Journal of Cardiovascular Disorders最新文献

Effects of Barberry Capsules on Serum Zinc and Copper in Individuals with Metabolic Syndrome 杨梅胶囊对代谢综合征患者血清锌、铜的影响

Journal of Cardiovascular Disorders Pub Date : 2022-03-16 DOI: 10.26420/jcardiovascdisord.2022.1050

S. M, Shaghi F, Safarian H, Saffar S, Tavallaei S, Navaei-Alipour N, Shabani N, Ferns Ga, Ghayour-Mobarhan M, Darroudi S, Kermany T, Zilae M

{"title":"Effects of Barberry Capsules on Serum Zinc and Copper in Individuals with Metabolic Syndrome","authors":"S. M, Shaghi F, Safarian H, Saffar S, Tavallaei S, Navaei-Alipour N, Shabani N, Ferns Ga, Ghayour-Mobarhan M, Darroudi S, Kermany T, Zilae M","doi":"10.26420/jcardiovascdisord.2022.1050","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2022.1050","url":null,"abstract":"Aim: In current study, we aimed to investigate the effects of barberry on serum copper (Cu), zinc (Zn) and superoxide dismutase (SOD) levels in subjects with MetS, because of it are the anti-inflammatory and antioxidant properties. Methods: 106 Subjects were randomly assigned to 2 study groups: 1) A barberry group receiving capsules containing 600 mg barberry daily for 6 weeks (n=53); 2) Control group contained subjects taking one placebo capsule daily (n=53). Atomic absorption was used to measure serum zinc and copper. SOD activity was measured using a pyrogallol indirect spectrophotometric assay. Results: The results showed that there was no significant difference in changes in serum zinc between the barberry and placebo groups (p=0.620). There were significant differences in changes in serum copper between the 2 study groups (p<0.001). Moreover, there were significant differences in Zn/ Cu changes between the barberry and placebo groups (p=0.027). In addition, there were significant differences in changes in serum SOD1 between the study groups (p=0.077). Conclusion: The results of the current study showed that barberry supplementation (600mg daily) for 6 weeks can increase serum copper and SOD1 levels and decrease the Zn/Cu ratio in patients with MetS.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121214032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers and Facilitators to Uptake and Attendance of Secondary Cardiac Prevention Programmes for Indigenous New Zealanders 新西兰土著居民接受和参加二级心脏病预防方案的障碍和促进因素

Journal of Cardiovascular Disorders Pub Date : 2021-11-09 DOI: 10.26420/jcardiovascdisord.2021.1049

K. A

{"title":"Barriers and Facilitators to Uptake and Attendance of Secondary Cardiac Prevention Programmes for Indigenous New Zealanders","authors":"K. A","doi":"10.26420/jcardiovascdisord.2021.1049","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2021.1049","url":null,"abstract":"Aim: Cardiac Rehabilitation (CR) has good success in improving health outcomes after a heart event. There is poor enrolment and attendance of CR programmes worldwide, particularly for indigenous peoples, such as New Zealand (NZ) Maori. The present study aimed to provide in-depth interview information about barriers and facilitators of both enrolment and attendance in CR, as well as identifying potential solutions. Methods: Thirty-two semi-structured interviews with Maori referred to CR who either: did not enroll; enrolled but did not complete; and completed the programme. Interview topics were based on meta-syntheses and NZspecific information as well as suggested improvements. The transcripts were inductively analysed. Results: Barriers specific to enrolment were inadequate timing or format communication about CR. Time of day or day of week of sessions, and ability to find transportation to attend were barriers to attending. Group format and cultural focus were perceived as barriers to some, but facilitators for others (enrolment and attendance). Participants suggested ways to improve CR communication (enrolment), flexibility regarding content and timing of CR, and, provision of transport (enrolment and attendance), and, increased cultural focus (enrolment and attendance). Conclusions: Providing a greater variety and flexibility in CR programme design could potentially improve enrolment and attendance for indigenous and for non-indigenous clients. Offering CR sessions after hours, in locations that are easily accessible, having different formats such as: groups, individual versus online, or, indigenous- or European dominant-focus may mean that CR appeals to a larger group of CR patients.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127432033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical and Interventional Treatment of Refractory Angina 难治性心绞痛的内科与介入治疗

Journal of Cardiovascular Disorders Pub Date : 2021-10-15 DOI: 10.26420/jcardiovascdisord.2021.1048

Valchanov K, Tan Z, Valchanova A

引用次数: 0

An Overview of the Available Health System for Monitoring Non-Communicable Diseases in Malawi 马拉维监测非传染性疾病的现有卫生系统概述

Journal of Cardiovascular Disorders Pub Date : 2021-10-08 DOI: 10.26420/jcardiovascdisord.2021.1047

