Academia Open最新文献

{"title":"Comparison Of The Number Of Leukocytes, Lymphocytes, Monocytes and Neutrophils In Patients with Infectious and Non-Infectious Febriles","authors":"Nadiyatul Husna Shofaroh, Syahrul Ardiansyah","doi":"10.21070/acopen.9.2024.7486","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.7486","url":null,"abstract":"The examination parameters used to detect febris are leukocytes (WBC), erythrocytes (RBC), hemoglobin (Hb), hematocrit, and platelets. Leukocyte examination is very important to detect the cause of febris. The purpose of this study was to determine the comparison of the number of leukocytes, lymphocytes, monocytes, and neutrophils in patients with infectious and non-infectious febris. This study used a laboratory experimental research design, with quantitative methods. The research subjects were febris patients aged 0-5 years with a total of 60 patients. Data showing a significance value of p=0.000 (p<0.05) means that there is a comparison between the number of infectious and non-infectious febris leukocytes and the number of monocytes shows a significance value of p=0.003 (p<0.05) means that there is a comparison between the number of monocytes of infectious and non-infectious febris patients. While the number of lymphocytes showed a significance value of p=0.482 (p>0.05) meaning that there was no comparison between the number of lymphocytes with febris infection and non-infection, and the number of neutrophils showed a significance value of p=0.287 (p>0.05) meaning that there was no comparison between the number of neutrophils with febris infection and non-infection. Conclusion on the examination of the number of leukocytes, lymphocytes, monocytes, and neutrophils in infectious and non-infectious febris patients, there is a comparison in the number of leukocytes and monists between infectious and non-infectious febris patients. Highlight: Leukocyte exams crucial for febrile diagnosis. Variances in leukocyte and monocyte counts aid distinction. Unique cell count patterns reveal infection types. Keyword: Febris, Leukocytes, Lymphocytes, Monocytes, Neutrophils","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139270668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating Hepatitis B Transmission: Urgent Call for Global Vaccination Strategies Among Healthcare Professionals","authors":"Rayan Talaat Karali, Khalid Homod Algaydi, Abdulrahman G. Alharbi, Adel Muslim Alharbi, Mohammed Abdullah Alharbi, B. Alharbi, Majed Ghali Alharbi, Bader Awad Almohammadi, Khalid Adnan Shujaa, Ahmed Fahed Alanazi, Abdullah Ghali Alharbi","doi":"10.21070/acopen.9.2024.8240","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8240","url":null,"abstract":"This study investigates the impact of hepatitis B (HB) vaccination among healthcare professionals in the Medina region, addressing the global concern of HB infection transmission. With only 25% of healthcare workers vaccinated, a significant gap exists in immunization coverage. The study reveals a lack of awareness among participants regarding HBV transmission to patients. To mitigate this, the research emphasizes the urgent need for establishing HBV vaccine promotion programs in primary care settings. Results underscore the importance of targeted education for healthcare workers to enhance vaccination rates and ultimately protect patients from hepatitis B infection. The findings call for immediate intervention and global collaboration to implement effective strategies in healthcare settings. Highlight: Low Vaccination Rate: Only 25% of healthcare workers in the Medina region are vaccinated against hepatitis B, indicating a substantial gap in immunization coverage among this critical population. Awareness Gap: The study highlights a significant lack of awareness among participants regarding the transmission of HBV to patients, underscoring the need for targeted educational initiatives. Urgent Intervention: The research emphasizes the immediate need for the establishment of hepatitis B vaccine promotion programs in primary care settings, calling for global collaboration to implement effective strategies and protect patients from hepatitis B infection. Keyword: Hepatitis B Vaccination, Healthcare Professionals, Immunization Coverage, HBV Transmission, Primary Care Settings","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Baghdad's Urban Identity: A Comprehensive Study on the Dynamics of Urban Imprint","authors":"Asawer Abdulrahman Abbas, Shaimaa Hameed Hussein","doi":"10.21070/acopen.9.2024.8238","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8238","url":null,"abstract":"This research examines the \"urban imprint\" from an environmental and architectural perspective, focusing on Baghdad, Iraq. Analyzing Baghdad's urban evolution, considering social activities, ideological concepts, and economic factors, it