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Onco Zine - The International Oncology Network最新文献

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Crofelemer Reduces Diarrhea in Humans and Dogs Being Treated for Cancer, Recent Studies Show 最新研究表明，Crofelemer 可减少人类和狗在癌症治疗期间的腹泻次数
Onco Zine - The International Oncology Network Pub Date : 2024-07-13 DOI: 10.14229/onco.2024.07.12.001
Pablo Okhuysen, Allison Shrier
{"title":"Crofelemer Reduces Diarrhea in Humans and Dogs Being Treated for Cancer, Recent Studies Show","authors":"Pablo Okhuysen, Allison Shrier","doi":"10.14229/onco.2024.07.12.001","DOIUrl":"https://doi.org/10.14229/onco.2024.07.12.001","url":null,"abstract":"Diarrhea is an often-overlooked side effect of cancer therapy that can significantly impact patient outcomes and quality of life. In a study of patient-reported chemotherapy side effects, diarrhea was the second most common side effect reported after fatigue.In response to a patient’s diarrhea, a treating physician may reduce a therapeutic dose or discontinue the cancer therapy altogether, potentially worsening patient outcomes. Specifically, patients with cancer and diarrhea are 40% more likely to discontinue their cancer therapy Furthermore, the cost of care for patients with cancer and diarrhea is estimated to be nearly 2.9 times higher than for patients with cancer without diarrhea.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study Shows New Co-Star Receptor to be Promising in Cancer Treatment 研究显示新型共明星受体有望用于癌症治疗
Onco Zine - The International Oncology Network Pub Date : 2024-07-10 DOI: 10.14229/onco.2024.07.10.001
Peter Hofland
{"title":"Study Shows New Co-Star Receptor to be Promising in Cancer Treatment","authors":"Peter Hofland","doi":"10.14229/onco.2024.07.10.001","DOIUrl":"https://doi.org/10.14229/onco.2024.07.10.001","url":null,"abstract":"T-cell therapies such as engineered T-cell receptors or TCRs and Chimeric Antigen Receptors (CARs) T-Cell have, with a doubt, revolutionized the health outcomes for patients diagnosed with certain subsets of B cell leukemia or lymphoma, while, at the same time offer durable clinical responses. However, there are numerous challenges that limit the therapeutic efficacy of CAR T-cells in the treatment of solid tumors and hematological malignancies. Among the barriers to of these therapies are severe life-threatening toxicities, possible side effects such as cytokine release syndrome, modest anti-tumor activity, antigen escape, restricted trafficking, and limited tumor infiltration. To overcome the limitations, scientists have produced so called Co-stimulatory Synthetic T-cell receptor and Antigen Receptor or Co-STAR cells.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"9 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Concierge Catch: Better Access for a Few Patients Disrupts Care for Many 私人医生的陷阱：为少数患者提供更好的就医机会，却扰乱了许多患者的医疗服务
Onco Zine - The International Oncology Network Pub Date : 2024-07-01 DOI: 10.14229/onco.2024.07.01.001
John Rossheim
{"title":"The Concierge Catch: Better Access for a Few Patients Disrupts Care for Many","authors":"John Rossheim","doi":"10.14229/onco.2024.07.01.001","DOIUrl":"https://doi.org/10.14229/onco.2024.07.01.001","url":null,"abstract":"With the national shortage of primary care physicians reaching 17,637 in 2023 and projected to worsen, more Americans are paying for the privilege of seeing a doctor — on top of insurance premiums that cover most services a doctor might provide or order. Many people seeking a new doctor are calling a long list of primary care practices only to be told they’re not taking new patients.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbubbles: The Unlikely Key to Providing Accessible and Effective Cancer Treatments 微气泡：提供便捷有效的癌症治疗方法的关键所在
Onco Zine - The International Oncology Network Pub Date : 2023-11-23 DOI: 10.14229/onco.2023.11.23.001
Brandon H. McNaughton
{"title":"Microbubbles: The Unlikely Key to Providing Accessible and Effective Cancer Treatments","authors":"Brandon H. McNaughton","doi":"10.14229/onco.2023.11.23.001","DOIUrl":"https://doi.org/10.14229/onco.2023.11.23.001","url":null,"abstract":"For many years, the foundations of cancer treatments have been firmly set in surgery, chemotherapy, and radiotherapy. While these methods continue to be crucial pillars of treatment, new research has begun to transform the treatment landscape for people living with cancer. Over the past decade, scientists have shifted their focus inward, turning toward the patient’s own immune system as a treatment alternative.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139244503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embracing FAIR Data on the Path to AI-Readiness 在通往人工智能的道路上拥抱公平数据
Onco Zine - The International Oncology Network Pub Date : 2023-08-29 DOI: 10.14229/onco.2023.08.29.001
Christian Olsen
{"title":"Embracing FAIR Data on the Path to AI-Readiness","authors":"Christian Olsen","doi":"10.14229/onco.2023.08.29.001","DOIUrl":"https://doi.org/10.14229/onco.2023.08.29.001","url":null,"abstract":"Key principles of data management achieved via FAIR implementation can have positive effects on many aspects of R&D, from workflow efficiency to collaboration to costs. While machines offer incredible benefits in terms of the speed and scale at which they can process data, they lack the judgment, intuition, and contextual understanding that humans bring to the table. Making data FAIR is in essence making them more accessible to machines and humans alike.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123326847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are Price Controls Disrupting Clinical Trials and Stifling Medical Innovation? 价格管制是否扰乱了临床试验，扼杀了医学创新?
