{"title":"A virtual/digital pet Point-of-Care system for self-management of COPD patients","authors":"D. Arvind, T. Georgescu, W. Bao, C. A. Bates","doi":"10.1109/HI-POCT54491.2022.9744060","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744060","url":null,"abstract":"Pulmonary rehabilitation is recommended for COPD patients to help manage their long-term condition. The objectives of the point-of-care system are: remote observability of patients by continuous monitoring of their vital signs of respiratory rate and respiratory effort; encourage adherence to the pulmonary rehabilitation regime and correct execution of the exercises. The point-of-care system consists of the Respeck sensor device worn as a plaster on the chest to monitor respiratory rate/flow and physical activity, and a mobile app to (i) orchestrate the pulmonary rehabilitation exercises; (ii) an e-pet to engage the patient to exercise regularly; (iii) handle communication of Respeck data with the Cloud-based server. A dashboard provides the Care Team of physiotherapists, respiratory nurses and doctors with (i) the current status and historical trends of breathing rate/flow; (ii) classification of their static (lying down, sitting/standing, and dynamic (walking, running, climbing stairs) physical activities; (iii) correctness and frequency of their pulmonary rehabilitation exercises; (iv) level of interaction with their virtual/digital pet. Results are presented on the evaluation of the virtual/digital feature by respiratory physiotherapists ahead of deployment with COPD patients.Clinical Relevance—The point-of-care system can classify the correctness of the ten pulmonary rehabilitation exercises using machine learning techniques with a maximum accuracy of 93% to provide the Care Team confidence their charges are performing exercises correctly when unsupervised. Results are summarised for a survey of nine pulmonary physiotherapists on their evaluation of the efficacy of using the Respeck and the App in a Point-of-Care system (POCS) for COPD patients.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134619261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Wearable Exam Stress Dataset for Predicting Grades using Physiological Signals","authors":"Md. Rafiul Amin, D. S. Wickramasuriya, R. Faghih","doi":"10.1109/HI-POCT54491.2022.9744065","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744065","url":null,"abstract":"The study of psychological stress in real-world scenarios presents several challenges. Consequently, datasets available to researchers are also scarce. The aim of our study is to acquire such a dataset containing skin conductance measurements and use it to predict human performance. We collected skin conductance and skin temperature data from 10 subjects during three exams using wearable devices. We filter the skin conductance signals to obtain coarse-grained trendlines and then train classifiers to predict high and low grades based on the trendline features. We obtained maximum classification accuracies in the 70–80% range. We also obtained the mean trendlines indicating the general variation of stress levels during the exams. The findings indicate the preliminary viability of using wearable devices to predict performance during real-world stressors. Wearable monitoring presents unique challenges and it is our hope that this publicly-available dataset will aid in addressing some of them.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129504640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Capillary Flow Dynamics of Blood With Varied Hematocrit in Microfluidic Platforms","authors":"B. Nunna, Yudong Wang, N. Talukder, Eon Soo Lee","doi":"10.1109/HI-POCT54491.2022.9744073","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744073","url":null,"abstract":"Blood is a complex fluid with non-newtonian behavior. Though the blood plasma is newtonian in nature, the Red Blood Cells (RBCs) in the blood contribute to the non-newtonian behavior. The study of the influence of the hematocrit (percentage of RBCs in the whole blood) in the capillary flow of the whole blood is highly desired to understand the non-newtonian flow of blood and change on the flow dynamics of whole blood with different concentrations of RBCs. In the capillary flow dynamics, the study of contact angle and its variations play a key role. So, in this manuscript the contact angle of the whole blood drop and the flow velocity of the whole blood with different hematocrit on the polydimethylsiloxane (PDMS) surface is studied with detailed scientific experiments. The contact angle was measured for whole blood drop with hematocrit of 35%, 40%, 45%, and 50% as 34°, 38°, 44°, and 48° respectively. Also, the flow velocity that is directly influenced by the contact angle in the capillary flow is measured with whole blood with hematocrit of 35%, 40%, 45%, and 50% as 9.23 mm/s, 8.45 mm/s, 7.32 mm/s, and 6.67 mm/s respectively. The experimental results helps to conclude that the increased hematocrit in the whole blood is increasing the contact angle and decreasing the flow velocity.Clinical Relevance—The study of the capillary flow dynamics of whole blood with different hematocrit helps the physicians to establish more accurate analysis of blood flow with different concentrations of RBCs.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125430425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Hajij, Ghada Zamzmi, Rahul Paul, Lokenda Thukar
