Hormozgan Medical Journal最新文献

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Predicting the Meaning of Life Based on Moral Development, Cognitive Styles, and Hopefulness in Patients With Type 2 Diabetes 基于2型糖尿病患者道德发展、认知方式和希望的生命意义预测
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.22
Mona Ajabi, Seyedeh Zahra Sadati, Zohreh Zadhasan, S. Ouliaei
{"title":"Predicting the Meaning of Life Based on Moral Development, Cognitive Styles, and Hopefulness in Patients With Type 2 Diabetes","authors":"Mona Ajabi, Seyedeh Zahra Sadati, Zohreh Zadhasan, S. Ouliaei","doi":"10.34172/hmj.2022.22","DOIUrl":"https://doi.org/10.34172/hmj.2022.22","url":null,"abstract":"Background: Diabetes is the fifth leading cause of death in most countries of the world and causes disability, disability, high medical costs, and increased mortality. This study aimed to predict the meaning of life based on moral development, cognitive styles, and hopefulness in patients with type 2 diabetes (T2D). Methods: The statistical population of this descriptive-correlational study consisted of all patients of the Karaj Diabetes Association in 2019 (Iran), among whom 200 cases were selected by the convenience sampling method and Cochran formula. The Meaning of Life Questionnaire (2006), Kohlberg’s Moral development Test (1977), Kolb Cognitive Styles Scale (1981), and Snyder Hope scale (1996) were used for data collection. Pearson correlation test and multiple linear regression were applied to analyze the data by SPSS23, and the significance level was 0.05. Results: The results revealed that moral development (β=0.15, P=0.03), cognitive styles (β=0.38, P<0.001), and hopefulness (β=0.22, P<0.001) had a positive effect on the meaning of life. Conclusion: It can be concluded that moral development, cognitive styles, and hopefulness can predict the meaning of life among people with T2D, highlighting the importance of the role of the meaning of life in people with T2D.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129026443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effects of Sodium Valproate and Carbamazepine on Renal Function in Children With Epilepsy 丙戊酸钠与卡马西平对癫痫患儿肾功能影响的比较
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.25
Maryam Esteghamati, A. Moayedi, Ehsan Hoseinzadeh, Ghazal Zoghi
{"title":"Comparison of the Effects of Sodium Valproate and Carbamazepine on Renal Function in Children With Epilepsy","authors":"Maryam Esteghamati, A. Moayedi, Ehsan Hoseinzadeh, Ghazal Zoghi","doi":"10.34172/hmj.2022.25","DOIUrl":"https://doi.org/10.34172/hmj.2022.25","url":null,"abstract":"Background: Renal disorders have been observed with the long-term treatment of some antiepileptic drugs (AEDs). We aimed to compare the effects of carbamazepine (CBZ) and valproate (VPA) on renal function in children with epilepsy. Methods: This quasi-experimental study included children with epilepsy aged 2 months to 14 years who had persistently been receiving CBZ or VLP monotherapy for more than 6 months and were referred to Bandar Abbas Children’s Hospital, Bandar Abbas, Iran, 2019-2020. Demographic features, including age and sex, as well as family history of epilepsy, disease duration, and duration of treatment were recorded for each patient. Random blood and urine samples, along with 24-hour urine samples were collected from all the participants. Blood urea nitrogen (BUN), sodium, alkaline phosphatase (ALP), and pH were measured in blood samples. Glucose, protein, sodium, potassium, phosphorus, and creatinine were estimated in 24-hour urine samples. N-acetyl-beta-D-glucosaminidase (NAG) and pH were assessed in random urine samples. Results: Of the 80 children in this study with a mean age of 7.43±3.22 years, 58 (72.5%) were males. Children in both groups were comparable in terms of age, sex, family history of epilepsy, and disease and treatment duration. The urine NAG level was significantly higher in the VPA group compared to the CBZ group (P=0.010). Further, 24-hour urine protein and glucose levels were significantly higher in the VPA group. As for blood parameters, except for sodium (P=0.034), ALP (P<0.001), and pH (P=0.006) which were significantly higher in the CBZ group, other parameters were significantly higher in the VPA group. Conclusion: Overall, CBZ appears to be safer than VPA regarding its effects on renal function in children treated for epilepsy.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130691867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Rectal Teratoma Presenting as an Irritable Bowel-like Syndrome: A Case Report 原发性直肠畸胎瘤表现为肠易激综合征1例报告
