyl ester (LFX-PVM) — were synthesized. Then, the lipophilicity, in vitro chelate formation with aluminum chloride (AlCl3), chemical and enzymatic stability, minimum inhibitory concentrations (MICs) against some bacteria, and the efficacy in preventing chelate formation of prodrugs with aluminum hydroxide (Al(OH)3) in rabbits were evaluated. Results: The synthesized ester prodrugs of LFX exhibited high purity and higher lipophilicities than LFX depending on the ester moieties. MICs of the prodrugs against S. aureus, E. coli, and P. aeruginosa were more than 10 times higher than those of LFX. Prodrugs were stable chemically but unstable enzymatically and generated LFX in biological specimens. When AlCl3 solution was mixed with LFX solution in vitro, insoluble chelate complex was formed immediately. In rabbits, co-administration of Al(OH)3 with LFX reduced the oral bioavailability of LFX by approximately 40%. In contrast, no precipitation was observed when AlCl3 solution was mixed with each prodrug solution in vitro, and co-administration of Al(OH)3 exerted no significant effect on the oral bioavailability of LFX when each prodrug was administered in rabbits. Conclusion: The ester prodrug approach of LFX could be a feasible strategy for avoiding chelate formation with aluminum ion in vivo.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74271983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Determination of Benzo (α) pyrene in infant formula milk using high performance liquid chromatography and dispersive liquid–liquid microextraction 高效液相色谱-分散液液微萃取法测定婴儿配方奶粉中的苯并(α)芘

Infarma Pharmaceutical Sciences Pub Date : 2022-03-31 DOI: 10.34172/ps.2022.14

A. Faridi, Mahboon Nemati

引用次数: 0

Solubility of bosentan in polyethylene glycol 400 + water mixtures: Experimental and mathematical computations 波生坦在聚乙二醇400 +水混合物中的溶解度:实验和数学计算

Infarma Pharmaceutical Sciences Pub Date : 2022-03-30 DOI: 10.34172/ps.2022.13

Parisa Jafari, Elahahe Rahimpour, A. Jouyban

{"title":"Solubility of bosentan in polyethylene glycol 400 + water mixtures: Experimental and mathematical computations","authors":"Parisa Jafari, Elahahe Rahimpour, A. Jouyban","doi":"10.34172/ps.2022.13","DOIUrl":"https://doi.org/10.34172/ps.2022.13","url":null,"abstract":"Background. To discover the optimal solvent amounts for using in a particular application, it is vital to achieve some useful information in regard with suitable pure or mixed solvent and drugs equilibrium solubility in them. It is known that the low water solubility of drugs such as bosentan (BST) negatively effects its in vitro and in vivo kinetics of dissolution, affecting in turn and its bioavailability along with making several difficulties around designing of its liquid formulations. Methods. Solubility of BST in some mixtures of polyethylene glycol 400 (PEG 400) and water was experimentally determined at T = (293.15 to 313.15) K by using a common shake-flask technique followed by Uv-visible spectroscopic method. The experimental solubility data at 298.15 K and w1=0.0, 0.5 and 1.0 at other temperatures were then correlated by cosolvency models including the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the double log-log models and some un-measured solubility data are predicted based on the obtained trained models. Results. The results presented that the aqueous solubility of BST is increased by increasing mass fraction of PEG 400 as well as increasing temperature and reached the maximum value in neat PEG 400 at 313.15 K. Conclusion. The BST solubility in water improved by addition of PEG 400 into it. According to the average relative deviations obtained from the back-computed data with trained models which were < 8.0%, it concluded that the selected modes were able to predict the un-measured data with high reliability.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84929307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of choline-based ionic liquids as neoteric green solvents on aqueous solubility of lamotrigine and piroxicam drugs 胆碱基离子液体作为新绿色溶剂对拉莫三嗪和吡罗康类药物水溶性的影响

Infarma Pharmaceutical Sciences Pub Date : 2022-03-14 DOI: 10.34172/ps.2022.12

H. Shekaari, Negar Basteholia, Masumeh Mokhtarpour, M. T. Zafarani-Moattar

{"title":"Influence of choline-based ionic liquids as neoteric green solvents on aqueous solubility of lamotrigine and piroxicam drugs","authors":"H. Shekaari, Negar Basteholia, Masumeh Mokhtarpour, M. T. Zafarani-Moattar","doi":"10.34172/ps.2022.12","DOIUrl":"https://doi.org/10.34172/ps.2022.12","url":null,"abstract":"Background: The low aqueous solubility of three important drugs (betamethasone (BETA), meloxicam (MEL) and piroxicam (PIR)) have been increased by use of deep eutectic solvents (DESs) based choline chloride/urea (ChCl/U), choline chloride/ethylene glycol (ChCl/EG) and choline chloride/glycerol (ChCl/G) as new class of solvents at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the ChCl/EG, U and G with the molar ratios: 1:2. The solubility of drugs in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility of the investigated drugs increased with increasing the weight fraction of DESs. The solubility data were correlated by e-NRTL and Wilson models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were calculated. Conclusion: At the same composition of co-solvents and temperature, the BETA, PIR and MEL solubility was highest in (ChCl/U + water), (ChCl/U + water) and (ChCl/EG + water) respectively. The calculated solubility based on these models was in good agreement with the experimental values. In addition, the results show that, the main contribution for drugs solubility in the aqueous DES solutions is the enthalpy.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77661522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Surgery on Leukocyte Vitamin C Concentrations: A Systematic Review and Meta-Analysis 手术对白细胞维生素C浓度的影响:系统回顾和荟萃分析

