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Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism最新文献

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Immunobiology and Bone 免疫生物学与骨
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH128
R. Pacifici, M. Weitzmann
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引用次数: 1
Magnetic Resonance Imaging of Bone 骨磁共振成像
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH34
S. Majumdar
{"title":"Magnetic Resonance Imaging of Bone","authors":"S. Majumdar","doi":"10.1002/9781119266594.CH34","DOIUrl":"https://doi.org/10.1002/9781119266594.CH34","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132944867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rickets and Osteomalacia 佝偻病和骨软化症
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH89
M. Laurent, N. Bravenboer, N. V. Schoor, R. Bouillon, J. Pettifor, P. Lips
{"title":"Rickets and Osteomalacia","authors":"M. Laurent, N. Bravenboer, N. V. Schoor, R. Bouillon, J. Pettifor, P. Lips","doi":"10.1002/9781119266594.CH89","DOIUrl":"https://doi.org/10.1002/9781119266594.CH89","url":null,"abstract":"This chapter describes definition, etiology, pathophysiology, diagnosis, treatment and prevention of nutritional rickets and osteomalacia. Rickets and osteomalacia (from Greek osteon and malakia, bone softness) are diseases characterized by hypomineralization of bone matrix. Rickets occurs only in children (before epiphyseal closure) and additionally leads to abnormal growth plate development, stunting, and bone deformities. The causes of osteomalacia and rickets are similar and can be classified according to underlying mechanisms: Vitamin D deficiency or resistance; calcium deficiency independent of vitamin D; hypophosphatemic disorders; and mineralization inhibitors. Patients with rickets and osteomalacia related to vitamin D deficiency typically have very low serum 250-hydroxyvitamin D (25OHD) concentrations, that is below 15 to 30?nmol/L. Vitamin D deficiency rickets responds to small doses of vitamin D. Nutritional osteomalacia may be treated with remarkably low doses of calcium and vitamin D.","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131090918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Obesity and Skeletal Health 肥胖与骨骼健康
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH63
J. Compston
{"title":"Obesity and Skeletal Health","authors":"J. Compston","doi":"10.1002/9781119266594.CH63","DOIUrl":"https://doi.org/10.1002/9781119266594.CH63","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130763621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Genome‐Wide Association Studies 人类全基因组关联研究
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH47
D. Kiel, E. Duncan, F. Rivadeneira
{"title":"Human Genome‐Wide Association Studies","authors":"D. Kiel, E. Duncan, F. Rivadeneira","doi":"10.1002/9781119266594.CH47","DOIUrl":"https://doi.org/10.1002/9781119266594.CH47","url":null,"abstract":"Technological changes and newer statistical approaches have resulted in genome‐wide association studies (GWAS) with unprecedented success in identifying loci underlying common traits and diseases. Before the GWAS, the field of genetics of osteoporosis and fracture had been confined to a very large number of genome‐wide linkage and candidate gene association studies. GWAS use high‐throughput microarrays to genotype simultaneously in one or more individuals hundreds of thousands and even millions of the most common forms of genetic variation, single nucleotide polymorphisms (SNPs). The field of skeletal genetics has expanded beyond the early focus on the BMD phenotype exclusively. The largest GWAS meta‐analysis for skeletal phenotypes to date was recently reported by investigators using data from the UK Biobank Study. A recent study demonstrated how known genetic associations are successful predictors of drug mechanisms and success in clinical development. This is particularly the case in the musculoskeletal (BMD), which supports the use of genetics for drug‐target indication.","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"315 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132969183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fracture Liaison Service 裂缝联络服务
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH51
P. Geusens, J. Eisman, A. Singer, J. Bergh
{"title":"Fracture Liaison Service","authors":"P. Geusens, J. Eisman, A. Singer, J. Bergh","doi":"10.1002/9781119266594.CH51","DOIUrl":"https://doi.org/10.1002/9781119266594.CH51","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133688467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Diabetes and Fracture Risk 糖尿病和骨折风险
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH62
S. Ferrari, N. Napoli, A. Schwartz
{"title":"Diabetes and Fracture Risk","authors":"S. Ferrari, N. Napoli, A. Schwartz","doi":"10.1002/9781119266594.CH62","DOIUrl":"https://doi.org/10.1002/9781119266594.CH62","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114561042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton 影响骨骼的低磷酸酶和其他酶缺乏
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH115
M. Whyte
{"title":"Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton","authors":"M. Whyte","doi":"10.1002/9781119266594.CH115","DOIUrl":"https://doi.org/10.1002/9781119266594.CH115","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122773145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical Prevention and Treatment of Bone Metastases 骨转移的医学预防与治疗
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.CH104
C. Handforth, S. D’Oronzo, Janet E Brown
{"title":"Medical Prevention and Treatment of Bone Metastases","authors":"C. Handforth, S. D’Oronzo, Janet E Brown","doi":"10.1002/9781119266594.CH104","DOIUrl":"https://doi.org/10.1002/9781119266594.CH104","url":null,"abstract":"The presence of metastatic bone disease is a devastating \u0000complication that has signiicant impact on morbidity \u0000and mortality in cancer patients. Although the type, incidence, \u0000and consequences of bone metastases (BM) may \u0000vary between primary cancer sites, all patients with BM \u0000require consideration as to how both their primary \u0000tumour and their bone disease should be managed in \u0000terms of avoiding complications and maximizing both \u0000quality of life and survival. This chapter will describe \u0000normal bone turnover, the pathophysiology of BM, and \u0000the most common clinical sequelae. We will then explain \u0000the current evidence for the prevention and treatment of \u0000BM for the most osteotropic tumours (breast, prostate, \u0000lung, and renal).","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115894801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fibrillinopathies
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Pub Date : 2018-09-28 DOI: 10.1002/9781119266594.ch114
G. Gottesman, M. Whyte
{"title":"Fibrillinopathies","authors":"G. Gottesman, M. Whyte","doi":"10.1002/9781119266594.ch114","DOIUrl":"https://doi.org/10.1002/9781119266594.ch114","url":null,"abstract":"","PeriodicalId":303630,"journal":{"name":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122323501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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