Ukrainian Neurological Journal最新文献

{"title":"Cognitive and Emotional-Affective Disorders in Participants of Combat Actions with Traumatic Brain Injury (Review)","authors":"Ya.G. Saminin, L.I. Sokolova","doi":"10.30978/unj2023-1-4-28","DOIUrl":"https://doi.org/10.30978/unj2023-1-4-28","url":null,"abstract":"Traumatic brain injury (TBI) is one of the main threats to the life and health of combatants. The modern paradigm of military affairs leads to a progressive increase in the prevalence of traumatic brain injury among combatants [1]. The symptoms that typically develop in this group of patients may include emotional lability, sleep and memory impairment, fatigue, anxiety, depression, and anger attacks. The origin of these symptoms is discussed: whether it is a manifestation of organic brain damage (diffuse and focal damage to different parts of the brain) or a functional disease (a disorder associated with exposure to a psycho-traumatic situation) [2]. Approaches to solving this issue included a detailed study of the pathogenetic mechanisms of TBI [3], evaluation of the effectiveness of various principles of treatment of post-traumatic encephalopathy [4], studies of the prevalence of depression [5], post-traumatic stress disorder (PTSD) [6], dementia [7], addictions to use of psychoactive substances [8] in traumatic brain injury. At this stage of research in the field of neurotraumatology, it is generally accepted that TBI or its consequences can manifest as psychiatric symptoms. However, we cannot deny the role of other causative factors in the pathogenesis of mental disorders in military personnel, such as heredity, environmental influences, unhealthy lifestyles, and concomitant somatic and neurological diseases. The prevalence of neuropsychological disorders in TBI varies significantly according to literature data, which can potentially be related to different methodologies for assessing psychological indicators and different approaches to the formation of studied groups of patients. The determination of the etiology of psychological symptoms in combatants with TBI is a topic of debate.»It requires further research and can potentially improve approaches to the treatment and rehabilitation of military personnel. Correction of the consequences of a mild TBI is one of the main tasks in the rehabilitation of combatants. Addressing cognitive, behavioral, and emotional disorders can significantly enhance the quality of life for individuals in this patient group.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139280290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological tortuosity of the internal carotid arteries in childhood","authors":"P. Nikulnikov, V. Pichka, O. Kashyrova, Iu G Maksimov","doi":"10.30978/unj2022-3-56","DOIUrl":"https://doi.org/10.30978/unj2022-3-56","url":null,"abstract":"Objective — to identify the incidence of PT ICA in pediatric patients and assess their clinical significance depending on the clinical and anatomical forms.\u0000Methods and subjects. On the basis of the Department of Vascular Surgery of the Department of Emergency and Restorative Vascular Surgery of the Institute of Emergency and Restorative Surgery named after V. K. Husaka of the National Academy of Sciences of Ukraine, together with the Donetsk regional children’s psychoneurological dispensary, we conducted a screening study of brachiocephalic arteries in 420 children in the period from 2005 to 2007. The age of the patients is from 2 to 16 years, the average age is (9 ± 4) years. The control group consisted of 100 people without complaints, neurological deficits, and psycho‑emotional retardation. A comprehensive examination included an examination by a pediatrician, a pediatric neurologist, a cardiologist, a vascular surgeon, a psychoneurologist, a duplex scan of the brachiocephalic vessels, a study of cardiac hemodynamics (electrocardiography, echocardiography), and magnetic resonance imaging of the brain as indicated. The criteria for the hemodynamic significance of LV were considered to be: the presence of a septal inflection of the ICA, an angle < 60°, microaneurysms, loop formation, blood flow acceleration in the zone of LV > 140 cm/s, the value of the resistivity index in the presence of a microaneurysm < 0.5, in the absence of a microaneurysm > 0.7. The type of PZ ICA was determined according to the classification of J. Weibel and W. Fields (1965) with additions by J. Vollmar (1976).