Diabetes Updates最新文献

{"title":"Diabetes in pregnancy: A comparison of guidelines","authors":"Muneera Ahmed AlKhalifa, S. Hsu, Gulmeen Raza, M. Ismail","doi":"10.15761/du.1000152","DOIUrl":"https://doi.org/10.15761/du.1000152","url":null,"abstract":"Introduction: Diabetes in pregnancy is becoming increasingly prevalent worldwide and managing such patients remains challenging. The aim of this comparison is to help reach a consensus regarding the most reasonable approach to care for such patients and modify our institute’s guidelines where necessary. Methods: This is a review article comparing the most recent guidelines available concerning the diagnosis and management of diabetes in pregnancy, which includes both pre-gestational and gestational. The following guidelines will be compared; the National Institute for Health and Care Excellence (NICE), World Health Organization (WHO), American College of Obstetricians and Gynecologists (ACOG), American Diabetes Association (ADA), the Society of Obstetricians And Gynecologists Of Canada (SOGC), Canadian Diabetes Association (CDA), and the International Federation of Gynaecology and Obstetrics (FIGO). These recommendations will also be compared to the current guidelines set in our institute, King Hamad University Hospital (KHUH) in the Kingdom of Bahrain. Results: The similarities and differences between the guidelines will be highlighted in the form of tables and a brief discussion. The tables will emphasize the differences in screening, diagnosing, and managing diabetes in pregnancy. Conclusion: Updating our guidelines to remain consistent with international guidelines can help unify our institute’s approach to managing such patients thus ensuring the provision of the highest quality of care.","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"276 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115014749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence and predictors of poor glycemic control among adults with type 2 diabetes mellitus in ambulatory clinic of mettu karl referral hospital, southwestern oromia, Ethiopia: a prospective cross sectional study","authors":"Gudisa Bereda, Gemechis Bereda","doi":"10.15761/du.1000155","DOIUrl":"https://doi.org/10.15761/du.1000155","url":null,"abstract":"","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122846420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and severity of distal symmetrical polyneuropathy among patients with type 2 diabetes mellitus in zaria, nigeria","authors":"Kao Ys, F. Bello, Bansi Ik, A. Bakari, Yakubu Im, Y. Lawal","doi":"10.15761/du.1000142","DOIUrl":"https://doi.org/10.15761/du.1000142","url":null,"abstract":"Background: Distal symmetrical polyneuropathy (DSPN) is among the common and serious complications of diabetes mellitus (DM). However, there is paucity of data on its prevalence and severity in Northern Nigeria. The study was, therefore, aimed to determine the prevalence and severity of DSPN among type 2 DM subjects at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria. Method: This study was a cross-sectional comparative study of 330 type 2 diabetes subjects presenting consecutively at the endocrine clinic of ABUTH, Zaria and 165 healthy controls randomly selected from a community in Zaria. Socio-demographic data were obtained using an interviewer-administered questionnaire and subjects were physically examined. Biothesiometry and the United Kingdom Screening Test (UKST) were used to assess peripheral neuropathy in both cases and controls. Data was analysed with SPSS version-17 using Chi-square analysis and Student t-test. Results: The mean±SD age of the DM subjects was 49.60±9.81 years while that of the controls was 49.93±10.09 years (p=0.73). The prevalence of DSPN was 39.7% among type-2 diabetes patients and 6.1% among controls. Moderate and severe neuropathy were present in 30.3% and 6.0% of the diabetic subjects respectively. Conclusion: DSPN is commoner among people with diabetes mellitus when compared to healthy controls with a large proportion of subjects presenting with moderate severity. It is recommended that efforts be made to screen for DSPN among diabetes patients using simple and sensitive methods.","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131534950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the role of lipofilling technique in diabetic patients with primary breast cancer: the lack of studies in the literature","authors":"N. Fabbri, M. Chiozza, P. Carcoforo","doi":"10.15761/du.1000138","DOIUrl":"https://doi.org/10.15761/du.1000138","url":null,"abstract":"Breast cancer (BC) and diabetes are both a very common pathology in women, involving a large number of patients with a great impact on public health. To date, we know there is a strong linkage of these two different pathologies, for example in metabolic pathways, which may influence the choices of treatment. Studies have shown that BC in women with diabetes is often diagnosed in advanced stage compared with woman without diabetes and has a higher overall mortality following BC diagnosis (30-60%). This is a review of the English literature using the PubMed database that shows a lack of studies and knowledge about the consequences of this procedure in diabetic patients. Lipofilling in breast surgery is a safe technique with low morbidity and some advantages in condition of peripheric vasculopathy