Basic & Clinical Cancer Research最新文献

{"title":"Cancer Incidence, Mortality and Survival in Türkiye as of 2020","authors":"Sultan Eser, Hüseyin Örün, Ege Hamavioğlu, Fereshteh Lofti","doi":"10.18502/bccr.v14i1.14383","DOIUrl":"https://doi.org/10.18502/bccr.v14i1.14383","url":null,"abstract":"Background: Cancer registration is better understood with the Globocan project. In our article, we compiled the cancer incidence, mortality, and survival data of Türkiye. We presented incidence and mortality-related data from the Global Cancer Observatory, and survival-related data from CONCORD-3. Non-melanoma skin cancers (NMSC) were excluded from interpretations for all indicators. The number of new cancer cases in Türkiye with a population of more than 80 million was estimated as 227,310 people in total, 128,802 in men and 98,508 in women. In the same year, 125,788 people were estimated that died due to cancer, of which 78,633 were men and 47,155 were women. The age-standardized incidence rate per 100,000 (ASIR, world standard population) of all cancers except for NMSC was estimated to be 225.6 (283.0 for men and 184.0 for women). The five most common cancers were breast cancer with an ASIR of 46.6, following prostate cancer (ASIR = 42.5), lung cancer (ASIR = 40.0), colorectal cancer (ASIR = 20.6), and thyroid cancer (ASIR = 14.3). The age-standardized mortality rate per 100,000 (ASMR, world standard population) of all cancers was estimated to be 119.9 (171.0 for men, 81.1 for women). The top 5 most common cancers for both sexes and all age groups were lung, breast, colorectal, prostate, and thyroid cancers, respectively. On the other hand, the top 5 most common cancer-caused deaths for both sexes and all age groups were lung, colorectal, stomach, pancreas, and breast cancers, respectively. The top 5 cancers with the worst 5-year age-standardized net survival rate for the sites of cancers in Türkiye between 2010 and 2014 were as follows: pancreas 10.4%, lung 14.9%, liver 15.9%, esophagus 19.0% and stomach 24.9%. Not only existing and increasing potential behavioral and possible environmental/occupational and metabolic risk factors over time are a public health threat for Türkiye, but also some unchangeable factors e.g. the aging population and the prolongation of life expectancy are contributing to increased cancer incidence. The prevalences of tobacco use and obesity are alarming. Policies to combat risk factors should be strengthened, especially the implementation of legal regulation regarding tobacco control in the field to achieve control of tobacco-related cancers. Incidence, mortality, and survival data are also considered, and preventive strategies with public health principles should be strengthened. In addition, population-based cancer registries and research on cancer epidemiology based on the data released from these registries should be supported.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"138 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eribulin along with capecitabine in relapsed invasive breast cancer- a retrospective single-Institutional study","authors":"Soumita Poddar, Amitabha Chakrabarti, Bodhisattwa Dutta, Santu Mondal, Rejakul Islam, Azizul Purkait","doi":"10.18502/bccr.v14i2.14379","DOIUrl":"https://doi.org/10.18502/bccr.v14i2.14379","url":null,"abstract":"Background: Invasive breast cancer is the most commonly diagnosed cancer at present. Due to systemic nature of disease, chemotherapy plays an important role in treatment of invasive breast cancer. Relapse (loco-regional or metastatic) is not uncommon in this disease. Both eribulin and capecitabine are effective as single agent in relapsed disease. But in combination, efficacy of these two chemotherapeutic medicines are not properly known. In this single-Institutional retrospective study, Eribulin and capecitabine have been assessed as combination chemotherapy in patients with relapsed breast cancer. \u0000Materials and methods: Patients with relapsed breast cancer, having ER and/or PR positive, Her-2/neu negative or triple negative status and received eribulin alongwith capecitabine, were included in our study. Primary objective of this study was to assess response, progression-free survival (PFS) and overall survival (OS). Secondary objective was toxicity assessment. \u0000Results: 48 patients were included in our study. Median age of patients was 56 years. Thirty six (75%) patients had ER and/or PR positive status and twelve (25%) patients had ER/PR negative status. Five (10.4%) patients achieved complete response (CR). Thirty two (66.7%) patients achieved partial response (PR). Disease was stable (SD) in nine (18.8%) patients. Two (4.2%) patients suffered from progressive disease (PD). Median Progression-free survival (PFS) was 10.15 months. Mean of PFS of patients was 10.72 (95% CI- 9.72-11.72) months. Median overall survival (OS) was 18.15 months. Mean of overall survival of patients was 19.56 (95% CI- 17.9-21.22) months. Nineteen (39.6%) and three (6.2%) patients experienced grade 2 and grade 3 anemia respectively. Eighteen (37.5%) and two (4.2%) patients suffered from grade 2 and grade 3 neutropenia