Thursday 06 October 2022 from 13:00 to 14:10最新文献

{"title":"PO.3.67 Measuring IFNA2 levels by a single-molecule array in clinical practice of childhood-onset sle patients does matter; results from a single center longitudinal study","authors":"M. Verkaaik, Wahadat M Javad, H. Qi, C. Helden‐Meeuwsen, E. Huijser, Lotte van den Berg, J. Göpfert, Marco Schreurs, S. Kamphuis, M. Versnel","doi":"10.1136/lupus-2022-elm2022.96","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.96","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123192632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.1.21 Attainment of EQ-5D-3L full health state after therapy is associated with decelerated organ damage accrual in systemic lupus erythematosus","authors":"J. Lindblom, S. Zetterberg, A. Borg, S. Emamikia, G. von Perner, Y. Enman, E. Heintz, M. Regardt, D. Grannas, A. Gomez, I. Parodis","doi":"10.1136/lupus-2022-elm2022.52","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.52","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115246695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.4.91 Bank1 and IL-10+ B cells: bringing some light to the relationship between microbiota composition and autoimmunity development in a murine model of lupus","authors":"M. Botía-Sánchez, G. Galicia, D. Toro-Domínguez, L. Albaladejo-Marico, M. Alarcón‐Riquelme","doi":"10.1136/lupus-2022-elm2022.117","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.117","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128360648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.3.60 Association of left ventricular geometry abnormalities and disease activity in systemic lupus erythematosus patients","authors":"N. Guajardo-Jauregui, J. Azpiri-Lopez, D. Galarza-Delgado, I. Colunga-Pedraza, J. A. Cardenas-de la Garza, S. Lugo-Perez","doi":"10.1136/lupus-2022-elm2022.90","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.90","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129984693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.2.48 Incomplete systemic lupus erythematosus: clinical and immunological manifestations","authors":"T. Panafidina, T. Popkova, L. Kondrateva, Y. Gorbunova, E. Nasonov, A. Lila","doi":"10.1136/lupus-2022-elm2022.78","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.78","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133365314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.1.1 Afimetoran, a potent and selective inhibitor of human toll-like receptor 7 (TLR7) and tlr8, provides robust efficacy in a murine lupus model of advanced disease","authors":"S. Dudhgaonkar, A. Rudra, S. Ranade, S. Subramani, J. Nagar, P. Karunanithi, P. Bhutani, V. Kurawattimath, R. Zhang, H. Qiu, A. Dyckman, G. Schieven","doi":"10.1136/lupus-2022-elm2022.35","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.35","url":null,"abstract":"Purpose TLR7 and TLR8 (TLR7/8) are members of the TollLike Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type I/III interferons and promotes steroid resistance. TLR7/8 have been implicated in the initiation and progression of lupus, a disease associated with defects in the clearance of apoptotic debris which can activate these receptors. However, the effects of TLR7/8 inhibition in advanced lupus remain unclear. Afimetoran (BMS 986256) is a potent, selective, and orally bioavailable inhibitor of TLR7/8 currently in clinical development for immune mediated diseases. Previously, we observed that afimetoran inhibited the production of both interleukin-6 and interferon alpha in a dose-dependent manner in mice challenged with a TLR7 agonist. In this study, we examined the therapeutic efficacy of afimetoran in a murine model of advanced lupus. Methods NZB/W mice with advanced lupus (proteinuria > 100 mg/dL) were treated orally, once daily, with vehicle or afimetoran and/or prednisolone. The effects of treatment on survival, proteinuria, kidney histology, glomerular IgG deposition, cytokine-secreting cells, and circulating cytokines were measured. Results Afimetoran treatment resulted in near complete (92%) survival in the advanced lupus model, reaching 100% when combined with low-dose prednisolone; survival was 47% in mice treated with vehicle only (Table 1). In the advanced lupus model, afimetoran treatment reversed kidney tissue damage and proteinuria in all surviving animals. In contrast, treatment with low-dose prednisolone alone did not show significant modulation of proteinuria. Treatment with afimetoran reversed both the number of IgG-positive glomeruli and the amount of glomerular IgG deposition, and also reduced cytokine secreting cells and secreted cytokines to a greater extent than low-dose prednisolone alone. Conclusions Afimetoran displayed robust efficacy in a murine model of advanced lupus. Treatment with afimetoran led to improved survival, reversal of proteinuria and glomerular IgG deposition, suppression of kidney injury markers, and reductions in the proportion of cytokine-secreting cells and circulating cytokine levels. These results indicate that afimetoran, now being investigated in a phase 2 clinical trial (NCT04895696), may offer a novel therapeutic approach to the treatment of lupus.","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130096232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.2.40 High expression of CD11c+Tbet+ B cell in triple APL positive primary obstetric antiphospholipid syndrome patients","authors":"Y. Long, J. Zhao, X. Tian, M. Li, X. Zeng","doi":"10.1136/lupus-2022-elm2022.70","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.70","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"191 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132702879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.3.59 Echocardiographic abnormalities in systemic lupus erythematosus patients","authors":"N. Guajardo-Jauregui, I. Colunga-Pedraza, D. Galarza-Delgado, J. Azpiri-Lopez, J. A. Cardenas-de la Garza, S. Lugo-Perez","doi":"10.1136/lupus-2022-elm2022.89","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.89","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127669683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.2.27 Early changes in the circulating B cell compartment associated with response to treatment and occurrence of flares in patients receiving therapy for active systemic lupus erythematosus","authors":"M. Gatto, A. Gomez Gonzales, J. Lindblom, A. Doria, I. Parodis","doi":"10.1136/lupus-2022-elm2022.57","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.57","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"27 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130361373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PO.2.31 Different patterns of longitudinal changes in antinuclear antibodies titres in children with systemic lupus erythematosus","authors":"P. Morán Álvarez, C. Bracaglia, V. Messia, I. Caiello, F. De Benedetti, E. Marasco","doi":"10.1136/lupus-2022-elm2022.61","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.61","url":null,"abstract":"","PeriodicalId":306041,"journal":{"name":"Thursday 06 October 2022 from 13:00 to 14:10","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126474951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}