Chronobiology in Medicine最新文献_第9页

Sleep and Circadian Rhythm Disturbances in Eating Disorders 饮食失调中的睡眠和昼夜节律紊乱

Chronobiology in Medicine Pub Date : 2020-12-31 DOI: 10.33069/cim.2020.0027

Sojeong Kim, Heon-Jeong Lee

引用次数: 3

Opioid Withdrawal and Restless Legs Syndrome 阿片类药物戒断和不宁腿综合征

Chronobiology in Medicine Pub Date : 2020-12-15 DOI: 10.33069/cim.2020.0026

E. Park, Young-Min Park

引用次数: 2

Why Do We Need a Simple and Practical Circadian Biomarker? 为什么我们需要一个简单实用的昼夜生物标志物?

Chronobiology in Medicine Pub Date : 2020-12-15 DOI: 10.33069/cim.2020.0029

Heon-Jeong Lee

{"title":"Why Do We Need a Simple and Practical Circadian Biomarker?","authors":"Heon-Jeong Lee","doi":"10.33069/cim.2020.0029","DOIUrl":"https://doi.org/10.33069/cim.2020.0029","url":null,"abstract":"All living organisms, including humans, show rhythmic changes in physiological, biochemical, and behavioral parameters. These changes can help optimize energy use, prioritizing certain body functions at certain times of the day and saving energy at other times. Circadian rhythm with about 24-hour cycle controls various functions of human beings. The central and peripheral circadian clocks regulate the circadian rhythm in response to environmental signals such as sunlight, food, and body activity. Circadian variations have also been observed in many various diseases such as hypertension, coronary arterial diseases, bronchial asthma, epilepsy, mood disorders, and cancer [1]. Chronotherapeutic strategies to optimize the timing of therapeutic intervention is being developed in medical field and have been implemented in various circadian diseases. However, high cost of clinical trials incorporating chronopharmacological approaches and the absence of a reliable circadian biomarker to guide chronotherapeutics are important limitations in this area. Serum/salivary levels of melatonin and cortisol and core body temperature (CBT) rhythms have been considered as circadian biomarkers controlled by the master circadian clock located in hypothalamic suprachiasmatic nuclei [2,3]. Circadian rhythm in human being is commonly assessed by repeatedly measuring the CBT, the circadian profile in serum/salivary cortisol concentration during the day, or by measuring the dim-light melatonin-onset (DLMO). However, these can be invasive or impractical due to the complexity of the process and because they cannot be easily measured in everyday life. Therefore, development of a simple and reliable method for measuring circadian rhythm is needed. PERSPECTIVE eISSN 2635-9162 / https://chronobiologyinmedicine.org Chronobiol Med 2020;2(4):135-136 / https://doi.org/10.33069/cim.2020.0029 CIM","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127459457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Activation Changes in Insomnia: A Review of Functional Magnetic Resonance Imaging Studies 失眠症的脑激活变化:功能磁共振成像研究综述

Chronobiology in Medicine Pub Date : 2020-09-28 DOI: 10.33069/CIM.2020.0021

Yu-Yean Hwang, Seog-Ju Kim

引用次数: 2

Human Circadian Rhythm and Social Distancing in the COVID-19 Crisis COVID-19危机中的人类昼夜节律和社会距离

