{"title":"Peptide Cyclization Methodologies Amenable to in Vitro Display","authors":"H. Suga, Ata Abbas","doi":"10.51167/acm00018","DOIUrl":"https://doi.org/10.51167/acm00018","url":null,"abstract":"Display technology platforms offer their own unique set of challenges for chemical transformations, at the heart of which lies peptide macrocyclization. The amenable reactions for peptide macrocyclization on this platform need to meet a number of criteria like high reactivity, selectivity, mild conditions, irreversibility, and in many cases, a unique requirement to be assimilated into the translation machinery. Skillful utilization of these reactions has led to the formation of huge macrocyclic peptide libraries with varied linkages and topographies which have in turn led to the discovery of a number of hits for purposes such as drug discovery and others. Herein, we review those reactions which have mainly been applied in mRNA and phage display and discuss their technical characteristics and significance.","PeriodicalId":272074,"journal":{"name":"AsiaChem Magazine","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131111128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supramolecular Polymerization: Personal History and Outlook Towards a Sustainable Future","authors":"T. Aida, Kiyoshi Morishita","doi":"10.51167/acm00019","DOIUrl":"https://doi.org/10.51167/acm00019","url":null,"abstract":"2020 was a very special year for polymer science as the 100-year anniversary of its initiation by Staudinger. The past 100 years have been a prosperous time for polymer science, filled with discovery and innovation. Since plastics are lightweight, mechanically robust, and cheap, their use has proliferated, becoming pervasive in all sectors of society and ushering in the so-called heyday of plastics. At the same time, however, the plastics and rubbers developed by polymer science have caused catastrophic damage to the environment as long-lasting wastes continue to accumulate in the disposable age. Incinerating these materials generates carbon dioxide, which accelerates global warming while dumping them into the ocean results in their eventual disintegration into microplastics, small pieces that are consumed and accumulate in the food chain. As of 2015, only 9% of the 6300 million metric tons of plastics produced had been recycled,1 and unless far-reaching policies are adopted in the next decade to change the social structure that has so far been dependent on disposable polymers, global warming will continue to accelerate and it will certainly be difficult to pass on livable earth to future generations. Although this crisis is widely acknowledged, society has thus far been unable to give up such convenient and cheap materials. If we fail to shift our economic priorities or invent new materials as alternatives, it will be impossible to escape from this plastic world.","PeriodicalId":272074,"journal":{"name":"AsiaChem Magazine","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129213279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From structural to functional materials: a green way to produce functional biopolymers based on polypeptides","authors":"K. Numata, K. Tsuchiya","doi":"10.51167/acm00021","DOIUrl":"https://doi.org/10.51167/acm00021","url":null,"abstract":"","PeriodicalId":272074,"journal":{"name":"AsiaChem Magazine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121870603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AsiaChem MagazinePub Date : 2021-12-31DOI: 10.51167/acm00020.51167/acm00021
M. Abe, Zhe Wang, Rikuo Akisaka
{"title":"New Insights into Bond Homolysis Process and Discovery of Novel Bonding System (C–π–C) by Generating Long-lived Singlet Diradicals","authors":"M. Abe, Zhe Wang, Rikuo Akisaka","doi":"10.51167/acm00020.51167/acm00021","DOIUrl":"https://doi.org/10.51167/acm00020.51167/acm00021","url":null,"abstract":"In recent years, low-valent chemical species such as radicals and carbenes, which have been recognized as short-lived intermediates, have been isolated by appropriate molecular design, and their chemical properties have been investigated in detail experimentally. In particular, the discovery of isolable carbenes, which are now widely used as indispensable ligands in coordination chemistry and synthetic organic chemistry, has enabled the development of novel highly active catalysts.","PeriodicalId":272074,"journal":{"name":"AsiaChem Magazine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123650614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Chemical Society of Japan: Striving for Chemical Sciences and Technology for a Sustainable Human Society","authors":"M. Sawamoto","doi":"10.51167/acm00017","DOIUrl":"https://doi.org/10.51167/acm00017","url":null,"abstract":"The Chemical Society of Japan (CSJ), with a long history extending over 140 years and membership of ca. 24,000, is one of the world’s largest, most active, and internationally recognized societies in chemistry. The history of CSJ dates back to 1878 (just ten years after the Meiji Restoration, where Japan was reborn), when about twenty motivated and enthusiastic young scholars launched a small organization, the Chemical Society, in Tokyo for the advancement of chemistry. In the following year, the embryonic society was renamed The Tokyo Chemical Society and eventually the current name, The Chemical Society of Japan, in 1921. In 1948, shortly after World War II, the then CSJ merged with the Society of Chemical Industry, founded in 1898, into an integrated organization with the same name: ”The Chemical Society of Japan”. The integration was in part symbolic in defining the renewed CSJ’s perspective: CSJ consists of comparable numbers of individual members from both academia and industry along with supporting company affiliates; its activities cover virtually all segments of pure and applied chemistry along with diverse interdisciplinary areas now extended to physics, biology, medicine, materials, and advanced technology. Since 2011 CSJ is a public interest incorporated association, a nonprofit tax-exempt organization legitimately certified and under the jurisdiction of the Japanese Cabinet.","PeriodicalId":272074,"journal":{"name":"AsiaChem Magazine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121146537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}