{"title":"Normalizing Flow for Synthetic Medical Images Generation","authors":"Mustafa Hajij, Ghada Zamzmi, Rahul Paul, Lokenda Thukar","doi":"10.1109/HI-POCT54491.2022.9744072","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744072","url":null,"abstract":"Deep generative models, such as generative adversarial network (GAN) and variational autoencoder (VAE), have been utilized extensively for medical image generation. While these models made remarkable progress in medical image synthesis, they can not explicitly learn the probability density function of the input data and are highly sensitive to the hyperparameter selections. To mitigate these issues, a new type of deep generative model, called Normalizing Flows (NFs), have emerged in recent years. In this paper, we investigate NFs as an alternative for synthesizing medical images. In particular, we utilize realNVP, a popular NF model for the purpose of synthesizing medical images. To evaluate our synthesized images, we propose to utilize Wasserstien distance along with the permutation test to quantify the quality of the generated images. Within our quantifying metric, our results indicate that the two sample distributions, the first being the samples obtained from our NF model and second being the original dataset, are similar providing a promising indication of normalizing flow’s capability in medical images generation.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127793933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Cao, Joshua Finer, M. Megjhani, Daniel Nametz, Virginia Lorenzi, Lena Mamykina, Richard Meyers, S. Rossetti, Soojin Park
{"title":"Machine Learning Model Deployment Using Real-Time Physiological Monitoring: Use Case of Detecting Delayed Cerebral Ischemia","authors":"H. Cao, Joshua Finer, M. Megjhani, Daniel Nametz, Virginia Lorenzi, Lena Mamykina, Richard Meyers, S. Rossetti, Soojin Park","doi":"10.1109/HI-POCT54491.2022.9744076","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744076","url":null,"abstract":"Deploying machine learning models in a clinical setting is challenging. Here we demonstrated a modular model deployment pipeline for for ContinuOuS Monitoring tool for delayed cerebral IsChemia (COSMIC) that was successfully implemented on a trained and validated temporal machine learning algorithm that detects delayed cerebral ischemia after subarachnoid hemorrhage. The pipeline was able to ingest demographic data and near real-time continuous physiological data, run through a model, and output the results twice a day automatically. It was a highly collaborative effort among clinical neurologists, the research team, and the IT innovation team. We illustrate the technical run time challenges and mitigations in each of the three components of the pipeline: data, model (modular), and output communication. Future work is user-centered participatory design and rapid agile prototyping of effective model output communication and clinical trial of efficacy in order to understand how the clinical decision support tool performs and is adopted in a real clinical setting.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128220659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Explainability Analysis of Black Box SVM models for Hepatic Steatosis Screening","authors":"R. Deo, S. Panigrahi","doi":"10.1109/HI-POCT54491.2022.9744067","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744067","url":null,"abstract":"Non-Alcoholic Fatty Liver Disease (NAFLD) or HS is one of the major causes of chronic liver diseases worldwide. Identifying the NAFLD condition at an early stage allows for preventative care and potential disease remission.To this end, our research group is addressing this issue by developing a computational model for decision support for Hepatic Steatosis (HS) or NAFLD screening. Our recent work included the development of machine learning models using seven physiological parameters (demographic, lipids, and liver biochemical parameters). Although the developed models show potential for screening, there is a need for further improving the model performance. Considering the complex nature of this condition and its interaction with different physiological parameters, we identified the contribution of the individual parameters in predicting the target (HS). The objective of this paper is to identify how different features contribute to a given model prediction by using an explainable artificial intelligence (XAI) technique called Partial Dependency. Results from partial dependency analysis and plots are summarized in this paper along with insights related to model performance. We identified the top three individual important predictors (ALT, AST, and Glucose levels) for both male and female. The models both for the male and female populations were analyzed separately to incorporate the pathobiological difference in NAFLD morphology in male vs female population.Clinical Relevance—The current study and obtained results do not have immediate clinical implications. However, this work paves the path for a potential computational model, which after required validation and testing, could be used as a decision support system for Hepatic Steatosis screening.