Health Science Journal of Indonesia最新文献

{"title":"Do the port health officers at Soekarno-Hatta International Airports and Zainuddin Abdul Madjid International Airports have sufficient knowledge, attitude, and practice regarding emergency landing?","authors":"H. Herqutanto, A. Wijaya, B. Sampurna, Manaor F. L. Napitupulu, Ferdi Afian","doi":"10.22435/hsji.v12i1.4026","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4026","url":null,"abstract":"Background: : Emergency landing as an airport emergency requires quick and precise action by Port Health Office (PHO) as the medical coordinator. Medical treatment in an emergency landing is critical for the safety of disaster victims, based on the knowledge, attitudes and behavior of airport PHO officers. This study aimed to determine knowledge, attitude and behavior of PHO officers at Soekarno-Hatta International Airport (SOETTA) and Zainuddin Abdul Majid International Airport (ZAM) regarding emergency landings. \u0000Methods: This is an observational applying cross sectional design. Ninety-eight PHO officers from SOETTA airport and ZAM airport have participated, and their data was collected through questionnaires, and then analyzed based on knowledge, attitude, and practice toward emergency landing. \u0000Results: The knowledge of SOETTA PHO officers was sufficient in 63.5% officers, while it was 79.2% in ZAM. SOETTA PHO officers’ attitude was positive in 67.6% while in ZAM it was 54.16%. The behavior of SOETTA PHO officers was good in 55.4% officers while in ZAM it was 75%. \u0000Conclusion: The level of knowledge of SOETTA and ZAM PHO officers regarding emergency landings was sufficient. The attitude of SOETTA and ZAM PHO officers regarding emergency landings was positive. The behavior of SOETTA and ZAM PHO officers was good for emergency landings. \u0000Keywords: emergency landing, port health officer, knowledge, attitudes and practice \u0000  \u0000Abstrak \u0000Latar belakang: Emergency landing sebagai salah satu keadaan darurat bandara memerlukan tindakan yang cepat dan tepat oleh Kantor Kesehatan Pelabuhan (KKP) sebagai koordinator medis. Penanganan medis dalam emergency landing sangat menentukan keselamatan dan keamanan korban, yang berbasis pada pengetahuan, sikap dan perilaku petugas KKP bandara. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan, sikap dan perilaku petugas KKP Bandara Internasional Soekarno-Hatta (SOETTA) dan Bandara Internasional Zainuddin Abdul Majid (ZAM) terhadap emergency landing. \u0000Metode: Penelitian ini adalah sebuah studi obervasional dengan disain potong lintang. Sembilan puluh delapan petugas KKP dari 74 bandara SOETTA dan 24 bandara ZAM diambil datanya lewat kuesioner.dan selanjutnya dinilai pengetahuan, sikap dan perilaku terhadap emergency landing. \u0000Hasil: Sebanyak 63,5% petugas KKP SOETTA memiliki pengetahuan yang cukup sementara 79,2% petugas ZAM meiliki pengetahuan yang tergolong cukup. Untuk hasil sikap petugas KPP SOETTA yang tergolong positif 67,6% sementara di ZAM sikap petugas KPP yang tergolong positif 54,16%. Untuk hasil perilaku petugas KPP SOETTA yang tergolong baik 55,4% sementara di ZAM perilaku petugas KPP yang tergolong baik 75%. \u0000Kesimpulan: Tingkat pengetahuan petugas KKP SOETTA dan petugas KKP ZAM terhadap emergency landing tergolong cukup. Sikap petugas KKP SOETTA dan ZAM terhadap penanganan emergency landing positif. Perilaku petugas KKP SOETTA dan ZAM cukup baik terhadap emergency landing. \u0000Kata kunci: eme","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45521357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation of structural and binding affinity of insulin analog to the onset of action for diabetic therapy","authors":"G. Permatasari, D. Utomo, D. L. Purwaningroom, D. Soeatmadji","doi":"10.22435/hsji.v12i1.4783","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4783","url":null,"abstract":"Background: These days, insulin analog production has been improved and  becoming popular. The advantages of insulin analog have been extensively reviewed in terms of effectiveness compared to human insulin. Each of the insulin analog industries has claimed their safety and efficacy based on in vivo and in vitro to overcome type 2 diabetes. Hereby, we report