MOJ Cell Science & Report最新文献

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Has Kisspeptin found a place to be a biomarker in the differentiation of viability of early pregnancy-a short commentary Kisspeptin是否在早期妊娠生存能力的分化中找到了一个生物标志物的位置

MOJ Cell Science & Report Pub Date : 2018-08-29 DOI: 10.15406/MOJCSR.2018.05.00115

K. Kaur, G. Allahbadia, E. Singh

引用次数: 0

Epigenetic regulation mechanisms in stem cell differentiation 干细胞分化的表观遗传调控机制

MOJ Cell Science & Report Pub Date : 2018-07-31 DOI: 10.15406/MOJCSR.2018.05.00114

Burcu Biterge-Süt

{"title":"Epigenetic regulation mechanisms in stem cell differentiation","authors":"Burcu Biterge-Süt","doi":"10.15406/MOJCSR.2018.05.00114","DOIUrl":"https://doi.org/10.15406/MOJCSR.2018.05.00114","url":null,"abstract":"Pluripotent stem cells have the capability of differentiating into cells from all three germ layers endoderm, mesoderm and ectoderm; as well as an unlimited potency to self-renew, maintaining their stem cell identity. Embryonic stem cells that are derived from the inner cell mass of the mammalian blastocyst can give rise to a fully developed viable embryo with more than 200 different cell types, which essentially share the same genetic information, namely the DNA. The establishment of distinct cellular identities requires differential interpretation of this genetic information in the form of differential gene expression patterns, which is largely influenced by DNA accessibility and is modulated by mechanisms that are beyond DNA sequence, indicating epigenetic regulation. In eukaryotes, DNA is compacted into a macromolecular structure called chromatin. The packaging of DNA into chromatin is done in a dynamic manner so that the DNA can still be accessible to carry out cellular functions such as replication, transcription and DNA repair. The naked DNA first gets wrapped around the histone octamer containing two copies of each core histone H2A, H2B, H3 and H4, which constitutes the first step of compaction called the “beads on a string” conformation.1 Next, the linker histone H1 binds to the nucleosome at the DNA entry-exit point and further condenses the DNA into 30nm chromatin fiber. Metaphase chromosomes represent the most compact form of chromatin2","PeriodicalId":273682,"journal":{"name":"MOJ Cell Science & Report","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129930889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Misunderstanding of ATP involvement in inflammation and stages of inflammation 误解ATP参与炎症和炎症的阶段

MOJ Cell Science & Report Pub Date : 2018-07-02 DOI: 10.15406/MOJCSR.2018.05.00113

Gerd Wasser

{"title":"Misunderstanding of ATP involvement in inflammation and stages of inflammation","authors":"Gerd Wasser","doi":"10.15406/MOJCSR.2018.05.00113","DOIUrl":"https://doi.org/10.15406/MOJCSR.2018.05.00113","url":null,"abstract":"a specific detector of large increases in [eATP], such as those that occur on cell death`. Necrotic cells are considered to expel ATP.1,5 The applied concentration exceeded the physiological amount of 1μmol / ml full blood hundred-fold. Even in one of the latest publication 2012 of the New York Academy of Sciences researchers still believe that ATP is secreted by necrotic cells.6 Even though a publication by Welsch7 as early as 1994 in detail described the ATP content in the MCA and penumbra area after occlusion and reperfusion of the middle cerebral artery7 the apprehension is still propagated. From the pathophysiological point of view the release of ATP from necrotic tissue is not acceptable. These cells have undergone necrosis in the wake of total ATP depletion. The neuronal unit consists of endothelial cells, astrocytes, and neurons. In 1999 Magistretti published that neurons mainly metabolize lactate and are widely devoid of the glycolytic pathways.8 Whereas the astrocytes engage the endothelial cells by their processes and neurons the latter do not have access to the capillary system.9 Neurons do not metabolize glucose for energy production and therefore cannot produce ATP by glycolysis. Instead they are fed with lactate by astrocytes to meet metabolic demand and are extremely vulnerable to lack of oxygen.8","PeriodicalId":273682,"journal":{"name":"MOJ Cell Science & Report","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124067482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1