Safary E, Mtaita C

{"title":"An Overview of the Available Health System for Monitoring Non-Communicable Diseases in Malawi","authors":"Safary E, Mtaita C","doi":"10.26420/jcardiovascdisord.2021.1047","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2021.1047","url":null,"abstract":"Background: Non-Communicable Diseases (NCDs) are a major cause of morbidity and mortality in Malawi and they come second as the leading cause of death in adults after HIV and AIDS. The World Health Organization (WHO) highlighted the importance of NCD monitoring as a key action which were adopted by the Member States in addressing NCDs. The framework is composed of nine global targets and 25 indicators aimed at combating global mortality for the four main NCDs. This study aimed to examine the existing national NCD monitoring tools, activities and gaps in Malawi based on WHO Global Monitoring Framework for NCDs. Methods: A desk review was conducted from June to August 2021, to examine the existing national NCD monitoring tool in Malawi from multiple sources. Policy and program documents relating to NCD monitoring in Malawi from 2011 to 2021 were identified and analyzed. Results: The findings of this review are presented according to the three major themes of the Global Monitoring Framework: Health systems capacity, monitoring of risk factors, and monitoring of mortality and morbidity outcomes. Malawi has an NCD monitoring tool in place that is adequate for the WHO NCD Global Monitoring Framework. However, there are still gaps with data from monitoring health systems indicators of the framework and hence requires strengthening. Conclusion: The country must also look beyond these set of indicators and target increasing burden and impact of COVID-19 pandemic.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131481296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increase of Homocysteinemia/Hydrogen Sulfide (Hcy/H2S) Ratio Raises Cardiovascular Injuries 同型半胱氨酸血症/硫化氢(Hcy/H2S)比值升高可增加心血管损伤

Journal of Cardiovascular Disorders Pub Date : 2021-08-06 DOI: 10.26420/jcardiovascdisord.2021.1046

C. F

引用次数: 0

Worse Course and Bad Prognosis of COVID-19 in Hyper-Homocysteinemia: Role of Some B-Group Vitamins and of Other Compounds 高同型半胱氨酸血症患者COVID-19病程恶化及预后不良:部分b族维生素及其他化合物的作用

Journal of Cardiovascular Disorders Pub Date : 2021-07-22 DOI: 10.26420/jcardiovascdisord.2021.1045

C. F

{"title":"Worse Course and Bad Prognosis of COVID-19 in Hyper-Homocysteinemia: Role of Some B-Group Vitamins and of Other Compounds","authors":"C. F","doi":"10.26420/jcardiovascdisord.2021.1045","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2021.1045","url":null,"abstract":"Background: Increased homocysteine serum levels (HHcy) induce Endothelium Dysfunction (ED), responsible of the activation of some proinflammatory agents (“cytokine storm”), the imbalance between vasodilation and vasoconstriction with vasoconstrictive prevalence, increased oxidative stress and hyper-coagulability. Methods: All these events can worsen the course of COVID-19 in HHcy- patients, favoring the evolution towards vasculitis, thromboembolic complications, multi-organ dysfunction until acute respiratory distress and failure. Results: Therefore, Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) also called COVID-19, elapses more dangerously in patients affected by HHcy and can easily complicate with thromboembolic events. But, some vitamins of B-group and other substances could positively affect both high Hcy levels and thrombotic complications of SARS-CoV-2 happening in lungs and other districts. Conclusions: COVID-19 can have a dangerous evolution and a bad prognosis in patients with HHcy. Concerning this, some compounds seem to exert beneficial effects on HHcy, inflammatory and coagulopathic complications.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129767067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Longitudinal Study on Hematocrit Changes after Glifozins Exposure in Patients with Type 2 Diabetes 2型糖尿病患者格列净暴露后红细胞压积变化的纵向研究

Journal of Cardiovascular Disorders Pub Date : 2021-07-12 DOI: 10.26420/jcardiovascdisord.2021.1044

De las Nieves López Ma, C. RoblesMateos, Soriano Jj, O. BarónFernandez, Dominguez Lomeña Mj, Palomo Hernandez Am

引用次数: 3

Galectin-3 in Heart Failure with Preserved Ejection Fraction and Persistent Atrial Fibrillation Versus Sinus Rhythm. Correlation with Left Atrial Volume and N-Terminal Pro B-Type Natriuretic Peptide 半凝集素-3在保留射血分数和持续性心房颤动的心力衰竭与窦性心律中的作用。左房容积与n端前b型利钠肽的相关性

Journal of Cardiovascular Disorders Pub Date : 2021-07-09 DOI: 10.26420/jcardiovascdisord.2021.1043

