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Regulation by Nicotine of Food Intake and Body Weight: Implications for Obesity Treatment 尼古丁对食物摄入和体重的调节:对肥胖治疗的影响
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931104
Ming D. Li, J. Kane, O. Konu
{"title":"Regulation by Nicotine of Food Intake and Body Weight: Implications for Obesity Treatment","authors":"Ming D. Li, J. Kane, O. Konu","doi":"10.2174/1567204052931104","DOIUrl":"https://doi.org/10.2174/1567204052931104","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129273625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease 遗传背景对嗜离子性谷氨酸受体和神经营养因子生物学的影响:神经疾病中的突触连通性和功能
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052930925
Gregory N. Barnes and John T. Slevin
{"title":"Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease","authors":"Gregory N. Barnes and John T. Slevin","doi":"10.2174/1567204052930925","DOIUrl":"https://doi.org/10.2174/1567204052930925","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114374635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heparin Derivatives and Semisynthetic Biotechnological Heparins as Angiogenesis Inhibitors 肝素衍生物和半合成生物技术肝素作为血管生成抑制剂
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931087
M. Presta, D. Leali, H. Stabile, R. Ronca, M. Camozzi, E. Moroni, S. Nicoli, S. Liekens, Marco
{"title":"Heparin Derivatives and Semisynthetic Biotechnological Heparins as Angiogenesis Inhibitors","authors":"M. Presta, D. Leali, H. Stabile, R. Ronca, M. Camozzi, E. Moroni, S. Nicoli, S. Liekens, Marco","doi":"10.2174/1567204052931087","DOIUrl":"https://doi.org/10.2174/1567204052931087","url":null,"abstract":"Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell proliferation is observed in tumor neovascularization and in angioproliferative diseases. Tumors cannot grow as a mass above few mm unless a new blood supply is induced. It derives that the control of the neovascularization process may affect tumor growth and may represent a novel approach to tumor therapy. Angiogenesis is controlled by a balance between proangiogenic and antiangiogenic factors. The angiogenic switch represents the net result of the activity of angiogenic stimulators and inhibitors, suggesting that counteracting even a single major angiogenic factor could shift the balance towards inhibition. Heparan sulfate proteoglycans are involved in the modulation of the neovascularization that takes place in different physiological and pathological conditions. This modulation occurs through the interaction with angiogenic growth factors or with negative regulators of angiogenesis. Thus, the study of the biochemical bases of this interaction may help to design glycosaminoglycan analogs endowed with angiostatic properties. The purpose of this review is to provide an overview of the structure/function of heparan sulfate proteoglycans in endothelial cells and to summarize the angiostatic properties of synthetic heparin-like compounds, chemically modified heparins, and biotechnological heparins.","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133267866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Developments in the Synthesis and Evaluation of Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents 糖原磷酸化酶葡萄糖类似物抑制剂的合成与评价研究进展
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052930907
L. Somsák, V. Nagy, Zsuzsa Hadady, N. Felfoldi, T. Docsa, P. Gergely
{"title":"Recent Developments in the Synthesis and Evaluation of Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents","authors":"L. Somsák, V. Nagy, Zsuzsa Hadady, N. Felfoldi, T. Docsa, P. Gergely","doi":"10.2174/1567204052930907","DOIUrl":"https://doi.org/10.2174/1567204052930907","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123657419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators 雌激素受体调节剂作用的分子机制研究
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931140
M. Lloyd
{"title":"Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators","authors":"M. Lloyd","doi":"10.2174/1567204052931140","DOIUrl":"https://doi.org/10.2174/1567204052931140","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121396896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Updating the Dual Role of Brain Nitric Oxide in Neurodegeneration/Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches 更新脑一氧化氮在神经变性/神经保护中的双重作用:了解分子机制以设计药物方法
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052930899
A. Contestabile, Barbara Monti, A. Contestabile, E. Ciani
{"title":"Updating the Dual Role of Brain Nitric Oxide in Neurodegeneration/Neuroprotection: Understanding Molecular Mechanisms to Devise Drug Approaches","authors":"A. Contestabile, Barbara Monti, A. Contestabile, E. Ciani","doi":"10.2174/1567204052930899","DOIUrl":"https://doi.org/10.2174/1567204052930899","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131497786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Genomics-Based Target Mining and Validation of Biologically Active Small Molecules 基于化学基因组学的生物活性小分子靶标挖掘与验证
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931041
H. Kwon
{"title":"Chemical Genomics-Based Target Mining and Validation of Biologically Active Small Molecules","authors":"H. Kwon","doi":"10.2174/1567204052931041","DOIUrl":"https://doi.org/10.2174/1567204052931041","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133256135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Marijuana in CNS Disorders 医用大麻在中枢神经系统疾病中的作用
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931131
A. Platt
{"title":"Medical Marijuana in CNS Disorders","authors":"A. Platt","doi":"10.2174/1567204052931131","DOIUrl":"https://doi.org/10.2174/1567204052931131","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128141112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Combinatorial Synthesis of Small Molecule Libraries by Microwave Technology 微波技术组合合成小分子文库
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052930934
Chung‐Ming Sun
{"title":"Combinatorial Synthesis of Small Molecule Libraries by Microwave Technology","authors":"Chung‐Ming Sun","doi":"10.2174/1567204052930934","DOIUrl":"https://doi.org/10.2174/1567204052930934","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126651411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Potent and Selective A2A Adenosine Receptor Antagonists: Recent Improvement 强效和选择性A2A腺苷受体拮抗剂:最近的进展
Frontiers in Medicinal Chemistry - Online Pub Date : 2005-12-10 DOI: 10.2174/1567204052931069
B. Cacciari, G. Pastorin, S. Moro, G. Spalluto
{"title":"Potent and Selective A2A Adenosine Receptor Antagonists: Recent Improvement","authors":"B. Cacciari, G. Pastorin, S. Moro, G. Spalluto","doi":"10.2174/1567204052931069","DOIUrl":"https://doi.org/10.2174/1567204052931069","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122082087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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