Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering最新文献

{"title":"Experimental and Numerical Investigation on the Bio-Mechanical Performance of Femoral Trochanteric Fracture Fixation","authors":"H. Xia, Bingzhi Chen","doi":"10.1145/3403782.3403815","DOIUrl":"https://doi.org/10.1145/3403782.3403815","url":null,"abstract":"[Objective] To study the effect of postoperative fixation parameters on the biomechanical performance of femur under two kinds of fractures modes. [Method] Several human femurs samples with fracture were prepared and fixed adopting different parameters for the compression test via universal testing machine, the stress of femur and intramedullary nail under the trochanter was extracted. The geometric model of femoral fracture was created by three-dimensional reconstruction using Mimics software, and the finite element models of femur under two fracture modes were established in Hypermesh. The numerical analysis of femur under the vertical load was carried out using Abaqus, and the model was verified by compression experimental results. Based on the verified numerical model, the influence of the positions of lag screw, the angles between lag screws and intramedullary nail, and the implantation position of intramedullary nail were investigated through the combination of different factors. [Results] For the trochanteric fracture mode, the angle of 125° between the neck nail and the intramedullary nail, of the intramedullary nail was implanted at the intertrochanteric fossa, and the head-neck tension screw was located in the bottom position is beneficial to obtain better postoperative fixation performance. However, for the reserve fracture mode, the angle of 125° between the head-neck tension screw and the intramedullary nail, the intramedullary nail was implanted from the intertrochanteric tip, and the head-neck tension screw was fixed the top position, which is beneficial to obtain better postoperative fixation bio-mechanical performance. [Conclusion] The bio-mechanical performance of postoperative femur is affected by the comprehensive action of angle between the intramedullary nail and the head-neck tension screw, the position of the intramedullary nail, position of the head-neck tension screws, the biomechanical performance of the femur is also different with various fixation manner. The results and conclusions of this work may be of significant reference to the further investigation of treatment for femoral fracture.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125271026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Asthma Local Gene Network for Revealing its Relationship with Nutrient Metabolism Modules","authors":"Ruxin Li, Yu Yang, Xianlei Xu, Renhan Li, Yuchen Yang, Zhizhou Zhang, Changlu Guo","doi":"10.1145/3403782.3403800","DOIUrl":"https://doi.org/10.1145/3403782.3403800","url":null,"abstract":"The local gene network (LGN) method was utilized to construct the local gene network of asthma coupled with several nutrient metabolism modules, containing 13 asthma-related genes and 27 metabolic pathways in which they are involved. This network revealed the complex relationship between nucleotide metabolism, amino acid metabolism, carbohydrate metabolism and asthma genes. Among them, the most closely related to asthma LGN is the amino acid metabolism module, providing a primary technological basis for the study of mechanism of dietary effects on asthma.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117089385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Heart Sound Recognition Based on Instantaneous Frequency and Singular Value Decomposition","authors":"Sheng Miao, Lihui Zhong, Jingyu Hou, Jian'e Dong, Weilian Wang","doi":"10.1145/3403782.3403784","DOIUrl":"https://doi.org/10.1145/3403782.3403784","url":null,"abstract":"It is urgent to study the aided diagnosis of congenital heart disease (CHD) through heart sound due to the high risk of this disease especially in remote regions. In this study, a method based on instantaneous frequency using empirical mode decomposition (EMD) and singular value decomposition (SVD) was proposed to recognize abnormal heart sound. This method include three steps: Firstly, FIR filters were used to filter heart sound into different frequency bands, and then each band signal was decomposed as Intrinsic Mode Function (IMF) using EMD. Secondly, calculating Instantaneous phase using Hilbert transformation, and features were extracted based on singular value decomposition. Finally, support vector machine (SVM) and neural network (NN) were used to classify features to recognize abnormal heart sound. The experiment results show the 25-250 Hz and 250-1000 Hz has higher recognition rate 85.7% and 84.6% compared to other frequency band. The result confirms that there is a potential in heart sounds for the diagnosis of CHD in different frequency bands, but more clinical data is needed in further to verify the recognition effect of different frequency bands.