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.29
M. Pashaei, Amir Tahavori
{"title":"Primary Rectal Teratoma Presenting as an Irritable Bowel-like Syndrome: A Case Report","authors":"M. Pashaei, Amir Tahavori","doi":"10.34172/hmj.2022.29","DOIUrl":"https://doi.org/10.34172/hmj.2022.29","url":null,"abstract":"Background: Teratoma is a tumor comprised of three germinal layers classified as mature or immature in most cases. Most mature solid teratomas are benign but may turn malignant; therefore, complete resection is advised in these cases. They usually occur in women. Primary rectal teratomas are infrequent, and only a few cases have been described in the literature. Teratomas are the most common cystic that rise in the ovary, testicle, and retroperitoneum. They can also be solid and are better known as dermoid cysts. Case Presentation: We report a 34-year-old woman who were presented with intermittent constipation and diarrhea in Urmia Imam Khomeini Hospital in January 2020. After examination, a solid intra-rectal teratoma occurring mainly in the rectum was detected in this case. The patient underwent segmental colectomy and histology, which revealed squamous epithelium, fat cells, hair follicles, cartilaginous material, and granuloma suggestive of mature teratoma. Conclusion: The present case was a solid primary rectal teratoma, an uncommon disease with many misdiagnoses that can be differentiated from other diseases. In this case report, it is differentiated from irritable bowel syndrome (IBS).","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122961357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Disorders in First-Degree Relatives of Patients With Type 2 Diabetes in a Southern Coastal Region in Iran 伊朗南部沿海地区2型糖尿病患者一级亲属代谢紊乱
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.23
Ghazal Zoghi, R. Shahbazi, A. Atashabparvar, M. Mahmoodi, Alireza Dastvareh, S. Kheirandish, Masoumeh Kheirandish
{"title":"Metabolic Disorders in First-Degree Relatives of Patients With Type 2 Diabetes in a Southern Coastal Region in Iran","authors":"Ghazal Zoghi, R. Shahbazi, A. Atashabparvar, M. Mahmoodi, Alireza Dastvareh, S. Kheirandish, Masoumeh Kheirandish","doi":"10.34172/hmj.2022.23","DOIUrl":"https://doi.org/10.34172/hmj.2022.23","url":null,"abstract":"Background: Diabetes mellitus is a global health challenge. Metabolic disorders in first-degree relatives (FDRs) of patients with type 2 diabetes mellitus (T2DM) have been linked to a family history of diabetes. Objectives: This study aimed to investigate the frequency of metabolic syndrome (MetS), diabetes, and prediabetes in FDRs of patients with T2DM. Methods: This descriptive study included FDRs of patients with T2DM referred to the diabetes clinic of Shahid Mohammadi Hospital, Bandar Abbas, Iran in 2017. Waist circumference (WC) and blood pressure were measured for each participant. Fasting plasma glucose was measured in venous blood samples after 8-hour fasting. Two-hour plasma glucose was measured after a 75-g oral glucose tolerance test. Triglyceride and high-density lipoprotein were measured in venous blood samples after 12-hour fasting. The Adult Treatment Panel III (ATP III) and the International Diabetes Federation (IDF) criteria were used to diagnose MetS. Iranian-specific WC cutoffs from different studies were also used as alternatives for WC cutoffs in IDF criteria to form Iranian-specific MetS criteria. Results: This study included 300 FDRs (male: 33.7% vs. female: 66.3%) of patients with T2DM, with a mean age of 33.56±10.64 years. Among the participants, 19.7% had prediabetes and 8% had diabetes. MetS was diagnosed in 8.3% and 15% of the FDRs based on the ATP III and IDF criteria, respectively. The frequency of MetS ranged from 6.7% to 11.7% based on six different Iranian-specific WC cutoffs. Conclusion: The frequency of MetS, diabetes, and prediabetes was quite high in the FDRs of patients with T2DM. Screening for these metabolic disorders can help prevent future cardiovascular events in this specific group.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126203372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Levels of Interleukin-21 in Acute Kidney Injury After Cardiopulmonary Bypass Surgery 体外循环手术后急性肾损伤患者白细胞介素-21水平升高
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.21
N. Naderi, Mostafa Mohebkiya, H. Montazerghaem, M. Khayatian, M. Rahimzadeh