on the identification of highly effective analog-based insulin on structure and binding affinity computationally, to confirm its potential and give a broader point of view to insulin analog users. \u0000Methods: Five types of insulin analogs, Aspart, Glargine, Detemir, Lispro and Degludec, were analyzed. We grouped and clustered the sequence by alignment to identify the closeness and sequence similarity between samples, continued by superimposing analysis and undertaking binding affinity identification utilizing of a docking analysis approach. \u0000Results: Lispro had the least sequence similarity to other types, close to Aspart (96%) and Glargine (90.5%), while Detemir and Degludec showed 100% similarity we decide to only use Degludec for the next analysis. Furthermore, Lispro, Aspart, and Glargine exhibited structural similarity strengthened by the lack of significant difference in the RMSD data. Importantly, Aspart had the highest binding affinity score (-66.1 +/- 7.1 Kcal/mol) in the docking analysis to the insulin receptor (INSR) and similar binding site areas to human insulin.  \u0000Conclusion: Our finding revealed that the strength of insulin analogs towards insulin receptors is identic with its rapid mechanism in the human body. \u0000Keywords: computation, docking, insulin analog, sequence similarity, structure  \u0000  \u0000Abstrak \u0000Latar belakang: Saat ini, produksi analog insulin meningkat dan menjadi popular. Keuntungan analog insulin telah ditinjau secara ekstensif dalam hal efektivitas dibandingkan dengan insulin manusia. Masing-masing industri analog insulin mengklaim keamanan dan kemanjurannya berdasarkan in vivo dan in vitro untuk mengatasi diabetes tipe 2. Kami melaporkan identifikasi insulin analog yang efektif berdasarkan struktur dan afinitas pengikatan secara komputasi, untuk mengonfirmasi potensi serta memberikan sudut pandang yang lebih luas kepada pengguna insulin analog. \u0000Metode: Lima jenis analog insulin, Aspart, Glargine, Detemir, Lispro, dan Degludec, dianalisis. Kami membandingkan dan mengelompokkan urutan tersebut dengan penyelarasan untuk mengidentifikasi kedekatan dan kesamaan urutan antar sampel dilanjutkan dengan superimposing analysis dan melakukan identifikasi binding affinity menggunakan pendekatan analisis docking. \u0000Hasil: Lispro memiliki kemiripan sekuen paling rendah dengan jenis lainnya, mendekati Aspart (96%) dan glargine (90,5%), sedangkan Determir dan Degludec menunjukkan kemiripan 100% sehingga kami menggunakan Degludec untuk analisis selanjutnya. Selain itu, Lispro, Aspart, dan Glargine menunjukkan kesamaan struktural yang diperkuat oleh rendahnya nilai signifikansi pada ","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41533176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do the acute lymphoblastic leukemia and non-hodgkin lymphoma patients have a worse prognosis of COVID-19 infection in children?: a case report","authors":"Nadirah Rasyid Ridha, B. Fikri, Rahmawaty Rahimi, Amiruddin Laompo, Conny Tanjung, D. Daud, N. Massi","doi":"10.22435/hsji.v12i1.4467","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4467","url":null,"abstract":"Background: Coronavirus Disease 2019 (COVID-19) is a contagious disease caused by a new type of Coronavirus namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Children with tumors or autoimmune diseases are more susceptible, because of suppression of their immune system, chemotherapy, radiotherapy, or surgery on tumors. \u0000Case presentation: We present the clinical features 3 Acute Lymphoblastic leukemia and 1 Non-Hodgkin lymphoma patients who were infected with COVID-19 since July to August 2020 in our hospital. These were the first four cases identified as COVID-19 positive in Dr Wahidin Sudirohusodo Hospital. Case 1, 2, and 4 were diagnosed as moderate and common type of COVID-19, while case 3 was classified as severe type. They may be transmitted COVID-19 infection during hospitalization. All cases were recovered from COVID-19 after a combination therapy against virus, bacteria, and also respiratory support. \u0000Conclusion: Our case series of four pediatric cancer patients showed a good outcome after prompt treatment, suggesting that malignancy in children may not be a