aims to delineate characteristics contributing to the city's unique imprint. It underscores urban sprawl, population growth, and modernity's impact on the urban landscape, emphasizing the need for standards aligning with the city's identity. Findings reveal a dynamic process influenced by fixed and variable factors. Implications stress physical form assimilation to reflect local values, promoting sustainable urbanization. The study calls to halt Baghdad's urban deterioration, emphasizing the importance of regularly updating city-specific requirements for urban imprint. This research informs the global discourse on urban identity and design. Highlights:  This research explores the concept of \"urban imprint\" with a focus on Baghdad, analyzing its historical evolution and factors shaping its unique urban identity. It highlights the ongoing dynamics of urban imprint influenced by urban sprawl, population growth, and modernization. The study emphasizes the need for tailored urban design standards to preserve local identity and promote sustainable urbanization. Keywords: Urban Imprint, Baghdad City, Urban Identity, Sustainable Urbanization, Environmental Factors","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information and Communication Systems' Impact on Healthcare Quality: Insights from Medical City Complex Employees","authors":"Ola.B. Hashim","doi":"10.21070/acopen.9.2024.8237","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8237","url":null,"abstract":"This descriptive analytical study investigates the pivotal role of information and communication systems in enhancing the quality of medical services, drawing upon the perspectives of employees at Medical City Complex. Employing a semi-experimental approach with 40 participants from the Department of Medicine, the research delves into the understanding of information and communication systems and quality medical care. The study employs a three-section questionnaire, encompassing demographic information, dimensions of healthcare quality, and dimensions of information and communication systems. Validity and reliability of the questionnaire were rigorously established. The findings unveil significant trends, particularly in factors such as age and years of service, illustrating their links to healthcare quality and information and communication systems. Detailed analyses of healthcare quality dimensions (Tangibles, Reliability, and Assurance) and information system aspects (Management, Organization, and Information Technology) are presented. The study concludes by elucidating the impact of independent variables on dependent variables, providing invaluable insights for future research and decision-making in the healthcare sector, ultimately enhancing the quality of medical care and information systems. Highlights: Investigates the impact of information and communication systems on medical service quality. Utilizes a semi-experimental approach with 40 Department of Medicine employees. Highlights the influence of age and years of service on healthcare quality and information systems. Keywords:  Healthcare Quality, Information and Communication Systems, Employee Perspectives, Validity and Reliability, Healthcare Improvement","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Lutein Content in Leaves and Fruit of Lycium barbarum: Implications for Medicinal Applications","authors":"Omaima Saddam Zirjawi, U. M. N. Almousawi, A. Khamees","doi":"10.21070/acopen.9.2024.8158","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8158","url":null,"abstract":"Herbal medicine stands as a pivotal realm of contemporary research, offering substantial benefits with minimal side effects. Lycium barbarum, recognized for its abundant bioactive compounds, holds promise in treating various ailments, particularly in antiaging and antioxidative capacities. Carotenoids, notably lutein and zeaxanthin, constitute key bioactive compounds with diverse functions in both plant physiology and human health, including photo protection against intense light and detoxification of reactive oxygen species. This study meticulously examines the lutein content within leaves and fruit of L. barbarum, employing a uniform extraction method and solvent. The investigation illuminates significant variations in lutein content between the leaves and fruit, shedding light on potential applications in herbal medicine and nutraceuticals. Highlight: Herbal Medicine Advancements: This study underscores the pivotal role of herbal medicine in contemporary research, emphasizing its potential for providing substantial benefits with minimal side effects. Lycium barbarum's Therapeutic Potential: The research highlights Lycium barbarum's significance due to its rich array of bioactive compounds, particularly in addressing antiaging and antioxidative requirements. Bioactive Carotenoids in Focus: The study delves into the functions of essential bioactive compounds, lutein and zeaxanthin, elucidating their roles in plant physiology and human health, including their photoprotective and detoxifying properties. Keyword: Herbal Medicine, Lycium Barbarum, Bioactive Compounds, Carotenoids, Lutein Content","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139318188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoxazolidine Derivatives Exhibit Selective Antitumor Activity Against Breast Cancer Cells","authors":"Wijdan Abbas Eneama, Husam Hamza Salman, Mazin N`adhim Mousa","doi":"10.21070/acopen.9.2024.8148","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8148","url":null,"abstract":"Breast cancer, a leading cause of cancer-related mortality in women, necessitates effective therapeutic interventions. Heterocyclic compounds, prevalent in FDA-approved pharmaceuticals, play a pivotal role in drug development. This study focuses on isoxazolidine derivatives, a subgroup of nitrogen and oxygen-containing heterocycles, known for their potential in antitumor applications. A series of novel isoxazolidine compounds were synthesized and evaluated for their anticancer efficacy using MTT assays against MCF-7 and HdFn cell lines, alongside normal cells. Structural elucidation employed FT-IR, 13C-NMR, 1H-NMR, and E-I mass spectroscopy. Results revealed compound (IZ3) with an IC50 value of 32.49 µg/ml, demonstrating notable antitumor activity in MCF-7 cells compared to HdFn. Notably, compounds (IZ1 and IZ2) exhibited IC50 values of 64 µg/ml and 128 µg/ml, respectively. These findings underscore the potential of isoxazolidine derivatives as promising candidates for targeted breast cancer therapies, warranting further investigation in preclinical models and clinical trials. Highlight: Novel Isoxazolidine Compounds: Synthesized and Evaluated Selective Antitumor Activity: Demonstrated in MCF-7 Breast Cancer Cells Promising Therapeutic Candidates: Isoxazolidine Derivatives for Targeted Breast Cancer Therapy Keyword: Breast cancer, Isoxazolidine Derivatives, Antitumor Activity, Heterocyclic Compounds, Drug Development","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139317793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Hemingway's Depiction of War Violence: Psychological and Societal Impacts in Selected Novels","authors":"Emad Mohammad Abbar","doi":"10.21070/acopen.9.2024.8127","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8127","url":null,"abstract":"This study delves into the portrayal of war violence in four seminal novels by Ernest Hemingway, namely, \"A Farewell to Arms,\" \"For Whom the Bell Tolls,\" \"The Sun Also Rises,\" and \"To Have and Have Not.\" Employing a qualitative analysis, this research categorizes instances of war violence based on thematic implications, narrative techniques, and character responses, while considering contextual information from Hemingway's own wartime experiences. The analysis unveils that Hemingway's exploration of war violence transcends the physical battlefield, emphasizing the profound psychological traumas, moral quandaries, and societal scars it inflicts. Characters within these narratives grapple with disillusionment, existential anguish, and a sense of alienation, reflecting the multifaceted impacts of war on individuals and society. Hemingway's personal involvement in World War I and the Spanish Civil War greatly influences his portrayal of war violence, presenting it as not only an external conflict but an internal struggle that challenges ideologies, identities, and human resilience. The thematic recurrence across these novels underscores Hemingway's persistent examination of the enduring consequences of war. In essence, Hemingway's depiction of war violence serves as a lens through which to contemplate the profound psychological and societal repercussions of conflict, offering an enduring reflection on the devastating nature of war. Highlights : Qualitative analysis of Hemingway's war narratives. Psychological and moral dilemmas in war literature. Hemingway's personal experiences and their literary influence. Keywords : War Violence, Hemingway Novels, Psychological Impacts, Societal Consequences, Qualitative Analysis","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139320292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients","authors":"Heba Hani Hamzah, N. Jabbar","doi":"10.21070/acopen.9.2024.8120","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8120","url":null,"abstract":"This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in the pathogenesis of various disorders. With the advent of advanced technologies, accurate quantification of miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. This investigation explores the dynamic interplay between circulating microparticles and clinical phenotypes, offering