Fertility/Pregnancy最新文献

{"title":"2022-RA-976-ESGO ALK-rearranged lung cancer and uncomplicated pregnancies on Alectinib: dream o reality?","authors":"Eugenia Di Loreto, A. Viscardi, Cristina Maria Michela Matozzo, A. Familiari, Damiano Grippo, G. Polverino, F. Peccatori, G. Scarfone","doi":"10.1136/ijgc-2022-esgo.379","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.379","url":null,"abstract":"","PeriodicalId":292924,"journal":{"name":"Fertility/Pregnancy","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131611818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-962-ESGO Cancer in pregnancy: message in a bottle from tertiary center of Milan","authors":"Cristina Maria Michela Matozzo, A. Viscardi, Eugenia Di Loreto, E. Grossi, V. Accurti, Beatrice De Luca Carignani, C. Castellani, G. Scarfone","doi":"10.1136/ijgc-2022-esgo.378","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.378","url":null,"abstract":"2022-RA-962-ESGO Table 1 Patients’ characteristics with cancer in pregnancy Results The most common cancer was breast cancer (84.7%). Most of the cancer were diagnosed at an early stage, except for a case of IV stage lung cancer and a case of III stage ovarian cancer. Patients characteristics are shown in table 1. After multidisciplinary consultancy, patients were encouraged to continue the pregnancy and to receive a cancer treatment. Pregnancy management included standard prenatal care, ultrasound assessment of fetal growth in the third trimester and assessment of fetal wellbeing after chemotherapy administration. The mean gestational age at delivery was 36 weeks. Delivery was elective in 79% of cases, mainly due to the need to continue oncologic therapy. Mode of delivery was c-section in 56.2% and vaginal birth in 43.8%. Placental tissue was collected for histological analysis. All the babies were born alive, and only three required intensive care because of IUGR (Intrauterine Growth Restriction). No maternal, fetal or neonatal deaths were observed. Conclusion CIP is a rare but progressively increasing event. A multidisciplinary team including oncologists, obstetricians and pediatricians is crucial to balance the oncologic treatment with pregnancy management in order to avoid major neonatal complication due to iatrogenic prematurity beyond treatment’s side effects as well as safeguarding the patient therapeutic indication. 2022-RA-976-ESGO ALK-REARRANGED LUNG CANCER AND UNCOMPLICATED PREGNANCIES ON ALECTINIB: DREAM O REALITY? Eugenia Di Loreto, Anna Viscardi, Cristina Maria Michela Matozzo, Alessandra Familiari, Damiano Grippo, Gianpiero Polverino, Fedro Alessandro Peccatori, Giovanna Scarfone. Gynaecology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Milano, Milan, Italy; Maternal-fetal medicine, Fondazione Policlinico Agostino Gemelli, Roma, Italy; Fertility and Procreation Unit, PhD, Milan, Italy 10.1136/ijgc-2022-ESGO.379 Introduction/Background Lung cancer incidence is increasing in pregnancy, partially related to advanced maternal age. A subset of patients with non-small cell lung cancer (NSCLC) harbor an Anaplastic Lymphoma Kinase (ALK) gene rerrangement. ALK-inhibitors, such as Alectinib, are promising drug to treat ALK-rearranged NSCLC, but rare safety data regarding use during pregnancy are known. Methodology We report our experience in management of two patients treated with Alectinib during pregnancy for advanced ALK rearranged lung cancer, between 2018 and 2022. Results In 2018, a 31 years old women affected of metastatic ALK-rearranged lung cancer treated with Alectinib 600 mg twice daily became pregnant by spontaneous conception. The case, occurred to our attention at 7 weeks of pregnancy, was discussed within a multidisciplinary team: the patient decided to continue pregnancy and full-dose treatment. Mother and fetus were subjected to careful clinical and instrumental investigations until delivery. We determined the","PeriodicalId":292924,"journal":{"name":"Fertility/Pregnancy","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132583174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1433-ESGO Reproductive outcomes after conservative treatment in malignant ovarian germ cell tumors (MOGCTs) patients: a MITO-9 study","authors":"A. Bergamini, F. Vasta, L. Bocciolone, G. Scarfone, C. Cassani, G. Ferrandina, R. de Vivo, S. Danese, M. Filippo, Elisa Grassi, G. Cormio, S. Pignata, G. Mangili","doi":"10.1136/ijgc-2022-esgo.386","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.386","url":null,"abstract":"","PeriodicalId":292924,"journal":{"name":"Fertility/Pregnancy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133365851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-1396-ESGO Pregnancy- related vulvar cancer","authors":"Cristina Aur, D. Mocuta, Monica Boros","doi":"10.1136/ijgc-2022-esgo.383","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.383","url":null,"abstract":"","PeriodicalId":292924,"journal":{"name":"Fertility/Pregnancy","volume":"45 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132365298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022-RA-870-ESGO Fertility outcome of patients with stage I immature teratoma – do surgical approach and post-surgical treatment matter?","authors":"G. Marino, T. Grassi, Filippo Testa, Serena Negri, E. De Ponti, D. Giuliani, M. D. Marchette, F. Sina, Diletta Fumagalli, D. Vicini, Mariaclara Boccadutri, Maria Cristina Bonazzi, F. Landoni, R. Fruscio","doi":"10.1136/ijgc-2022-esgo.377","DOIUrl":"https://doi.org/10.1136/ijgc-2022-esgo.377","url":null,"abstract":"","PeriodicalId":292924,"journal":{"name":"Fertility/Pregnancy","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123343408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}