respectively. One patients experienced grade 2 thrombocytopenia. Nineteen (39.6%) patients experienced grade 2 diarrhoea. One patients suffered from grade 3 diarrhoea. Palmo-plantor erythrodysesthesia had been experienced by eight (16.7%) patients. Six (12.5%) patients suffered from grade 2 neuropathy. Two (4.2%) patients experienced grade 3 neuropathy. Fatigue had been experienced by 19 (39.6%) patients. \u0000Conclusion: Eribulin alongwith capectabine can be used in patients with relapsed invasive breast cancer, in whom anthracycline and taxane have previously been used; with response rate and survival better than either single agent chemotherapy. This regimen is important particularly for triple negative breast cancer (TNBC), where option for chemotherapy is limited.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium oxide 3- methoxy salen, a synthetic biologically active complex against HeLa and McCoy cell lines","authors":"Farah Golamirad, S. Zahri, A. Abdolmaleki, Abolfazl Bezaatpour, Seyed Mehdi Razavi","doi":"10.18502/bccr.v14i1.14389","DOIUrl":"https://doi.org/10.18502/bccr.v14i1.14389","url":null,"abstract":"Background: Vanadium is an essential dietary microelement that plays a key role in metabolic pathways and has anti-neoplastic effects. In this regard, vanadium oxide 3-methoxy salen complex was produced and its anticancer effects were evaluated against HeLa and McCoy cell lines. \u0000Methods: Schiff bases produced from equivalents of Vanadyl acetylacetonate [VO(acac)2] in methanol were used to make a vanadium oxide 3-methoxy salen complex. Then, The antioxidant property of compound, cell viability and cytotoxicity assay, DNA fragmentation analysis and determination of the apoptosis pathway genes were evaluated. \u0000Results: The result showed that the compound with an RC50 value of 126.3 µM demonstrated considerable free radical scavenging activity. The combination strongly suppressed the viability and proliferation of HeLa and McCoy cell lines in a dose-dependent manner, with IC50 values of 213 µM and 175 µM, respectively. When the viability and cytotoxicity values of the treated cells were compared, it was discovered that the cells had died of apoptosis, which was validated by DNA fragmentation analysis. Capspase 3, Bcl2 antagonist/killer, and Bcl2 associated X protein (Bax) gene expression levels all increased significantly in a quantitative investigation of apoptotic pathway genes, with 2-CT values of 2.36, 2.63, and 3.18, respectively. \u0000Conclusion: In HeLa and McCoy malignant cell lines, lower quantities of the complex caused programmed cell death. This potential of complex can be used in cancer chemoprevention and cancer therapy.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"1071 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Resilience and Mindfulness with Mental toughness by the Mediating Role of Self-Compassion in Cancer Patients","authors":"Maryam Abedini, Ali Yaghobi Joibari","doi":"10.18502/bccr.v14i1.14390","DOIUrl":"https://doi.org/10.18502/bccr.v14i1.14390","url":null,"abstract":"Object: The aim of this study was to evaluate the relationship between resilience and mindfulness with mental toughness mediated by self-compassion in cancer patients. \u0000Method: The method of this research is descriptive and the correlational research design is structural equation modeling. The statistical population in this study included cancer patients in 1399 who were selected by purposive sampling. The sample consisted of 200 cancer patients (male and female) referred to the Oncology Clinical Center of Imam Hossein Hospital in Tehran. To collect data from the Short Form of Mindfulness Mind Scale, the Resilience Scale, the Compassion Scale Form, and the mental toughness Scale were used. The bootstrap method was used to analyze the intermediate relationships. \u0000Results: The results showed that the direct effect of resilience and mindfulness on self-compassion was significant with coefficients of (0.27) and (0.29). The direct effect of mindfulness on mental toughness, (0.056) was not significant, but the direct effect of resilience on mental toughness (0.31) was significant. The indirect effects of resilience and mindfulness on mental toughness with mediating role of self- compassion were significant respectively with coefficients (0.089) and (0.092). \u0000Conclusion: The results of the research have practical implications for health professionals and psychologists and it can be concluded that Resilience and Mindfulness by the mediating role of self-compassion effects on the mental toughness of cancer patients.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"160 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subependymal giant cell astrocytoma, report of a rare case","authors":"Behnaz Darvishi, Negin Farhad, Mazaher Ramezani","doi":"10.18502/bccr.v14i1.14385","DOIUrl":"https://doi.org/10.18502/bccr.v14i1.14385","url":null,"abstract":"Tuberous sclerosis complex (TSC) is a rare genetic disease that is inherited autosomal dominantly and may be associated with subependymal giant cell astrocytoma (SEGA) in 10-20% of cases. Different phenotypes are related to the form of lesions in different parts of the body, including skin, brain, kidneys, lungs, and heart. The age of the patient, the location of the tumor, and associated skin or neurological lesions may guide the pathologist for a definite diagnosis. Here we report a case of SEGA in an adolescent with TSC. Neurological clues including seizure and mental retardation, facial angiofibroma, renal mass, and histopathology examination of the brain tumor culminated in the diagnosis of TSC and SEGA.