{"title":"Analysis of coexisting neuronal populations in optogenetic and conventional BOLD data","authors":"Henning U. Voss, Ana I. Domingos","doi":"10.1109/SPMB.2012.6469467","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469467","url":null,"abstract":"Modeling the hidden neuronal and hemodynamic sources of the blood-oxygenation-level-dependent (BOLD) signal allows for location-dependent parameter estimation that potentially contains more information about brain activation than the general linear model. Here we propose a generalization of the Buxton-Mandeville-Friston BOLD model for more than one neuronal population sharing common hemodynamics within a voxel and demonstrate that new hemodynamic response functions can result. Further, it is demonstrated that two neuronal contributions can be disentangled by parameter estimation from simulated data under certain conditions including differing neuronal efficacies and relaxation parameters. Finally, previously unexplained observations in optogenetic fMRI data are successfully modeled using this approach. This mapping of neuronal and hemodynamic sources could provide novel functional markers for not necessarily optogenetic clinical applications in a more specific way than standard clinical MRI protocols.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127873189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Bayesian approach to inferring fiber tract bundle labels in Diffusion Tensor Imaging","authors":"Xuwei Liang","doi":"10.1109/SPMB.2012.6469458","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469458","url":null,"abstract":"Aiming for achieving anatomically meaningful results in automatic unsupervised clustering of reconstructed white matter (WM) fiber tracts in Diffusion Tensor Imaging (DTI), we present a Bayesian approach enabling to incorporate prior anatomical knowledge and handle outliers easily. Particularly, the distribution of WM fiber tracts is described by a Gaussian mixture model. By applying the Bayesian theorem, we are able to evaluate the posterior probability that a fiber tract belongs to each target bundle based on both the probability distribution and prior anatomical information. A fiber tract is labeled into a target bundle with which the maximum posterior probability occurs. If all calculated posterior probabilities are smaller than a user defined threshold, the fiber tract is labeled as an outlier. The prior anatomical information is represented by the target fiber tract bundles' prior distribution which can be obtained by anatomical studies and may be amended by further researches. The fact that this type of prior information is less dependent on individual brain structures than that in some existing methods makes this approach useful in group studies. Real DTI datasets are used to assess the performance of the method. Experimental results show that this technique is feasible and may have potential applications in group analysis of WM fiber tracts in DTI.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"375 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134129573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Robustness analysis of sparsity based tumor localization under tissue configuration uncertainty","authors":"M. Pourhomayoun, M. Fowler, Zhanpeng Jin","doi":"10.1109/SPMB.2012.6469463","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469463","url":null,"abstract":"Knowing the exact position of the tumor is a very critical prerequisite in radiation therapy. Since the position of the tumor changes because of respiration or patient movements, a real-time tumor tracking method must be applied during the process of radiation therapy in order to deliver a sufficient dose of radiation to the tumor region without damaging the surrounding healthy tissues. In this paper, we develop a novel tumor positioning method based on spatial sparsity and then we investigate the sensitivity of this method to the uncertainty of tissue configuration. The proposed method is easier to implement, non-iterative, faster and more accurate compared to common magnetic transponder based approaches. The performance of the proposed method is evaluated in two different cases: (1) when the tissue configuration is perfectly determined (acquired beforehand by MRI or CT) and (2) when there are some uncertainties about the tissue boundaries. The results demonstrate the satisfactory accuracy and high performance of the proposed method, even when the tissue boundaries are imperfectly known.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115098492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Podilchuk, M. Bajor, W. Stoddart, L. Barinov, W. Hulbert, A. Jairaj, R. Mammone
{"title":"Speckle reduction using stepped-frequency continuous wave ultrasound","authors":"C. Podilchuk, M. Bajor, W. Stoddart, L. Barinov, W. Hulbert, A. Jairaj, R. Mammone","doi":"10.1109/SPMB.2012.6469470","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469470","url":null,"abstract":"Medical Ultrasonography is a valuable imaging technology for medical diagnostics and to guide interventional procedures. Ultrasound imaging is particularly useful in breast cancer detection and diagnosis for women with dense breast tissue where traditional mammography may fail to detect suspicious areas. However, ultrasound imaging suffers from speckle noise, an inherent characteristic of all coherent imaging techniques due to the presence of sub-resolution scatterers. Speckle noise produces a reduction in contrast resolution which is responsible for the overall lower effective resolution of ultrasound compared to x-ray or MRI imaging. In the case of breast imaging, ultrasound speckle can mask small details such as low contrast tumors or micro-calcifications, which may be an early indication of breast cancer. This limitation prevents ultrasound from displacing mammography as the gold standard for breast cancer screening. In conventional pulsed ultrasound imaging systems, de-noising techniques are used to minimize the effect of speckle noise. However, research shows that there is a tradeoff between the effectiveness of speckle reduction techniques and image resolution. We introduce stepped-frequency continuous wave ultrasound imaging which provides a framework where speckle reduction techniques are particularly effective, resulting in higher quality images with an improved SNR and significantly lower speckle noise while maintaining the spatial resolution of the original scan so that small lesions of interest are visible to the radiologist.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"453 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116180783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new complexity-based algorithmic procedures for electroencephalogram (EEG) segmentation","authors":"B. Darkhovsky, A. Piryatinska","doi":"10.1109/SPMB.2012.6469462","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469462","url":null,"abstract":"Electroencephalogram (EEG) signals are complex and non-stationary. To analyze and model EEG records the segmentation of the signal into (quasi)- stationary intervals is needed. In this paper we propose a novel approach for the segmentation problem that occurs in “long” EEG records. This approach utilizes the concept of complexity of a continuous function. The complexity of a continuous function is defined as the fraction of the function values necessary to recover the original function via a certain fixed family of approximation methods without exceeding a given error. We applied this approach to the EEG signal of neonates to identify sleep stages. Our results showed 82-86% average agreement with the manual scoring provided by an expert pediatric neurologist.