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The Molecular Pathology of Pulmonary Fibrosis 肺纤维化的分子病理学
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-17
Joan G. Clark
{"title":"The Molecular Pathology of Pulmonary Fibrosis","authors":"Joan G. Clark","doi":"10.1201/9781003210016-17","DOIUrl":"https://doi.org/10.1201/9781003210016-17","url":null,"abstract":"The connective tissue in normal lung confers mechanical strength and elastic recoil properties that allow the lung to undergo repeated cycles of expansion and relaxation. Pulmonary fibrosis develops as a consequence of a wide variety of insults to the lung. Heterogeneity among patients with pulmonary fibrosis may also be reflected in the activity and rate of progression of disease. Intraalveolar connective tissue may also be present, and in some instances, it is the predominant finding. In advanced stages of pulmonary fibrosis, the normal architecture of the lung is partially obliterated: the alveoli are replaced by dense, disorganized connective tissue, and the terminal airways are dilated and thickened, giving the lung a “honeycomb” appearance. The pivotal role of lung connective tissue in the pathogenesis of pulmonary fibrosis has been appreciated for some time. Diverse experimental approaches, utilizing model systems of varying levels of biological complexity, have been employed in investigations aimed at elucidating the biochemical basis of pulmonary fibrosis.","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131988968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Connective Tissue 血管结缔组织
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-9
Richard Mayne
{"title":"Vascular Connective Tissue","authors":"Richard Mayne","doi":"10.1201/9781003210016-9","DOIUrl":"https://doi.org/10.1201/9781003210016-9","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133926207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Matrix Interactions: Biochemistry of Close and Tight-Focal Adhesive Contacts of Fibroblasts to Extracellular Matrices 细胞-基质相互作用:成纤维细胞与细胞外基质紧密黏附接触的生物化学
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-10
M. Lark, L. Culp
{"title":"Cell-Matrix Interactions: Biochemistry of Close and Tight-Focal Adhesive Contacts of Fibroblasts to Extracellular Matrices","authors":"M. Lark, L. Culp","doi":"10.1201/9781003210016-10","DOIUrl":"https://doi.org/10.1201/9781003210016-10","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114673605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genetic Diseases of Collagen in Animals 动物胶原蛋白的遗传疾病
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-16
R. Minor, J. Wootton, Donald F. Patterson, J. Uitto, Donald Bartel
{"title":"Genetic Diseases of Collagen in Animals","authors":"R. Minor, J. Wootton, Donald F. Patterson, J. Uitto, Donald Bartel","doi":"10.1201/9781003210016-16","DOIUrl":"https://doi.org/10.1201/9781003210016-16","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129883676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elastin 弹性蛋白
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1036/1097-8542.214850
J. Davidson
{"title":"Elastin","authors":"J. Davidson","doi":"10.1036/1097-8542.214850","DOIUrl":"https://doi.org/10.1036/1097-8542.214850","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116929204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microfibrillar Component of the Elastic Fibers Morphology and biochemistry 弹性纤维微纤维组分的形态与生物化学
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-4
E. Cleary
{"title":"The Microfibrillar Component of the Elastic Fibers Morphology and biochemistry","authors":"E. Cleary","doi":"10.1201/9781003210016-4","DOIUrl":"https://doi.org/10.1201/9781003210016-4","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117245344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Intracellular Degradation as a Modulator of Collagen Production 细胞内降解作为胶原蛋白生产的调节剂
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-12
D. S. Neblock, R. Berg
{"title":"Intracellular Degradation as a Modulator of Collagen Production","authors":"D. S. Neblock, R. Berg","doi":"10.1201/9781003210016-12","DOIUrl":"https://doi.org/10.1201/9781003210016-12","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115966904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Molecular Organization of Basement Membrane 基膜的分子组织
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-8
D. Woodley
{"title":"The Molecular Organization of Basement Membrane","authors":"D. Woodley","doi":"10.1201/9781003210016-8","DOIUrl":"https://doi.org/10.1201/9781003210016-8","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115532350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Collagen Family of Proteins 胶原蛋白家族
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-2
R. Burgeson, N. Morris
{"title":"The Collagen Family of Proteins","authors":"R. Burgeson, N. Morris","doi":"10.1201/9781003210016-2","DOIUrl":"https://doi.org/10.1201/9781003210016-2","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134164829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular and Cutaneous Complications of Diabetes Mellitus 糖尿病的血管和皮肤并发症
Connective Tissue Disease Pub Date : 2021-07-29 DOI: 10.1201/9781003210016-24
A. J. Perejda
{"title":"Vascular and Cutaneous Complications of Diabetes Mellitus","authors":"A. J. Perejda","doi":"10.1201/9781003210016-24","DOIUrl":"https://doi.org/10.1201/9781003210016-24","url":null,"abstract":"","PeriodicalId":262745,"journal":{"name":"Connective Tissue Disease","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117272557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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