Encyclopedia of Bone Biology最新文献

Abaloparatide Treatment for Osteoporosis 阿巴巴拉肽治疗骨质疏松症

Encyclopedia of Bone Biology Pub Date : 2018-11-02 DOI: 10.1530/ENDOABS.59.S4.1

F. Cosman

{"title":"Abaloparatide Treatment for Osteoporosis","authors":"F. Cosman","doi":"10.1530/ENDOABS.59.S4.1","DOIUrl":"https://doi.org/10.1530/ENDOABS.59.S4.1","url":null,"abstract":"Abstract Parathyroid hormone related peptide (PTHrP) is a paracrine factor produced by osteoblast lineage cells, which has a role in the regulation of bone remodeling and fracture repair. Early preclinical and clinical studies indicated that exogenous administration of PTHrP could have anabolic activity on the skeleton similar to that seen with exogenous PTH, but had potent vasodilatory effects which limited its clinical utility. Abaloparatide (Abalo) is a synthetic PTHrP(1-34) analog with 70% homology to PTHrP and 40% homology with Parathyroid hormone (PTH). Like PTH and PTHrP, Abalo interacts with the PTH1 receptor, however Abalo has higher affinity for the RG subtype of the Receptor and lower affinity for the R0 conformation (vs. PTH), resulting in relatively greater stimulation of bone formation and lesser bone resorption in preclinical models. Short-term clinical studies confirmed that Abalo had potent dose dependent anabolic activity with increases in BMD at the higher doses that were equal to or larger than that seen with PTH. In the Abalo Pivotal Trial, 2463 postmenopausal women with osteoporosis were randomized to blinded daily subcutaneous Abalo vs. placebo or open label PTH1-34. At 18 months, spine BMD had increased similarly with Abalo and TPTD, however, hip BMD increments were faster and significantly larger with Abalo. Consistent with the BMD effects, over 18 months, Abalo reduced vertebral fracture incidence by 86% and nonvertebral fracture incidence by 43%. The fracture risk reductions were sustained after both groups transitioned to antiresorptive medication. Abalo is a potent anabolic agent for treatment of osteoporosis and can be considered as initial therapy in patients at high risk for fracture.","PeriodicalId":302927,"journal":{"name":"Encyclopedia of Bone Biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122364144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid and Bone 甲状腺和骨骼

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11227-9

C. H. Gouveia, L. Capelo, Bianca Neofiti-Papi, A. Zallone

引用次数: 0

Bone Marrow Adipose Tissue 骨髓脂肪组织

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11207-3

W. Cawthorn

引用次数: 0

FGF23 and Klotho in Chronic Kidney Disease 慢性肾脏疾病中的FGF23和Klotho

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/B978-0-12-801238-3.11275-9

Abul Fajol, H. Komaba, M. Fukagawa

引用次数: 0

Copyright 版权

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-814081-9.09983-0

引用次数: 0

Animal Models of Cancer-Associated Hypercalcemia 癌症相关高钙血症的动物模型

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.62269-9

T. Rosol

引用次数: 0

Wnt Signaling in Cartilage Development 软骨发育中的Wnt信号

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11187-0

R. Yasuhara, Y. Usami, M. Enomoto-Iwamoto

引用次数: 2

Osteoblast Differentiation 成骨细胞分化

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11172-9

Fanxin Long

引用次数: 18

Bone and Metabolic Control 骨与代谢控制

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11226-7

Alexandre Chamouni, F. Oury

引用次数: 0

Bone Structure and Function 骨结构与功能

Encyclopedia of Bone Biology Pub Date : 1900-01-01 DOI: 10.1016/b978-0-12-801238-3.11551-x

X. Guo, Y. Hu, A. Dinescu

引用次数: 0