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"300 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114581901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantification of motion artifacts in 4DCT using global Fourier analysis","authors":"Jie Wei, Guang Li","doi":"10.1109/SPMB.2012.6469468","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469468","url":null,"abstract":"Motion artifacts in 4-Dimensional computed tomography (4DCT) impose a potential problem in tumor and anatomy delineation, causing a systematic error in radiotherapy treatment planning. In patients, frequency and amplitude of motion artifacts appearing in 4DCT are currently manually evaluated by scrolling through all 4DCT images. This is a tedious, time consuming and error-prone process with an outcome that may be difficult for comparison among patients. In this study, we propose an automatic approach to evaluate the motion artifacts in 4DCT using Discrete Fourier transform. Instead of applying Fourier transform in local macro-blocks as done in ordinary signal processing and computer vision applications, we discover that 4DCTs of severe motion artifacts demonstrate special behavioral properties in their spectral domain after a global Fourier transform, which can be exploited to effectively quantify the severity of motion artifacts in 4DCT images via a band-passing analysis. This is the first effort in creating a computerized algorithm to evaluate the motion artifacts with a quantitative and objective evaluation with encouraging performances. Further study will be conducted with more patient data with more rigorous 4-dimensional analysis in the near future.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124029306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unobtrusive vital signs monitoring with range-controlled radar","authors":"C. Graichen, J. Ashe, M. Ganesh, Lijie Yu","doi":"10.1109/SPMB.2012.6469454","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469454","url":null,"abstract":"Researchers at General Electric have developed a prototype demonstration system that can identify motion and measure breathing and heart rate in periods without general body motions using a range-controlled radar device, similar to motion detectors available in home security systems. With continuous monitoring of the activity and physical vital signs, warning criteria can be used to identify potential crises augmenting existing observational systems without requiring the observed individual to wear or attach any special devices. This has potential applications in correctional facilities to complement observation for inmates at risk of suicide. It has healthcare applications where attaching traditional vital sign monitoring equipment is difficult such as for neonatal or burn patients.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124575193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spatial and temporal analysis of interictal activity in the epileptic brain","authors":"P. McCall, M. Cabrerizo, M. Adjouadi","doi":"10.1109/SPMB.2012.6469459","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469459","url":null,"abstract":"In clinical and research settings numerous algorithms have been developed for the analysis of electroencephalographic (EEG) data in the diagnosis of epilepsy and throughout the process of localizing the seizure onset zone (SOZ). This research highlights the merging of two major detection algorithms for the identification of High-Frequency Oscillations (HFO), also known as ripples, and Interictal Spikes (IIS) in both the spatial and temporal domain. IIS and HFO have become recognized as reliable biomarkers in identification of the epileptic focus in the cortex of epileptic patients. While IIS, commonly referred to as spikes, have classically been used for the diagnosis of epilepsy and for source localization techniques, ripples have been associated with more generalized cortex regions of interest and surrogate biomarkers for the seizure onset zone (SOZ). This research aims to combine these two analyses by correlating HFO and IIS events in the time domain for each electrode recording with the goal of yielding a more complete understanding of the abnormal electrical activity of the cortex in epileptic patients. Results are offered in the form HFO and IIS events per electrode as well as a surface representation of the number of temporally superimposed HFO and IIS per electrode.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115996541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siddharth Samsi, Wael N. Jarjour, Ashok K. Krishnamurthy
{"title":"Glomeruli segmentation in H&E stained tissue using perceptual organization","authors":"Siddharth Samsi, Wael N. Jarjour, Ashok K. Krishnamurthy","doi":"10.1109/SPMB.2012.6469464","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469464","url":null,"abstract":"Systemic Lupus Erythematosus involvement of the kidneys is associated with high morbidity and mortality. Inter-observer variability can also lead to an incorrect assessment of the disease. Computer aided image analysis can potentially be used to advance the understanding, diagnosis and treatment of Lupus. Our research focuses on the image analysis of kidney biopsies for quantifying tissue characteristics relevant to Lupus. In this paper we describe an algorithm for identifying glomeruli in H&E stained mouse renal biopsies. The proposed approach uses color segmentation to identify all objects in the image that potentially correspond to the Bowman's space around the glomeruli. This is followed by a perceptual grouping procedure to group objects based on their size, location and orientation.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130352270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distribution of intravascular and extravascular extracellular volume fractions for neovascularization assessment by dynamic contrast-enhanced magnetic resonance imaging","authors":"Yi Sun, Ze-bing Ye","doi":"10.1109/SPMB.2012.6469466","DOIUrl":"https://doi.org/10.1109/SPMB.2012.6469466","url":null,"abstract":"This study proposes and investigates the distribution of intravascular and extravascular extracellular volume fractions (DIEEF) as a noninvasive biomarker for neovascularization assessment by DCE-MRI. Two estimation methods without knowing the artery input function are developed. The mean square error of DIEEF estimate in the presence of noise and incomplete data is analyzed. Simulation result shows that DIEEF can be accurately estimated even when signal to noise ratio is as low as 5 dB. Tested on a model of atherosclerotic rabbits, DIEEF of aorta plaques is positively correlated with the histological neovessel count with correlation coefficient of 0.940 and P-value of 0.017 and outperforms six existing semiquantitative parameters.","PeriodicalId":300561,"journal":{"name":"2012 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132420163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}