{"title":"Elevated Levels of Interleukin-21 in Acute Kidney Injury After Cardiopulmonary Bypass Surgery","authors":"N. Naderi, Mostafa Mohebkiya, H. Montazerghaem, M. Khayatian, M. Rahimzadeh","doi":"10.34172/hmj.2022.21","DOIUrl":"https://doi.org/10.34172/hmj.2022.21","url":null,"abstract":"Background: It is well-established that complications following cardiopulmonary bypass (CPB) such as acute kidney injury (AKI) lead to worse outcomes and higher mortality. Considering the importance of the post-CPB inflammatory cytokine cascade, we first assessed the post-operative interleukin (IL)-21 serum level and its association with AKI development after CPB. Methods: In this experimental before-after study, 40 patients with confirmed CPB-AKI in the Jorjani Heart Center, Bandar Abbas (from January 2017 to September 2018) were compared with 50 non-AKI patients. AKI was defined according to the Acute Kidney Injury Network. The IL-21 serum level was measured using an enzyme-linked immunosorbent assay before and 12 hours after surgery. The association between IL-21 and other variables was evaluated by correlation analyses. Results: The IL-21 serum level was significantly higher post-operation compared to its level before surgery in AKI (21.4±6.3 and 15.7±5.5, P<0.001) and non-AKI (19.1±6.4 and 13.7±6.3, P<0.001) patients, but no significant differences were observed between AKI and non-AKI patients. Age, body mass index, and creatinine were not significantly correlated with the IL-21 serum level 12 hours post operations in AKI and non-AKI subjects. Conclusion: Serum IL-21 concentrations were significantly increased in CPB patients after operation, which may contribute to the post-CPB inflammatory response syndrome. Our data did not confirm any association between increased IL-21 levels and CPB-AKI risk.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132421202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Metabolic Syndrome in Vitiligo Patients in Comparison With the Control Group 白癜风患者代谢综合征患病率与对照组比较
Hormozgan Medical Journal Pub Date : 2022-07-01 DOI: 10.34172/hmj.2022.24
S. Shamsi meymandi, Mahin Aflatoonian, M. Khalili, Masoumeh Sarvandi
{"title":"Prevalence of Metabolic Syndrome in Vitiligo Patients in Comparison With the Control Group","authors":"S. Shamsi meymandi, Mahin Aflatoonian, M. Khalili, Masoumeh Sarvandi","doi":"10.34172/hmj.2022.24","DOIUrl":"https://doi.org/10.34172/hmj.2022.24","url":null,"abstract":"Background: Vitiligo is an autoimmune pigmentary skin disease. Recently, the association of chronic inflammatory conditions with metabolic syndrome (MS) and oxidative stress has been demonstrated in skin diseases such as lichen planus and psoriasis. In this study, the prevalence of MS in patients with vitiligo was compared to the control group. Methods: This case-control study included 65 patients with vitiligo and 65 healthy participants in the control group who have referred to the dermatologic clinic in the Afzalipour Hospital of Kerman University of Medical Sciences, Iran. Demographic features and laboratory data of participants were collected and analyzed by SPSS 16 using chi-square and independent t tests. Results: There was no significant difference between the two groups in terms of age, gender, and body mass index (BMI). The mean values of MS parameters were not significant between the two groups. Systolic hypertension (HTN) was significantly higher in the vitiligo group than in the control group (P=0.03). Increasing the length of the disease by one year increased the chance of MS occurrence by 7%. Conclusion: In the current study, systolic HTN was significantly higher in vitiligo patients compared to the control group. MS was also more common in vitiligo patients than in the control group, but the result was not statistically significant.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114655081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 and Hepatic Encephalopathy: A Narrative Review COVID-19与肝性脑病:叙述性回顾
Hormozgan Medical Journal Pub Date : 2022-04-01 DOI: 10.34172/hmj.2022.19
Nahid Davoodian, Elias Kargar-Abargouei, Maryam Arab Firouzjaei
