Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki最新文献_第2页

Determination of rational sample size in parasitological studies by bootstrap method 用自举法确定寄生虫学研究中合理样本量

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-07

S. Shvydka, S. Levchuk, Yelizoveta Sarabeeva

引用次数: 0

The efficacy of natural acaricide application against Ixodidae (Ixodes ricinus) 天然杀螨剂对蓖麻伊蚊的防治效果

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-04

N. Voronova, V. Horban, V. Bohatkina

引用次数: 3

Peripheral blood indices in women with development of ovarian hyperstimulation 卵巢过度刺激患者外周血指标的变化

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-02

O. Bekasova, K. Ivanova, V. Kopiika, N. Avramenko, O. Kabachenko

引用次数: 0

Effect of endoxane on the immune system of rats 内毒素对大鼠免疫系统的影响

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-01

R. Aminov, Oleksandr Frolov, A. Aminova, A. Grankina, A. Sviridenko

引用次数: 0

Helminth parasites of grey mullets (Teleostei: mugilidae) in the mediterranean region: a review 地中海地区灰鲻鱼的寄生虫研究进展

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-08

V. Sarabeev, Ie. V. Tkach

{"title":"Helminth parasites of grey mullets (Teleostei: mugilidae) in the mediterranean region: a review","authors":"V. Sarabeev, Ie. V. Tkach","doi":"10.26661/2410-0943-2019-1-08","DOIUrl":"https://doi.org/10.26661/2410-0943-2019-1-08","url":null,"abstract":"Helminths are a diverse and rich group of fish parasites, some of which are dangerous pathogens of epidemic potential. The present review is focused on helminth parasites from grey mullets (Mugilidae) in the Mediterranean and Azov-Black Seas. These fish are of great economic importance, for supplying food and recreation services. This study covers helminth parasites of six species: Mugil cephalus (L.), Chelon labrosus (Risso), C. auratus (Risso), C. ramado (Risso), C. saliens (Risso) and Planiliza haematocheila (Temminck, Schlegel). This paper gives a brief overview of the history of taxonomic and faunistic studies of helminth parasites from grey mullets in the Mediterranean. The history of the helminth parasites from grey mullets goes back to over 200 years ago to the first species described by Rudolphi in 1819. One hundred and four helminth species have been recorded in about 130 published papers. Fewer than 10 species have been recorded prior to 1900. Since 1960s, taxonomic efforts have rapidly increased, reaching the highest level in the first decade of the 21st century. Only one new species has been recorded in Mediterranean mullets in the last decade. We suggest that the decrease in the number of described species observed in the last decade is the consequence of previous intensive taxonomic efforts results in the actual estimation of species diversity for the studied area. Digeneans and specialist (oioxenic and stenoxenic) parasites dominated in the structure of helminth fauna of mullets. The highest richness of helminths is found in the Azov-Black Seas mullets, while the poorest in the Eastern Mediterranean. A relatively large number of species (20) identified only to generic or family levels remain the taxonomic subject of future studies.","PeriodicalId":295885,"journal":{"name":"Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127166053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Assessment of the biological effects of 4-hydrazinoquinoline derivatives 4-肼喹啉衍生物的生物效应评价