Chronobiology in Medicine Pub Date : 2020-05-28 DOI: 10.33069/cim.2020.0013

Heon-Jeong Lee

{"title":"Human Circadian Rhythm and Social Distancing in the COVID-19 Crisis","authors":"Heon-Jeong Lee","doi":"10.33069/cim.2020.0013","DOIUrl":"https://doi.org/10.33069/cim.2020.0013","url":null,"abstract":"Social distancing is a set of non-pharmaceutical interventions and measures that may be recommended during pandemics. Social distancing is practiced to prevent the spread of a contagious disease by increasing the physical distance or reducing the number of times people come into close contact with each other [1]. Social distancing has become a strong shield in the fight against the virus causing coronavirus disease 2019 (COVID-19). To curtail the spread of COVID-19 and avoid overburdening the healthcare systems, several social distancing measures have been enforced, including closure of schools and workplaces, isolation, and restriction of public movement. Although social distancing is effective to prevent COVID-19 transmission [2], it has various social, economic, and health problems. One of them is increasing the risk of circadian rhythm disturbances due to the loss of daily routine and irregular pattern of living. Therefore, practice of social distancing should not be the only emphasis. Concomitantly, it is important to maintain the daily routine of life and ensure regular circadian rhythms. Maintaining the circadian rhythm is essential for good health. The circadian clock, which is found in almost every organ of the body and the brain, is pivotal for a well-functioning immune system. Synchronization of the circadian rhythms in the lungs, heart, liver, and brain ensure continuation of routine physiological processes. It also ensures the maintenance of a healthy immune system that can effectively fight and defeat the virus. Recent studies demonstrate the importance of circadian rhythms and sleep in Human Circadian Rhythm and Social Distancing in the COVID-19 Crisis","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121465818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Delayed Circadian Rhythms and Pars Tuberalis Dysfunction in Mood Disorders 情绪障碍患者的昼夜节律延迟和结节部功能障碍

Chronobiology in Medicine Pub Date : 2020-03-31 DOI: 10.33069/cim.2020.0001

D. Kripke

{"title":"Delayed Circadian Rhythms and Pars Tuberalis Dysfunction in Mood Disorders","authors":"D. Kripke","doi":"10.33069/cim.2020.0001","DOIUrl":"https://doi.org/10.33069/cim.2020.0001","url":null,"abstract":"Professor Lee’s discussion of circadian misalignment associated with bipolar disorder explained the convincing evidence that circadian rhythm phase delaying is associated with bipolar disorder [1]. Indeed, much objective evidence indicates behavioral association, as well as evidence of causality, both for bipolar disorder and for unipolar major depressions. The skin fibroblasts from bipolar patients grown in tissue culture in-vitro had longer free-running circadian periods [2]. Moreover, the subjective chronotype (e.g., degree of delayed sleep phase) of bipolar patients predicted their response to lithium, with the more delayed patients having poorer responses [3]. This corresponds to other evidence from cell cultures that depressed patients have longer intrinsic circadian rhythms in vitro [4]. Associations with particular genetic polymorphisms have been suggested. In a broader sense, massive genome-wide association studies and Mendelian randomization analyses confirmed the causal role of genetic polymorphisms in circadian rhythm characteristics and resultant mood variations [5]. The responses of bipolar patients to morning bright light therapy, wake therapy, and imposed sleep schedule advances confirm the relevance of circadian interventions to therapeutic management [6,7]. It has been suggested that morning bright light, by suppressing morning melatonin, facilitates hypothalamic pars tuberalis release of thyrotropin (T3) into the hypothalamus, with subsequent regulation of pituitary gonadotropins and ACTH [8]. Lack of adequate light or too much light at unfavorable times may lead to pars tuberalis dysfunction. Delayed Circadian Rhythms and Pars Tuberalis Dysfunction in Mood Disorders","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130192114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency 睡眠时间短、注意力不集中、抑郁与智能手机成瘾倾向之间间接关系的中介作用

Chronobiology in Medicine Pub Date : 2020-03-31 DOI: 10.33069/cim.2020.0004

Yoon-Seok Kim, So-Jin Lee, Chul-Soo Park, B. Kim, Cheol-Soon Lee, B. Cha, Dongyun Lee, Jae-Won Choi, Young-Ji Lee, Jiyeong Seo

引用次数: 9

Artificial Illumination in the Prison: General Recommendation for Prisoner and Associated Staffs 监狱人工照明:给囚犯和相关工作人员的一般建议

Chronobiology in Medicine Pub Date : 2019-12-31 DOI: 10.33069/cim.2019.0024

Z. A. Khan, A. Chattoraj

引用次数: 1

Comparison of Morning and Evening/Night Dosing on the Efficacy of Escitalopram in Major Depressive Disorder at Naturalistic Setting 自然环境下艾司西酞普兰早晚给药对重度抑郁症疗效的比较

