Klinicist最新文献_第6页

A TWO-YEAR FOLLOW-UP OF A FEMALE PATIENT WITH RECURRENT PULMONARY THROMBOEMBOLISM AFTER SUCCESSFUL COMBINED TREATMENT 对一例成功联合治疗后复发性肺血栓栓塞的女性患者进行为期两年的随访

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-2-40-47

I. Baranova, M. V. Zaikina, L. Sokolova, L. G. Tokareva, G. Ivanova, S. Biryukov, E. Filippov

引用次数: 0

SECONDARY OSTEOARTHRITIS IN RHEUMATOID ARTHRITIS 类风湿关节炎中的继发性骨关节炎

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-1-24-29

I. Starodubtseva, L. Vasilyeva

{"title":"SECONDARY OSTEOARTHRITIS IN RHEUMATOID ARTHRITIS","authors":"I. Starodubtseva, L. Vasilyeva","doi":"10.17650/1818-8338-2015-1-24-29","DOIUrl":"https://doi.org/10.17650/1818-8338-2015-1-24-29","url":null,"abstract":"The paper considers the problems of comorbidities in patients with rheumatoid arthritis (RA). Two or more RA-related conditions were diag-nosed according to the results of the QUEST-RA program implemented in 34 countries. Osteoarthritis along with hypertension, hyperlipid-emia, and osteoporosis was detected among the most commonly diseases. Owing to expanded diagnostic capabilities, the recognition and treatment of the comorbidities have recently received much attention, as embodied in the draft Association of Rheumatologists of Russia Guidelines for RA management (2014; Part 1). The concept and major characteristics of secondary osteoarthritis in RA are analyzed. It is precisely the inflammatory process and underlying disease-related risk factors, including treatment, that have impact on the development of secondary osteoarthritis and patients’ quality of life as a whole. All this allows an inference about the mechanisms closely inter-twined with the underlying disease for the development of secondary osteoarthritis, which initiates cartilage damage and further remodeling. Primary and secondary osteoarthritis was comparatively analyzed. Particular emphasis is placed on current cartilage biomarkers, their diagnostic value and role in monitoring the efficiency of treatment in clinical trials. The paper provides a comparative analysis of detectable serum and urine biomarkers according to the results of the complex analysis made by the National Institutes of Health. Particular attention is given to cartilage oligomeric matrix protein (COMP). Foreign authors’ investigations suggest that there is a relationship between serum COMP levels and disease severity and joint X-ray changes. There is evidence for the efficacy of hyaluronic acid used in the treatment of secondary osteoarthritis in patients with RA.","PeriodicalId":30685,"journal":{"name":"Klinicist","volume":"9 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67767304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CURRENT POSSIBILITIES OF ANTICOAGULANT THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION 心房颤动患者抗凝治疗的当前可能性

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-3-15-21

M. Gilyarov, E. Konstantinova, A. I. Trukhin

引用次数: 1

ANALYSIS OF OUTPATIENT PHYSICIANS, PRESCRIPTION OF DISAGGREGANT THERAPY FOR PATIENTS AFTER ACUTE MYOCARDIAL INFARCTION AND/OR CORONARY ANGIOPLASTY WITH STENT IMPLANTATION WITHIN THE RECVAD REGISTRY 门诊医生的分析，急性心肌梗死和/或冠状动脉成形术患者支架植入术后的崩解治疗处方

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-3-34-39

A. V. Zagrebelnyi, S. Martsevich, M. M. Lukyanov, E. G. Pereverzeva, A. Vorobyev, S. Yakushin, S. Boitsov

引用次数: 0

PHYSICAL ACTIVITY AND ITS IMPORTANCE FOR THE PREVENTION OF CARDIOVASCULAR DISEASES 体育活动及其对预防心血管疾病的重要性