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121399444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leapfrogging Medical AI in Low-Resource Contexts Using Edge Tensor Processing Unit","authors":"Priyanshu Sinha, J. Gichoya, S. Purkayastha","doi":"10.1109/HI-POCT54491.2022.9744071","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744071","url":null,"abstract":"With each passing year, the state-of-the-art deep learning neural networks grow larger in size, requiring larger computing and power resources. The high compute resources required by these large networks are alienating the majority of the world population that lives in low-resource settings and lacks the infrastructure to benefit from these advancements in medical AI. Current state-of-the-art medical AI, even with cloud resources, is a bit difficult to deploy in remote areas where we don’t have good internet connectivity. We demonstrate a cost-effective approach to deploying medical AI that could be used in limited resource settings using Edge Tensor Processing Unit (TPU). We trained and optimized a classification model on the Chest X-ray 14 dataset and a segmentation model on the Nerve ultrasound dataset using INT8 Quantization Aware Training. Thereafter, we compiled the optimized models for Edge TPU execution. We find that the inference performance on edge TPUs is 10x faster compared to other embedded devices. The optimized model is 3x and 12x smaller for the classification and segmentation respectively, compared to the full precision model. In summary, we show the potential of Edge TPUs for two medical AI tasks with faster inference times, which could potentially be used in low-resource settings for medical AI-based diagnostics. We finally discuss some potential challenges and limitations of our approach for real-world deployments.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134068781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Tabei, Mostafa M Abohelwa, Daniel Davis, Pooja Sethi, K. Nugent, Jo Woon Chong
{"title":"A Novel Smartphone-based & Personalized Atrial Fibrillation Detection: A Preliminary Study","authors":"F. Tabei, Mostafa M Abohelwa, Daniel Davis, Pooja Sethi, K. Nugent, Jo Woon Chong","doi":"10.1109/HI-POCT54491.2022.9744074","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744074","url":null,"abstract":"This paper aims to propose a novel system that can be used for personalized atrial fibrillation (AF) detection using smartphone photoplethysmogram (PPG) signals. First, we detect atrial fibrillation (AF) signals from normal heart rhythm signals, and then the AF smartphone PPG signals are used for personalized AF detection. We extracted 19 features from the fiducial and non-fiducial information of smartphone PPG signals. These features were used for both classifying AF signals from normal signals and personalized AF detection of each subject. The ensemble algorithms with the boosting and bagging functions were used for both the AF detection from normal and personalized AF detection processes. We achieved 100% accuracy for detecting AF signals from normal signals and 96.08%. for personalized AF detection. These preliminary results indicate that our proposed system can be used for personalized AF detection and management which has been recently gained attention from researchers.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114699391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A System-On-Chip Assay for Bilirubin Levels Measurement in Whole Blood Using Photodegradation Kinetics","authors":"Jean Pierre Ndabakuranye, S. Prawer, A. Ahnood","doi":"10.1109/HI-POCT54491.2022.9744057","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744057","url":null,"abstract":"Bilirubin is clinically confirmed as a biomarker for liver health and is used to assess the prognosis of cirrhosis. Optical and chemical methods have long been utilized for blood bilirubin biosensing. While spectrophotometric techniques provide more accurate results, measurements may not be practical due to the instrument complexity and space requirements as they require volumetric equipment and reagents are sometimes preprocessed. These steps are rather time-consuming and can be detrimental in cases of emergency. Several studies have attempted and used the dual-wavelength approach to overcome these limitations; however, although this creates the possibility of Point-of-Care (PoC) and fast testing, it suffers from reduced accuracy. This paper investigated the feasibility of PoC bilirubin monitoring by photodegradation kinetics using a system-on-chip (SoC). Porcine blood was used, and bilirubin levels were kept within the pathophysiological ranges projected from healthy individuals (<1.2 mg/dL) and cirrhotic patients (up to 50 mg/dL). Our findings suggest that bilirubin can be measured with high sensitivity in blood using bilirubin degradation profiles. This technique can be incorporated with the dual-wavelength approach to increase the reliability and accuracy of point-of-care testing for bilirubin levels, primarily for neonatal hyperbilirubinemia and cirrhotic adults.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121081820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kirigami-Patterned Highly Stable and Strain Insensitive Sweat pH and Temperature Sensors for Long-term Wearable Applications","authors":"Tanzila Noushin, N. I. Hossain, Shawana Tabassum","doi":"10.1109/HI-POCT54491.2022.9744070","DOIUrl":"https://doi.org/10.1109/HI-POCT54491.2022.9744070","url":null,"abstract":"Strain-insensitive wearable sensors have garnered substantial attention owing to their high precision sensing irrespective of body movements such as bending, stretching, and twisting motions. This work reports integrated, strain-insensitive pH and temperature sensors fabricated on a biaxially stretchable kirigami structure to quantitively measure the sweat pH levels and body temperature. Notably, an impressive strain-invariant response was demonstrated by the pH and temperature sensors under an applied biaxial tensile strain up to 220% and torsional strain up to 360°. By depicting an excellent combination of cost-effective fabrication, flexible kirigami structure, breathable notches, high linearity of response, and skin conformity, our device will open a promising new route in the application of skin-inspired wearable sensors.","PeriodicalId":283503,"journal":{"name":"2022 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123560413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}