RRNMF Neuromuscular Journal最新文献_第5页

Access to Healthcare: More primary care and no financial barriers for anyone 获得医疗保健:更多初级保健，任何人都没有经济障碍

RRNMF Neuromuscular Journal Pub Date : 2023-06-19 DOI: 10.17161/rrnmf.v4i2.19563

Joshua Freeman

引用次数: 0

Quantitative sensory testing in a large cohort of neuropathy patients 大量神经病变患者的定量感觉测试

RRNMF Neuromuscular Journal Pub Date : 2023-06-19 DOI: 10.17161/rrnmf.v4i2.19513

A. Lizarraga, Salman F Bhai, G. Wolfe, L. Herbelin, S. Nations, Morgan McCreary, D. Saperstein, R. Barohn

{"title":"Quantitative sensory testing in a large cohort of neuropathy patients","authors":"A. Lizarraga, Salman F Bhai, G. Wolfe, L. Herbelin, S. Nations, Morgan McCreary, D. Saperstein, R. Barohn","doi":"10.17161/rrnmf.v4i2.19513","DOIUrl":"https://doi.org/10.17161/rrnmf.v4i2.19513","url":null,"abstract":"Background: \u0000Quantitative sensory testing (QST) is a subjective but reliable and quantifiable method to detect patient thresholds to different sensory stimuli. QST is used to measure small- and large-fiber nerve function and can be used in conjunction with other diagnostic modalities in the evaluation of peripheral neuropathy (PN). The utility of QST to distinguish among different types of PN, however, has not been explored. The objective of the study was to evaluate if different patterns of QST abnormalities could distinguish between PN types. \u0000Methods: \u0000This single-center retrospective cohort study evaluated the frequency of QST abnormalities to vibratory, cold and heat detection thresholds in a large population of PN cases evaluated at the University of Texas Southwestern Medical Center peripheral neuropathy clinic between 1995-2000. PN was categorized by etiology. \u0000Results: \u0000A total of 559 QST studies were performed in this study. The average age of patients (n=557) was 60 years with a male-to-female ratio of 1:1. The most common diagnosis was cryptogenic sensory polyneuropathy (CSPN, n=294), followed by Charcot–Marie–Tooth disease (n=84)). Meta-regression of vibration and cold indicate that the expected proportion of abnormal responses is less for the vibration test (p = 0.0002), relative to the cold test. However, no differences were observed between diagnoses. \u0000Conclusions: \u0000Though abnormal QST thresholds were seen in most patients with PN, patterns of QST abnormalities do not distinguish between different types of PN. The routine clinical utility of QST is likely limited.","PeriodicalId":309700,"journal":{"name":"RRNMF Neuromuscular Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124921689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival of the Fittest 适者生存

RRNMF Neuromuscular Journal Pub Date : 2023-06-19 DOI: 10.17161/rrnmf.v4i2.19959

E. Rowe, Vernon D. Rowe

引用次数: 0

A novel MUSK mutation in a patient with CMS9 一名CMS9患者的新型MUSK突变

RRNMF Neuromuscular Journal Pub Date : 2023-06-19 DOI: 10.17161/rrnmf.v4i2.18588

J. Elliott

引用次数: 0

Under the Watchful Eye of the Knife 在刀的注视下

RRNMF Neuromuscular Journal Pub Date : 2023-06-19 DOI: 10.17161/rrnmf.v4i2.19854

Michael Abraham

引用次数: 0

Emergent Comorbid Events in First Year of Immunomodulatory Treatment in Adults With Generalized Myasthenia Gravis treated in a Neurology Clinic: A Retrospective Review 神经病学临床治疗的成人全身性重症肌无力患者免疫调节治疗第一年的紧急共病事件:回顾性回顾