contributor factor for COVID-19 recovery. \u0000Keywords: COVID-19; acute lymphoblastic leukemia; non-hodgkin lymphoma; children \u0000  \u0000Abstrak \u0000Latar belakang: Covid-19 (Coronavirus disease 2019) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Anak yang menderita kanker atau penyakit autoimun lebih rentan tertular karena penurunan system kekebalan tubuh, dampak kemoterapi, radioterapi, atau operasi tumor. \u0000Penyajian kasus: Kami melaporkan 3 pasien leukemia limfoblastik akut  dan 1 pasien limfoma non-Hodgkin yang terinfeksi Covid-19 sejak Juli-Agustus 2020. Kasus tersebut adalah 4 kasus pertama yang teridentifikasi Covid-19 di Rumah Sakit Dr. Wahidin Sudirohusodo. Kasus 1,2, dan 4 terdiagnosis positif Covid -19 derajat sedang, sedangkan kasus 3 tergolong berat. Mereka kemungkinan terinfeksi Covid-19 saat perawatan. Semua kasus dinyatakan sembuh dari Covid-19 setelah pemberian obat anti virus, antibiotik, dan alat bantu pernapasan. \u0000Kesimpulan: Serial kasus dari 4 pasien kanker anak dengan outcome yang baik setelah pengobatan yang cepat mengindikasikan bahwa penyakit keganasan pada anak kemungkinan bukan faktor yang berkontribusi dalam kesembuhan Covid-19. \u0000Kata kunci:  COVID-19; leukemia limfoblastik akut; limfoma non-hodgkin; anak \u0000  \u0000 ","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47249690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the tariff method and physicians in determining stroke as the cause of deaths using verbal autopsy in areas with a limited number of physicians: cases in Indonesia","authors":"E. Indriasih, M. Budiharsana","doi":"10.22435/hsji.v12i1.4805","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4805","url":null,"abstract":"Background: Physician-certified verbal autopsy (PCVA) is the primary method used to determine the cause of death in Indonesia, although it is very costly and problematic to use in areas where physicians are not widely available with most deaths occur at home. The Tariff method has been piloted to obtain an alternative approach that does not require a physician to determine the cause of death. This validation study presents how the Tariff captures the correctness and distinctiveness of stroke symptoms to the PCVA. \u0000Methods: Medical records of 298 adult deaths that occured in four teaching hospitals in the Jakarta from  January 1, 2015 to March 2017 were collected prospectively. Verbal Autopsy (VA) was applied using the 2014 WHO instrument diagnosed by a trained physician (PCVA) and by Tariff method. The validity of the VA was assessed by comparing the PCVA diagnoses with the Tariff diagnoses, referring to the best standard. \u0000Results. Sensitivity, specificity and positive predictive value (PPV) of VAs using physician’s diagnosis (PCVA) for stroke were 73.9%, 73.5% and 93.4% respectively. The corresponding sensitivity, specificity and positive predictive value (PPV) of VAs diagnosed by the Tariff method were 75%, 61% and 91%. The negative predictive values (NPV) of both techniques were low, 35.6% and 32.6% respectively. \u0000Conclusion: The performance of the Tariff method for stroke was almost similar with  PCVA, and with a narrower variation, or more consistent than PCVA. Therefore, the Tariff method is a potential alternative to be used on a large scale, because the difficult geographical conditions where physician are not widely available for causes of deaths with distinct signs and symptoms. \u0000Keywords: verbal autopsy, sensitivity, specificity, determining cause of death, physician, tariff method \u0000  \u0000Abstrak \u0000Latar Belakang: Autopsi verbal yang disertifikasi oleh dokter (PCVA) merupakan metode utama yang digunakan untuk memastikan penyebab kematian di Indonesia. Meskipun sangat mahal dan bermasalah untuk digunakan di daerah di mana dokter tidak banyak tersedia dan sebagian besar kematian terjadi di rumah. Metode Tarif telah diujicobakan untuk mendapatkan pendekatan alternatif yang tidak memerlukan dokter untuk menentukan penyebab kematian. Studi validasi ini menyajikan bagaimana Tarif menangkap kebenaran dan kekhasan gejala stroke dibandingkan dengan PCVA. \u0000Metode: Rekam medis dari 298 kematian orang dewasa yang terjadi di empat rumah sakit studi di wilayah