{"title":"Perceived climate justice","authors":"","doi":"10.1038/s41558-024-02184-y","DOIUrl":"10.1038/s41558-024-02184-y","url":null,"abstract":"Aspirations for a just society can motivate individuals to engage in climate action; however, public awareness of climate justice remains low, and the extent of injustice within the climate crisis is often underestimated.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"14 11","pages":"1107-1107"},"PeriodicalIF":29.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41558-024-02184-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kexin Ai, Bowen Liu, Xiaomei Chen, Chuxin Huang, liping Yang, Weiya Zhang, Jianyu Weng, Xin Du, Kongming Wu, Peilong Lai
{"title":"Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies","authors":"Kexin Ai, Bowen Liu, Xiaomei Chen, Chuxin Huang, liping Yang, Weiya Zhang, Jianyu Weng, Xin Du, Kongming Wu, Peilong Lai","doi":"10.1186/s13045-024-01625-7","DOIUrl":"https://doi.org/10.1186/s13045-024-01625-7","url":null,"abstract":"Chimeric antigen receptor (CAR)-T cell therapy demonstrates substantial efficacy in various hematological malignancies. However, its application in solid tumors is still limited. Clinical studies report suboptimal outcomes such as reduced cytotoxicity of CAR-T cells and tumor evasion, underscoring the need to address the challenges of sliding cytotoxicity in CAR-T cells. Despite improvements from fourth and next-generation CAR-T cells, new challenges include systemic toxicity from continuously secreted proteins, low productivity, and elevated costs. Recent research targets genetic modifications to boost killing potential, metabolic interventions to hinder tumor progression, and diverse combination strategies to enhance CAR-T cell therapy. Efforts to reduce the duration and cost of CAR-T cell therapy include developing allogenic and in-vivo approaches, promising significant future advancements. Concurrently, innovative technologies and platforms enhance the potential of CAR-T cell therapy to overcome limitations in treating solid tumors. This review explores strategies to optimize CAR-T cell therapies for solid tumors, focusing on enhancing cytotoxicity and overcoming application restrictions. We summarize recent advances in T cell subset selection, CAR-T structural modifications, infiltration enhancement, genetic and metabolic interventions, production optimization, and the integration of novel technologies, presenting therapeutic approaches that could improve CAR-T cell therapy’s efficacy and applicability in solid tumors.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"7 1","pages":""},"PeriodicalIF":28.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dupuytren contracture treatments compared","authors":"Sarah Onuora","doi":"10.1038/s41584-024-01186-6","DOIUrl":"https://doi.org/10.1038/s41584-024-01186-6","url":null,"abstract":"In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dupuytren contracture.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"27 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in attribution","authors":"","doi":"10.1038/s41558-024-02189-7","DOIUrl":"10.1038/s41558-024-02189-7","url":null,"abstract":"As attribution studies evolve in complexity and become more present in public discourse, care is needed to ensure that the associated uncertainties and relevant contexts remain clear.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"14 11","pages":"1108-1108"},"PeriodicalIF":29.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41558-024-02189-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Public attention and the Amazon","authors":"Lingxiao Yan","doi":"10.1038/s41558-024-02186-w","DOIUrl":"10.1038/s41558-024-02186-w","url":null,"abstract":"","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"14 11","pages":"1116-1116"},"PeriodicalIF":29.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed I. Abdo, Daolin Sun, Zhaoji Shi, Mohamed K. Abdel-Fattah, Jiaen Zhang, Yakov Kuzyakov
{"title":"Conventional agriculture increases global warming while decreasing system sustainability","authors":"Ahmed I. Abdo, Daolin Sun, Zhaoji Shi, Mohamed K. Abdel-Fattah, Jiaen Zhang, Yakov Kuzyakov","doi":"10.1038/s41558-024-02170-4","DOIUrl":"https://doi.org/10.1038/s41558-024-02170-4","url":null,"abstract":"<p>Intensification of farming since the Green Revolution has led to large increases in yield but has also increased anthropogenic greenhouse gas emissions. Here, by providing a global comprehensive cradle-to-gate quantification from seed to yield, we show that the global warming potential (GWP) of conventional agriculture of grain crops has increased eightfold from 1961 to 2020, whereas the sustainability index (SI) has decreased threefold. Tillage, synthetic fertilizers and irrigation together accounted for 90% of the increased GWP, linked to tenfold increases in fertilization and groundwater use and more than doubled mechanized and irrigated areas. We highlight regions with high GWP and low SI, such as South Asia, and project further threefold increases in agriculture GWP by 2100 compared with 2020 (3.3 ± 0.73 PgCO<sub>2</sub>e) driven by declined use efficiency of the inputs. Green energy and climate-smart agriculture techniques can reduce the projected GWP in 2100 to 2.3 PgCO<sub>2</sub>e and increase the SI fourfold.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"142 1","pages":""},"PeriodicalIF":30.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber
{"title":"Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation","authors":"Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber","doi":"10.1186/s13045-024-01622-w","DOIUrl":"https://doi.org/10.1186/s13045-024-01622-w","url":null,"abstract":"Mitochondrial DNA (mtDNA) variants in patients with myelodysplastic neoplasms (MDS) are shown to be prognostic of outcomes after allogeneic hematopoietic cell transplantation (allo-HCT). However, the prognostic impact of donor mtDNA variants is unknown. Here, we performed whole-genome sequencing on 494 donors who were matched to MDS patients enrolled in the Center for International Blood and Marrow Transplant Research (CIBMTR). We evaluated the impact of donor mtDNA variants on recipients’ transplantation outcomes, including overall survival, relapse, relapse-free survival, and transplant-related mortality. The optimism-adjusted bootstrap method was employed to evaluate the prognostic performance of models that include donor mtDNA variants alone and combined with MDS- and HCT-related clinical factors. In the entire donor cohort, we identified 1,825 mtDNA variants, including 67 potential pathogenic variants. Genetic variants on MT-CYB and MT-ND5 genes were identified as independent predictors of posttransplant outcomes. Integration of donor mtDNA variants into the models based on the International Prognostic Scoring System-Revised (IPSS-R) could capture more prognostic information for MDS patients. Sensitivity analysis in 397 unrelated donors obtained similar results. More importantly, we found that incorporating donor mtDNA variants with donor age and the degree of HLA-matching could help to identify “suboptimal” younger HLA-well-matched unrelated donors and “optimal” older HLA-partially/mismatched unrelated donors. Our study shows that mtDNA variants in donors, including those from unrelated donors, hold prognostic value for MDS patients undergoing allo-HCT and augment the prognostic stratification of current scoring systems. These findings present an opportunity to refine donor selection strategies and improve posttransplant outcomes for MDS patients.","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry Bioconjugate","volume":"48 1","pages":""},"PeriodicalIF":28.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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