RRNMF Neuromuscular Journal Pub Date : 2023-02-07 DOI: 10.17161/rrnmf.v3i4.16214

N. Katyal, Brian Blankenship, N. Narula, Eric A Grisham, R. Govindarajan

{"title":"Emergent Comorbid Events in First Year of Immunomodulatory Treatment in Adults With Generalized Myasthenia Gravis treated in a Neurology Clinic: A Retrospective Review","authors":"N. Katyal, Brian Blankenship, N. Narula, Eric A Grisham, R. Govindarajan","doi":"10.17161/rrnmf.v3i4.16214","DOIUrl":"https://doi.org/10.17161/rrnmf.v3i4.16214","url":null,"abstract":"Background: Current treatments for myasthenia gravis, including immunomodulatory therapies, are associated with significant comorbid events. \u0000Method: Retrospective chart review of all adults diagnosed with generalized myasthenia gravis in our clinic over 5 years to evaluate potential associations between treatment regimens and emergent comorbid events according to system organ class. Comorbid events were categorized by affected system organ class as endocrine, neuropsychiatric, musculoskeletal, gastrointestinal, pulmonary, cardiovascular, urologic, infectious, and hematologic. MG treatment regimens at the latest available date during the 1-year follow-up were categorized by corticosteroid use and further stratified by medication class and combination therapy. \u0000Result: A total of 68 patients were included in the analysis (corticosteroid group, n = 43; non-corticosteroid group, n = 25). We found no significant differences in the frequencies of comorbid events between patients whose regimens included corticosteroids and patients with corticosteroid-free regimens. Patients who received pyridostigmine, high-dose corticosteroids, and corticosteroid-sparing agents in combination experienced higher incidences of emergent endocrine and neuropsychiatric events than those who received other corticosteroid-containing treatments. \u0000Conclusion: Polypharmacy that included high-dose corticosteroids was associated with a greater incidence of new endocrine and neuropsychiatric comorbid events within 1 year of diagnosis","PeriodicalId":309700,"journal":{"name":"RRNMF Neuromuscular Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133963327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FDA should protect the American people, and Pharma should pay! FDA应该保护美国人民，制药公司应该付钱!

RRNMF Neuromuscular Journal Pub Date : 2023-02-07 DOI: 10.17161/rrnmf.v3i4.18548

Joshua Freeman

引用次数: 0

Steroid Responsive Acute Inflammatory Demyelinating Polyneuropathy Induced by an Immune Check Point Inhibitor 免疫检查点抑制剂诱导的类固醇反应性急性炎性脱髓鞘性多神经病变

RRNMF Neuromuscular Journal Pub Date : 2023-02-07 DOI: 10.17161/rrnmf.v3i4.18080

N. Al-Bustani, Z. Hussain

引用次数: 0

Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis: follow up survey 重症肌无力患者对COVID-19大流行知识和认知的随访调查

RRNMF Neuromuscular Journal Pub Date : 2023-02-07 DOI: 10.17161/rrnmf.v4i1.18415

Yingkai Li, Y. Harada, Marjan Cobbaert, V. Juel, L. Hobson‐Webb, S. Raja, N. González, J. Guptill

{"title":"Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis: follow up survey","authors":"Yingkai Li, Y. Harada, Marjan Cobbaert, V. Juel, L. Hobson‐Webb, S. Raja, N. González, J. Guptill","doi":"10.17161/rrnmf.v4i1.18415","DOIUrl":"https://doi.org/10.17161/rrnmf.v4i1.18415","url":null,"abstract":"Introduction \u0000We previously conducted a survey study in April 2020 at the beginning of the SARS-CoV-2 (COVID-19) pandemic to understand how it affected patients with myasthenia gravis (MG). Since then, significant advances have occurred in the following areas: knowledge about the SARS-CoV-2 virus, infection risk mitigation, patient management, risks for MG patients, and a global vaccination program. We conducted a follow-up survey in February 2021 to assess how these advances impacted the care and perception of MG patients. \u0000Methods \u0000We conducted a prospective online survey study of MG patients at a large academic practice in the Duke Health System. \u0000Results \u0000Seventy-eight patients participated in the survey including 55 from previous survey and 23 newly identified patients. The top reported change in the interaction with healthcare providers was an increase in telemedicine visits (74%). The median satisfaction score (0-100 scale) for telemedicine visits was 74. Ninety-six percent of survey participants expressed concern about pandemic and nearly half of participants showed anxiety based on Generalized Anxiety Disorder-7 score. The top 3 concerns related to COVID-19 were getting hospitalized (62%), exacerbation (62%) and death (53%). \u0000Discussion \u0000Although the results of follow-up survey were overall similar to the previous study, most of patients switched from in-person clinic visits to telemedicines. The overwhelmingly large portion of patients continue to have concern and anxiety for pandemic but the patients with severe symptoms have higher anxiety scores. \u0000Conclusion \u0000This follow-up survey demonstrated the adjustment of MG patients to new methods of communication, significant psychological impact of COVID-19 on them and their good healthcare literacy. ","PeriodicalId":309700,"journal":{"name":"RRNMF Neuromuscular Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128163638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel DOK7 mutation causing limb-girdle congenital myasthenic syndrome 一种新的导致四肢带状先天性肌无力综合征的DOK7突变

RRNMF Neuromuscular Journal Pub Date : 2023-02-07 DOI: 10.17161/rrnmf.v3i4.18087

A. Reynolds, A. Lin, Leo H. Wang

引用次数: 0