Chronobiology in Medicine Pub Date : 2019-12-31 DOI: 10.33069/cim.2019.0029

Kyu-Man Han, Ho-Kyoung Yoon

{"title":"Comparison of Morning and Evening/Night Dosing on the Efficacy of Escitalopram in Major Depressive Disorder at Naturalistic Setting","authors":"Kyu-Man Han, Ho-Kyoung Yoon","doi":"10.33069/cim.2019.0029","DOIUrl":"https://doi.org/10.33069/cim.2019.0029","url":null,"abstract":"Objective: Recent epidemiological and clinical studies have revealed that timing medications to the individual’s biological clock could improve their effectiveness and reduce side effects. We aimed to investigate the association of escitalopram dosing time with treatment response and changes in global depressive and insomnia symptoms after 8-week of antidepressant treatment in a naturalistic setting in patients with major depressive disorder (MDD). Methods: A total of 71 patients with MDD taking escitalopram were recruited from the outpatient psychiatric clinic in a university hospital. The severity of depressive symptoms of all patients was assessed using the 17-item Hamilton Depression Rating Scale (HDRS) at the baseline and 8-week after the antidepressant treatment. The patients were classified into the Morning or Evening/Night group according to their time of escitalopram single dose. Results: The time of escitalopram single dose (morning vs. evening/night) was not associated with treatment response after 8-week of treatment when controlling for potential confounding factors in patients with MDD. No significant difference in changes in total HDRS score and insomnia-related subscale score was observed between the Morning and Evening/ Night groups. Conclusion: The present study suggests that the time of escitalopram single dose did not affect the treatment response or changes in global depressive and insomnia symptoms after 8-week of antidepressant treatment in a naturalistic setting.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133173938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Function and Effects of Body Position in Patients with Obstructive Sleep Apnea 阻塞性睡眠呼吸暂停患者的肺功能及体位的影响

Chronobiology in Medicine Pub Date : 2019-12-31 DOI: 10.33069/cim.2019.0025

S. Kim, H. Kang, W. Ban, S. H. Lee

{"title":"Pulmonary Function and Effects of Body Position in Patients with Obstructive Sleep Apnea","authors":"S. Kim, H. Kang, W. Ban, S. H. Lee","doi":"10.33069/cim.2019.0025","DOIUrl":"https://doi.org/10.33069/cim.2019.0025","url":null,"abstract":"Purpose: Obstructive sleep apnea (OSA) is known to be associated with upper airway collapse during sleep. However, OSA has also been suggested to have effects on the lower airway. This study examined the association between pulmonary function test (PFT) results and OSA according to the severity of OSA and the presence of obesity. Changes in PFT results with body position (sitting vs. supine) were also analyzed. Methods: A total of 46 patients who were diagnosed with OSA were included in this study. Patients were grouped according to the severity of OSA and the presence of obesity. Results: Obese, severe OSA patients tended to show poorer pulmonary function than non-obese, mild-to-moderate OSA patients. Forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC; sitting), peak expiratory flow (PEF; sitting), and forced expiratory flow during the middle half of the FVC (FEF25-75; supine) were significantly lower in the severe OSA group than the mild-to-moderate OSA group (P=0.020, P=0.044, and P=0.042, respectively). Positional change from sitting to the supine position significantly reduced pulmonary function in the total OSA patient population. The effect of body position on PFT results was greater in non-obese, mild-to-moderate OSA patients. FEF25-75 in the sitting position was still significantly related to the apnea-hypopnea index in OSA patients after adjusting for other factors (P=0.048). Conclusions: This study indicated that relationships exist between lower airway function, body position, and OSA. The PFT is a simple test that can provide useful information about the upper and lower airways in OSA patients.","PeriodicalId":277997,"journal":{"name":"Chronobiology in Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129221078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1