{"title":"COVID-19 and Hepatic Encephalopathy: A Narrative Review","authors":"Nahid Davoodian, Elias Kargar-Abargouei, Maryam Arab Firouzjaei","doi":"10.34172/hmj.2022.19","DOIUrl":"https://doi.org/10.34172/hmj.2022.19","url":null,"abstract":"The 2019 novel coronavirus (COVID-19) has been known as a highly pandemic virus that is characterized by a severe multiorgan pathology. Generally, cardio-respiratory complications are the dominant manifestations in patients infected with COVID-19. Since the coronavirus targets angiotensin-converting enzyme (ACE) receptors, however, the virus is also likely to exhibit multiorgan complications. Some retrospective cohorts as well as case studies have shown varying degrees of increased alanine transaminase (ALT)/aspartate transaminase (AST) in COVID-19 infections. A limited number of histopathological studies examining the liver have also reported an acute portal necrosis of this organ. Some other studies investigating the patients with COVID-19 have documented an acute hepatic encephalopathy with altered mental status. Beyond doubt, having a greater awareness of these complications positively contributes to timely and effective management and treatment of the patients. The present review article, therefore, aimed to highlight the consequences of developing hepatic encephalopathy for patients with COVID-19, its possible multifaceted mechanisms, and the management of neurological complications in these infected patients.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114280040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Knowledge and Performance of Nurses in Dealing with COVID-19 Disease: A Cross-sectional Study in Southern Iran 伊朗南部地区护士应对COVID-19疾病的知识和绩效评估
Hormozgan Medical Journal Pub Date : 2022-04-01 DOI: 10.34172/hmj.2022.15
H. Heshmati, Asiyeh Pormehr-Yabandeh, P. Yousefi, Razieh Beigi-Broujeni, Shide Rafat, Fahimeh Timnak
{"title":"Evaluation of the Knowledge and Performance of Nurses in Dealing with COVID-19 Disease: A Cross-sectional Study in Southern Iran","authors":"H. Heshmati, Asiyeh Pormehr-Yabandeh, P. Yousefi, Razieh Beigi-Broujeni, Shide Rafat, Fahimeh Timnak","doi":"10.34172/hmj.2022.15","DOIUrl":"https://doi.org/10.34172/hmj.2022.15","url":null,"abstract":"Background: The prevalence of coronavirus disease 2019 (COVID-19) is on the rise worldwide. Since nurses are in close contact with infected people, they are a component of the infection transmission chain. Therefore, their knowledge and performance regarding COVID-19 prevention and protection methods can help break the transmission chain. This study aimed to evaluate the self-care level of nurses in charge of caring for patients with COVID-19. Methods: The study population in this descriptive-analytical and cross-sectional study included all nursing staff working in the hospitals affiliated with the Hormozgan University of Medical Sciences. A sample size of 110 nurses was determined adopting the convenience sampling. Data were collected using demographic information as well as questionnaires developed by the researchers to measure the knowledge and performance of the nurses responsible for dealing with COVID-19 patients. Results: A total of 158 nurses with a mean age of 33.77±6.92 years participated in the present study, 85.4% of who were female. Half of the participants (51.3%) showed generally good and excellent levels of self-care. Average scores of the knowledge and performance of nurses increased significantly with an increase in age and work experience (P<0.05). Moreover, the knowledge scores of nurses working in internal wards and intensive care unit (ICU) as well as the performance scores of nurses working in internal wards were lower than those of nurses working in COVID-19 wards. Conclusion: It was found that nurses had relatively good knowledge and performance in dealing with COVID-19 patients. However, various factors such as work experience, age, place of work, etc. may have affected the knowledge and performance of nurses. Therefore, it was recommended that the training of medical staff should be organized so that the efforts to control the epidemic were not negatively affected by unintentional errors but were positively directed towards controlling the disease.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121321438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hip Muscle Flexibility After Six Weeks of Lumbar Stabilization and Global Postural Reeducation Exercises in Men With Movement Control Dysfunction: A Randomized Clinical Trial 一项随机临床试验:对运动控制功能障碍的男性进行6周腰椎稳定和整体姿势再教育训练后的髋关节肌肉灵活性
Hormozgan Medical Journal Pub Date : 2022-04-01 DOI: 10.34172/hmj.2022.13
A. Rahmani, H. Minoonejad, F. Seidi, Yousef Moghadas Tabrizi