Onco Zine - The International Oncology Network Pub Date : 2023-08-15 DOI: 10.14229/onco.2023.08.15.001
H. Rajasimha
{"title":"Are Price Controls Disrupting Clinical Trials and Stifling Medical Innovation?","authors":"H. Rajasimha","doi":"10.14229/onco.2023.08.15.001","DOIUrl":"https://doi.org/10.14229/onco.2023.08.15.001","url":null,"abstract":"While pricing controls imposed by the Inflation Reduction Act of 2022 (IRS) may appear positive for patients in the short term, and is considered a step forward in improving affordability of, and access to, innovative medical treatments, these controls may have unintended consequences on biopharmaceutical drug development programs and investments in the long term unless this pressure is offset by the opportunity to modernize the way clinical trials are conducted.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127327524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Power of Clinically-Driven Technology and Member-Centric Approaches in Cancer Care 临床驱动技术和以会员为中心的癌症治疗方法的力量
Onco Zine - The International Oncology Network Pub Date : 2023-08-02 DOI: 10.14229/onco.2023.08.02.002
Clarice Holmes
{"title":"The Power of Clinically-Driven Technology and Member-Centric Approaches in Cancer Care","authors":"Clarice Holmes","doi":"10.14229/onco.2023.08.02.002","DOIUrl":"https://doi.org/10.14229/onco.2023.08.02.002","url":null,"abstract":"Cancer is a complex disease that challenges even the most well-versed clinicians. However, clinical technology has become a powerful tool for navigating this complexity. By consolidating vast amounts of oncology-specific data and harnessing advanced algorithms, technology platforms infused with clinical knowledge empower healthcare payers and providers to make well-informed decisions and enhance the quality of care delivered to cancer patients.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133357668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why are Patient Registries Key to Accelerating Rare Disease Research? 为什么患者登记是加速罕见病研究的关键?
Onco Zine - The International Oncology Network Pub Date : 2023-07-28 DOI: 10.14229/onco.2023.07.28.002
Padma Rammoorthy
{"title":"Why are Patient Registries Key to Accelerating Rare Disease Research?","authors":"Padma Rammoorthy","doi":"10.14229/onco.2023.07.28.002","DOIUrl":"https://doi.org/10.14229/onco.2023.07.28.002","url":null,"abstract":"The World Health Organization (WHO) defines Rare disease as a disorder which affects less than 6.5 to 10 per 10,000 people (Rabiei). In the European Union, the definition narrows down to 5 in 10,000 people, while in the United States, a rare disease is defined as a condition that affects fewer than 200,000 people. By these definitions there are more than 6800 (“Rare Diseases”) rare diseases. While the exact cause for most rare diseases are not known, several of these are usually traced to mutations in a single gene, which would essentially be passed down from one generation to the next. That is the reason we see these rare diseases running in families.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127781231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data Integrity in GxP Relevant Areas: A Hot Topic in the Pharmaceutical Sector GxP相关领域的数据完整性:制药行业的热门话题
Onco Zine - The International Oncology Network Pub Date : 2023-06-18 DOI: 10.14229/onco.2023.06.18.012
Olena Chervonenko
{"title":"Data Integrity in GxP Relevant Areas: A Hot Topic in the Pharmaceutical Sector","authors":"Olena Chervonenko","doi":"10.14229/onco.2023.06.18.012","DOIUrl":"https://doi.org/10.14229/onco.2023.06.18.012","url":null,"abstract":"The world around us provides us with an abundance of data at every moment of every day and we constantly analyze this data to make decisions. In this process, the attributability, accuracy, legibility, permanence, contemporaneousness, and originality of the data we receive are of utmost importance. So, what does “data” mean? Data is a formalized representation of information suitable for communication, interpretation, or processing, according to ISO/IEC 2382:2015. Data integrity (DI) is the property of data where accuracy and consistency are preserved regardless of changes made, according to the same ISO/IEC standard.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130200659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Multicomponent Biomarker Approach Will Shift Cancer Care 多组分生物标志物方法将改变癌症治疗
Onco Zine - The International Oncology Network Pub Date : 2023-06-12 DOI: 10.14229/onco.2023.06.12.010
O. Sharon
{"title":"A Multicomponent Biomarker Approach Will Shift Cancer Care","authors":"O. Sharon","doi":"10.14229/onco.2023.06.12.010","DOIUrl":"https://doi.org/10.14229/onco.2023.06.12.010","url":null,"abstract":"For many years we have been working towards creating a paradigm shift in cancer care, and precision oncology is rapidly evolving, with the potential to revolutionize our current standards and guidelines. But while we have made giant strides in our understanding of the disease, the current approach to biomarker development is still simplistic and fragmented, limiting our ability to understand the underlying biology of the patient’s cancer, tailor treatment to individual patients, monitor treatment response, detect early signs of relapse, and identify potential new targets for therapy. True precision oncology requires a comprehensive and integrated approach to biomarker development to really make a dent.","PeriodicalId":301285,"journal":{"name":"Onco Zine - The International Oncology Network","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121386983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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