Recent Advances in Zebrafish Researches最新文献

Control of Programmed Cell Death During Zebrafish Embryonic Development 斑马鱼胚胎发育过程中细胞程序性死亡的控制

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.17863/CAM.25035

N. Popgeorgiev, B. Bonneau, J. Prudent, G. Gillet

引用次数: 6

The Roles of Estrogen, Nitric Oxide, and Dopamine in the Generation of Hyperkinetic Motor Behaviors in Embryonic Zebrafish (Danio rerio) 雌激素、一氧化氮和多巴胺在胚胎斑马鱼高运动行为产生中的作用

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.73869

Conor Snyder, Reid Wilkinson, A. Woodard, A. Lewis, D. Wood, Easton Haslam, T. Hogge, Nicole Huntley, J. Pierce, K. Ranger, L. Melendez, Townsend Wilburn, B. Kiel, T. Krug, Kaitlin R. Morrison, A. Lyttle, W. Bell, J. Turner

{"title":"The Roles of Estrogen, Nitric Oxide, and Dopamine in the Generation of Hyperkinetic Motor Behaviors in Embryonic Zebrafish (Danio rerio)","authors":"Conor Snyder, Reid Wilkinson, A. Woodard, A. Lewis, D. Wood, Easton Haslam, T. Hogge, Nicole Huntley, J. Pierce, K. Ranger, L. Melendez, Townsend Wilburn, B. Kiel, T. Krug, Kaitlin R. Morrison, A. Lyttle, W. Bell, J. Turner","doi":"10.5772/INTECHOPEN.73869","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.73869","url":null,"abstract":"Both estrogen (E2) and nitric oxide (NO) have been shown to affect motor function, in part, through regulation of dopamine (DA) release, transporter function, and the elicitation of neuroprotection/neurodegeneration of healthy neurons, as well as in neurodegenerative conditions such as Parkinson’s disease (PD). Currently, the “gold standard” treatment for PD is the use of levodopa (l-DOPA). However, patients who experience long-term l-DOPA and a monamine oxidase inhibitor (MAOI) treatment may develop unwanted side effects such as hyperkinesia which can be exacerbated by female Parkinsonian patients also on E2 replacement therapy. The current study was designed to determine whether embryonic zebrafish treated with either E2 or l-DOPA/MAOI develop a de novo-induced hyperkinetic movement disorder that relies on the NO pathway to elicit this hyperkinetic phenotype. Results from this study indicate that 5 days post-fertilization (dpf), fish treated with an l-DOPA + MAOI co-treatment or E2 elicited the development of a de novo hyperkinetic phenotype. In addition, the de novo l-DOPA + MAOI- and E2-induced hyperkinetic pheno - types are dependent on NO and E2 for its initiation and recovery. In conclusion, these find ings point to the central role both NO and E2 play in the facilitation of de novo hyperkinesia.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116223058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of PSR in Zebrafish (Danio rerio) at Early Embryonic Development PSR在斑马鱼早期胚胎发育中的作用

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74622

Wan-Lun Taung, Jen-Leih Wu, Jiann-Ruey Hong

{"title":"The Role of PSR in Zebrafish (Danio rerio) at Early Embryonic Development","authors":"Wan-Lun Taung, Jen-Leih Wu, Jiann-Ruey Hong","doi":"10.5772/INTECHOPEN.74622","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74622","url":null,"abstract":"During development, the role of the phosphatidylserine receptor (PSR) in the professional removal of apoptotic cells that have died is few understood. Programmed cell death (PCD) began during the shield stage (5.4 hpf), with dead cells being engulfed by a neighboring cell that showed a normal-looking nucleus and the nuclear condensation multi-micronuclei of an apoptotic cell. Recently, in the zebrafish model system, PS receptor played a new role on corpse cellular cleaning for further normal development during early embryonic development, which also correlated with tissues’ or organs’ complete development and organogenesis. In the present, we summary new story that a transcriptional factor, YY1a, in the upstream of PSR is how to regulate PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development, especially the development of organs such as the brain and heart. YY1a/PSRmediated engulfing system may involve in diseases and therapy. This engulfing system may provide new insight into phosphatidylserine receptor how to dynamitic interaction with apoptotic cell during priming programmed cell death.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130540755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Zebrafish Aging Models and Possible Interventions 斑马鱼衰老模型和可能的干预措施