{"title":"Hip Muscle Flexibility After Six Weeks of Lumbar Stabilization and Global Postural Reeducation Exercises in Men With Movement Control Dysfunction: A Randomized Clinical Trial","authors":"A. Rahmani, H. Minoonejad, F. Seidi, Yousef Moghadas Tabrizi","doi":"10.34172/hmj.2022.13","DOIUrl":"https://doi.org/10.34172/hmj.2022.13","url":null,"abstract":"Background: Exercise therapy is one of the most effective methods for dealing with low back pain. The present study aimed to compare to examine the effects of two protocols, i.e., six weeks of lumbar stability exercises (LSE) and global postural reeducation exercises (GPR), followed by a subsequent period of non-training on hip muscle flexibility in men with chronic non-specific low back pain (NSLBP) with lumbar movement control impairment (MCI). Methods: In this randomized clinical trial, 46 men suffering from NSLBP with lumbar MCI were selected and randomly divided into three groups (i.e., two exercise groups - one control group). Training intervention groups were allowed to perform exercises for 6 weeks, three sessions per week. Universal goniometer was used to measure the flexibility of hip muscles (i.e., hamstring, rectus femoris, external rotator, and tensor fasciae latae). Repeated measures ANOVA was utilized to compare the effect and durability of the two training protocols on the dependent variables at a significant level. Results: The results showed that both training methods increased hamstring muscle flexibility (P=0.001). GPR method was found superior in increasing the flexibility of the right hip of the subjects in the post-test (P=0.032) and follow-up (P=0.024). However, no significant differences were observed in the other hip muscles flexibility. Conclusion: It was concluded that the GPR method, compared to the lumbar stabilization method, had a greater potential to increase the flexibility of shortened muscles by enhancing the contraction of the antagonist muscles to avoid postural asymmetry. It seems both training protocols were effective in improving hamstring muscle flexibility in people with NSLBP suffering from MCI and this result was observed after both training and 4 weeks of inactivity.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126435953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats 高强度间歇训练对饮食性肥胖大鼠内源性和外源性心肌凋亡通路的影响
Hormozgan Medical Journal Pub Date : 2022-04-01 DOI: 10.34172/hmj.2022.12
Kameleh Astani, J. Bashiri, H. Pourrazi, M. Nourazar
{"title":"The Effect of High Intensity Interval Training on the Intrinsic and Extrinsic Pathways of Myocardial Apoptosis in Diet-Induced Obese Rats","authors":"Kameleh Astani, J. Bashiri, H. Pourrazi, M. Nourazar","doi":"10.34172/hmj.2022.12","DOIUrl":"https://doi.org/10.34172/hmj.2022.12","url":null,"abstract":"Background: Diet-induced obesity is associated with several cardiovascular diseases and myocardial apoptosis. This study aimed to investigate the effect of high intensity interval training (HIIT) on the myocardial apoptosis in the diet-induced obese rats. Methods: Thirty-two male rats, after an obesity induction period, were randomly selected and assigned to four groups including non-obese control (NOC; n=8), basal obese control (BOC; n=8), obese control (OC; n=8), and obese+HIIT (OT; n=8). NOC and BOC groups were sacrificed before the training period. The OT group underwent a HIIT program performed 5 times/week over 12 weeks. Rat hearts were removed 48 hours after the last training session. The Bax, Bcl-2, cytochrome-c, Bid, caspase-8, as well as caspase-3 protein expressions were analyzed using western blotting. Data were analyzed using independent t test. Results: After obesity induction period, the Bax, Bid, cytochrome-c, caspase-8, caspase-3 proteins, and Bax/Bcl-2 in BOC were found to be significantly higher than those in NOC (P=0.025, P=0.0001, P=0.013, P=0.017, P=0.01, P=0.18, respectively). However, Bcl-2 protein in BOC was detected to be significantly lower than that in NOC (P=0.025). The results obtained after completing HIIT training showed that Bid, cytochrome-c, caspase-8, caspase-3, and Bax/Bcl-2 in OT were lower than those in OC (P=0.005, P=0.039, P=0.001, P=0.04, P=0.05, respectively). However, Bcl-2 protein in OT was significantly higher than that in OC (P=0.004). No significant difference was found between OT and OC regarding Bax protein (P=0.32). Conclusion: Diet-induced obesity may have exacerbated the myocardial apoptosis through both intrinsic and extrinsic pathways. However, it seemed that HIIT training significantly prevented the increase of myocardial apoptosis in obese rats.","PeriodicalId":271947,"journal":{"name":"Hormozgan Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132139650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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