EMJ CardiologyPub Date : 2022-08-26DOI: 10.33590/emjcardiol/22c9177
OPEN Health
{"title":"The Clock Is Ticking: The Imminent Need to Re-evaluate the Standard of Care in the 90-Day High-Risk Post-Acute Myocardial Infarction Period","authors":"OPEN Health","doi":"10.33590/emjcardiol/22c9177","DOIUrl":"https://doi.org/10.33590/emjcardiol/22c9177","url":null,"abstract":"This CSL Behring-supported symposium took place during the European Society of Cardiology (ESC) 2021 Congress. Experts P. Gabriel Steg Cardiology Department, Hôpital Bichat-Claude-Bernard, Paris, France, and the Université de Paris, France; and Kausik Ray, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, UK; Imperial Clinical Trials Unit, Imperial College London, UK; and Commercial Trials, Imperial College London, UK, discussed the clinical significance of the early post-acute myocardial infarction\u0000(AMI) period and the risk of recurrent events despite optimal recommended standard of care.\u0000\u0000Steg highlighted data from a retrospective registry study as well as several randomised controlled trials, suggesting that recurrent cardiovascular (CV) events appeared to accrue quickly in the early post-AMI period. He proposed that this may be an important timeframe for additional therapeutic interventions and warrants further investigation. \u0000\u0000Ray highlighted guideline recommendations for secondary prevention, currently focused on lipid-lowering and antiplatelet therapies. Ray presented data from several randomised controlled trials of lipid-lowering therapies, demonstrating that despite therapeutic advances and guideline-recommended treatments, there is a residual risk of recurrent CV events post-AMI. Ray suggested that additional therapeutic targets should be explored to further reduce the incidence of recurrent CV events post-AMI.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115369832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2022-08-09DOI: 10.33590/emjneurol/10192391
E. Høgestøl
{"title":"EAN Congress Interview – Einar August Høgestøl","authors":"E. Høgestøl","doi":"10.33590/emjneurol/10192391","DOIUrl":"https://doi.org/10.33590/emjneurol/10192391","url":null,"abstract":"","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128535999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2022-06-29DOI: 10.33590/emjcardiol/22-00093
Edward Richardson, A. Hall, Chris Hare, P. L. Le Page, Andrew R J Mitchell
{"title":"Screening for Heart Disease in the Age of Digital Health Technologies: Who, When, and How?","authors":"Edward Richardson, A. Hall, Chris Hare, P. L. Le Page, Andrew R J Mitchell","doi":"10.33590/emjcardiol/22-00093","DOIUrl":"https://doi.org/10.33590/emjcardiol/22-00093","url":null,"abstract":"Heart disease affects much of the world’s population, yet many people have no idea that they could have something wrong with them. An opportunity therefore exists for targeted screening for conditions such as cardiovascular disease, heart rhythm changes, valvular heart disease, structural abnormalities, and more subtle, rarer inherited heart conditions. At the same time, the rapid development of digital health technologies and clinical support systems is providing patients and their doctors access to augmented intelligence solutions to diagnose these conditions. This article will focus on how the emerging field of digital health technology can aid screening for heart disease and explore its usefulness in disease specific and population specific groups.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127750585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2022-04-19DOI: 10.33590/emjcardiol/21-00247
Shams Reaz, Christianne Jafari
{"title":"Silent Myocardial Infarction in Hypereosinophilic Syndrome Overlapped with JAK2-Mediated Essential Thrombocytosis: A Case Report","authors":"Shams Reaz, Christianne Jafari","doi":"10.33590/emjcardiol/21-00247","DOIUrl":"https://doi.org/10.33590/emjcardiol/21-00247","url":null,"abstract":"A 61-year-old male with chronic cough, paraesthesia of the extremities, and sinusitis presented for acute worsening of symptoms despite initial treatment with antibiotics and prednisone. Emergency department evaluation revealed mild elevated troponin without ECG changes in absence of coronary symptoms, but markedly elevated eosinophil count and an abnormal chest CT. A nuclear stress test revealed basal and inferoseptal dyskinesis with fixed apical defect. Left heart catheterisation revealed multiple coronary stenosis requiring intervention. Further extensive work-up confirmed a diagnosis of hypereosinophilic syndrome complicated with respiratory, cardiac, gastroenterological, and neurological involvement. The patient was initially treated with a high dose of intravenous steroid and hydroxyurea. Flow cytometry revealed negative FIP1L1-PDGFRA gene rearrangement, but was positive for JAK2 V617F mutation and perinuclear antineutrophil cytoplasmic antibodies/cytoplasmic antineutrophil cytoplasmic antibodies, indicating possible overlap of eosinophilic granulomatosis with polyangiitis.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114604099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2022-03-21DOI: 10.33590/emjcardiol/21-00229