Jakarta pada 1 Januari 2015 hingga Maret 2017 dikumpulkan secara prospektif. Autopsi verbal (AV) dilakukan dengan menggunakan instrumen WHO 2014 yang didiagnosis oleh dokter terlatih (PCVA) dan metode Tarif. Validitas AV dinilai dengan membandingkan diagnosis PCVA dengan diagnosis metode Tarif, mengacu pada baku mutu. \u0000Hasil. Sensitivitas, spesifisitas dan nilai prediksi positif (PPV) dari AV dengan diagnosis dokter (PCVA) untuk stroke adalah 73,9%, 73,5% dan 93,4%. Sensitivitas, spesifisitas, da","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42452596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helmet use behavior and its relation to head injury of road traffic accident in Indonesia (Basic Health Research, 2018)","authors":"Lusianawaty Tana, D. Delima, N. Kusumawardani, Lely Indrawati","doi":"10.22435/hsji.v12i1.4655","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4655","url":null,"abstract":"Background: Nationally, the prevalence of injuries tends to increase from 7.5% in 2007, 8.2% in 2013, and 9.2% in 2018. The main cause of injuries is motorcycle accidents (40.6%), which most occur on the highway (42.8%). This is a further analysis of Indonesia Basic Health Research (Riskesdas) 2018 data, to assess the role of  sociodemography on helmet use behavior and head injuries due to traffic accident.   \u0000Methods: The 2018 Basic Health Research was a cross-sectional research, based on data from individuals aged 5 years old and above, who analyzed with helmet use behavior and the incidence of head injuries due to traffic accident as dependent variables. The independent variables consist of sociodemographic characteristics, the role of individual in accident, and the impact of the accident. The data were analyzed by bivariate and multivariate, and taking into account the complex sample in 5% confidence level. \u0000Results: The results showed that 44.4% from 19122 individuals aged five years old and above had good behavior in using helmets. The determinants of helmet use behavior were age, gender, education, occupation, economic status, location and area of residence (adjusted OR 1.15—4.5; p≤0.02). The result from14.1% of respondents who had a head injuries caused by traffic accidents. The risk of head injuries due to traffic accidents was 1.17 times (95% CI  1.02—1.35; p 0.03) in the unhelmeted group compared to the helmeted group.  \u0000Conclusion: Helmet use behavior is connected with the reduction of head injuries due to traffic accidents. Counseling and monitoring of helmet use is need to be improved, especially for the youth category. \u0000Keywords: head injury,  traffic accident, helmet use \u0000  \u0000Abstrak \u0000Latar belakang: Secara nasional, prevalensi cedera cenderung meningkat dari 7,5 % pada tahun 2007, 8,2 % pada 2013, dan 9,2 % pada 2018. Penyebab utama dari cedera adalah kecelakaan bermotor (40,6 %), dan kebanyakan terjadi di jalan raya (42,8 %). Ini merupakan analisis lanjut data Riset Kesehatan Dasar (Riskesdas) 2018 untuk menilai peran sosiodemografi terhadap perilaku penggunaan helm dan hubungan perilaku penggunaan helm dengan cedera kepala akibat kecelakaan lalu lintas. \u0000Metode: Riskesdas 2018 adalah riset potong lintang. Data individu umur 5 tahun ke atas dianalisis dengan perilaku penggunaan helm dan kejadian cedera kepala akibat kecelakaan lalu lintas sebagai variabel terikat. Variabel bebas terdiri dari karakteristik sosiodemografi, peran individu dalam kecelakaan, dan dampak kecelakaan.  Data dianalisis secara bivariat dan multivariat dengan memperhitungkan complex sample dan 5 % tingkat kepercayaan. \u0000Hasil: Hasil menunjukkan bahwa 44,4% dari 19.122 individu umur 5 tahun ke atas mempunyai perilaku yang baik dalam menggunakan helm. Determinan perilaku penggunaan helm adalah umur, jenis kelamin, pendidikan, pekerjaan, status ekonomi, lokasi dan area tempat tinggal (adjusted OR 1,15—4,5; p≤0,02). Sejumlah 14,1% individu mengalami cedera kepal","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48522457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between anthropometric profiles and somatotype with 100 meter sprint amongst Indonesian sprint athletes","authors":"E. Purnomo, N. Arovah, Alfonsia