Beyond acid-fast: diagnosis and treatment of TB in the 21st Century最新文献

S40 Reducing numbers, increasing complexity: an evaluation of enhanced case management in the north central London tuberculosis service 2013 to 2020 减少数量，增加复杂性:2013年至2020年伦敦中北部结核病服务加强病例管理的评估

Beyond acid-fast: diagnosis and treatment of TB in the 21st Century Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.46

T. Crocker-Buque, A. Sanaie, H. Booth, D. Creer, I. Cropley, S. Lozewicz, J. Potter, J. White, M. Lipman

引用次数: 0

S39 Is the treatment of latent tuberculosis infection amongst recent migrants safe and effective in primary care? S39在初级保健中对新近移徙者潜伏性结核感染的治疗安全有效吗?

Beyond acid-fast: diagnosis and treatment of TB in the 21st Century Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.45

M. Burman, D. Zenner, A. Copas, L. Goscé, H. Haghparast-Bidgoli, P. White, V. Hickson, O. Greyson, D. Trathen, R. Ashcroft, A. Martineau, I. Abubakar, C. Griffiths, H. Kunst

{"title":"S39 Is the treatment of latent tuberculosis infection amongst recent migrants safe and effective in primary care?","authors":"M. Burman, D. Zenner, A. Copas, L. Goscé, H. Haghparast-Bidgoli, P. White, V. Hickson, O. Greyson, D. Trathen, R. Ashcroft, A. Martineau, I. Abubakar, C. Griffiths, H. Kunst","doi":"10.1136/thorax-2021-btsabstracts.45","DOIUrl":"https://doi.org/10.1136/thorax-2021-btsabstracts.45","url":null,"abstract":"TNF-a, IL2 and CCL7 had very low raw biomarker concentrations. In Phase II, based on above results, we analysed IFN-g, CXCL10 and CCL2 in a further 60 patients (table 1). CXCL10 achieved the highest increase in TP results for ATB diagnosis, with 43 TP compared with 26 TP results for QFTGIT. MSD-measured IFN-g detected 41 TP results, while CCL2 only detected 26 TP. All three biomarkers demonstrated >35% loss of specificity compared to QFT-GIT. The QFTGIT sensitivity and specificity values in our study population were 45.6% and 80% respectively. A ‘triple-test’ combining IFN-g, CXCL10 and CCL2 results achieved sensitivity 83.3% and specificity 12.1%. Conclusion Our study provides a unique and novel gating method for efficiently assessing the diagnostic performance of candidate biomarkers for ATB diagnosis. Our study population was purposely engineered to compare candidate biomarkers to QFT-GIT in a clinically-relevant manner and we hope our study design will aid future, targeted efforts for high-quality biomarker follow-up studies.","PeriodicalId":286308,"journal":{"name":"Beyond acid-fast: diagnosis and treatment of TB in the 21st Century","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116730089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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S37 Dual step interferon-gamma release assay testing can improve tuberculosis (TB) risk stratification in contacts of pulmonary TB: a prospective adult household contact cohort study S37:一项前瞻性成人家庭接触者队列研究:双步骤干扰素γ释放试验检测可以改善肺结核接触者的结核病(TB)风险分层

Beyond acid-fast: diagnosis and treatment of TB in the 21st Century Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.43

JW Kim, J. Nazareth, J. Lee, G. Woltmann, A. O’Garra, R. Verma, P. Haldar

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S41 The diagnostic work up of pleural tuberculosis and the utility of GeneXpert: 5 year experience from a tertiary centre 胸膜结核的诊断工作和GeneXpert的应用:来自三级中心的5年经验

Beyond acid-fast: diagnosis and treatment of TB in the 21st Century Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.47

H. Aung, K. Balasundaram, J. Goss, H. Patel, P. Haldar, R. Panchal

引用次数: 0

S38 Evaluation of mycobacterium tuberculosis-specific IFN-g, TNF-a, CXCL10, IL2, CCL2, CCL7 and CCL4 levels for active tuberculosis diagnosis S38结核分枝杆菌特异性IFN-g、TNF-a、CXCL10、IL2、CCL2、CCL7和CCL4水平对活动性结核诊断的评价

Beyond acid-fast: diagnosis and treatment of TB in the 21st Century Pub Date : 2021-11-01 DOI: 10.1136/thorax-2021-btsabstracts.44

A. Fries, V. Mandagere, R. Parker, M. Tolosa-Wright, L. Berrocal-Almanza, L. Hoang, A. Boakye, A. Halliday, A. Lalvani

引用次数: 0