\u0000Results. Hemodynamically significant ISA was detected in 108 (25.7 %) children of the main group (in 32 (30 %) boys and 76 (70 %) girls), the presence of transient ischemic attacks was in 8 (7.4 %), ischemic stroke was in 5 (4.6 %) school‑age patients due to disease progression. The most clinically unfavorable clinico‑anatomical forms are S‑like PZ ICA (42 (39 %)) and loop formation (11 (10 %)). The most frequent neurological disorders in preschool children caused by the pathological tortuosity of the internal carotid arteries are delayed language development (29 (27 %), impaired adaptation in a team, delayed self‑care skills (delayed in neuropsychological development) (33 (31 %)), impaired emotional sphere and behavior (irritability, mild excitability) (84 (78 %)), sleep disturbances (16 (15 %)). The most serious neurological disorders in children with pathological tortuosity of the internal carotid arteries occur during the school period, which is the result of the progression of early cerebrovascular insufficiency. At this age, the following manifestations of early cerebrovascular insufficiency are typical: headache (100 (93 %)), decreased vision (35 (32 %)), decreased performance at school (88 (82 %)), irritability, anxiety, reduced work capacity, attention disorders (96 (89 %)), cerebral circulation disorders (5 (4.6 %)).Predominant neurological disorders i","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116003178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neuroimaging comparisons of acute cerebrovascular accident against the background of ­COVID‑19","authors":"H. Symonenko","doi":"10.30978/unj2022-3-49","DOIUrl":"https://doi.org/10.30978/unj2022-3-49","url":null,"abstract":"Objective — to compare clinical data with the results of neuroimaging methods of brain research in patients with acute cerebrovascular accident against the background of ­COVID‑19. \u0000Methods and subjects. The medical histories of 72 patients (47 (65.3 %) men and 25 (34.7 %) women) with the diagnosis of acute cerebrovascular accident and coronavirus infection were retrospectively analyzed. In the reception department, all patients with suspected stroke were examined by a neurologist, all patients were examined with a computed tomography scan of the brain, and a smear was taken for polymerase chain reaction (PCR) for ­SARS‑CoV‑2. If necessary, the patient was consulted by a neurosurgeon. Part of the patients underwent MRI. \u0000Results. Out of 72 patients with appositive PCR test, 46 (63.9 %) had a severe general condition, 26 (36.1 %) had a moderate condition. The average age of patients was 71.7 years (72.2 in men and 70.9 in women). Out‑of‑hospital polysegmental pneumonia developed in 24 (33.3 %) cases. 16 (22.2 %) patients died: (23.4 % of the total number of men) and 5 (20.0 % of the total number of women). According to clinical data and CT data, ischemic stroke developed mainly in the carotid basin (50 (69.4 %) cases): in the left carotid basin (LCB) in 33 cases (45.8 %) and in the right carotid basin (RCB) in 17 cases (23.6 %). In 13 (18.1 %) cases stroke was registered in the vertebrobasilar basin (VBB). According the ST scan and anamnesis, in 6 (8.3 %) cases of accidents in the LCB there were repeated: 5 (6.9 %) — in the VBB (including: left cerebellar hemisphere, right cerebellar hemisphere, right occipital lobe) and in the RCB. In 4 (5.6 %) cases of repeated stroke in the RCB, it was transferred twice to another side of RCB, once to the LCB, and once to the VBB. In all 3 (4.2 %) cases of recurrent stroke in the VBB, it was transferred three times in the carotid basin: twice of the RCB and once to the LCB. 3 patients (4.2 %) were diagnosed with transitional ischemic attack at the VBB (all of them are middle‑aged — 36 — 43 years old). According to CT and clinical data, hemorrhagic stroke was registered in 6 patients (8.3 % of cases). \u0000Conclusions. Risk factors for the occurrence of HPMC against the background of COVID‑19 are the advanced age and male gender of the patients, as well as the presence of chronic cardiovascular and cerebrovascular diseases. The cases are characterized by a predominant lesion of the large vessels of the left carotid basin, repeated strokes with the appearance of a new focus in another basin, frequent deep lesions in the area of the basal nuclei, as well as background changes in brain tissue during neuroimaging examination. A severe course, complicated by lung and heart failure, prevails, especially when out‑of‑hospital polysegmental, usually bilateral, COVID‑19 pneumonia occurs. \u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116392728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical reinnervation of the dentate anterior muscle in long-term idiopathic neuropathy of the long thoracic nerve: a case report","authors":"O. Gatskiy, I. Tretyak, V. Tsymbaliuk, Ya.V. Tsymbaliuk, A. Tretiakova, Hao-li Jiang","doi":"10.30978/unj2022-3-61","DOIUrl":"https://doi.org/10.30978/unj2022-3-61","url":null,"abstract":"Cases of pterygoid deviation (deviation) of the scapula are associated with dysfunction of the muscles of the primary stabilizers of its superior medial and inferior medial edges. One of the factors of KDL is idiopathic neuropathy of the long thoracic nerve (LPN). The ineffectiveness of therapeutic methods of treatment of KDL can be compensated by the use of surgical correction methods. Carrying out decompression of the DGN makes it possible to achieve partial regression in 87 % of patients and complete regression of the deficiency — in 62 % in terms of up to 6 months. The method of selective targeted reinnervation of nerve structures — neurotization is devoid of a number of disadvantages of traditional surgical methods, makes it possible to eliminate the influence of the time factor on the complex process of denervation/reinnervation and ensures the predictability of the outcome.