Purnamasari","doi":"10.22435/hsji.v12i1.3155","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.3155","url":null,"abstract":"Background: One hundred meter sprint was influenced by various internal and external factors. Somatotype and anthropometry profiles are possibly to be one of the factors that predicts performance. The aims of this study were to assess the anthropometry and somatotype profiles obtained from an example of Indonesian team university male sprinters and to elucidated potential correlations between anthropometry profile and somatotype with the 100m sprint. \u0000Methods: It was recorded that 20 selected sprint athletes participated as representatives from Indonesia in the XVIII ASEAN University Games with an averaged age (20.0 ± 0.92 year old). Anthropometric assessment includes height, weight, skinfold (triceps, supra-spinale, subscapula, suprailiaca, abdomen, calf, front thigh and chest)), two bicondylar widths (humerus and femur) and two circumferences (biceps and femur). The somatotype assessment was based on the Health & Carter method. Body fat percentage was assessed using the equation determined by Berzerk et al. (1963). Body Mass Index is calculated from body mass divided by height squared (kg/m2). Multicorrelation matrix and simple linear regression were used to assess the potential correlation between somatotype profile and anthropometry with the 100m sprint. \u0000Results: The average value of ectomorph-mesomorph-endomorph was 3.40-4.08-0.84 BMI at 20.6 0.6, while the fat percentage was 9.2 ± 0.8. There were no significant correlation and regression slope found between somatotype profile and anthropometry with the 100m sprint. \u0000Conclusion:  Most of the athletes representing Indonesia at the ASEAN University Games were mesomorphs and ectomorphs. They had low endomorph score fat percentage. Body shape requirements was not related to the 100m sprint. Further investigation is recommended to amplify the findings. \u0000Keywords: body composition, somatotype, sprinter \u0000  \u0000Abstrak \u0000Latar belakang: Lari seratus meter dipengaruhi oleh berbagai faktor internal dan eksternal. Profil somatotipe dan antropometri diperkirakan merupakan salah satu diantara faktor yang dapat memprediksi kinerja. Tujuan dari penelitian ini adalah untuk menilai antropometri dan somatotipe yang diperoleh dari sampel pelari putra perguruan tinggi Indonesia dan menjelaskan potensi korelasi antara antropometri dan somatotype dengan lari 100 meter. \u0000Metode: Tercatat 20 atlet sprinter terpilih sebagai perwakilan dari Indonesia di ASEAN University Games XVIII dengan rata-rata umur (20.0±0.92 tahun). Penilaian antropometri meliputi tinggi, berat badan, lipatan kulit (trisep, supra-spinale, subskapula, suprailiaka, abdomen, betis, paha depan dan dada), dua lebar bicondylar (humerus dan femur) dan dua lingkar (bisep dan femur). Penliaian somatotipe didasarkan dari metode Heath & Carter. Presentasi lemak tubuh dinilai sebagai persamaan yang ditentukan oleh Berzerk et al. (1963). Indeks Masa Tubuh dihitung dari masa tubuh yang dibagi dengan tinggi badan kuadrat (kg / m2). Matrix multikorelasi dan regre","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48543927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of pediatric traumatic brain injury: study from Wongsonegoro Regional Public Hospital in Semarang","authors":"Andrew Robert Diyo, Nadisa Tiofunda Budiman, Natashia Olivia Christian, Riky Pratama","doi":"10.22435/hsji.v12i1.4076","DOIUrl":"https://doi.org/10.22435/hsji.v12i1.4076","url":null,"abstract":"Background: Traumatic brain injury is one of the leading causes of morbidity and mortality in the world, as well as disability in the pediatric group. This study aimed to describe the characteristics of pediatric traumatic brain injury patients, considering the lack of data in Indonesia. Methods: We conducted a descriptive-retrospective study at Wongsonegoro Regional Public Hospital Semarang. Data were extracted from medical records of patients admitted during the period of January 2017-December 2019 using a purposive sampling method. Results: Out of 296 patients, most of the patients were male (59.13%; 66.30%). Based on age group, the highest percentage was found in the (11-18-year-old) (40.87%) in