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131630657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Detect Foodborne Pathogenic Microorganisms","authors":"Jingxuan Wei","doi":"10.1145/3403782.3403804","DOIUrl":"https://doi.org/10.1145/3403782.3403804","url":null,"abstract":"Food safety has always been the focus of the community, and since a variety of food safety issues occurred frequently these years, it has become a sensitive topic of people's concern. Therefore, it is important and necessary to develop scientific and advanced technology for food safety inspection to guarantee public health and prevent foodborne diseases. At present, a large proportion of food contamination is due to microbial pollution, which has highlighted the essentiality of microorganism detection in food. There are many kinds of microorganisms in food, some can cause diseases, and some can produce metabolites that cannot be ignored, so microorganisms in food, especially some pathogenic microorganisms are often used as an important indicator of food safety. In order to reduce the probability of microbial contamination, the detection technology has been widely used and improved during these years. The classic method for detecting the foodborne microorganisms are mainly based on conventional culture, which is time consuming and labor-cost. Recently, various approaches have been established and developed, including polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA) and biosensors-based methods. In addition, other new approaches are emerging to improve the result of detection. In this article, we focus on common types of foodborne pathogenic microorganisms and major rapid, sensitive, and easy-performing approaches applied for detection to prevent foodborne diseases.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132675511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compare among Three Immunotherapies Against Cancer: Vaccine Immunotherapy, Immune Checkpoint Blockade and Adoptive Immunotherapy","authors":"Han Zhou","doi":"10.1145/3403782.3403786","DOIUrl":"https://doi.org/10.1145/3403782.3403786","url":null,"abstract":"Cancer is the second leading cause of morbidity and mortality after cardiovascular diseases. Compared with the traditional cancer therapies including chemotherapy and radiotherapy, which have significant side-effects, the immunotherapies of cancer, including vaccine immunotherapy, immune checkpoint blockade and adaptive immunotherapy, are catching more and more attention. The following passage compares and contrasts the theories, targeted audience, advantages and disadvantages of each of these three immunotherapies. Vaccine immunotherapy has the weakest side-effects among the three, and is also the cheapest one. The immune checkpoint blockade is relatively cheap compared with the adaptive immunotherapy and has a larger range of targeted tumors compared with the vaccine immunotherapy. Adaptive immunotherapy can be specifically designed for different patients and different kinds of tumors to achieve optimal efficacy. Further researches about vaccine immunotherapy may focus on finding the specific cause of tumors and find more tumors that can be treat by vaccines. Finding a more effective and specific inhibitory receptor and antigen are two important ways for further developments of immune checkpoint therapy and adaptive immunotherapy respectively. All of the three kinds of immunotherapies are promising, and for different kinds of tumors, patients can choose different immunotherapies to get a better therapeutic effect.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124768236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study and Prediction of Bone Strength of Rats with Different Intensity of Swimming Therapy Based on Synchrotron Radiation","authors":"Wanyu Li, Jun Xu, Jun Zhao, Han Guo, Jianqi Sun","doi":"10.1145/3403782.3403814","DOIUrl":"https://doi.org/10.1145/3403782.3403814","url":null,"abstract":"The most serious health consequence of osteoporosis is a fracture, which is life-threaten and causes a large economic and social burden. However, as the gold standard for clinical diagnosis, bone mineral density (BMD) has significant limitations in fracture risk assessment. Therefore, the purpose of this study is to explore new evaluation criteria for osteoporotic bone quality to better predict bone strength and prevent the occurrence of osteoporotic fractures. In this study, we evaluated the bone strength of rats osteoporotic model with different intensity of swimming therapy based on the synchrotron radiation X-ray imaging. By quantitatively comparing changes of bone microstructural parameters in lumbar vertebra and femur, it was found that swimming therapy has effects on both lumbar and femur, in which the femur are more sensitive. It suggests that femur may be more suitable for the diagnosis and efficacy evaluation of osteoporosis than the lumbar vertebra. By analyzing the correlations between bone microstructure and bone strength, we found that bone volume fraction (BV/TV) and structure model index (SMI) are proper predictors of bone strength than BMD. Selecting a suitable diagnosis site and predictors that more representative of bone strength can provide the basis for fracture risk assessment and efficacy evaluation.