\u0000A 27‑year‑old male attended the department with pain in the right shoulder joint, limitation of flexion in the right shoulder joint to 130°, external rotation of the shoulder to 75°, abduction of the right shoulder to 150°. The function of the right deltoid muscle is within the normal range (M5 according to the British MRC scale), KDL at rest (static) and during movements (dynamic). The duration of the disease is about 7 months. Electroneuromyography (EMG) revealed a violation of the conduction of motor fibers of the DGN and a long‑standing denervation process without signs of reinnervation in the dentate anterior muscle (DAM). The patient underwent neurotization of the DGN with the anterior portion of the thoraco‑spinal nerve (PP GSN) according to the method of C. B. Novak and S. E. Mackinnon. A follow‑up examination of the patient was carried out 9, 15 and 19 months after surgical reinnervation. In addition to clinical neurological examination, ENMG was performed. The pain in the right shoulder girdle regressed completely. Full regression of the KDL at rest (static) and partial during movements (dynamic) of the right upper limb was noted. The ENMG data confirmed the reinnervation of the PZM. The use of a more aggressive surgical approach — neurotization made it possible to bring the axons with preserved function (PP GSN) closer to the end motor plates of the non‑functioning nerve (DGN), which contributed to achieving a positive functional result — the restoration of PZM. Selective use of PP GSN made it possible to preserve the functionality of the latissimus dorsi muscle at the expense of preserving the posterior portion of the nerve donor.\u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133365059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myasthenia gravis complicated by the development of COVID-19: an analysis of case series","authors":"M. Marchuk, M. Zinchenko, L. Sokolova","doi":"10.30978/unj2022-3-25","DOIUrl":"https://doi.org/10.30978/unj2022-3-25","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disease characterized by increased dynamic muscleweakness. Patients with myasthenia gravis are united by the phenomenon of deterioration of the clinicalcondition after infection, refusal of treatment or taking certain medications, surgical intervention, exposureto heat and stress. In the context of the COVID‑19 (Coronavirus disease 2019) pandemic, the study ofpatients with myasthenia gravis and a new infectious disease may reveal new pathogenetic patterns andchange the therapeutic strategy. \u0000Objective — to identify clinical and paraclinical, therapeutic regularities in patients with MG and COVID‑19. \u0000Methods and subjects. From April 2021 to November 2021, the course of MG against the background ofCOVID‑19 in 11 patients was analyzed. The control group consisted of 7 patients with COVID‑19, butwithout MG. General clinical, neurological, instrumental, laboratory and statistical examination methods,scales Myasthenia Gravis Foundation of America (MGFA), The Quantitative Myasthenia Gravis Score (QMGS), Myasthenia Gravis Activities of Daily Living (MG‑ADL), The National Early Warning Score 2 (NEWS2) and questionnaires were used. \u0000Results. In the experimental and control groups, the level of SpO2 when breathing atmospheric air wascorrelated with the presence of bronchial asthma (BA) (r = –0.791), diabetes mellitus (DM) (r = –0.553),hypertension (r = –0.301). A positive correlation (r = 0.271) was found between the presence of MG and the level of SpO2 when breathing atmospheric air, which may be associated with the intake of pyridostigmine anda decrease in muscle mass in patients with MG. Presence of a relationship between the NEWS2 indicatorwith DM (r = 0.501), BA (r = 0.483), obesity (r = 0.376), hypertension (r = 0.352), multinodular goiter (r = 0.204), hydrothorax (r = 0.204) and MG (r = 0.120). In the myasthenia group, a relationship was established between the duration of treatment for COVID‑19 and body mass index (BMI) (r = 0.523), age (r = 0.504), pyridostigmine intake (r = –0.243) and weight (r = 0.228). NEWS2 in the experimental group was correlated with pyridostigmine intake (r = –0.386), weight (r = 0.355) and BMI (r = 0.256). Duration of treatment for COVID‑19 was associated with duration of MG (r = 0.570), obesity (r = 0.572), and BMI (r = 0.526). NEWS2 is related to the level of SpO2 when breathing atmospheric air (r = — 0.907), hemoglobin (r = –0.847) and vital capacity of the lungs (VC) (r = –0.699). Obesity (r = 0.787), anemia (r = 0.684) and BA were correlated with NEWS2. The finding of an inverse correlation between NEWS2 and pyridostigmine intake (r = –0.684) was promising. Soft palate paresis (r = –0.614), dysphagia (r = –0.614) and nasality (r = –0.545) were correlated with a decrease in VC. A correlation was found between VC and the NEWS2 (r = –0.699). The duration of