C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE最新文献

{"title":"Serum Biomarker Levels and Mortality Across Subtypes of Pulmonary Arterial Hypertension","authors":"K. Hirsch, S. Nolley, D. D. Ralph, P. Leary, S. G. Rayner","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4909","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4909","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132600550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Operative NT-pro-BNP Is a Strong Predictor of Pre-Operative Hemodynamics and Post-Operative Complications After Pulmonary Thromboendarterectomy in Patients with Operable Chronic Thromboembolic Pulmonary Hypertension","authors":"E.A. Keiler, K. Kerr, N. Kim, M. Madani, D. Papamatheakis, D. Poch, V. Pretorius, J.Z. Yang, T. Fernandes","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4923","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4923","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132072251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Effort Provides a Reproducible Remote Assessment of 6-Minute Walk Test","authors":"D. Lachant, A. Light, E. Kennedy, M. Lachant, R. White","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4922","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4922","url":null,"abstract":"Rationale: 'Cardiac Effort' (CE), the total number of heart beats used during the 6-minute walk test (6MWT) divided by walk distance (beats/m), improves reproducibility in the 6MWT and correlates with right ventricular function in pulmonary arterial hypertension (PAH). The SARS-CoV-2 pandemic made in-office 6MWT challenging. We aimed to determine 1) whether a chestbased accelerometer could estimate 6MWT distance in the clinic and remotely;2) the reproducibility of CE measured during a remote 6MWT;and 3) the safety of remote 6MWT. We also compared measures of heart rate (HR) derived from electrocardiogram (ECG) and wrist-based photoplethysmography (PPG) during the 6MWT in PAH. Methods: This was a singlecenter, prospective observational study with IRB approval completed October 2020-April 2021. Group 1 PAH subjects on stable therapy for >90 days completed 4-6 total 6MWT during a 2 week period to assess reproducibility;we anticipated no clinical change during this short interval. The first and last 6MWT were performed in the clinic;2-4 remote 6MWT were completed at participant's discretion. Participants did not wear masks but did wear the MC10 Biostamp nPoint sensors to measure ECG HR and accelerometry. Two blinded readers estimated 6MWT distance using raw accelerometry data. We measured PPG HR with a wrist Nonin 3150 pulse oximeter during clinic 6MWT only. Averages of clinic variables and remote variables were used for paired Student's t test, Bland-Altman Plot, or Pearson correlation. Results: We enrolled 20 participants: 80% female;60% connective tissue disease;and 65% on initial combination therapy with ambrisentan and tadalafil. There was a wide range in baseline, clinicperformed 6MWT distance (220 -570 m). The median length of the remote 'hallway' was 40 ft. For clinic walks, there was 0.10% average difference between the directly observed and Biostamp accelerometry-estimated 6MWT distance with a strong correlation of r=0.99, p<0.0001 (figure 1). The 6MWT distance estimated using Biostamp in the clinic was greater than what was estimated remotely, 405 m vs. 389 m, p=0.007. There was no clear difference between clinic or remote CE, 1.83 beats/m vs 1.93 beats/m, p=0.14, or Borg Dyspnea Index, 3.5 vs 3.4, p=0.35. There were no safety concerns. PPG undercounted total HR expenditure during 6MWT compared to Biostamp (629 vs 719, p<0.0001). Conclusion: Remote 6MWT was feasible, appeared safe, and 6MWT distance was shorter than clinic distance. CE calculated by ECG HR and accelerometer-estimated distance provides a reproducible remote assessment of exercise tolerance, comparable to the clinic measured value. (Figure Presented).","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134421586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning-Based Automated Workflow for the Interpretation of the Echocardiogram for the Presence of LV Dysfunction and Probability of Pulmonary Hypertension","authors":"J. Tromp, B. Claggett, M. Frost, M. Iversen, N. Prasad, M. Petrie, J. Ezekowitz, S. Solomon","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4919","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4919","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117128079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of CircTREM1 in Peripheral Blood Monocyte Cells on Prognosis of Idiopathic Pulmonary Arterial Hypertension","authors":"P. Yuan, Y.-Y. Sun","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4910","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4910","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116761116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamics and Survival in Systemic Sclerosis-Associated Pulmonary Hypertension","authors":"H. J. Hassan, M. Naranjo Tovar, T. Housten Harris, A. Balasubramanian, C. Simpson, T. Kolb, R. Damico, S. Mathai, P. Hassoun","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4916","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4916","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130003844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of oxygenation on acute vasodilator challenge in pulmonary arterial hypertension","authors":"M. Rockstrom, Y. Jin, R. A. Peterson, P. Hountras, D. Badesch, S. Gu, B. Park, J. Messenger, L. M. Forbes, W. Cornwell, T. Bull","doi":"10.1101/2023.04.27.23289235","DOIUrl":"https://doi.org/10.1101/2023.04.27.23289235","url":null,"abstract":"Background: Identification of long-term calcium channel blocker (CCB) responders with acute vasodilator challenge is critical in the evaluation of patients with pulmonary arterial hypertension. Currently there is no standardized approach for use of supplemental oxygen during acute vasodilator challenge. Methods: Retrospective analysis of patients identified as acute vasoresponders, treated with CCBs. All patients had hemodynamic measurements in three phases: 1) at baseline; 2) with 100% fractional inspired oxygen; and 3) with 100% fractional inspired oxygen plus inhaled nitric oxide (iNO). Patients were divided into two cohorts. Those meeting the definition of acute vasoresponsiveness from phase 2 to phase 3 were labeled ?iNO Responders.? Those who did not reach the threshold of acute vasoresponsiveness from phase 2 to phase 3 but did meet the definition from phase 1 to phase 3 were labeled ?Oxygen Responders.? Survival, hospitalization for decompensated right heart failure, duration of CCB monotherapy, and functional data were collected. Results: iNO Responders, when compared to Oxygen Responders, had superior survival (100% vs 50.1% 5-year survival, respectively), fewer hospitalizations for acute decompensated right heart failure (0% vs 30.4% at 1 year, respectively), longer duration of CCB monotherapy (80% versus 52% at 1 year, respectively), and superior six-minute walk distance. Conclusion: Current guidelines for acute vasodilator testing do not standardize oxygen coadministration with iNO. This study demonstrates that adjusting for the effects of supplemental oxygen before assessing for acute vasoresponsiveness identifies a cohort with superior functional status, tolerance of CCB monotherapy, and survival while on long-term CCB therapy.","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133012391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of a New Definition of Pulmonary Hypertension in a Cohort of Patients at 5,280 Feet","authors":"A. Longino, K.R. Mcleod, W. Cornwell, J. Messenger, T. Bull","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4913","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4913","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125169817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Index: A Misleading Parameter in Risk Assessment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension","authors":"H. J. Hassan, M. Naranjo Tovar, T. Housten Harris, A. Balasubramanian, C. Simpson, T. Kolb, R. Damico, S. Mathai, P. Hassoun","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4917","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4917","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130286404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selexipag Experience in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (PAH-CTD): Real-World Experience from EXPOSURE","authors":"S. Gaine, P. Escribano, A. Muller, R. Klement, S. Söderberg, T. Lange","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4914","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4914","url":null,"abstract":"","PeriodicalId":286050,"journal":{"name":"C105. CIVIC CENTER: PULMONARY VASCULAR DISEASE","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122035476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}