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"867 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed Tomography Guided Transthoracic Lung Biopsy: Evaluating Risk Factors of Post-Procedure Pneumothorax- A Multivariate Analysis","authors":"F. Shera, Shera Tahleel Altaf, Shah Omair Ashraf, Robbani Irfan, Choh Naseer Ahmad, Gojwari Tariq Ahmad, Dar Abdul Majeed, Shah Sonaullah","doi":"10.18502/bccr.v14i1.14387","DOIUrl":"https://doi.org/10.18502/bccr.v14i1.14387","url":null,"abstract":"Background: CT Guided lung biopsy is a common procedure in our department and pneumothorax is one of its commonest complications. To study the incidence of pneumothorax after CT guided lung biopsy and the various factors associated with the risk of developing pneumothorax after biopsy. \u0000Materials and Methods: Our study was a retrospective observational study. We analyzed 360 cases of lung biopsy performed using 18G Coaxial needle for assessing the incidence of post- procedure pneumothorax. The risk factors for pneumothorax were evaluated by univariate analysis, followed by multivariate logistic regression analysis to know the independent risk factors of pneumothorax. \u0000Results: The incidence of pneumothorax in our study was 41.9% (151/360 cases). On univariate analysis, we identified the following as risk factors of post-procedure pneumothorax: the presence of emphysema, smaller lesion size, Greater lesion depth, Lateral position, multiple passes and acute angulation of needle trajectory. On multivariate logistic regression analysis these were also revealed to be independent risk factors of post-procedure pneumothorax. \u0000Conclusion: Independent risk factors of post procedure pneumothorax are the presence of emphysema, smaller lesion size, greater lesion depth, Lateral position, multiple passes and acute angulation of needle trajectory. Of these lateral position is a novel predictor of pneumothorax that has been scarcely mentioned in literature. As such the radiologist should be prepared for managing pneumothorax in cases with one or more of these risk factors","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"1 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Changes in miR-7113-3p, miR-6721-5p, and MAP2K1 gene expressions in tumor and normal tissues of patients with oral cancer","authors":"Kebria Mohammadi, Mahshid Rafi, Hadiseh Mohammadpour, F. Jamshidian","doi":"10.18502/bccr.v14i2.14378","DOIUrl":"https://doi.org/10.18502/bccr.v14i2.14378","url":null,"abstract":"Background: Squamous cell carcinoma of the oral cavity (OSCC) is one of the most common cancers in the Head and Neck Squamous Cell Cancer (HNSCC) group. The increasing frequency of oral carcinomas and their late-stage appearance is a major worldwide health concern. MicroRNAs (miRNAs) play an important role in cancer growth and progression, as the available relevant data indicate. However, no information is available about the parts miR-7113-3p and miR-6721-5p taken in OSCC. In the present study, the expression of MAP2K1, miR-7113-3p, and miR-6721-5p was examined to determine their possible biological role in the advancement of oral squamous cell carcinoma. \u0000Methods: Quantitative Real-Time PCR was applied to investigate the mRNA expression of MAP2K1, miR-7113-3p, and miR-6721-5p in fresh frozen OSCC tissues and adjacent normal fresh frozen tissues of 30 patients and then, the relationship between MAP2K1 Expression and clinical parameters was studied. \u0000Results: MAP2K1 expression dramatically increased in tumor tissues compared to the normal tissues, while miR7113-3p and miR-6721-5p expression significantly decreased. Furthermore, a statistical correlation of p=0.04 was also observed between increased MAP2K1 expression and Perineural invasion. In addition, the downregulation of miR-7113-3p was positively correlated with the overexpression of MAP2K1 (p=0.0218), and a negative correlation was observed between the downregulation of miR-6721-5p and overexpression of MAP2K1 (p=0.7771). \u0000Conclusion: Based on the findings, miR-7113-3p, and miR-6721-5p might be prospective biomarkers for OSCC patients and can be utilized to detect OSCC at an early stage of its diagnosis. MAP2K1 overexpression is linked to the development of OSCC and Perineural invasion.