COVID‑19 (r = –0.646) and patient age (r = –0.626) were correlated with VC. \u0000Conclusions. MG with the addition of COVID‑19 te","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115993449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The folate-centric concept of pathogenesis and GBINC personalized multidisciplinary approach to the clinical management of children with neuropsychiatric syndromes. Review","authors":"D. Maltsev","doi":"10.30978/unj2022-3-5","DOIUrl":"https://doi.org/10.30978/unj2022-3-5","url":null,"abstract":"Solving the problem of children’s neuropsychiatric diseases is a priority task of modern medicine. The latest scientific achievements in the field of genetics, molecular biology and immunology, which demonstrate biochemical and immune‑dependent ways of formation of human neuropsychiatric disorders, shed light on the mechanisms of brain damage in children with ASD. These research give reason for optimism about overcoming this severe psychiatric pathology in the future thanks to the implementation of genetic, biochemical and immunodiagnostic approaches, as well as metabolic and immunotherapeutic interventions with neuroprotective effects. Currently, the folate‑centric concept of polygenic inheritance of predisposition to the development of neuropsychiatric syndromes in children with multisystem damage has been established. Biochemical and immune‑dependent (infectious, autoimmune, immunoinflammatory, and allergic) pathways of microbe‑induced autoimmune inflammatory encephalopathy with neuropsychiatric clinical manifestations are discussed in the context of the folate‑centric concept. Taking into account the new data, two personalized multidisciplinary approaches to the management of children with ASD and other neuropsychiatric syndromes are proposed. The first approach of J. J. Bradstreet et al. (2010) is based on the empirical analysis of a large group of laboratory biomarkers, the relevance of which has been demonstrated in clinical studies, and the targeted correction of abnormalities identified by biomarkers (so‑called biomarker‑guided interventions). In 2022, Frye R. developed a multidisciplinary personalized approach called BaS‑BiSTOR (collect Baseline data, search for Symptoms, measure Biomarkers, Select Treatment, Observe for Response), which systematizes and stratifies diagnostic and treatment interventions based on the assessment of biomarkers. In order to improve existing recommendations regarding specific subtypes of neuropsychiatric syndromes in children, this article proposes an improved personalized multidisciplinary approach to the clinical management of patients with autistic spectrum disorders and neuropsychiatric manifestations associated with genetic deficiency of the folate cycle, called GBINS (Genetic‑Biochemical‑Immunological‑Neurological‑Symptomatic evaluation). There are reasons to believe that the successful testing in clinical practice of evidence‑based personalized multidisciplinary diagnostic and treatment strategies will allow making a breakthrough in the clinical management of children with severe mental disorders in the near future, which will provide not only the possibility of recovery from a prognostically unfavorable and currently incurable neuropsychiatric disorder, but also and will contribute to stopping the large‑scale threatening epidemic of neuropsychiatric syndromes in the modern child population. \u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130308094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of an epigenetic diet on migraine patients","authors":"O. Kopchak, O. Hrytsenko","doi":"10.30978/unj2022-3-34","DOIUrl":"https://doi.org/10.30978/unj2022-3-34","url":null,"abstract":"Migraine is a common type of primary headache disorder, distinguished by recurrent attacks of moderate to severe unilateral throbbing pain, often accompanied by symptoms such as nausea, photophobia, and phonophobia. \u0000Objective — to study the effect of epigenetic diet on frequency and intensity of migraine headache attacks, indicators of psycho‑emotional status and quality of life of migraine patients. \u0000Methods and subjects. 130 people aged from 18 to 55 years (average age — 38.6 ± 8.3 years) were examined, of which 15 (11.5 %) were men and 115 (88.4 %) were women. The patients were distributed into two groups: group A — patients who followed an epigenetic diet enriched with 5 mg of folic acid, group B — patients who did not follow any diet. The diagnosis of migraine was confirmed using the criteria of the International Headache Society. Before the study, all participants were assessed using the Work Disability Assessment Scale (MIDAS). Also, the frequency of headache was determined in all patients. Headache intensity was assessed using a visual analog scale (VAS). Psychoemotional status at the beginning and at the end of the study was assessed using the Hamilton Anxiety Scale and the Beck Depression Scale. In all patients, the content of folic acid and homocysteine in the blood was determined using an immunochemical method with electrochemiluminescence