{"title":"Systemic Polyarteritis Nodosa","authors":"M. Koster","doi":"10.32388/7tfjj9","DOIUrl":"https://doi.org/10.32388/7tfjj9","url":null,"abstract":"Systemic polyarteritis nodosa (PAN; is a chronic systemic necrotizingvasculitis of adults and childrenaffecting small- and medium-sized vessels and characterized by formation of microaneurysms leading to serious generalized disease and multi-organ involvement.","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126627043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Croci, M. Bonacini, F. Muratore, L. Boiardi, N. Pipitone, C. Salvarani
{"title":"Pathogenesis","authors":"S. Croci, M. Bonacini, F. Muratore, L. Boiardi, N. Pipitone, C. Salvarani","doi":"10.1002/mus.26665","DOIUrl":"https://doi.org/10.1002/mus.26665","url":null,"abstract":"Hashimoto's thyroiditis (HT) is one of the most prevalent autoimmune diseases provoked in genetically susceptible individuals by several triggers. Immune-regulatory genes such as HLA, CTLA-4, and PTPN22 play a major role in the pathogenesis of autoimmune thyroiditis. The thyroid-specific gene currently showing the association with HT (and also Graves' disease) is the gene for thyroglobulin (Tg). The VDR gene is another HT predisposing gene, common for other organ-specific autoimmune diseases such as type-I diabetes or Addison's disease. Furthermore, cytokine genes such as IFN-γ, IL-4, or TGF-β indicate the association with the development and severity of HT. A complex interaction between genetic and non-genetic factors results in enhanced thyroid antigen presentation and reduced immune tolerance leading to predominantly Th1-type autoimmunity, thyroid destruction, and clinical disease. The exact mechanisms of initiation and progression of HT are yet to be clarified. This chapter explores the pathogenesis of Hashimoto's disease.","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114891799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging","authors":"F. Alibaz-Oner, Haner Direskeneli","doi":"10.1007/978-3-030-67175-4_10","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_10","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121338629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous Vasculitis","authors":"D. Prieto-Peña, T. Pina, M. González-Gay","doi":"10.1007/978-3-030-67175-4_18","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_18","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128914856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous Polyarteritis Nodosa","authors":"M. Koster, J. S. Valinotti","doi":"10.1007/978-3-030-67175-4_13","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_13","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124864757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology and Genetics","authors":"F. Cantini, C. Nannini","doi":"10.1007/978-3-030-67175-4_2","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_2","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125237161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Large and Medium Size Vessel and Single Organ Vasculitis","authors":"","doi":"10.1007/978-3-030-67175-4","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"73 4 Pt 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131816560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognosis and Disease Activity","authors":"F. Alibaz-Oner, H. Direskeneli","doi":"10.1007/978-3-030-67175-4_11","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_11","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114971481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment and Management","authors":"M. Schirmer, R. McCutchan","doi":"10.1007/978-3-030-67175-4_7","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_7","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129628186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Manifestations, Differential Diagnosis, and Laboratory Markers","authors":"N. Pipitone","doi":"10.1007/978-3-030-67175-4_4","DOIUrl":"https://doi.org/10.1007/978-3-030-67175-4_4","url":null,"abstract":"","PeriodicalId":295914,"journal":{"name":"Large and Medium Size Vessel and Single Organ Vasculitis","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127354745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}