Cardiovascular Medicine最新文献

{"title":"The SWISS PCI Survey – coronary and structural heart interventions in Switzerland 2020","authors":"J. Boeddinghaus, O. Gaemperli, P. Meier, O. Muller, F. Nietlispach, L. Raeber, D. Weilenmann, R. Jeger","doi":"10.4414/cvm.2022.02201","DOIUrl":"https://doi.org/10.4414/cvm.2022.02201","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41662754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of a Tattoo during Subcutaneous ICD Implantation with Uncompromised Device Function","authors":"D. Inderbitzin, A. Saguner, J. Steffel, Aaron Imhof, A. Breitenstein","doi":"10.4414/cvm.2022.02199","DOIUrl":"https://doi.org/10.4414/cvm.2022.02199","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46598298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGTL-2 Inhibitors and Heart Failure","authors":"M. Maeder, H. Rickli, M. Buser","doi":"10.4414/cvm.2022.02206","DOIUrl":"https://doi.org/10.4414/cvm.2022.02206","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47421704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Permanent HIS bundle pacing – a valid alternative to biventricular cardiac resynchronization therapy?","authors":"Gabriela Hilfiker","doi":"10.4414/cvm.2022.02188","DOIUrl":"https://doi.org/10.4414/cvm.2022.02188","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45406838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic miss leading to neoatherosclerosis and very late stent thrombosis","authors":"M. Madanchi, G. Cioffi, Adrian Attinger-Toller, R. Kobza, M. Bossard, F. Cuculi","doi":"10.4414/cvm.2022.02195","DOIUrl":"https://doi.org/10.4414/cvm.2022.02195","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48882623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic cascade screening for familial hypercholesterolemia in Switzerland","authors":"D. Nanchen, J. Beer, A. Gallino","doi":"10.4414/cvm.2022.02193","DOIUrl":"https://doi.org/10.4414/cvm.2022.02193","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46139286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoptysis and unintentional weight loss in a 46-year old patient – always a pulmonary problem?","authors":"Tobias Hfflinghaus, Lena Gerstner, Wieser Stephan, Meyer Matthias","doi":"10.4414/cvm.2022.02197","DOIUrl":"https://doi.org/10.4414/cvm.2022.02197","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48465754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bempedoinsäure – Ein neuer Lipidsenker als Monotherapie und in Kombination mit Ezetimibe zusätzlich zu Statinen","authors":"Thomas F. Lscher, C. Mueller, Konstantinos Koskinas, Isabella Sudano Noll, Franois Mach","doi":"10.4414/cvm.2022.02183","DOIUrl":"https://doi.org/10.4414/cvm.2022.02183","url":null,"abstract":"Die Cholesterinhypothese ist eines der am besten dokumentierten Konzepte der modernen Medizin mit über zweieinhalb Millionen Patienten, die in randomisierten kontrollierten Langzeitstudien mit Statinen vsersus Placebo, verschiedenen Statinen im Vergleich oder verschiedenen Dosierungen desselben Statins eingeschlossen wurden [1]. Alle diese Untersuchungen zeigen einheitlich, dass eine Senkung des Cholesterins, insbesondere des Low-density lipoproteins (LDL-C), dosisabhängig zu einer Reduktion von Herzinfarkt, Hirnschlag und verfrühtem Tod um ca. 25% pro Jahr führt [2]. Die absolute Risikoreduktion durch eine LDL-C Senkung hängt von der Höhe des individuellen Risikos, der Höhe des Cholesterins sowie dem Ausmass und der Dauer der LDL-C Senkung ab [2]. Entsprechend wurden die Statine seit Ende der 80erJahre zunehmend bei allen Herzpatienten, vor allem denjenigen mit koronarer Herzkrankheit, aber auch bei noch gesunden Individuen (mit kardiovaskulären Risikofaktoren, wie erhöhtem Cholesterin, Hypertonie oder Diabetes) eingesetzt. Die Statine senken die Cholesterinproduktion in der Leber, die etwa 85% des Gesamtpools von Cholesterin im Körper ausmacht, durch Hemmung der HMG-Coenzyme-A Reduktase. Dies führt zu einer Hochregulation der hepatischen LDL-Rezeptoren mit nachfolgender Senkung der LDL-Serumkonzentration. Die Statine gehören zu den wohl wirksamsten und am besten verträglichen Medikamenten der kardiovaskulären Medizin und werden entsprechend breit verwendet. Von der Potenz her, sind Atorvastatin, Pitavastatin und Rosuvastatin, die wirksamsten Statine, welche das LDLCholesterin dosis-abhängig bis zu 50% senken, gefolgt von Simvastatin, Fluvastatin und schliesslich Pravastatin, der am wenigsten wirksamen Substanz [3, 4]. Zusätzlich zu den Statinen wird vermehrt auch eine Kombination mit Ezetimib verwendet, einem Hemmer des Niemann-Pick C1-like Proteins 1 (NPC1L1) im Darm. Damit wird die Cholesterinaufnahme aus der Nahrung reduziert, wodurch es zu einer Senkung des LDL-Cholesterins um etwa 20–25% kommt [5]. Die Hemmung der intestinalen Cholesterinresorption wirkt synergistisch mit derHemmung der hepatischen Cholesterinsynthese. a Center for Molecular Cardiology, University of Zurich, Switzerland; b Royal Brompton and Harefield Hospitals and National Heart and Lung Institute, Imperial College, London U.K.; c Foundation for Cardiovascular Research – Zurich Heart House, Zurich, Switzerland; d Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland; e Department of Cardiology, Bern University Hospital, Bern, Switzerland; f Cardiology, University Heart Center, University Hospital and University of Zurich, Switzerland; g Cardiology Division, University of Geneva, Switzerland; h Department of Cardiology, University Hospital of Leipzig, Germany Thomas F. Lüschera,b,c, christian muellerd, Konstantinos c. Koskinase, Isabella Sudanof, François machg, ulrich Laufsh Bempedoinsäure – Ein neuer Lipidsenk","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45813380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wide-complex tachycardia in a 90-year old man with a dual-chamber pacemaker","authors":"A. Vella, Philipp Suter, D. Graf, Hari Vivekanantham","doi":"10.4414/cvm.2022.02192","DOIUrl":"https://doi.org/10.4414/cvm.2022.02192","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42927232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of an ECG-algorithm for identification of the infarct-related artery in inferior myocardial infarction in clinical practice","authors":"Beate Buchmann, Tim Rnz, P. Bonetti","doi":"10.4414/cvm.2022.02190","DOIUrl":"https://doi.org/10.4414/cvm.2022.02190","url":null,"abstract":"","PeriodicalId":29995,"journal":{"name":"Cardiovascular Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43390437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}