Embryology - Theory and Practice最新文献

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Introductory Chapter: New Theory and Technology in Early Clinical Embryogenesis 导论:早期临床胚胎发生的新理论和新技术
Embryology - Theory and Practice Pub Date : 2019-08-28 DOI: 10.5772/intechopen.88331
Bin Wu
{"title":"Introductory Chapter: New Theory and Technology in Early Clinical Embryogenesis","authors":"Bin Wu","doi":"10.5772/intechopen.88331","DOIUrl":"https://doi.org/10.5772/intechopen.88331","url":null,"abstract":"ratio transfer. the effect of on human babies that ART patient age is significantly than normal delivered women; the gestation of fresh and frozen embryo transfer has the same as normal deliver baby gestation days, but multi-baby birth women have shorter gestation days; there is no significant difference on early birth between fresh embryo transfer single babies and normal delivered babies, but multi-babies have a higher early birth rate, and frozen embryo transfer has lower early birth rate; there is no significant difference between male and female babies although fresh embryo transfer looks like more male babies and frozen embryo transfer has more female babies; there is no significant difference on the baby weight between ART singleton babies and normal babies, male baby weight is more female babies, and multi-baby birth weights have significant lower singletons, while transfer babies have significant heavier birth weight than fresh embryo transfer. These results showed that the singleton with ART treatment does not have any significant difference normal single babies on gestation days, early birth rate, baby birth weight, multi-baby birth has rate day and weight. transfer","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121273370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of Assisted Reproductive Technology (ART) on Babies Born: Compared by IVF Laboratories of Two Countries 辅助生殖技术(ART)对婴儿出生的影响:两国试管婴儿实验室比较
Embryology - Theory and Practice Pub Date : 2019-07-09 DOI: 10.5772/INTECHOPEN.87842
Linda Wu, Jinzhou Qin, Dikai Zhang, Minqi Zhang, Suzhen Lu, Jennifer Howell, T. Gelety, Bin Wu
{"title":"Effect of Assisted Reproductive Technology (ART) on Babies Born: Compared by IVF Laboratories of Two Countries","authors":"Linda Wu, Jinzhou Qin, Dikai Zhang, Minqi Zhang, Suzhen Lu, Jennifer Howell, T. Gelety, Bin Wu","doi":"10.5772/INTECHOPEN.87842","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87842","url":null,"abstract":"Assisted reproductive technology (ART) has been widely used for infertility treatment, but many people have concern about their baby’s health. The objective of this chapter is to provide some detailed data about the effect of ART on human birth babies by analyzing the data from in vitro fertilization (IVF) centers in two countries. All recent records related to a baby’s birth including mother’s age, gestational days, baby’s sex, and birth weight data were collected and analyzed according to fresh or frozen embryo transfer procedure. Normal delivery data without ART were used as control. The result showed that ART patient age is significantly older than non-IVF women; the gestation of fresh and frozen embryo transfer is the same as normal spontaneous conception gestation days, but women pregnant with multiple gestations have shorter gestational period and early birth rate as well as low birth weight; and there is no significant difference in the baby’s weight between ART singleton babies and normal conception babies, but male babies weight is more than female babies, and multiple gestation’s birth weights are significantly lower than singletons, while frozen embryo transfer babies have significantly heavier birth weight than fresh embryo transfer. Also, the frozen embryo transfer technique may significantly decrease premature birth rate. Thus, frozen embryo transfer may be recommended as a health strategy in ART.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129943636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Application of In Vitro Maturation of Oocytes 卵母细胞体外成熟的临床应用
Embryology - Theory and Practice Pub Date : 2019-06-28 DOI: 10.5772/INTECHOPEN.87773
Xiaolin La, J. Zhao, Zhihui Wang
{"title":"Clinical Application of In Vitro Maturation of Oocytes","authors":"Xiaolin La, J. Zhao, Zhihui Wang","doi":"10.5772/INTECHOPEN.87773","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87773","url":null,"abstract":"In vitro maturation (IVM) is a technique used to induce immature oocytes collected in different periods of embryonic growth. The rates vary for immature oocytes collected from different clinical sources to potentially develop into embryos and achieve live birth. As an effective treatment method, IVM can be used to treat patients with polycystic ovary syndrome (PCOS), ovarian hyperresponsiveness, and hyporesponsiveness, as well as to preserve the fertility of cancer patients. This technology has been used worldwide for the birth of thousands of healthy babies. The improvement in clinical IVM technology mainly focuses on the IVM medium and the optimization of the culture environment and operation process. At present, with the improvement in the in vitro fertilization (IVF) efficiency and culture systems, a natural cycle or mild stimulation may be more suitable for women receiving IVF treatments. A new treatment option was proposed to combine natural cycle/ mild stimulation IVF with IVM. In particular, the combination of mild stimulation IVF and IVM is not only expected to become a viable alternative to current standard treatments but may also become a potential option of first-line treatment.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"06 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121759615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Role of Neuroendocrine in Embryo Implantation 神经内分泌在胚胎着床中的作用