operative patients and 5-10-year-old (37.57%) in non-operative patients. The most common cause of traumatic brain injury in operative patients was falling from motor vehicle (37.39%) while in non-operative patients was falling while playing (32.60%). The most common type of injury in operative patients was epidural hematoma (49.57%) and in non-operative patients was brain concussion (53.59%). Most of the patients had minor head injury (75.65%; 81.22%). Most of operative patients spent 3-5 days (64.35%) in the hospital while most of non-operative patients spent 1-3 days (72.37%). Of all the subjects, the majority of patients recovered and discharged. Conclusion: remains as the most common type of pediatric traumatic brain injury in this study. This study provides an overview of traumatic brain injury in children and shows the importance of enforcing driving rules and supervision by parents which play an important role in child safety. Keywords: pediatric, traumatic brain injury, Indonesia   Abstrak Latar belakang: Cedera kepala merupakan salah satu penyebab utama morbiditas dan mortalitas di dunia, serta disabilitas pada kelompok pediatri. Penelitian ini bertujuan untuk mendeskripsikan karakteristik pasien pediatri dengan cedera kepala, mengingat minimnya data cedera kepala pada anak di Indonesia.  Metode: Penelitian ini merupakan penelitian deskriptif-retrospektif di RSUD Wongsonegoro Semarang. Data diambil dari rekam medis pasien anak yang dirawat selama periode Januari 2017-Desember 2019 dengan menggunakan metode purposive sampling. Hasil: Dari 296 pasien, sebagian besar merupakan laki-laki (59,13%; 66,30%). Berdasarkan kelompok umur, persentase tertinggi pada kelompok operatif terdapat pada (40,87%) dan pada kelompok non operatif terdapat pada kelompok usia 5-10 tahun (37,57%). Penyebab tersering cedera kepala pada pasien operatif yakni jatuh dari kendaraan bermotor (37,39%) sementara pada pasien non operatif penyebab tersering berupa jatuh saat bermain (32,60%). Jenis cedera kepala tersering pada pasien operatif adalah Epidural Hematoma (49,57%) dan pada pasien non-operatif berupa commotio cerebri (53,59%). Kebanyakan pasien mengalami cedera kepala ringan (75,65%; 81,22%). Sebagian besar pasien operatif dirawat selama 3-5 hari (64,35%) se","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68500505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory preparedness to support the Covid-19 pandemic respond in Indonesia","authors":"U. Mulyani, Amir Su'udi, V. Setiawaty, K. Aryastami, A. Suwandono, N. Puspandari, Syachroni Syachroni, Made Susilawati, H. Hendarwan","doi":"10.22435/hsji.v11i2.4089","DOIUrl":"https://doi.org/10.22435/hsji.v11i2.4089","url":null,"abstract":"Latar belakang: Penyakit jenis baru COVID-19 yang disebabkan oleh virus corona menjadi  sebuah pandemic di akhir tahun 2019. Kota Wuhan (China) merupakan lokasi pertama terdeteksinya kasus COVID-19. Tanpa adanya kecurigaan apapun penyakit ini dengan cepatnya menyebar ke seluruh dunia mengikuti alur mobilitas manusia. Dalam kondisi tersebut sistem kesehatan di setiap negara tampak kelabakan khususnya dalam pengendalian transmisi penyakit. Studi ini ingin mengidentifikasi  kesiapan jejaring laboratorium kesehatan di Indonesia. \u0000Metode: Penilaian cepat dilakukan terhadap ketersediaan dan kesiapan laboratoriaum dalam pennanganan pandemi Covid-19. Pengumpulan data dilakukan melalui pengisian questioner yang dikirim secara elektronik. Waktu pelaksanaan adalah minggu ketiga dan keempat, Maret 2020. Terdapat 44 laboratorium jejaring laboratorium dibawah Kementerian Kesehatan yang menjadi subjek penelitian, dan sebanyak 33 yang merespon secara lengkap Variabel ketersediaan, kecukupan dan kebutuhan bahan dan alat. \u0000Hasil: Jejaring laboratorium kesehatan dibawah Kementerian Kesehatan sudah terbentuk sejak tahun 2009. Dengan terjadinya pandemic COVID-19 Surat Keputusan Menteri Kesehatan telah direvisi hingga dua kali agar dapat  meningkatkan kapasitas dan memperluas jejaring ke seluruh wilayah NKRI. Hasil studi menunjukkan, laboratorium  jejaring  dibawah Kementerian Kesehatan belum siap dalam menghadapi pandemic COVID-19. Dua jenis laboratorium jejaring yaitu laboratorium surveillans maupun laboratorium diagnostic memiliki