Fortune Journal of Rheumatology最新文献

Correlation Analysis between NETosis Biomarkers and Peripheral Immune Cells in a Preclinical Model of Ischemic Stroke 缺血性卒中临床前模型中NETosis生物标志物与外周免疫细胞的相关性分析

Fortune Journal of Rheumatology Pub Date : 2021-07-21 DOI: 10.21203/rs.3.rs-717960/v1

Junxiang Yin, Michael Wu, Tasha Mohseni, Adam Kindelin, Saif Ahmad, A. Ducruet, A. Ahmad, M. Waters

{"title":"Correlation Analysis between NETosis Biomarkers and Peripheral Immune Cells in a Preclinical Model of Ischemic Stroke","authors":"Junxiang Yin, Michael Wu, Tasha Mohseni, Adam Kindelin, Saif Ahmad, A. Ducruet, A. Ahmad, M. Waters","doi":"10.21203/rs.3.rs-717960/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-717960/v1","url":null,"abstract":"\u0000 Neutrophil extracellular traps formation (NETosis) facilitates thrombosis and contributes to reperfusion resistance - a major challenge encountered during the treatment of acute ischemic stroke. The effect of acute stroke on plasma NETosis biomarkers remains unclear. In this study, young adult C57BL/6 wildtype (WT) mice were subjected to acute brain ischemia-reperfusion (IR) injury. The IR-subjected mice exhibited a drastic increase in plasma citrullinated histone 3 (CitH3) and neutrophil elastase (NE) on day 1 (p < 0.05) while deoxyribonucleic acid (DNA) and myeloperoxidase (MPO) reached their peak levels on day 3. IR-subjected mice also showed a significant increase in peripheral neutrophils and decline in peripheral leukocytes, lymphocytes, and monocytes on day 1 and day 2 (p < 0.05). The ratios of neutrophil to lymphocyte, neutrophil to leukocyte, and lymphocyte to monocyte dramatically increased on day 1 (p < 0.05). Plasma NE, CitH3 and MPO were positively correlated with peripheral neutrophil and the ratio of neutrophil to lymphocyte, but inversely correlated with peripheral lymphocyte (p < 0.05). Our data suggest that there are time dependent changes in plasma NETosis biomarkers. Therefore, targeting these biomarkers before their peak may offer potential therapeutic options to reduce cerebral infarction and prevent functional deterioration after acute ischemic stroke.","PeriodicalId":309938,"journal":{"name":"Fortune Journal of Rheumatology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123706199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracolumbar Fascia Enthesopathy as a Cause of Low Back Pain: A Retrospective and Follow-up Study 胸腰筋膜性腰痛是引起腰痛的原因:一项回顾性和随访研究

Fortune Journal of Rheumatology Pub Date : 2021-02-23 DOI: 10.21203/rs.3.rs-219002/v1

O. A. Tabesh, R. Ghossan, S. H. Zebouni, R. Faddoul, M. Revel, F. Fayad

{"title":"Thoracolumbar Fascia Enthesopathy as a Cause of Low Back Pain: A Retrospective and Follow-up Study","authors":"O. A. Tabesh, R. Ghossan, S. H. Zebouni, R. Faddoul, M. Revel, F. Fayad","doi":"10.21203/rs.3.rs-219002/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-219002/v1","url":null,"abstract":"\u0000 Aim. To evaluate ultrasonography findings of Thoracolumbar Fascia (TLF) enthesis in patients with low back pain (LBP) due to iliac crest pain syndrome (ICPS). Method. The ultrasonographic and clinical findings of 60 patients with LBP due to ICPS were compared to those of 30 healthy volunteers with no LBP. Thickness of the TLF was measured with ultrasound (US) at its insertion on the iliac crest. Results. Forty-eight women and 12 men with a mean age of 42.1±11.3 years were diagnosed with ICPS. In patients, the mean thickness of the TLF was 2.51±0.70mm in affected sides compared to 1.81±0.44mm in the contralateral unaffected sides. The mean thickness difference of 0.82mm between the affected and non-affected sides was statistically significant (95%CI, 0.64-0.99, P<0.0001). In volunteers, the mean thickness of the TLF was 1.6±0.2mm. The mean thickness difference of 0.89mm between the affected sides of patients and volunteers was statistically significant (95%CI, 0.73-1.06, P<0.0001). Forty-two patients who didn’t improve with conservative therapy, received injections of methylprednisolone acetate and 1% lidocaine around the TLF enthesis. All patients reported complete relief of their LBP within 20 minutes of the injections thanks to the lidocaine anesthetic effect. Fifty-six (93.3%) patients were reached by phone for a long-term follow-up. Among them, 33 (58.9%) patients experienced a sustained complete pain relief after a mean follow-up of 45±19.3 months (range, 3-74 months). Conclusion. our findings suggest that TLF enthesopathy is a potential cause of nonspecific LBP that can be diagnosed using US.","PeriodicalId":309938,"journal":{"name":"Fortune Journal of Rheumatology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125324192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real Life Switching from Infliximab Innovator to Biosimilar in Rheumatic Diseases: A 6-Month Single-Centre Prospective Observational Study 风湿病从英夫利昔单抗创新药物到生物仿制药的转变:一项为期6个月的单中心前瞻性观察研究