Embryology - Theory and Practice Pub Date : 2019-06-25 DOI: 10.5772/INTECHOPEN.87863
Fen-Ting Liu, Rong-Gang Li
{"title":"The Role of Neuroendocrine in Embryo Implantation","authors":"Fen-Ting Liu, Rong-Gang Li","doi":"10.5772/INTECHOPEN.87863","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87863","url":null,"abstract":"Neuroendocrine integration, an integration of the nervous system and endocrine system as its name implies, plays a critical role in the reproductive system. However, less progress has been made in the particular effects of neuroendocrine on embryo implantation. Recently, some significant knowledges have been gained on the regulation of neuroendocrine in embryo implantation. This chapter will summarize the current state of knowledges about the impaction of neuroendocrine on embryo implantation and discuss potential strategy to get higher pregnancy rate and to reduce recurrent implantation failure (RIF) possibility through modulating the neuroendocrine systems.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125165414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Oocyte Activation Failure: Physiological and Clinical Aspects 卵母细胞活化失败:生理和临床方面
Embryology - Theory and Practice Pub Date : 2019-02-07 DOI: 10.5772/INTECHOPEN.83488
N. Hojnik, B. Kovačič
{"title":"Oocyte Activation Failure: Physiological and Clinical Aspects","authors":"N. Hojnik, B. Kovačič","doi":"10.5772/INTECHOPEN.83488","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.83488","url":null,"abstract":"Despite successful treatment of infertility with assisted reproductive technology (ART), total fertilization failure (TFF) after in vitro fertilization (IVF) and even after intracytoplasmic sperm injection (ICSI) still occurs. In the current chapter, the incidence and etiology of TFF after ICSI are described. The literature on physiology of oocyte activation, electrical properties of gametes’ membranes, and ion currents is reviewed. Calcium oscillations play an essential role in fertilization, and calcium ions act as secondary messengers in different metabolic pathways and cellular processes during oocyte activation. The contribution of oocyteand spermrelated causes of fertilization failure is discussed. Many studies on the physiology of fertilization in mammals have shown that oocyte activation is triggered by the sperm factor. Methods for artificial oocyte activation (AOA) try to bypass fertilization failure by influencing physiological processes that are crucial for successful fertilization. Activation can be induced with the use of electrical, mechanical, or chemical stimuli that elevate intracellular concentrations of calcium ions. Different AOA methods and their success and safety are presented.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"639 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115110483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Background Proteins in Human Chorionic Gonadotropin Pharmaceutical Formulations of Different Origins 不同来源的人绒毛膜促性腺激素药物制剂中的蛋白质
Embryology - Theory and Practice Pub Date : 2019-01-18 DOI: 10.5772/INTECHOPEN.82652
T. Panić-Janković, G. Mitulovič
{"title":"Background Proteins in Human Chorionic Gonadotropin Pharmaceutical Formulations of Different Origins","authors":"T. Panić-Janković, G. Mitulovič","doi":"10.5772/INTECHOPEN.82652","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82652","url":null,"abstract":"Gonadotropins, including human chorionic gonadotropin (hCG), have been used since and for several decades to treat infertility by ovarian stimulation. hCG is the most important protein for embryogenesis and embryo development and implantation in uterus upon fertilization of oocytes. The hCG used for in-vitro fertilization (IVF) is being extracted from urine of pregnant women, and it does inevitably contains other proteins secreted into urine. The presence of other proteins varies from batch to batch, and it can be significantly high. Due to the fact that many of the proteins identified in these formulations can trigger an allergic reaction, which, in turn, can affect the embryogenesis and prevent embryo implantation, it is very important to check the amount and type of contaminant proteins in pharmaceutical formulations. It was found that the total protein content varied from batch to batch, and a large number of contaminant urinary proteins were identified in all analyzed samples except for the recombinant product.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121357133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Blastocyst Formation and Development 人类囊胚形成与发育
