Effects of Barberry Capsules on Serum Zinc and Copper in Individuals with Metabolic Syndrome

S. M, Shaghi F, Safarian H, Saffar S, Tavallaei S, Navaei-Alipour N, Shabani N, Ferns Ga, Ghayour-Mobarhan M, Darroudi S, Kermany T, Zilae M
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Abstract

Aim: In current study, we aimed to investigate the effects of barberry on serum copper (Cu), zinc (Zn) and superoxide dismutase (SOD) levels in subjects with MetS, because of it are the anti-inflammatory and antioxidant properties. Methods: 106 Subjects were randomly assigned to 2 study groups: 1) A barberry group receiving capsules containing 600 mg barberry daily for 6 weeks (n=53); 2) Control group contained subjects taking one placebo capsule daily (n=53). Atomic absorption was used to measure serum zinc and copper. SOD activity was measured using a pyrogallol indirect spectrophotometric assay. Results: The results showed that there was no significant difference in changes in serum zinc between the barberry and placebo groups (p=0.620). There were significant differences in changes in serum copper between the 2 study groups (p<0.001). Moreover, there were significant differences in Zn/ Cu changes between the barberry and placebo groups (p=0.027). In addition, there were significant differences in changes in serum SOD1 between the study groups (p=0.077). Conclusion: The results of the current study showed that barberry supplementation (600mg daily) for 6 weeks can increase serum copper and SOD1 levels and decrease the Zn/Cu ratio in patients with MetS.
杨梅胶囊对代谢综合征患者血清锌、铜的影响
目的:本研究旨在探讨杨梅具有抗炎和抗氧化作用,对MetS患者血清铜(Cu)、锌(Zn)和超氧化物歧化酶(SOD)水平的影响。方法:106名受试者随机分为2个研究组:1)杨梅组,每日服用杨梅胶囊600 mg,连续6周(n=53);2)对照组:每日服用1粒安慰剂胶囊(n=53)。原子吸收法测定血清锌、铜。采用邻苯三酚间接分光光度法测定SOD活性。结果:结果显示,两组患者血清锌含量变化无显著性差异(p=0.620)。两组患者血清铜含量变化差异有统计学意义(p<0.001)。此外,枸杞组和安慰剂组的锌/铜变化也有显著差异(p=0.027)。此外,两组患者血清SOD1变化差异有统计学意义(p=0.077)。结论:本研究结果表明,在MetS患者中,连续6周补充杨梅(600mg / d)可提高血清铜和SOD1水平,降低Zn/Cu比值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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