S39 Is the treatment of latent tuberculosis infection amongst recent migrants safe and effective in primary care?

Abstract

TNF-a, IL2 and CCL7 had very low raw biomarker concentrations. In Phase II, based on above results, we analysed IFN-g, CXCL10 and CCL2 in a further 60 patients (table 1). CXCL10 achieved the highest increase in TP results for ATB diagnosis, with 43 TP compared with 26 TP results for QFTGIT. MSD-measured IFN-g detected 41 TP results, while CCL2 only detected 26 TP. All three biomarkers demonstrated >35% loss of specificity compared to QFT-GIT. The QFTGIT sensitivity and specificity values in our study population were 45.6% and 80% respectively. A ‘triple-test’ combining IFN-g, CXCL10 and CCL2 results achieved sensitivity 83.3% and specificity 12.1%. Conclusion Our study provides a unique and novel gating method for efficiently assessing the diagnostic performance of candidate biomarkers for ATB diagnosis. Our study population was purposely engineered to compare candidate biomarkers to QFT-GIT in a clinically-relevant manner and we hope our study design will aid future, targeted efforts for high-quality biomarker follow-up studies.