Embryology - Theory and Practice Pub Date : 2018-11-20 DOI: 10.5772/INTECHOPEN.82095
H. P. Lubis, B. Halim
{"title":"Human Blastocyst Formation and Development","authors":"H. P. Lubis, B. Halim","doi":"10.5772/INTECHOPEN.82095","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82095","url":null,"abstract":"The preimplantation period of human embryo development is remarkable and characterized by successive changes in terms of genetic control, physiology, and morphology of the embryo. Human preimplantation embryo development is characterized by the initial phase of embryo development, the phase before the embryo implantation process. In normal conditions, after fertilization, the embryo grows until the blastocyst stage. The blastocyst grows as the cells divide and the cavity expands, where it “hatches” from the zona pellucida to implant into the endometrium. Reprogramming and programming are continuous processes in the embryo that encompasses fusion of the egg and sperm pronuclei; epigenetic reprogramming and modification, an extensive wave of degradation of maternal transcripts, and activation of the nascent human embryonic genome and aneuploidy can occur in this stage. The embryo produces cytokines, growth factors, and receptors for endometrial signals in the apposition stage.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127813525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Present and Future of Embryo Cryopreservation 胚胎冷冻保存的现状与未来
Embryology - Theory and Practice Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80587
Iavor K. Vladimirov, D. Tacheva, V. Dobrinov
{"title":"The Present and Future of Embryo Cryopreservation","authors":"Iavor K. Vladimirov, D. Tacheva, V. Dobrinov","doi":"10.5772/INTECHOPEN.80587","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80587","url":null,"abstract":"Embryo freezing technologies have widely been used in human IVF practice and in animal industry. In this chapter, we will review the development of embryo freezing technology and the application of the method, which will concentrate on discussion of the arguments in favor of and against freezing, as well as the latest results of success rates, comparing them with the other basic assisted reproductive technologies methods. Then, we will present our viewpoint for the future application of embryo freezing methods and their place in reproductive medicine. The analysis of facts and suggestions should enable researchers to rethink the position of cryobiology in reproductive medicine. It should be considered that the method of cryopreservation is not only a technology for storing embryos but also a method of embryo treatment that can potentially improve the success rates in infertile couples. There is also a theory that describes the “treatment” effect of freezing an embryo, which may explain the higher success rates of frozen embryo transfer (FET) compared to fresh embryo transfer (ET). The authors of the “Theory about the Embryo-Cryo treatment” believe that freezing and thawing could activate endogenous survival and repair mechanisms in preimplantation embryos.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127617656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bovine Embryonic Development to Implantation 牛胚胎发育到着床
Embryology - Theory and Practice Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80655
L. Valadão, H. Silva, F. M. Silva
{"title":"Bovine Embryonic Development to Implantation","authors":"L. Valadão, H. Silva, F. M. Silva","doi":"10.5772/INTECHOPEN.80655","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80655","url":null,"abstract":"Throughout this chapter, we will express the embryonic development from fertilization, commonly called conception, to the implantation. It is well docu-mented that preimplantation is considered a critical period for embryo development in ruminants, in which high pregnancy loss occurs; in fact, several authors point out that 50–75% of blastocysts fail to implant. The high rate of implantation failure is one reason why pregnancy typically requires on average two ovulation cycles to achieve. Events involved in the embryo growth and survival are directly or indirectly related to cytokines, steroids, metabolites, and growth factors. When one of these compounds fails, it normally leads to the death of the embryo or fetus. As known, the period required for full development of a fetus in utero is referred to as gestation, and it is commonly subdivided into two distinct periods. The first 2 weeks of prenatal development are referred to as the pre-embryonic stage. By the end of the embryonic period, all of the organ systems are structured in rudimentary form, and the embryo shifts to the fetus from the ninth week of gestation until birth.","PeriodicalId":299862,"journal":{"name":"Embryology - Theory and Practice","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115387654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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