M. Bertoni, Traini Am, A. Celli, C. Bini, A. Bracciali, M Foretic, D. Me

{"title":"Galectin-3 in Heart Failure with Preserved Ejection Fraction and Persistent Atrial Fibrillation Versus Sinus Rhythm. Correlation with Left Atrial Volume and N-Terminal Pro B-Type Natriuretic Peptide","authors":"M. Bertoni, Traini Am, A. Celli, C. Bini, A. Bracciali, M Foretic, D. Me","doi":"10.26420/jcardiovascdisord.2021.1043","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2021.1043","url":null,"abstract":"Background: Galectin-3 (Gal-3) is considered both a profibrotic biomarker in Heart Failure with preserved Ejection Fraction (HFpEF) and a biomarker of atrial remodeling in Atrial Fibrillation (AF). The Left Atrial Volume Index (LAVI) is an echocardiographic parameter considered an index of left atrial remodeling. Aim of this study was to analyse the relation of Gal-3 levels with both LAVI and N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in patients with HFpEF and Persistent AF (HFpEF-PAF). Methods: Serum Gal-3 and NT-proBNP, along with LAVI were measured. A comparison of such parameters between 49 patients with HFpEF-PAF and 53 patients with HFpEF and sinus rhythm (HEpEF-SR) was made. Results: Galectin-3, NT-proBNP and LAVI were significantly higher in patients with HFpEF-PAF compared to HFpEF-SR (23±7 ng/mL vs 19.5±8.5 ng/mL, p=0.027; 3,406.8±2,321.9 pg/mL vs 1,459.6±1,372 pg/mL, p<0.001; 40.1±11mL/m² vs 28.4±7.7 mL/m², p<0.001, respectively). In HFpEF-PAF, Gal- 3 showed a significant correlation with both NT-proBNP (r=0.40, p=0.0038) and LAVI (r=0.28, p=0.044). We found a significant association between patients with higher levels of Gal-3 >17.8 ng/mL and HFpEF-PAF (p=0.002). Finally, a multivariate logistic regression analysis adjusted for age, sex and traditional clinical AF risk factors showed that Gal-3 >17,8 ng/mL (OR 3.862, 95% CI 1.416 to 10.532, p=0.008) was an independent predictor of PAF. Conclusions: In patients with HFpEF-PAF Gal-3 was higher and related with both NT-proBNP and LAVI. The latter correlation may be relevant because LAVI is considered an index of left atrial remodeling. Moreover, higher levels of Gal-3>17,8 ng/mL were an independent predictor of PAF.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125152418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable Devices: A Future Useful Tool for Detection of Silent Ischemia in Patients with Diabetes? 可穿戴设备:检测糖尿病患者无症状缺血的未来有用工具?

Journal of Cardiovascular Disorders Pub Date : 2021-07-07 DOI: 10.26420/jcardiovascdisord.2021.1042

Vlachakis Pk, A. Tentolouris, I. Kanakakis, I. Eleftheriadou, D. Alexopoulos

引用次数: 0

Epigallocatechin Gallate (EGCG) – A Novel Covalent NF- κB Inhibitor: Structural and Molecular Characterization 表没食子儿茶素没食子酸酯(EGCG) -一种新型共价NF- κB抑制剂:结构和分子表征

Journal of Cardiovascular Disorders Pub Date : 2021-06-07 DOI: 10.26420/jcardiovascdisord.2021.1041

Reddy At, Lakshmi Sp, Varadacharyulu N.Ch, Kodidhela Ld

{"title":"Epigallocatechin Gallate (EGCG) – A Novel Covalent NF- κB Inhibitor: Structural and Molecular Characterization","authors":"Reddy At, Lakshmi Sp, Varadacharyulu N.Ch, Kodidhela Ld","doi":"10.26420/jcardiovascdisord.2021.1041","DOIUrl":"https://doi.org/10.26420/jcardiovascdisord.2021.1041","url":null,"abstract":"Tea contains antioxidant catechins thought to exert health-promoting protective effects against conditions involving chronic inflammation, such as cardiovascular diseases. The most abundant catechin in tea is Epigallocatechin Gallate (EGCG), thought to be a key contributor to tea’s health-promoting actions. EGCG exerts protective cardiovascular effects via its antioxidant, antiinflammatory, hypolipidemic, anti-thrombogenic, and anti-hypertensive actions. Because EGCG inhibits the strong proinflammatory gene-inducing transcription factor NF-κB, we analyzed the chemical and molecular details of the mechanism by which EGCG mediates NF-κB inhibition. We quantified and mapped key parameters of its chemical reactivity including its electrophilic Fukui ƒ+ function, in silico covalent binding, and identified its frontier Molecular Orbitals (MOs) and nucleophilic susceptibility. These physical and chemical reactivity parameters revealed that the bond-forming MOs are distributed on the B ring of the EGCG oxidized state with nucleophilic susceptibility, and that this B ring has properties that favor participating in a Cys-alkylating 1,4-addition reaction. Molecular modeling and docking analysis further revealed that EGCG bonds covalently with Cys-38 of NF-κB-p65, and thereby inhibits its DNA binding ability. We also generated a model pharmacophore based on the EGCG-NF-κB complex. We conclude that EGCG covalently binds to NF-κB-p65 and inhibits it by abolishing its DNA binding, by chemical mechanisms that may inform design of EGCG derivatives as novel anti-inflammatory agents.","PeriodicalId":309705,"journal":{"name":"Journal of Cardiovascular Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116307929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0