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.75554

Dilan Celebi-Birand, Begun Erbaba, A. T. Ozdemir, HulusiKafaligonul, M. Adams

{"title":"Zebrafish Aging Models and Possible Interventions","authors":"Dilan Celebi-Birand, Begun Erbaba, A. T. Ozdemir, HulusiKafaligonul, M. Adams","doi":"10.5772/INTECHOPEN.75554","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.75554","url":null,"abstract":"Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the lifespan increases, there will be a need for maintaining a healthy state for these individuals. Our current knowledge on types and durations of potential anti-aging therapies is quite limited. Recently the zebrafish has emerged as a promising model for understanding the cognitive and neurobiological changes during aging, as well as its use with potential anti-aging interventions. Like humans this model organism ages gradually, displays similar behavioral properties and social characteristics, and in addition, there is a wealth of molecular and genetic tools to uncover the cellular mechanism that contribute to age-related cognitive declines. Drug effect and toxicity can be easily tested in the zebrafish. Therefore, this animal model can provide information about potential therapies that could be translated directly into human populations or provide a more focused treatment direction for testing in other mammalian animal models. The zebrafish will be a powerful tool for uncovering the mysteries of the aging brain.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127508580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Zebra Fitness: Learning and Anxiety After Physical Exercise in Zebrafish 斑马健身:斑马鱼运动后的学习与焦虑

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74103

M. Silveira, J. Silveira, Thaís Agues-Barbosa, MiguelCarvalho, P. F. Silva, A. Luchiari

{"title":"Zebra Fitness: Learning and Anxiety After Physical Exercise in Zebrafish","authors":"M. Silveira, J. Silveira, Thaís Agues-Barbosa, MiguelCarvalho, P. F. Silva, A. Luchiari","doi":"10.5772/INTECHOPEN.74103","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74103","url":null,"abstract":"In the recent years, a new branch of physical training has emerged, the high-intensity interval training (HIIT). In contrast to continued exercise regime used in most of the trainings, HIIT proposes a regime of short periods of maximum intensity exercising and brief less intense recovery periods, which are repeated until complete exhaustion. HIIT is calling the attention of those who search for fast escalation in physical performance; however, the stress caused by this type of training may affect other systems functioning, such as cognition. Thus, we investigated the effects of two physical regime protocols, traditional endurance and HIIT on zebrafish learning, memory, and anxiety-like behav ior. To that, fish were trained for 30 days and submitted to a latent learning test, objects discrimination test, and novel tank test. Our results showed that HIIT does not affect long lasting memory, evaluated through the latent learning task, but it impairs discriminative learning. On the other hand, both training protocols decrease anxiety-like behavior. This study confirms that zebrafish show good performance in learning tasks and that cognitive performance is dependent upon the regime of physical exercise and cognitive task used. objects discrimination, novel tank, Danio rerio for basic translational research of the effects of physical activity/training on cognition and behavior.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116143091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish Model of Cognitive Dysfunction 斑马鱼认知功能障碍模型

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74456

Brandon Kar Meng Choo, M. Shaikh

{"title":"Zebrafish Model of Cognitive Dysfunction","authors":"Brandon Kar Meng Choo, M. Shaikh","doi":"10.5772/INTECHOPEN.74456","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74456","url":null,"abstract":"Cognitive dysfunction is an impairment in one or more of the six cognitive domains (com- plex attention, executive function, learning and memory, language, perceptual motor and social cognition). The effect of pharmacological interventions can be studied using animal models of cognitive dysfunction, which are typically split into pharmacological , developmental and genetic models. Rodents are the most commonly used animal spe- cies for modelling cognitive dysfunction, although multiple models and test locations are often recommended to improve validity. Researchers thus unfortunately need to balance the validity of their experimental designs with financial, logistical and cost constraints. Zebrafish could be the answer to this conundrum as one of their many advantages over rodents is their high breeding rate which makes high-throughput screening more feasible and thus increases cost-effectiveness. The popularity of zebrafish has been increasing in recent times, as measured by the increasing number of zebrafish research publications. It is thus unsurprising that several zebrafish models of cognitive dysfunction have already been developed, together with zebrafish tests designed to measure zebrafish cognitive performance. Future research will undoubtedly lead to the development of new zebraf - ish models of cognitive dysfunction, as well as validate current ones to pave the way for widespread adoption.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124222868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Zebrafish or Danio rerio: A New Model in Nanotoxicology Study 斑马鱼或斑马鱼:纳米毒理学研究的新模型