detection. \u0000Results. When analyzing the data before the start of the study, it was found that the average concentration of folic acid in group A was 2.8 ± 3.6 ng/ml and was significantly lower than in group B (p = 0.003). The average level of homocysteine was different in both groups (р = 0.04). In group A, against the background of using an epigenetic diet, the average level of folic acid remarkably increased (p = 0.001), and the average level of homocysteine significantly decreased (p = 0.003). Also, in group A, a notable decrease in the intensity and frequency of headache was found (р = 0.02; р = 0.04), a decrease in the average level of anxiety according to the Hamilton scale (from 15.0 ± 3.5 points to 9 ± 2 points) (p = 0.03). A direct relationship between the level of homocysteine and the score on the Hamilton Anxiety Scale and the MIDAS scale was established, as well as a negative correlation between the level of folic acid and the score on the Beck Depression Scale. \u0000Conclusions. Evidence of the influence of changes in the content of homocysteine and folic acid in the blood of patients with migraine against the background of an epigenetic diet on the severity of headache and quality of life was revealed. The use of an epigenetic diet in the prevention and treatment of migraine needs further study, as it is difficult to predict the final effect of the diet due to its low specificity to the epigenome and the large number of interactions between the active components of the diet. \u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125870200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adaptation and validation of the Ukrainian version of the Standardized Evaluation of Pain (StEP) — a tool for assessing neuropathic pain in the lower back in patients with ankylosing spondylitis","authors":"I. Kedyk, Y. Shalkovskyi, I. Shapoval, M. Stanislavchuk","doi":"10.30978/unj2022-3-39","DOIUrl":"https://doi.org/10.30978/unj2022-3-39","url":null,"abstract":"Objective — to create a Ukrainian‑language version of the Standardized Evaluation of Pain (StEP) through translation and cross‑cultural adaptation with subsequent validation in patients with ankylosing spondylitis (AS). \u0000Methods and subjects. The translation and cross‑cultural adaptation of the StEP questionnaire was carried out in accordance with the standard recommendations of the Guidelines for the process of cross‑cultural adaptation of self‑report measures. 49 patients with a diagnosis of AS according to the modified New York criteria and duration of pain in the lower back ≥ 3 months and 31 persons of the control group were examined. AS activity in patients was assessed using the ASDAS (Ankylosing Spondylitis Disease Activity Score) and BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), functional status — according to the BASFI (Bath Ankylosing Spondylitis Functional Index) and BASMI (Bath Ankylosing Spondylitis Metrology Index) indices. The ASQoL (Ankylosing Spondylitis Quality of Life Questionnaire) index was used to assess the quality of life of AS patients. The intensity of pain in AS patients was determined using a visual analog scale. The Leeds assessment of neuropathic symptoms and signs (LANSS) and the DN4 questionnaire (Douleur Neuropathique en 4 Questions) were used to compare the results of the StEP questionnaire. The statistical analysis of the results was carried out using the methods of variational statistics using the SPSS22 software package (SPSS Inc.). \u0000Results. According to disease activity indices, high and very high disease activity prevailed in patients with AS: the average value according to ASDAS was 3.8 ± 0.8, according to BASDAI — 5.5 ± 1.2. Functional disorders according to BASFI were 5.2 ± 1.8 on average, range of motion in the spine according to BASMI was 5.2 ± 2.3. The quality of life of patients with AS according to ASQoL was on average 8.3 ± 4.4. Pain intensity according to the visual analog scale — 6.1 ± 1.5. The reliability of the Ukrainian‑language version of the StEP questionnaire was assessed by the test‑retest method with an interval of 7 days in 22 patients with AS. The analysis of the received data proved the high reliability of the StEP questionnaire (intraclass correlation coefficient was 0.987). Cronbach’s alpha coefficient (0.987) confirmed the internal consistency of the Ukrainian version of the StEP questionnaire. The sensitivity of the StEP questionnaire showed a close pairwise correlation (Spearman’s correlation coefficient — 0.955). Testing of the StEP questionnaire in patients with AS revealed the presence of neuropathic pain in 55.1 % of cases. The average value of the StEP questionnaire in AS patients was 4.6 ± 5.3, in the control group it was 0.1 ± 0.4. The final values of the StEP questionnaire were statistically significantly correlated with LANSS and DN4 indicators (p < 0.01). \u0000Conclusions. The Ukrainian‑language version of the StEP questionnaire was created, and its cross‑cul","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129831888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of