Uzma Gul, Khin Kay Kay Kyaw, S. Munir
{"title":"Undiagnosed Hidradenitis Suppurativa Associated with Acute Myocardial Infarction: A Case Report","authors":"Uzma Gul, Khin Kay Kay Kyaw, S. Munir","doi":"10.33590/emjcardiol/21-00229","DOIUrl":"https://doi.org/10.33590/emjcardiol/21-00229","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic inflammatory disease believed to be a risk factor for cardiovascular events. Traditional cardiovascular risk factors, such as metabolic syndrome, often coexist with HS. Chronic inflammatory conditions may underlie cardiovascular events in young patients or those with few traditional risk factors. A 34-year-old female was admitted to the authors’ tertiary care hospital with acute anterior ST-segment elevation myocardial infarction, and underwent a successful primary percutaneous coronary intervention to their left anterior descending artery. They were a smoker, had a high BMI, and had a positive family history of premature coronary artery disease. During their admission, the patient disclosed that they had discharging lesions under their left breast. The patient had a long-standing history of multiple discharging lesions alternating with disfiguring scars that had started in their late childhood; however, despite this leading to self-dissatisfaction, they did not seek medical advice.\u0000\u0000Examination revealed plaques and scarring in both axillae and a chronic abscess under the left breast, the swabs from which were sterile, as is consistent with HS. The laboratory results showed a raised troponin and white cell count with mildly elevated levels of C-reactive protein. The patient was managed with standard acute coronary syndrome treatment and a course of oral doxycycline, and awaits further treatment by dermatology and plastic surgery. The morbidity of HS is grossly underestimated. This case study highlights that HS has significant cardiovascular implications, in addition to psychological impacts, and that underlying systemic inflammation may promote rapid atherosclerosis. Further research into pathogenesis and strategies to prevent adverse cardiovascular events are needed.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129329955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2022-02-21DOI: 10.33590/emjcardiol/21-00165
Elisabetta Palmerini, F. De Tommasi, Tamara Taddei, S. Amidei, G. Falsini
{"title":"Idarucizumab in Emergent Pericardiocentesis: A Case Report of Dabigatran-Induced Haemopericardium and Cardiac Tamponade","authors":"Elisabetta Palmerini, F. De Tommasi, Tamara Taddei, S. Amidei, G. Falsini","doi":"10.33590/emjcardiol/21-00165","DOIUrl":"https://doi.org/10.33590/emjcardiol/21-00165","url":null,"abstract":"Haemopericardium has rarely been described in association with the use of a non-vitamin K antagonist oral anticoagulant. Cardiac tamponade is a life-threatening condition that usually requires urgent pericardiocentesis. Here, the authors report a case of haemopericardium with cardiac tamponade during dabigatran therapy for atrial fibrillation in a patient with chronic coronary syndrome, treated effectively with reversal agent idarucizimab before pericardiocentesis. To the authors’ knowledge, this is only the third report of dabigatran-induced haemopericardium.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117353071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EMJ CardiologyPub Date : 2021-10-11DOI: 10.33590/emjcardiol/20-00246
Layal Mansour, Soha Fakhreddine, M. Saliba, S. Kabbani
{"title":"Hydroxychloroquine- and Azithromycin-Induced \u0000Transient Left-Bundle Branch Block in a Patient with \u0000COVID-19","authors":"Layal Mansour, Soha Fakhreddine, M. Saliba, S. Kabbani","doi":"10.33590/emjcardiol/20-00246","DOIUrl":"https://doi.org/10.33590/emjcardiol/20-00246","url":null,"abstract":"Background: COVID-19 has emerged and rapidly spread worldwide due to the high infectivity of the novel coronavirus. A new regimen consisting of a combination of hydroxychloroquine and azithromycin has been under evaluation for efficacy and side effects, especially cardiotoxicity.\u0000\u0000Case summary: A 58-year-old man was admitted to the hospital for COVID-19 pneumonia. His initial ECG showed sinus tachycardia. He was started on combination therapy of azithromycin and hydroxychloroquine. After the second dose of hydroxychloroquine and initial dose of azithromycin, his ECG showed complete left-bundle branch block (LBBB). The treatment was stopped, and the patient had no cardiac symptoms. On Day 8 of admission, his repeat ECG showed an absence of LBBB.\u0000\u0000Discussion: The cumulative dose of hydroxychloroquine observed in patients treated for malaria or systemic diseases is cardiotoxic, and few cases of LBBB, have been reported. It is, however, not known whether the use of azithromycin in association with a small dose of hydroxychloroquine induces transient LBBB.","PeriodicalId":284912,"journal":{"name":"EMJ Cardiology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115544277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}