Infarma Pharmaceutical Sciences Pub Date : 2022-03-12 DOI: 10.34172/ps.2022.11

N. Travica, K. Ried, I. Hudson, A. Scholey, A. Pipingas, A. Sali

{"title":"The Effects of Surgery on Leukocyte Vitamin C Concentrations: A Systematic Review and Meta-Analysis","authors":"N. Travica, K. Ried, I. Hudson, A. Scholey, A. Pipingas, A. Sali","doi":"10.34172/ps.2022.11","DOIUrl":"https://doi.org/10.34172/ps.2022.11","url":null,"abstract":"Abstract Background Vitamin C (ascorbic acid) is a micronutrient imperative for many bodily functions, with research revealing its functional support of leukocytes. The purpose of this meta-analysis was to determine the effects of surgery on leukocyte vitamin C concentrations by assessing the amount and longevity of post-operative leukocyte vitamin C change. Data Sources We searched the PUBMED, SCOPUS, SciSearch and the Cochrane Library databases for relevant research papers. Studies were included until January 2022, with no time limits. Studies that reported means and standard deviations of leukocyte/buffer layer vitamin C concentrations before and after surgery were included into the meta-analysis. The meta-analysis comprised of eight studies. Results Seven studies (which included 8 individual studies) were included into our meta-analysis. Combined data from the meta-analysis displayed a significant depletion in mean leukocyte vitamin C concentrations during the first 24 hours following the surgery by a mean of 5.37 µg/108 (32.3%) (CI = -6.35, -4.40) (n = 6, p < 0.001) and during the first post-operative week by 4.43 µg/108 (23%) (-7.27, -1.58) (n = 7, p < 0.001). However, this depletion was followed by an uprise in mean ascorbic acid leukocyte concentrations of 0.93 µg/108 (4.8%) (-0.79, 2.66) (n = 6, p = 0.29) at 7 days (or beyond) post-operatively. Conclusion Significant post-operative leukocyte vitamin C depletions were particularly observed during the first post-operative week. Further research is required to validate the observed results and to determine whether the observed depletions may be linked to compromised immunological function and pathophysiologies that arise during the post-operative period.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81350617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of metformin on cardiac troponin-I and ST resolution in patients with ST elevation myocardial infarction undergoing thrombolytic therapy 二甲双胍对接受溶栓治疗的ST段抬高型心肌梗死患者心肌肌钙蛋白- i和ST段溶解的影响

Infarma Pharmaceutical Sciences Pub Date : 2022-03-04 DOI: 10.34172/ps.2022.10

N. Aslanabadi, Samineh Beheshtirouy, Sina Mashayekhi, Zahra Heidari, S. Hamedani, Taher Entezari-Maleki

{"title":"The impact of metformin on cardiac troponin-I and ST resolution in patients with ST elevation myocardial infarction undergoing thrombolytic therapy","authors":"N. Aslanabadi, Samineh Beheshtirouy, Sina Mashayekhi, Zahra Heidari, S. Hamedani, Taher Entezari-Maleki","doi":"10.34172/ps.2022.10","DOIUrl":"https://doi.org/10.34172/ps.2022.10","url":null,"abstract":"Abstract Background: Thrombolytic therapy is a key in the management of ST elevated myocardial infarction (STEMI). Metformin implies a series of cardioprotective effects. We aimed to investigate how pretreatment with metformin could affect cardiac troponin I (cTnI) levels following reteplase therapy amid STEMI patients. Methods: A pilot randomized clinical trial was carried out in 84 patients with STEMI undergoing thrombolytic therapy with reteplase. The metformin group (n = 42) received a single dose of 1000 mg metformin orally before receiving reteplase, while the control group (n = 42) received only reteplase. The serum level of cTnI was measured at baseline, 8, 16, 24, and 32 hours after the admission to assess myocardial damage. Results: No significant differences were observed in cTnI levels at baseline (p = 0.657), 8 (p = 0.93), 16 (p = 0.690), 24 (p = 0.217), and 32 (p = 0.517) hours after STEMI diagnose between two groups. The mean differences were also not significant for changes of cTnI at baseline and other time frames. Conclusion: The results of the present study indicated that early use of 1000 mg metformin prior to reteplase could not reduce the level of cTnI in STEMI patients.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74540654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0