kondisi yang sama. Ketersediaan bahan dan alat laboratorium standar masih tergolong rata-rata, bahkan dari sisi kecukupannyapun masih  jauh dibawah kapasitas kebutuhan dalam penanganan specimen COVID-19. Kondisi yang sama juga tampak untuk bahan pendukung laboratorium termasuk alat pelindung diri untuk petugas. \u0000Kesimpulan: Kesiapan laboratorium sebagai bagian dari system kesehatan dalam kondisi pandemic masih lemah. Keberadaan alat penunjang diagnose khususnya untuk penyakit menular harus dilengkapi sesuai dengann type laboratorium. Pandemi COVID-19 menjadi alarm dalam menghadapi era baru dan antisipasi masalah dimasa yang akan datang. \u0000Kata kunci: Kesiapan laboratorium, COVID-19, Indonesia \u0000  \u0000Abstract \u0000Background: A novel coronavirus disease called COVID-19 has become pandemic in late 2019. Wuhan City was the first place detected as the source of the pandemic. Without suspicion, it spreads over the world, along with human mobility. In such a condition, every country seems quite stuttering to prepare its health system to prevent its people from the possible transmission. This paper aims to describe the preparedness of the networking laboratory in Indonesia. \u0000Methods: We conducted a rapid assessment of laboratory availability and preparedness to respond to the Covid-19 pandemic. We held the data collection on the third and fourth week of March 2020 by sending an electronic questionnaire to all 44 networking laboratories under the Ministr","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44107753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of death among children hospitalized with social insurance (BPJS): a cross sectional study using hospital claim data","authors":"Cicih Opitasari, Rossa Avrina, A. B. Anggraini","doi":"10.22435/hsji.v11i2.3951","DOIUrl":"https://doi.org/10.22435/hsji.v11i2.3951","url":null,"abstract":"Latar belakang: Angka kematian di rumah sakit merupakan salah satu indikator yang digunakan untuk mengukur kinerja dan kualitas pelayanan. Tujuan penelitian ini untuk menganalisis  faktor risiko kematian pada anak yang dirawat dengan BPJS kesehatan di satu rumah sakit di Jakarta. \u0000Metode: Penelitian potong lintang pada satu rumah sakit pemerintah di Jakarta. Sampel menggunakan semua data klaim pasien BPJS selama periode Januari - Desember 2017. Semua pasien BPJS  berusia di bawah 18 tahun yang dirawat dimasukkan dalam analisis. Regresi logistik digunakan untuk menganalisis faktor risiko kematian anak. \u0000Hasil: Dari total 18,941 jumlah pasien BPJS yang dirawat, sebanyak 3689 data anak yang dianalisis. Proporsi angka kematian anak selama satu tahun sebesar 7,3%. Kasus dengan tingkat keparahan derajat II memiliki risiko kematian 11,51 kali lipat [rasio odds suaian (ORa) = 11,51; IK=7,45-17,78; P = 0,000] dibandingkan tingkat keparahan penyakit derajat I, sedangkan kasus dengan tingkat keparahan derajat III beresiko terhadap kematian 33,97 kali lipat (ORa = 33,97;IK=19,93-57,91; P = 0,000). Selain itu, anak yang memiliki indikasi dirawat di ICU meningkatkan risiko kematian  14,21 kali lipat (ORa = 14,21; IK=9,15-22,08; P= 0,000) dibandingkan yang tidak ada indikasi ICU. Kondisi tertentu yang timbul pada  periode perinatal meningkatkan risiko kematian anak 7,65  kali lipat (ORa = 7,65  ; IK=1,81-32,35;P = 0,006) dibandingkan penyakit pada sistem muskuloskeletal dan jaringan ikat. \u0000Kesimpulan: Tingkat keparahan penyakit, indikasi ICU dan kondisi tertentu yang timbul pada  periode perinatal adalah faktor risiko kematian anak yang paling sering di rumah sakit \u0000Kata kunci: Faktor risiko, kematian, anak, BPJS \u0000  \u0000Abstract \u0000Background: Hospital death rate is one of the indicators used to measure hospital performance and quality of care, especially the overall hospital death rate. This study aims to analyze the risk factors of death among children hospitalized with social insurance (BPJS) in one hospital in Jakarta. \u0000Methods: This was a cross-sectional study conducted in one government hospital in Jakarta. The sample was all individual claim data of BPJS patients who were hospitalized during the period of January to December 2017. All BPJS patients aged below 18 years admitted into the pediatric wards were included