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-3-10-14

S. Yakushin, E. Filippov

引用次数: 0

NON-RHEUMATIC MYOCARDITIDES NON-RHEUMATIC MYOCARDITIDES

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-3-46-51

N. Shostak, A. Klimenko, V. Shemenkova, T. K. Loginova

{"title":"NON-RHEUMATIC MYOCARDITIDES","authors":"N. Shostak, A. Klimenko, V. Shemenkova, T. K. Loginova","doi":"10.17650/1818-8338-2015-9-3-46-51","DOIUrl":"https://doi.org/10.17650/1818-8338-2015-9-3-46-51","url":null,"abstract":"prior infection and use of some drugs) and the presence of the symptoms of myocardial lesion (chest pain, dyspnea, rhythm and conduction disturbances) may sug gest an idea on the possible development of myocarditis. Laboratory studies show an elevation of cardiospecific enzymes and the signs of an inflammatory response. Endomyocardial biopsy (EMB) is the gold standard for the diagnosis of myocarditis to the present day. The diag nostic value of the method is limited by technical feasibilities, the skills of medical staff, and the development of possible complications. Gadolinium magnetic resonance imaging that can visualize myocardial inflammatory foci may be used as an alternative to EMB. The de veloped criteria are of definite diagnostic value; however, the problems in making diagnosis and differential diagnosis remain unsolved. There are no specific myocarditis treatment methods and regimens. Symptomatic therapy is most commonly used depending on the existing manifestations of myocarditis. The intake of nonsteroidal antiinflammatory drugs and glucocorticosteroids is now a point open to question. It is necessary to remember about the prevention of infectious myocarditis and the sanitization of existing foci of infection in the body.","PeriodicalId":30685,"journal":{"name":"Klinicist","volume":"6 1","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67768931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА НОРМОКАЛЬЦИЕМИЧЕСКОГО ВАРИАНТА ГИПЕРПАРАТИРЕОЗА 甲状腺功能亢进规范性钙变体的鉴别诊断

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-4-47-52

Н. А. Кравчун, И В Чернявская, Ю. А. Титова, Т И Ефименко

{"title":"ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА НОРМОКАЛЬЦИЕМИЧЕСКОГО ВАРИАНТА ГИПЕРПАРАТИРЕОЗА","authors":"Н. А. Кравчун, И В Чернявская, Ю. А. Титова, Т И Ефименко","doi":"10.17650/1818-8338-2015-9-4-47-52","DOIUrl":"https://doi.org/10.17650/1818-8338-2015-9-4-47-52","url":null,"abstract":"Objective: to describe a case of normocalcemic hyperparathyroidism. Materials and methods. A female patient aged 51 years sought medical advice for complaints of spinal column and bone pains, periodic dizziness, and hand numbness. The patient underwent clinical and biochemical blood tests, determination of the blood levels of calcium, phosphorus, parathyroid hormone, concentrations of total vitamin D, calciuria, electrocardiography, thyroid ultrasonography, and neck computed tomography. Results. Based on her complaints, examination evidence, evaluation of the clinical presentations of the disease, and objective and instrumental examination findings, the patient was diagnosed with left parathyroid adenoma and primary hyperparathyroidism; stage II hypertensive disease, grade I, a moderate risk; retinal angiopathy of both eyes; stage I dyscirculatory encephalopathy with liquor and venous dyscirculation and moderate vestibular ataxia; urolithiasis; kidney stones; and spondylosis mainly involving the lumbar spine. The diagnostic determinants for verifying the diagnosis were the results of neck computed tomography, namely: the signs of space-occupying lesion in the projection of the left parathyroid gland; the blood level of parathyroid hormone 118.6 pg/ml (normal value (N) 9.5–75.0 pg/ml); total vitamin D 21.64 nmol/l (N 75–250 nmol/l); and calcium 2.48 mmol/l (N 2.15–2.50 mmol/l). The history of urolithiasis, repeated lithotripsy, as well as spondylosis with lumboischalgia was an absolute indication for surgical treatment. Conclusion. The practical interest in this case is due to the complexity of diagnosing normocalcemic hyperparathyroidism after vitamin D deficiency. The early stages of primary hyperparathyroidism are asymptomatic and frequently give rise to irreversible renal complications, causing renal failure and, as a consequence, disability. This clinical case demonstrates the importance of routinely determining vitamin D concentrations, which in turn triggers parathyroid adenomas.","PeriodicalId":30685,"journal":{"name":"Klinicist","volume":"9 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67768586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

REHABILITATION IN CARDIOLOGY AND CARDIOSURGERY 心脏病学和心脏外科康复

Klinicist Pub Date : 2015-01-01 DOI: 10.17650/1818-8338-2015-9-2-13-22

N. Galtseva

引用次数: 8

СЛУЧАЙ ОСТЕОПОРОЗА ПОЗВОНОЧНИКА У МУЖЧИНЫ С КАЛЬЦИНИРОВАННЫМ АОРТАЛЬНЫМ СТЕНОЗОМ В ПОЖИЛОМ ВОЗРАСТЕ 老年人患有钙主动脉狭窄的男性脊柱骨质疏松症。

Klinicist Pub Date : 2014-07-15 DOI: 10.17650/1818-8338-2013-1-55-59

Н. Ю. Карпова, Надежда Александровна Шостак, М. А. Рашид, С. М. Сороколетов, Татьяна Викторовна Казакова

引用次数: 0

SUBACUTE MYOCARDITIS: MYTHS AND REALITY 亚急性心肌炎:神话与现实

Klinicist Pub Date : 2014-07-01 DOI: 10.17650/1818-8338-2011-5-4-76-79

P. Shesternya, V. Shulman, K. V. Zlodeev, E. A. Suglobova, D. Yurin

引用次数: 0