Acta paediatrica sinica最新文献

Immunogenicity and Reactogenicity of Two Recombinant Hepatitis B Vaccines in Healthy Adolescents on Two-dose Healthy Adolescents on Two-dose Schedule 两种重组乙型肝炎疫苗在健康青少年中的免疫原性和反应原性

Acta paediatrica sinica Pub Date : 1999-06-30 DOI: 10.7097/APS.199906.0157

Chih‐Cheng Chen, Mei‐Hwei Chang, Hung-Chang Lee, S. Twu, A. Safary

{"title":"Immunogenicity and Reactogenicity of Two Recombinant Hepatitis B Vaccines in Healthy Adolescents on Two-dose Healthy Adolescents on Two-dose Schedule","authors":"Chih‐Cheng Chen, Mei‐Hwei Chang, Hung-Chang Lee, S. Twu, A. Safary","doi":"10.7097/APS.199906.0157","DOIUrl":"https://doi.org/10.7097/APS.199906.0157","url":null,"abstract":"This is an open, randomized study to compare the immunogenicity and reactogenicity of two recombinant hepatitis B virus (HBV) vaccines. The HBV-NF is a new formulation with a new adjuvant phenoxyethanol which replaced the conventional adjuvant of a commercially available recombinant HBV vaccine (Engerix-B). These two vaccines had the same 20/μg hepatitis B surface antigen (HBsAg). They were administered to the deltoid muscle of 116 healthy adolescents, aged between twelve and eighteen years, according to the 0, 6-month schedule. Serum was taken at month 0, 1, 6, and 7. Antibody to HBsAg was tested by radioimmunoassay. Geometric mean titers of both vaccines displayed no significant difference at month 1, 6, and 7. Following the second dose of vaccine, the seroprotection titer (10 mIU/ml) rates at month 7 were 90.9% in HBV-NF and 93.4% in Engerix-B, respectively (p=0.43). The incidences of local and general adverse reactions were from 3% to 7% without significant difference between the two vaccines and the reactions were all mild and tolerable. Based on this study, regimens of this two-dose schedule proved to be safe and immunogenic, which may provide a cost-effective alternative for HBV mass vaccination program in adolescents.","PeriodicalId":306859,"journal":{"name":"Acta paediatrica sinica","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131648353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Myelitis and Neuritis Assoclated with Multiple Herpesvirus Infections 与多发性疱疹病毒感染相关的急性脊髓炎和神经炎

Acta paediatrica sinica Pub Date : 1999-04-05 DOI: 10.7097/APS.199904.0118

Yu-Chia Hsieh, C. Young, Li-Min Huang, Yu‐Zen Shen

{"title":"Acute Myelitis and Neuritis Assoclated with Multiple Herpesvirus Infections","authors":"Yu-Chia Hsieh, C. Young, Li-Min Huang, Yu‐Zen Shen","doi":"10.7097/APS.199904.0118","DOIUrl":"https://doi.org/10.7097/APS.199904.0118","url":null,"abstract":"Abstract: We report a three-year-old boy who suffered from myelitis and neuritis which were considered to be associated with herpesvirus infection. Initial manifestations of this patient were lethargy, hoarseness, weakness and ataxia. He developed fever and exudative tonsilitis two weeks prior to this illness. Upon physical examination, decreased muscle power and deep tendon reflex of four extremities were disclosed. Romberg test was positive as well. There was no cerebellar sign. Examination of cerebrospinal fluid showed albuminocytologic dissociation (protein: 294mg/dl, cell count: 1). Nerve conduction velocity study revealed marked slowing of both motor and sensory nerves. Magnetic resonance image showed bright signal in T2 image of cervical cord (from C2 to C4), especially at the dorsal aspect. The positive IgM antibodies against these three viruses confirmed active infection with human herpesvirus type 6, cytomegalovirus, and Epstein-Ban virus (EBV). Furthermore, significant rise of IgG antibody against cytomegalovirus and EBV was demonstrated. The presence of antibody against EBNA in the first serum sample indicated a reactivated EBV infection. This report illustrated the association of herpesvirus infection and neuropathy and myelitis. Whether the more severe clinical manifestation was due to multiple herpesvirus infections awaits further study.","PeriodicalId":306859,"journal":{"name":"Acta paediatrica sinica","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1999-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122390249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Mastoiditis in Children 儿童急性乳突炎

Acta paediatrica sinica Pub Date : 1999-04-05 DOI: 10.7097/APS.199904.0072

Cheun-Bin Jiang, N. Chiu, D. Liang, Kuo‐Sheng Lee, M. Shu, F. Haung

引用次数: 0

Juvenile Chronic Arthritis in Taiwan 台湾青少年慢性关节炎

Acta paediatrica sinica Pub Date : 1999-04-05 DOI: 10.7097/APS.199904.0034

Chih-Jen Wu, Wen-I. Lee, Mei-Hui Yang, Jing-Long Huang

引用次数: 0

The Level of Type 3 T-helper Cells in Anaphylactoid Purpura Patients 过敏性紫癜患者3型t辅助细胞的水平

Acta paediatrica sinica Pub Date : 1999-04-05 DOI: 10.7097/APS.199904.0037

Miao‐Tzu Huang, S. Lin, M. Tsai, B. Chiang