in the analysis. The logistic regression was used to analyze the risks of children death \u0000Results: A total of 18.941 BPJS inpatients in the hospital was identified, out of them 3689 met the inclusion criteria. The proportion of death in children during one year was 7.3%. Illness severity level II had 11.51-fold [adjusted odds ratio (ORa)=11.51;CI=7.45-17.78; P=0.000]] meanwhile severity level III had 33.97-fold higher risk of children death (ORa=33.97; CI=19.93-57.91;P=0.000) compared to children with severity level I. Children who had ICU indicator increase risk of children death at 14.21 -fold (ORa=14.21;IK=9.15-22.08;P= 0.000) compared to those ","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44659478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico analysis of antihypertensive and hepatotoxicity potential of the n-butanol fraction of the methanol extract of of cantaloupe (Cucumis melo var. cantalupensis)","authors":"D. Laila, Dianita Rifqia Putri, G. Permatasari","doi":"10.22435/hsji.v11i2.3629","DOIUrl":"https://doi.org/10.22435/hsji.v11i2.3629","url":null,"abstract":"Latar belakang: Hipertensi merupakan faktor risiko utama penyakit kardiovaskular. Penduduk Indonesia cenderung mengkonsumsi herbal dalam terapi hipertensi dalam mempertahankan kadar tekanan darah seperti buah blewah (Cucumis melo var. cantalupensis). Namun mekanisme kerja buah blewah dalam menurunkan tekanan darah, dan potensi toksisitasnya jika dikonsumsi dalam jangka panjang masih belum jelas. Tujuan studi ini adalah untuk menganalisis mekanisme antihipertensi dari buah blewah dan potensi toksiknya melalui pendekatan in silico. \u0000Metode: Bubuk blewah kering dimaserasi menggunakan metanol absolut, difraksinasi menggunakan n-butanol. Uji fitokimia dilakukan dengan metode LC-MS, kemudian senyawa bioaktif ditelusuri hingga SMILESnya di PubChem. Analisis QSAR untuk analisis potensi antihipertensi dilakukan dengan PASS server. Kelas toksisitas dan potensi hepatotoksisitas dianalisis menggunakan ProTox-II, dilanjutkan dengan analisis networking menggunakan STITCH dan STRINGdb. \u0000Hasil: Setidaknya terdapat 434 jenis senyawa yang terdapat pada fraksi n-butanol dari ekstrak metanol buah blewah (FBEMB). Berdasarkan analisis STITCH dan STRINGdb, FBEMB dapat bekerja dalam menurunkan tekanan darah melalui mekanisme aksi seperti senyawa amlodipine, yang menstabilkan saluran kalsium tipe-L yang terisi tegangan dalam konformasi tidak aktifnya. Dengan demikian, mencegah kontraksi myocyte yang bergantung pada kalsium dan vasokonstriksi. FBEMB mungkin berpotensi hepatotoksik melalui mekanisme kerja senyawa seperti itrakonazol yang menghambat enzim sitokrom P450 yang mempengaruhi gangguan pada sintesis ergosterol, dan efavirenz yang memiliki efek neurotoksik. Penghambatan sitokrom P450 dapat menyebabkan toksisitas obat dan kerusakan hati. \u0000Kesimpulan: FBEMB dapat bekerja dalam menurunkan tekanan darah melalui mekanisme penstabilan saluran kalsium tipe-L yang terisi tegangan dalam konformasi tidak aktifnya. \u0000Kata kunci: in silico, antihipertensi, hepatotoksisitas, blewah \u0000  \u0000Abstract \u0000Background: Hypertension is a major cardiovascular disease risk factor. Indonesian people tend to consume herbal medicine to maintain hypertension therapy, i.e cantaloupe (Cucumis melo var. cantalupensis). However, the mechanism of action of cantaloupe in lowering blood pressure and toxicity potential for long term consumption is unclear. The study aimed to analyze the antihypertensive mechanism of cantaloupe and its toxic potential through the in silico. \u0000Methods: The dried cantaloupe powder was macerated using absolute methanol, then fractionated using n-butanol. The phytochemical test was done by LC-MS method, then the bioactive compounds were traced to their SMILES in the PubChem. The QSAR analysis of the antihypertensive potential was done using the PASS server. The toxicity class and hepatotoxicity potential were analyzed using ProTox-II, followed by networking analysis using STITCH and STRINGdb. \u0000Results: At least 434 types of compounds were shown in the n-butanol fraction of the ","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42910431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}