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.26880011

A. Anjum, W. L. Ng, A. Sebastian, J. Devlin, A. Fraser

{"title":"Real Life Switching from Infliximab Innovator to Biosimilar in Rheumatic Diseases: A 6-Month Single-Centre Prospective Observational Study","authors":"A. Anjum, W. L. Ng, A. Sebastian, J. Devlin, A. Fraser","doi":"10.26502/fjr.26880011","DOIUrl":"https://doi.org/10.26502/fjr.26880011","url":null,"abstract":"Background: Although Inflectra, biosimilar infliximab, has been approved by the EMA since September 2013 for all licensed indications of Remicade (innovator infliximab) but there is a paucity of real-world data and guidelines regarding switching from innovator Remicade to Inflectra. \u0000 \u0000Objectives: To explore efficacy, safety, and retention rate of biosimilar Inflectra when switching from Remicade, in patients with rheumatic diseases. \u0000 \u0000Methods: Informed consent was sought from all patients attending our rheumatology unit to undertake a switching programme. Baseline demographics and clinical characteristics were obtained before switching to Inflectra. Disease activity and safety assessment were undertaken before and then every 12 weeks after switching. The retention rate of Inflectra switch patients was compared with a cohort of non-switch Inflectra naive (11 patients) and historic Remicade (31 patients) patients. \u0000 \u0000Results: Thirty out of thirty-one patients {median (IQR) age 50 (18), 20F} with various rheumatic diseases (9 with diagnosis of AS, 6 with RA, 6 with Behcet’s disease, 3 with Enteropathic arthritis, 2 with psoriatic arthritis) agreed to the switch. There was no statistical difference noted between pre-switch and 6 months post-switch mean values of PGA (p=0.37), BASDAI (p=0.60), ASDAS-CRP (p=0.90), DAS28CRP (p=0.85), DAS28ESR (p=0.45), CRP (p=0.09), Behcet’s disease activity score (p=0.77) and HAQ-DI (p=0.18). The retention rate on Inflectra switch was 86.7% as compared to 90.9% in the Inflectra naive cohort and 100% for historic Remicade cohort. \u0000 \u0000Conclusion: These results demonstrate that in this cohort at 6 months Inflectra is comparable to Remicade in efficacy and there are no new safety signals.","PeriodicalId":309938,"journal":{"name":"Fortune Journal of Rheumatology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124817486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Musculoskeletal Manifestations among Egyptian HCV Patients Receiving Direct Antivirals (DAAS) Therapy 接受直接抗病毒药物(DAAS)治疗的埃及HCV患者的肌肉骨骼表现