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123009054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Anuran Antimicrobial Peptides Using AdaBoost and Improved PSSM Profiles","authors":"Haoyi Fu, Zicheng Cao, Mingyuan Li, Xinnan Xia, Shunfang Wang","doi":"10.1145/3403782.3403807","DOIUrl":"https://doi.org/10.1145/3403782.3403807","url":null,"abstract":"Antimicrobial resistance is one of our most serious health threats. Antimicrobial peptides (AMPs) are natural immune molecules that are commonly found in organisms. Over the last few decades several AMPs have been approved as drugs by FDA. We collected antimicrobial peptide sequences from the DAPA database and constructed a benchmark dataset. And we used PSSM profiles and spatial autocorrelation to design a new feature extraction method. This method can generate a smoother and standardized feature matrix and can find correlations between amino acids at different positions, helping to identify sequences with antimicrobial activity. The results show that the performance of our method is better than state-of-the-art feature extraction methods, and it can be used for many different classifiers.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134402936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GSK-J4, a Histone Demethylase JMJD3 Inhibitor, Modulates Immune-related Protein Expression on Colon Cancer Cells","authors":"Fangfang Li, Yunan Zhao, Zhongnan Yu, Gong Chen","doi":"10.1145/3403782.3403794","DOIUrl":"https://doi.org/10.1145/3403782.3403794","url":null,"abstract":"Objective: To investigate the biological effects of histone demethylase JMJD3 on mouse colon cancer MC38 cells. Methods: Cells were treated with different concentrations of J4. At the indicated time points, cell morphology was monitored and cell number was counted. The expression level of genes related with immune escape or response was measured by flow cytometry and real-time PCR (qRT-PCR). Results: Compared with DMSO group, treatment of J4 significantly reduced cell number. With flow cytometry and qRT-PCR analysis, mRNA and protein expression of MHC-class I, CXCL9 and others in J4 treated group were significantly up-regulated. Conclusion: J4 can inhibit proliferation of MC38 cells, enhance expression of genes related to antigen presentation and ability of secreting chemokines, suggesting that JMJD3 may have important therapeutic relevance for treating colon cancer.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"185 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116279821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome Analysis on the Effect of Tartary Buckwheat Polysaccharide on the Liver of NAFLD-Model Mice","authors":"Litao Zhang, Q. Ren, Qian Chen","doi":"10.1145/3403782.3403818","DOIUrl":"https://doi.org/10.1145/3403782.3403818","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. NAFLD represents a wide range of liver diseases, from steatosis to nonalcoholic steatohepatitis. NAFLD is considered as the liver manifestation of metabolic syndrome, which is closely related to obesity, diabetes and cardiovascular disease. Our study found that tartary buckwheat polysaccharide had a good effect on the NAFLD model mouse. However, the underlying mechanism of tartary buckwheat polysaccharide on NAFLD is still unclear. So, RNA-Seq was used to analyze the mRNA expression in the liver of mouse between NAFLD model group and polysaccharide treatment group to find the target of tartary buckwheat polysaccharide. 4937 DEGs (differently expressed genes) were obtained, among which, 2511 genes were up-regulated and 2426 were down-regulated. GO enrichment analysis showed that oxidation-reduction process was the most sharply changed category, and most of gene involved lipid metabolism. Pathway enrichment analysis showed that most significant pathways are involved in glucose and lipid metabolism. In NAFLD pathways, the key transcription factor: SOCS3, SREBP-1c and XBP1 were all down-regulated, indicating that tartary buckwheat polysaccharide can inhibit the de novo fat synthesis to alleviate NAFLD.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121614222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Influencing Factors of Chinese Elderly Users' Intention to Adopt MHealth Based on the UTAUT2 Model","authors":"Zengmei Lan, Hong Liu, Chao Yang, Xiaohui Liu, G. Sorwar","doi":"10.1145/3403782.3403798","DOIUrl":"https://doi.org/10.1145/3403782.3403798","url":null,"abstract":"With an increasingly aging population in China, chronic diseases associated with aging cannot be ignored. Mobile health (mHealth) applications have shown potentials because of their ease of use and convenience. However, mHealth is still in its early stage of development and its adoption rate has not been noticeably improved in China. The growth of is contingent on its adoption by users especially by elderly users, and therefore a study is warranted to investigate factors influencing users' intention to adopt mHealth. This study is based on the Unified Theory of Acceptance and Use of Technology 2. Wide range of factors from behavior to cultural background to government health policy being considered, this research was carried out among the elderly in China to understand influencing factors on users' intention to adopt mHealth. The research findings will facilitate the development of strategies for mHealth and provide a reference for perfecting medical service system for the elderly by the government, meet the growing demand for medical services by the aging adult, and ultimately improve the health of the aging adult.","PeriodicalId":260405,"journal":{"name":"Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127107988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}