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surgical management of melanotic prognoma tumor of Infancy – A case report","authors":"Shilpa Hazare, Isha Hazarey, Jitendra Hazarey, Pritish Bhansali, Vishal Mahant, Rashiqua Sadiya","doi":"10.18502/bccr.v14i3.14355","DOIUrl":"https://doi.org/10.18502/bccr.v14i3.14355","url":null,"abstract":"Melanotic neuroectodermal tumors (MNTI) also known as retinal anlage tumor and melanotic progonoma is highly aggressive lesion found in children within 6 months of age. It is a relatively rare pathology and is also rare to metastasise. MNTI can be seen in various locations within the oral cavity, the most common being maxillary jaw. Presently advent technology of has enabled us to utilise various different modalities ranging from radical excision, incomplete resection to chemotherapy. Chemotherapy is preferred in cases of contraindication of surgical approaches. The results regarding each approach can be mixed, successful tumour regression or complete failure. The present article focuses on successful subtotal excision of MNTI in a one year old infant.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"2 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138586148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Psychotherapy Interventions and Mental Activity in Control of Pain in Patients with Breast Cancer","authors":"Sepideh Farahani, Sanaz Fakhim, Shahin Amiri, Fatemeh Mousavi, Mehdi Azad","doi":"10.18502/bccr.v14i3.14356","DOIUrl":"https://doi.org/10.18502/bccr.v14i3.14356","url":null,"abstract":"Background and aim: Pain is known as the greatest complication of cancer and cancer-related therapies. Therefore, control of pain has been considered with pharmaceutical and non-pharmaceutical methods. This study was performed to survey of mental and psychological activities in control of pain in patients with breast cancer. \u0000Methods and materials: 166 patients with breast cancer were selected randomly in a specialist hospital in Tehran, Iran and the questionnaire, and the consent letter was completed by them. Patients were categorized into three groups; first group includes patients with great spirits and hope for complete recovery. Second group includes patients with major depression, and third group includes patients with moderate spirits. Most data in this study were for the primary group. \u0000Results: According to data, in the deviation group, no acceptable mean of pain was obtained. In the hypothesis group, mean of pain was more passable. In the group which patients were conversed with own, mean of pain was more than previous two groups. The lowest mean of pain was related to the negative hypothesis group, and the highest mean of pain was related to patients who were prayed and hoped. \u0000Conclusion: The obtained results showed that deviation and activity of mental are good way to control and reduce of pain. This method is without side effects, inexpensive and accessible, which reduces of pain in patients. This study suggests that use of mental activity is a non-pharmacological treatment to reduce of pain in outpatient and hospitalized patients.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking and alcohol, both alone and in combination, for risk of gastric cancer: A systematic review","authors":"Fatemeh Hosseinie, Mahdieh Farhanji, Ali Meshkinyazd, M. Khakzad","doi":"10.18502/bccr.v14i2.14380","DOIUrl":"https://doi.org/10.18502/bccr.v14i2.14380","url":null,"abstract":"Introduction: Stomach cancer is the fifth most common cancer and the fourth leading cause of cancer deaths worldwide in 2020. Moderately increased risk of stomach cancer has been associated with tobacco smoking and Alcohol drinking. In this systematic review, we summarized the current knowledge on the relation between smoking and alcohol, both alone and in combination, to the risk of gastric cancer. \u0000Method: This study was conducted in 2023 with a structured overview in the Science Directe , PubMed, Web of Science (ISI) databases. We investigated the studies that were published between 2010 and 2023. In the first step, articles were extracted based on their titles and abstracts; the quality of 58 articles was evaluated using the STORBE tool. Inclusion criteria were English language (first step), year of the study and the study type (second step). \u0000Findings: Of these 39 articles, 17 ones were case-control studies, 21 were cohort studies, one was a descriptive study. eleven articles were related to alcohol consumption and risk of gastric cancer, twenty-three articles were related to smoking and risk of gastric cancer, five articles were related smoking and alcohol consumption in combination and risk of gastric cancer. Many studies reported a significant association between alcohol and gastric cancer risk. Also, three studies showed that smoking acts as a risk factor for developing gastric cancer only in certain genotype and not in all people. \u0000Conclusion: Based on the best our knowledge and present studies, consumption of alcohol and smoking are risk factors of gastric cancer. It is better to conduct more studies on this issue in different populations in the future. We also suggest that future studies focus more on the intracellular mechanisms of these associations than on epidemiological outcomes.","PeriodicalId":280576,"journal":{"name":"Basic & Clinical Cancer Research","volume":"4 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138586096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}