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.26880032

Marwa A Besar, A. Abd El Salam, Asmaa F Enin, Doaa A Anter

{"title":"Musculoskeletal Manifestations among Egyptian HCV Patients Receiving Direct Antivirals (DAAS) Therapy","authors":"Marwa A Besar, A. Abd El Salam, Asmaa F Enin, Doaa A Anter","doi":"10.26502/fjr.26880032","DOIUrl":"https://doi.org/10.26502/fjr.26880032","url":null,"abstract":"Introduction: Hepatitis C is a worldwide problem; the treatment of chronic HCV has been revolutionized with the introduction of the oral Direct-Acting Antiviral (DAA) drugs. The efficacy in eradication of extrahepatic and hepatic manifestation leads to its widely spread of these medications, but there is musculoskeletal side effect reported with its use. Objectives: Assess musculoskeletal manifestation in HCV patients receiving Direct Antivirals Therapy (DAATs) attending Rheumatology & Immunology Unit in internal medicine department in Mansoura university Hospital. Result: Majority of studied patients (n=200) were 64% females and 36% were male. The most frequent involved joint was the knee 55% (110), while the least affected joint was the wrist 6% (12) and the shoulder joint 8%. It was observed that bone pain (71.1%) especially at shoulder joint (64.3%) and back (60.7%) were associated with Sofosbuvir+ Daclatasvir but were statistically insignificant. Arthralgia was presenting manifestation in 63% with patients received Sofosbuvir +Daclatasvir and dominated in the wrist joint (66.7%), knee joint (65.5%), shoulder joint (62.5%) but it was statistically insignificant. Back pain was evident in patients treated by DAAs for 12 weeks (27.7%) than those received it for 24 weeks (11.8%) and it was statistically significant p* = 0.050. Conclusion: Musculoskeletal disorders reported mainly with sofosbuvir and daclatasvir especially for 12-week duration and the most affected age group (more than 55year).","PeriodicalId":309938,"journal":{"name":"Fortune Journal of Rheumatology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134174023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presumed Giant Cell Arteritis presenting as Sequential Bilateral 6th Nerve Palsies: Case Report and Review of Literature 假定巨细胞动脉炎表现为连续的双侧第六神经麻痹:病例报告和文献回顾

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.26880030

Mustafa Al-Chalabi, Meghana Ranabothu, Nameer Aladamat, Khaled Gharaibeh, Ajaz Sheikh

{"title":"Presumed Giant Cell Arteritis presenting as Sequential Bilateral 6th Nerve Palsies: Case Report and Review of Literature","authors":"Mustafa Al-Chalabi, Meghana Ranabothu, Nameer Aladamat, Khaled Gharaibeh, Ajaz Sheikh","doi":"10.26502/fjr.26880030","DOIUrl":"https://doi.org/10.26502/fjr.26880030","url":null,"abstract":"Giant CELL ARTERITIS (GCA) is a systemic autoimmune disease that classically presents with jaw claudication, temporal headache and transient visual loss, affecting mostly people above the age of 50 years. However, diplopia due to cranial nerve 6 palsy (CN VI) has been rarely reported in GCA. Moreover, bilateral CN VI palsies, occurring in a sequential fashion in GCA is exceedingly rare. We report a case of a 70-year-old man who was admitted to our hospital twice within the span of one month with persistent binocular diplopia due to sequential, bilateral, CN VI palsies (right followed by left CN VI palsy) with associated eye pain, temporal headache, malaise and joint pain. The inflammatory markers including Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) were elevated at both admissions. He was treated with intravenous steroids with a complete resolution of his binocular diplopia, eye pain and temporal headache. Despite a negative biopsy of the temporal artery for evidence of inflammation, he was diagnosed with GCA by rheumatology, considering the fact that GCA pathology may have a patchy distribution, and a negative biopsy does not rule it out absolutely. This case underscores the importance of recognizing GCA as a differential diagnosis in patients presenting with binocular diplopia.","PeriodicalId":309938,"journal":{"name":"Fortune Journal of Rheumatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128728273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular Joint Dysfunction as a Cause of Facial Pain- A Case Report 颞下颌关节功能障碍引起面部疼痛1例

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.2688003

N. Devaraj

引用次数: 3

Acknowledgement to Authors, Reviewers and Editors of Fortune Journal of Rheumatology in 2021 感谢《财富风湿病杂志》2021年的作者、审稿人和编辑

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/FJR.26880024

Fortune Journals

引用次数: 0

Transient Osteoporosis of the Hip: State of the Art and Review of Literature 髋关节短暂性骨质疏松症:现状及文献综述

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.2688007

A. Aprato, A. Conti, P. Triolo, R. Piana, A. Massè

引用次数: 6

Corticosteroids as a cause of Catastrophic Rheumatoid Arthritis 皮质类固醇是灾难性类风湿关节炎的一个原因

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.2688005

E. Pelechas, T. Memi, N. Gerolymatou, Georgios Zouzos, P. Karagianni

引用次数: 1

Procedures Guided by Ultrasonography in Injectable Treatments in Knee, Hip and Shoulder Pathologies 超声引导下的膝关节、髋关节和肩部病变注射治疗程序

Fortune Journal of Rheumatology Pub Date : 1900-01-01 DOI: 10.26502/fjr.2688001

Renato Luiz Bevilacqua de Castro, Sergio Ricardo Neto, Breno Pazinatto Antonio, J. F. Lana, Fernanda Santiago Bassora

引用次数: 1