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74834

M. Brundo, A. Salvaggio

引用次数: 6

Excitation and Excitation-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening 斑马鱼心脏的兴奋和兴奋-收缩耦合:斑马鱼模型在药物筛选中的意义

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74257

M. Vornanen, J. Haverinen, M. Hassinen

引用次数: 5

Transient-Receptor Potential (TRP) and Acid-Sensing Ion Channels (ASICs) in the Sensory Organs of Adult Zebrafish 成年斑马鱼感觉器官中的瞬时受体电位(TRP)和酸感离子通道(asic)

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74492

A. Germanà, J. Muriel, R. Cobo, O. García-Suárez, J. Cobo, J. Vega

{"title":"Transient-Receptor Potential (TRP) and Acid-Sensing Ion Channels (ASICs) in the Sensory Organs of Adult Zebrafish","authors":"A. Germanà, J. Muriel, R. Cobo, O. García-Suárez, J. Cobo, J. Vega","doi":"10.5772/INTECHOPEN.74492","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74492","url":null,"abstract":"Sensory information from the aquatic environment is required for life and survival of zebrafish. Changes in the environment are detected by specialized sensory cells that convert different types of stimuli into electric energy, thus originating an organ-specific transduction. Ion channels are at the basis of each sensory modality and are responsible or are required for detecting thermal, chemical, or mechanical stimuli but also for more complex sensory processes as hearing, olfaction, taste, or vision. The capacity of the sensory cells to preferentially detect a specific stimulus is the result of a characteristic com- bination of different ion channels. This chapter summarizes the current knowledge about the occurrence and localization of ion channels in sensory organs of zebrafish belonging to the superfamilies of transient-receptor potential and acid-sensing ion channels that are involved in different qualities of sensibility superfamilies in the sensory organs of zebraf- ish. This animal model is currently used to study some human pathologies in which ion channels are involved. Furthermore, zebrafish is regarded as an ideal model to study in vivo the transient-receptor potential ion channels.","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115137984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Monitoring and Assessment of Cd2+ Stress Using Zebrafish (Danio rerio) 斑马鱼Cd2+应激的监测与评价

Recent Advances in Zebrafish Researches Pub Date : 2018-05-30 DOI: 10.5772/INTECHOPEN.74454

Zongming Ren, Yuedan Liu

{"title":"The Monitoring and Assessment of Cd2+ Stress Using Zebrafish (Danio rerio)","authors":"Zongming Ren, Yuedan Liu","doi":"10.5772/INTECHOPEN.74454","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74454","url":null,"abstract":"Pollution on the Earth is ubiquitous across ecosystems from the land to the ocean. Various sources contribute to pollution including industrial (e.g. chemicals), agricultural (e.g. pesticides) and domestic (e.g. transportation) pollutants’ ecosystems and substrate environment (e.g. contamination in water). The extensive use of chemicals in agriculture, forests and wetlands may impair biological communities. Due to the lack of target specificity, these chemicals can cause severe and persistent toxic effects on nontarget aquatic species, including bacteria, invertebrates and vertebrates. Different degrees of biological response have been presented according to intensities of different chemicals. The cadmium (Cd2+) contamination in aquatic environment has attracted more and more attention due to its toxic characteristics, for example, accumulation in environment, nondegradability and the potential threat to the ecosystem. Knowledge and understanding of these conditions have led to the development of new monitoring and assessment technologies based on biological and chemical methods. This chapter covers new monitoring technologies and environment assessment of Cd2+ stress using zebrafish (Danio rerio), which include the behaviour responses, metabolism and electrocardiogram (ECG).","PeriodicalId":301425,"journal":{"name":"Recent Advances in Zebrafish Researches","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131799750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1