European Journal of Pharmaceutical Research最新文献

筛选

英文中文

Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation 利用亮氨酸改善吸入负载环丙沙星的麦芽糖微粒的空气动力学特性

European Journal of Pharmaceutical Research Pub Date : 2019-03-13 DOI: 10.34154/2019-EJPR.01(01).PP-02-11/EURAASS

Barbara Lamy, D. Serrano, P. O'Connell, W. Couet, S. Marchand, A. Healy, F. Tewes

{"title":"Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation","authors":"Barbara Lamy, D. Serrano, P. O'Connell, W. Couet, S. Marchand, A. Healy, F. Tewes","doi":"10.34154/2019-EJPR.01(01).PP-02-11/EURAASS","DOIUrl":"https://doi.org/10.34154/2019-EJPR.01(01).PP-02-11/EURAASS","url":null,"abstract":"Ciprofloxacin (CIP) apparent permeability and absorption rate across the pulmonary epithelium can be controlled by its complexation with copper (II) ion. The aim of the current study was to formulate CIP-Cu-loaded microparticles comprising three main excipients, calcium carbonate, maltose and L-leucine, and to process by spray drying so as to generate particles with suitable aerodynamic properties for pulmonary delivery using a dry powder inhaler. Different maltose:calcium carbonate ratios were used to prepare microparticles, and the role of the excipients on the particles’ physicochemical properties, stability, and aerosolization characteristics were investigated. All the formulations without L-leucine were fully X-ray amorphous. In the presence of L-leucine, diffraction peaks of low intensity were observed, which were attributed to the crystallization of the L-leucine at the particle surfaces. The addition of L-leucine modified the particle morphology and reduced the median geometric and aerodynamic diameters to 3.2 and 3.4 µm, respectively. The fine particle fraction of powder emitted from a Handihaler® device was increased up to 65.4%, predicting high total lung deposition. Stability studies showed that the powder X-ray diffraction pattern did not change over 21 months of storage in desiccated conditions, suggesting a good physical stability of the optimized formulation comprised of CIP-Cu, maltose and L-Leucine.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131234185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

A focus of the nanoprecipitation by solvent displacement: example of poly(MAOTIB) intended to in vivo applications 溶剂置换纳米沉淀法的焦点:poly(MAOTIB)在体内应用的例子

European Journal of Pharmaceutical Research Pub Date : 2019-03-13 DOI: 10.34154/2019-EJPR.01(01).PP-20-26/EURAASS

Justine Wallyn, T. Vandamme, N. Anton

{"title":"A focus of the nanoprecipitation by solvent displacement: example of poly(MAOTIB) intended to in vivo applications","authors":"Justine Wallyn, T. Vandamme, N. Anton","doi":"10.34154/2019-EJPR.01(01).PP-20-26/EURAASS","DOIUrl":"https://doi.org/10.34154/2019-EJPR.01(01).PP-20-26/EURAASS","url":null,"abstract":"Through this study, we propose to specifically focus on a particular stage of the fabrication of polymeric nanoparticles intended to be used as contrast agent for biomedical X-ray imaging. These nanoparticles, made from nanoprecipitation of preformed polymer, poly(MAOTIB) (poly(2-methacryloyloxyethyl(2,3,5-triiodobenzoate))) follow a solvent displacement process. This method, widely used in literature, is sensitive to the formulation and process parameters such as nature and concentrations of surfactant and polymer, solvent / non-solvent ratio, rate of addition of one phase in the other one, respective volumes of the phase, and homogenization shearing rate. On the other hand, in function of the aimed administration route, the final suspension should obey to specific constraints on final product, e.g. size range and polydispersity, final particle concentration (i.e. iodine concentration) and surfactant concentration. In the present work, we report a specific investigation on the nanoprecipiation of poly(MAOTIB) in tetrahydrofuran, dropped in water or ethanol (as non-solvent) and stabilized by nonionic surfactant. The objective is to show and explain the potentials and limitations of such the process, but also to provide a guidance on the way to optimize it.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128281863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-step and low-energy method to prepare solid lipid nanoparticles and nanostructured lipid carriers using biocompatible solvents 利用生物相容性溶剂制备固体脂质纳米颗粒和纳米结构脂质载体的单步低能方法

European Journal of Pharmaceutical Research Pub Date : 2019-03-13 DOI: 10.34154/2019-EJPR.01(01).PP-12-19/EURAASS

A. Date, M. Nagarsenker

{"title":"Single-step and low-energy method to prepare solid lipid nanoparticles and nanostructured lipid carriers using biocompatible solvents","authors":"A. Date, M. Nagarsenker","doi":"10.34154/2019-EJPR.01(01).PP-12-19/EURAASS","DOIUrl":"https://doi.org/10.34154/2019-EJPR.01(01).PP-12-19/EURAASS","url":null,"abstract":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLCs) are widely being explored for improving dermal/transdermal and oral delivery of drugs, neutraceuticals and cosmeceuticals. High-pressure homogenization (HPH) is the most commonly used preparation method for SLN/NLCs. SLN/NLCs preparation by the HPH requires high energy input and longer duration. Here, we describe a simple yet innovative low-energy method to prepare SLN/NLCs in a single-step using biocompatible solvents. We first show that biocompatible solvents such as Transcutol P, Soluphor P, N-methyl pyrrolidone, and glycofurol can solubilize glyceryl monostearate, glyceryl behenate, and glyceryl distearate to a variable degree. Our pre-formulation studies showed that only GMS could be transformed into SLN or NLCs despite high solubility of the lipids investigated indicating the importance of solvent-lipid interaction parameter in our preparation method. Finally, we show that SLN and NLCs of glyceryl monostearate with size < 150 nm and acceptable polydispersity index can be easily developed using Transcutol P as a biocompatible solvent and polyoxyl-40-stearate (MYS-40) as a stabilizer. As the Transcutol P has excellent acceptability for dermal/transdermal and oral route, there is no need to remove the residual Transcutol P (5% v/v) from the prepared glyceryl monostearate SLN/NLCs. Thus, our method offers a simple yet innovative way to prepare GMS SLN/NLCs suitable for dermal/transdermal and oral applications.","PeriodicalId":299907,"journal":{"name":"European Journal of Pharmaceutical Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114085106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

首页上一页