similar to diabetes such as local radiotherapy; however, there may be an unpredictable graft resorption, which ranges from 25%-80%, probably as result of ischemia and lack of neoangiogenesis. Despite the increased use of lipofilling in breast surgery, some queries remain, and both the high number of diagnoses of breast cancer and the increase of cases of diabetes will lead to consider dedicated surgical pathways. To answer this query, prospective studies are needed.","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130662129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canagliflozin improves glycemic control and body weight and reduces insulin doses in patients with type 2 diabetes treated with insulin in real practice","authors":"F. Carral, D. Cabo, J. Al, M. Cayon","doi":"10.15761/DU.1000121","DOIUrl":"https://doi.org/10.15761/DU.1000121","url":null,"abstract":"Introduction: Canagliflozin is a class of oral anti-diabetic agent with limited real-world experience reported in patients treated with insulin. Objective: The aim of this study was to evaluate effectiveness and safety of the administration of canagliflozin in patients with type 2 diabetes mellitus (T2DM) treated with different insulin regimens. Methods: A retrospective observational study of patients with T2DM treated with insulin who were prescribed canagliflozin from June 2015 to December 2016 at four endocrinology clinics in the South of Spain was designed. 12 months changes in anthropometric variables, glycemic control, insulin doses, anti-diabetic drugs and adverse events were assessed after canagliflozin administration. Results: 92 patients with T2DM treated with insulin (44 women, mean age 61.2 ± 10.0 years old and mean BMI: 35.2 ± 11.2 kg/m 2 ) were studied. Improvement was observed in HbA1c (8.7 ± 1.6 vs. 7.2 ± 0.8%; p <0.01), body weight (92.4 ± 20.9 vs. 87.1 ± 19.5 kg; p <0.01) and waist circumference (112.4 ± 17.0 vs. 105.0 ± 21.7; p: 0.04), with a reduction of insulin doses (57.7 ± 38.9 vs. 35.1 ± 32.5 IU/day, p <0.01) and insulin injections per day (2.1 ± 1.2 vs. 1.1 ± 0.8, p<0.01) after 12 months of canagliflozin administration. 49% of the patients reached HbA1c ≤ 7% and 12 patients (13%) completely suspended treatment with insulin. 15 patients (16.3%) experienced mild adverse events and canagliflozin administration was suspended in 9 patients (9.8%). Conclusions: Canagliflozin administration in patients with T2DM treated with insulin was associated with an improvement in glycemic control and body weight and with a reduction of insulin doses with limited and mild adverse events.","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115794221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Labeling of DNA Amyloid Sensor with Plasma, and the Glycemic Factor, for Photonic Detection of Alzheimer's in Blood","authors":"R. Cuero, D. Agudelo, L. Sánchez, J. Londoño","doi":"10.15761/du.1000147","DOIUrl":"https://doi.org/10.15761/du.1000147","url":null,"abstract":"This investigation was carried out based on the integrative approach at the cellular, molecular and atomic level. Therefore, our aim was to develop two DNA sensors that detect Alzheimer’s disease related β-amyloid protein in blood using synthetic and molecular biology. The DNA sensors were constructed in E. Coli or Saccharomyces cerevisiae using genetic sequences and they were tested in terms of fluorescence expression units (FSU) when mixed with human blood plasma using a fluorescence detector. This amyloid sensor was also confirmed using photonic Raman technology, and corroborated by analyzing the purified protein using SDS-PAGE gel electrophoresis, which product was confirmed by using different sizes of Macrosep Advance Centrifugal devices. The intensity of the detection was enhanced by labeling the fluorescence targeted molecules in samples which were conjugated with fluorescent dyes. Fluorescence results were comparable to clinical and MRI results. The DNA sensor was able to detect β-amyloid protein in different type of patients. Results were also correlated with the glycemic levels of the patients. Influence of metals on expression of amyloid protein was also demonstrated through ELISA and Western Blot assays. Due to the highly correlation between fluorescence intensity and levels of β-amyloid, these results were used to classify patients according to the severity of Alzheimer’s (i.e. Group1: Alzheimer’s Diagnosed; Group2: Pre-Alzheimer’s; and Group3: Normal) in addition to clinical medical symptoms (e.g., memory loss, cognitive impairment such as mental disorientation and/or mental confusion) and MRI results. Statistical analysis showed that the groups were well categorized based on the three selected parameters. Group 1 showed the highest fluorescence total mean followed by Group 2, as compared to Group 3, which exhibited the lowest total mean. Gender seemed to be an associate factor at time of the disease onset. These results suggest the advantage of using this method for early detection of Alzheimer’s disease as well as the importance of metals for triggering the expression of β-amyloid protein. *Correspondence to: Cuero R, PhD, 15310 Misty Dawn, Trl Cypress, TX, USA, Tel: (832) 477-5510; E-mail: olimpa@aol.com","PeriodicalId":309709,"journal":{"name":"Diabetes Updates","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127305889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}