superior oblique myokymia with pregabalin. Review of a clinical case","authors":"Y. V. Kurus, S. Kyryliuk, T. Nehrych","doi":"10.30978/unj2022-3-67","DOIUrl":"https://doi.org/10.30978/unj2022-3-67","url":null,"abstract":"Superior oblique myokymia is a rare idiopathic disease, characterized by sudden, spontaneous, unilateral, rhythmic contractions of the superior oblique muscle and typically presents with monocular oscillopsia and diplopia. This pathological condition most often affects middle‑aged patients without concomitant systemic diseases. The aim of the article was to study the features of the clinical course, diagnosis and methods of treatment of superior oblique myokymia based on a clinical case. A review of a clinical case of superior oblique myokymia in a patient born in 1983 is presented. The diagnosis was established on the basis of clinical manifestations in the form of sudden episodes of vertical oscillopsia and diplopia in the field of vision of the right eye, which occurred both spontaneously during prolonged work at the computer, driving a vehicle, and in response to light stimulation. A 38‑year‑old patient described the disease as the presence of periodic attacks, during which blurred vision, doubling and movement of objects in the field of vision of the right eye occurred for 2 — 3 seconds, after which the vision returned to normal. The number of attacks was up to 100 per day and significantly worsened the patient’s quality of life. During the neurological examination, an episode of vertical oscillopsia with diplopia was revealed when light was directed at the right eye. No other pathological changes were observed in the nervous system, eyes and other systems and organs, which was confirmed by laboratory and instrumental examination methods, examinations and consultations of different specialists. The patient had a positive therapeutic effect in the treatment of superior oblique myokymia with pregabalin at a dose of 150 mg per day. Recommendations to reduce the time spent working at the computer and to adopt a healthy lifestyle were important. \u0000Thus, superior oblique myokymia is a rare pathological condition manifested by sudden episodes of monocular vertical oscillopsia and diplopia. Pregabalin can be considered as the medication of choice in the treatment of this disease. Further research is needed to establish unified treatment guideline. \u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"210 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122515040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modern view of approaches of neuroprotective therapy in patients with ischemic stroke. Review","authors":"O. Kyrychenko, S. Moskovko","doi":"10.30978/unj2022-1-12","DOIUrl":"https://doi.org/10.30978/unj2022-1-12","url":null,"abstract":"Timely use of neuroprotectors for treatment of ischemic stroke should prevent or inhibit the pathogenetic mechanisms that lead to apoptosis of brain cells, both in the nucleus of the infarct and in the ischemic penumbra. The concept of neuroprotection has a sufficient scientific basis, but the questions of its effectiveness, safety and optimal points of application remain controversial, taking into account the available results of clinical trials. Currently, two pharmacological agents are most commonly used as neuroprotective agents in ischemic stroke (IS) — Cerebrolysin and Edaravon (in the Ukrainian pharmaceuзtical market — Xavron). They have the broadest evidence base and are favored by practitioners to provide the potential for recovery in the post­stroke period.\u0000Objective — to investigate the available evidence base of results of admission and effectiveness of neuroprotective agents — Cerebrolysin and Edaravon in treatment of IS: the impact to the outcome of treatment during hospita period and in the medium term.\u0000A search was conducted for studies and metaanilysis for the Key words «schemic stroke», «neuroprotection», «edaravon», «cerebrolysin» in the PubMed database and the Cochrane Library, published between 2010 and 2022.The selection criteria for publications were the availability of a full text or a detailed summary in English.\u0000Given the results of research, the clinical effects of neuroprotective therapy are significant. However, there are reports of questionable results, the probable causes of which may be: failure to take into account the level of neurological deficit at the time of hospitalization, as well as the therapeutic window for the appointment of the drug and the dosage regimen. The outcome on the 90th day of treatment could be influenced by factors such as comorbid pathology, complications of the hospital period, as well as different approaches to rehabilitation measures.\u0000Large clinical trials with more sophisticated patient selection criteria are needed to determine the importance of neuroprotective agents in the complex intensive care of patients with IS.\u0000 ","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115095921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}