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-06

Y. Romanenko, O. Klimova, O. Brazhko

{"title":"Assessment of the biological effects of 4-hydrazinoquinoline derivatives","authors":"Y. Romanenko, O. Klimova, O. Brazhko","doi":"10.26661/2410-0943-2019-1-06","DOIUrl":"https://doi.org/10.26661/2410-0943-2019-1-06","url":null,"abstract":"Lipophilicity, biological activity and acute toxicity are important indicators of the viability of drugs. These indicators primarily depend on the chemical structure of the compound, the diversity of functional groups and their quantity. Using ChemDraw, a combinatorial library was created and the lipophilicity and solubility of 4-hydrazinoquinoline oxo acid derivatives were studied. A lipophilic non-polar substance dissolves in the lipid layer of the cell membrane, and the higher the lipophilicity, the greater the ability to penetrate through the cell membrane into substances. In parallel, the solubility of the substances was determined. Virtual studies using PASS Online made it possible to predict biological activity for 4-hydrazinopochid quinoline and their analogues having a methyl group in the 2nd position of azaheterocycles (4-hydrazinoquinaldins). The LD50 value is one of the important characteristics of acute toxicity. The goals of studying acute toxicity are to determine the harmless, toxic, lethal doses of a substance, its ability to cumulate, and also the causes of death of animals. Acute toxicity of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinylidene)pentanedioate was experimentally investigated. The cytotoxic effect of the compounds was tested on cell division and cell growth of cucumber roots (kind «Konkurent»). The study of the growth-regulating activity of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinoylidene)pentanedioate showed that this salt is most active as a cytokine and is classified as a toxicological classification for low toxic substances. Studies on prokaryotes have shown that the pigment-stimulating ability is enhanced in proportion to the concentration of lithium (E)-2-(2-(2-methylquinolin-4-yl)hydrazinoylidene)pentanedioate in nutrient media for individual cultures.","PeriodicalId":295885,"journal":{"name":"Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128652982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute toxicity and hypoglycemic activity of 7-chloro-4-thiosubstituted quinoline 7-氯-4-硫代喹啉的急性毒性和降糖活性

Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki Pub Date : 1900-01-01 DOI: 10.26661/2410-0943-2019-1-03

A. Bogdan, Serhiy Brazhko, I. Labenskaya, O. Brazhko

{"title":"Acute toxicity and hypoglycemic activity of 7-chloro-4-thiosubstituted quinoline","authors":"A. Bogdan, Serhiy Brazhko, I. Labenskaya, O. Brazhko","doi":"10.26661/2410-0943-2019-1-03","DOIUrl":"https://doi.org/10.26661/2410-0943-2019-1-03","url":null,"abstract":"The search for effective and safe pharmacological drugs for the treatment of diabetes is remaining highly valuable issue due to the chronic course of the disease and the need to use antipyretic drugs during the rest of life. Currently, various hypoglycemic agents are presented in the pharmaceutical market and the safety of their application is in priority. The activity of 4-thio-7-chloroquinoline derivatives as potential hypoglycemic drugs was studied here. The hypoglycemic activity was determined using a One Touch Ultra Plus Flex meter. The approach to glucose determination by this method is based on the reaction of glucose contained in the blood sample with flavin adenine dinucleotide dependent glucose dehydrogenase in the test strip, with the formation of a small electric current. The strength of this current calculates the level of glucose in the blood serum. Sodium 3-(7-chloroquinolin-4-ylthio)propionate demonstrates a high hypoglycemic activity after its intragastric administration. This compound significantly reduces glucose levels in rats up to 18.1% when compared with baseline and other compounds. 2-(7-Chloroquinoline-4-ylthio)propane and 2-acetamido-3-(7-chloroquinolin-4-ylthio)propanoic acid had little or no effect on serum glucose. The administration of compound 3 3-(7-chloroquinolin-4-ylthio)propionic acid in experimental animals increases the serum glucose on 19,6% comparing to the basic level. Acute toxicity of 4-thio7-chloro-substituted quinoline was determined with the Prozorovsky express method. The substances were administered once intraperitoneally as a thin aqueous suspension in saline solution (stabilizer - Twin 80) or as a solution of not more than 1 ml. The relationship between the structure of the test compounds and their toxicity is analyzed. It has been established that the mean lethal dose (LD50) of these compounds ranges from 200-800 mg/kg and is classified as low toxic that corresponds to the fourth class of toxicity.","PeriodicalId":295885,"journal":{"name":"Vìsnik Zaporìzʹkogo nacìonalʹnogo unìversitetu. Bìologìčnì nauki","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122381138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1