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Multicomponent Reactions towards Heterocycles最新文献

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Solid‐Phase Heterocycle Synthesis Using Multicomponent Reactions 多组分反应的固相杂环合成
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch4
L. G. Ceballos, D. Pacheco, B. Westermann, Daniel G. Rivera
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引用次数: 0
Multicomponent‐Switched Reactions in Synthesis of Heterocycles 杂环化合物合成中的多组分开关反应
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch8
V. Chebanov, Serhiy M. Desenko, V. Lipson, N. Gorobets
{"title":"Multicomponent‐Switched Reactions in Synthesis of Heterocycles","authors":"V. Chebanov, Serhiy M. Desenko, V. Lipson, N. Gorobets","doi":"10.1002/9783527832439.ch8","DOIUrl":"https://doi.org/10.1002/9783527832439.ch8","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114885918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterocycles as Inputs in MCRs : An Update 杂环作为mcr的输入:最新进展
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch1
Ouldouz Ghashghaei, Marina Pedrola, C. Escolano, R. Lavilla
{"title":"Heterocycles as Inputs in\u0000 MCRs\u0000 : An Update","authors":"Ouldouz Ghashghaei, Marina Pedrola, C. Escolano, R. Lavilla","doi":"10.1002/9783527832439.ch1","DOIUrl":"https://doi.org/10.1002/9783527832439.ch1","url":null,"abstract":"Multicomponent reactions (MCRs) hold a privileged position in organic synthesis and are currently gaining momentum in the fields where a fast access to high levels of structural diversity is needed. This is especially important in medicinal chemistry and key to drug discovery. In this endeavor, as the vast majority of small-molecule drugs are of heterocyclic nature, the interplay of heterocycles with MCRs becomes significant [1]. Although the majority of work has been devoted to the synthesis of heterocyclic adducts from non-heterocyclic reactants [2, 3], we will focus, however, on the intrinsic reactivity of basic heterocycles as a source of synthetically useful MCRs (Scheme 1.1). This approach, still quite unexplored in the MCR context, is arguably a rich source of novel, complex scaffolds. There is a wide choice of commercially available heterocyclic inputs, which together with their often-exclusive reactivity make this perspective simple, conceptually attractive, and synthetically productive. In this chapter, we describe a representative selection of relevant results in the last six years, as the field has experienced impressive growth since our last revision [4], and an exhaustive account is out of scope. This update groups the highlighted processes according to the main reactivity modes defining the MCRs: concerted, radical, metal-catalyzed, carbonyl/imine, and isocyanide-based processes. Finally, a miscellany section is included to cluster those MCRs that do not clearly fit in the classification. Occasionally, some significant post-transformations and applications have been detailed.","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124761208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Index 指数
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.index
{"title":"Index","authors":"","doi":"10.1002/9783527832439.index","DOIUrl":"https://doi.org/10.1002/9783527832439.index","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129267789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles 流动化学在多组分杂环化合物合成中的应用
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch6
Chiara Lambruschini, L. Moni, A. Basso
{"title":"The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles","authors":"Chiara Lambruschini, L. Moni, A. Basso","doi":"10.1002/9783527832439.ch6","DOIUrl":"https://doi.org/10.1002/9783527832439.ch6","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126707552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis of Heterocycles Via MCRs mcr绿色合成杂环化合物
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch5
Wei Zhang
{"title":"Green Synthesis of Heterocycles Via\u0000 MCRs","authors":"Wei Zhang","doi":"10.1002/9783527832439.ch5","DOIUrl":"https://doi.org/10.1002/9783527832439.ch5","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121749406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis of Saturated Heterocycles via Multicomponent Reactions 多组分反应合成饱和杂环化合物
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch11
C. K. Andrade, C. E. Salvador, T. Rosalba, Lucília Zeymer Alves Corrêa, Luan A. Martinho, Yuri R.B. Sousa
{"title":"Synthesis of Saturated Heterocycles via Multicomponent Reactions","authors":"C. K. Andrade, C. E. Salvador, T. Rosalba, Lucília Zeymer Alves Corrêa, Luan A. Martinho, Yuri R.B. Sousa","doi":"10.1002/9783527832439.ch11","DOIUrl":"https://doi.org/10.1002/9783527832439.ch11","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123919402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicomponent Syntheses of Heterocycles by Catalytic Generation of Alkynoyl Intermediates 炔基中间体催化合成多组分杂环
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch10
Jonas Niedballa, T. Müller
{"title":"Multicomponent Syntheses of Heterocycles by Catalytic Generation of Alkynoyl Intermediates","authors":"Jonas Niedballa, T. Müller","doi":"10.1002/9783527832439.ch10","DOIUrl":"https://doi.org/10.1002/9783527832439.ch10","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122806514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicomponent Reactions and Asymmetric Catalysis 多组分反应与不对称催化
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch12
Melody E. Boëtius, Eelco Ruijter
{"title":"Multicomponent Reactions and Asymmetric Catalysis","authors":"Melody E. Boëtius, Eelco Ruijter","doi":"10.1002/9783527832439.ch12","DOIUrl":"https://doi.org/10.1002/9783527832439.ch12","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116627164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Trends in Metal‐catalyzed MCRs Toward Heterocycles 金属催化mcr向杂环方向发展的新趋势
Multicomponent Reactions towards Heterocycles Pub Date : 2021-11-26 DOI: 10.1002/9783527832439.ch13
Lilia Fuentes‐Morales, L. D. Miranda
{"title":"Recent Trends in Metal‐catalyzed\u0000 MCRs\u0000 Toward Heterocycles","authors":"Lilia Fuentes‐Morales, L. D. Miranda","doi":"10.1002/9783527832439.ch13","DOIUrl":"https://doi.org/10.1002/9783527832439.ch13","url":null,"abstract":"","PeriodicalId":281637,"journal":{"name":"Multicomponent Reactions towards Heterocycles","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130039681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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