valuable insights into disease intricacies. The research narrows its focus to recent developments in employing circulating microparticles as biomarkers for prevalent inflammatory disorders, including infections endemic to thalassemia patients in the city of Diwaniyah, Iraq. Current findings paint a promising future for the utilization of circulating microparticles in the management of inflammatory diseases. In conclusion, this comprehensive exploration of miRNA's regulatory role in globin gene expression has the potential to revolutionize the landscape of thalassemia, ameliorating clinical manifestations and symptoms of this debilitating hemoglobinopathy. The identification of miRNAs implicated in the disease's pathophysiology not only paves the way for novel diagnostic markers but also opens new horizons for therapeutic interventions. Highlights : MiRNA Significance: MicroRNAs play a pivotal role in the pathogenesis of various disorders, offering potential insights into disease mechanisms. Circulating Microparticles: Extracellular circulating microparticles are stable blood-based indicators, holding promise for disease diagnostics and management, especially in the context of inflammatory disorders. Thalassemia Insights: This study highlights the potential impact of miRNAs on globin gene expression, offering new avenues for the diagnosis and treatment of thalassemia, a debilitating hemoglobinopathy. Keywords : MicroRNAs (miRNAs), Circulating Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139320390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Synthesis of Thiopyrimidine Compounds from Dibenzo-18-Crown-6 and Evaluation of Antibacterial Activity","authors":"Zena Abdali, Raheem Jameel Mahesein","doi":"10.21070/acopen.9.2024.8121","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.8121","url":null,"abstract":"In this study, we present a novel synthesis approach for the production of thiopyrimidine compounds, including P-OH-Thiopyrimidine, P-NO2-Thiopyrimidine, and P-Cl2-Thiopyrimidine, from the precursor compound dibenzo-18-crown-6 (DB-18-CE-6). These thiopyrimidine compounds have shown significant potential for various applications, particularly as antibacterial agents. The synthesis involved the reaction of DB-18-CE-6-derived alpha-beta unsaturated ketones with thiourea in a basic medium, resulting in successful cyclization. The synthesized thiopyrimidine compounds were evaluated for their antibacterial activity against common bacterial strains, including Streptococcus, Staphylococcus, and Proteus, and compared to the antibiotic Azithromycin. The results demonstrated that the thiopyrimidine compounds (Z, Z1, Z2, Z3) exhibited excellent antibacterial activity, surpassing Azithromycin, and highlighting their potential as effective alternatives to combat bacterial infections. This research opens new avenues for the development of antibacterial agents and emphasizes the significance of thiopyrimidine compounds in addressing bacterial resistance issues. Highlights :  Novel synthesis of thiopyrimidine compounds from DB-18-CE-6. Evaluation of antibacterial activity against Streptococcus, Staphylococcus, and Proteus. Potential of thiopyrimidine compounds as effective antibacterial agents. Keywords : Thiopyrimidine compounds, Antibacterial activity, DB-18-CE-6, Novel synthesis, Bacterial resistance.","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139320641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumer Loyalty: Brand Perception, Trust, Product Quality, and the Mediating Role of Customer Satisfaction","authors":"Muhammad Eko Rizky, Misti Hariasih","doi":"10.21070/acopen.9.2024.5562","DOIUrl":"https://doi.org/10.21070/acopen.9.2024.5562","url":null,"abstract":"This study investigates the influence of brand image, brand trust, and product quality on consumer loyalty towards Converse footwear, utilizing customer satisfaction as an intervening variable. Conducted among Converse shoe consumers in Sidoarjo, the research employs a quantitative approach with accidental sampling. Data is collected through questionnaires distributed to consumers. Path analysis using SPSS reveals that brand image, brand trust, and product quality significantly affect consumer loyalty through customer satisfaction as an intervening factor. These findings provide valuable insights for brand management and marketing strategies in the global footwear industry. Highlights: The study focuses on consumer loyalty in the context of Converse footwear. It highlights the role of customer satisfaction as an intervening variable. Findings provide insights for global brand management and marketing strategies. Keywords: Brand Image, Brand Trust, Product Quality, Consumer Loyalty, Customer Satisfaction","PeriodicalId":299489,"journal":{"name":"Academia Open","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}