Journal of Natural Health Product Research最新文献

A Pilot Crossover Study of Berberine and its Short-Term Effects on Blood Glucose Levels in Healthy Volunteers 小檗碱及其对健康志愿者血糖水平短期影响的初步交叉研究

Journal of Natural Health Product Research Pub Date : 2023-07-24 DOI: 10.33211/jnhpr.33

Chuck Chang, Min Du, Kyle Roh, Yun Chai Kuo, Yiming Zhang, Mary Hardy, R. Gahler, J. Solnier

{"title":"A Pilot Crossover Study of Berberine and its Short-Term Effects on Blood Glucose Levels in Healthy Volunteers","authors":"Chuck Chang, Min Du, Kyle Roh, Yun Chai Kuo, Yiming Zhang, Mary Hardy, R. Gahler, J. Solnier","doi":"10.33211/jnhpr.33","DOIUrl":"https://doi.org/10.33211/jnhpr.33","url":null,"abstract":"Introduction: Different berberine preparations were evaluated for their effectiveness on lowering blood glucose in a pilot, open-label, crossover study conducted in healthy adults. Methods: Fourteen healthy volunteers of both sexes were recruited, and seven completed all treatments in the study. Study participants ingested one of three berberine preparations containing 500mg of berberine, respectively. A one week wash out period was included between treatments. A control group was included to measure the participants’ baseline response to a 75g glucose solution without any treatment. The following interventions were administered: berberine powder in hard gelatin capsules, berberine in an oil matrix encapsulated in soft-gelatin capsules, and berberine in LipoMicel® matrix encapsulated in soft-gelatin capsules. Blood glucose concentrations in each participant were monitored from pre-dose baseline, before the capsules were ingested, until up to 3 hours after the capsules were ingested. Results: LipoMicel Berberine treatment led to reduced blood glucose concentrations Area Under Curve (AUC, mean difference: 1.57; 95% CI: 0.021 – 3.12; P = 0.046; Cohen’s d = 1.53) and reduced maximum glucose concentration (Gmax, mean difference: 1.07; 95% CI 0.004 – 2.14; P = 0.049; Cohen’s d = 1.52) compared to the control group when no-treatment was given. No adverse events related to berberine treatments were reported by participants throughout the study period. Conclusions: LipoMicel Berberine was effective in lowering blood glucose levels by 12% after two 500mg doses. Berberine in other formulations may require a longer dosing regimen before blood glucose lowering effects can be demonstrated.","PeriodicalId":258100,"journal":{"name":"Journal of Natural Health Product Research","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116658617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of the 19th Annual Conference of the Natural Health Products Research Society of Canada: New Frontiers in NHP Research 加拿大天然保健品研究协会第19届年会摘要:NHP研究的新领域

Journal of Natural Health Product Research Pub Date : 2023-06-19 DOI: 10.33211/jnhpr.38

Pierre S. Haddad, D. St-Pierre, A. Cuerrier, Anika Singh, Connie Kehler, Braydon Hall

引用次数: 0

Paradise Tree Extract (Simarouba glauca) Selectively Induces Cell Death, Enhances Efficacy of Common Chemotherapeutics and Reduces Their Toxicity in In-Vitro and In-Vivo Models of Breast Cancer 天堂树提取物(Simarouba glauca)在体外和体内乳腺癌模型中选择性诱导细胞死亡，提高普通化疗药物的疗效并降低其毒性

Journal of Natural Health Product Research Pub Date : 2023-05-11 DOI: 10.33211/jnhpr.29

A. Pupulin, C. Raad, D. Wear, Abby Raad, Lauren Pupulin, C. Vegh, S. Pandey

{"title":"Paradise Tree Extract (Simarouba glauca) Selectively Induces Cell Death, Enhances Efficacy of Common Chemotherapeutics and Reduces Their Toxicity in In-Vitro and In-Vivo Models of Breast Cancer","authors":"A. Pupulin, C. Raad, D. Wear, Abby Raad, Lauren Pupulin, C. Vegh, S. Pandey","doi":"10.33211/jnhpr.29","DOIUrl":"https://doi.org/10.33211/jnhpr.29","url":null,"abstract":"Background: Although chemotherapeutics have proven to be effective in treating metastatic breast cancer, their limited target selectivity has resulted in adverse side effects, rendering them unsuitable for long-term usage. Alternatively, certain natural extracts provide a promising strategy to selectively target cancer while being safe to consume. Specifically, paradise tree (Simarouba glauca) has shown potential anti-tumour activity; however, its efficacy against cancer, mechanism of action, and interaction with standard chemotherapies have not been investigated. Method: We have demonstrated the anti-tumour activity of ethanolic paradise tree extract (PTE) in triple-negative and ER-positive breast cancer cell lines and its interaction with chemotherapeutics when used in combination. The anti-tumour efficacy of PTE was evaluated through the expression of apoptotic biochemical markers as well as changes in cell morphology. For mechanistic studies, fluorogenic dyes were used to quantify reactive oxygen species production and mitochondrial membrane potential destabilization. Results: Our results have shown that PTE selectively triggers apoptosis in breast cancer cells while having limited effects on noncancerous cells. Importantly, we have found that PTE enhances the anti-tumour efficacy of chemotherapeutics, cisplatin and Taxol, when given in combination, while reducing their toxicity in noncancerous cells. Furthermore, PTE inhibits growth of human tumour xenografts in immunocompromised mice. Importantly, PTE in combination with Taxol and cisplatin had the best anti-tumour effect. Conclusion: Our findings suggest that PTE could be a safe and effective treatment for breast cancer. Most importantly, as a supplement to chemotherapeutic regimens, it could enhance anti-tumour effects and reduce chemo-related toxicity.","PeriodicalId":258100,"journal":{"name":"Journal of Natural Health Product Research","volume":"62 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131077500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial Structural Characterization of Complex Polysaccharide Isolated from Sugar Maple (Acer saccharum Marsh) Bark and its Anti-Inflammatory Activity 糖枫树皮复合多糖的部分结构特征及其抗炎活性

Journal of Natural Health Product Research Pub Date : 2023-02-14 DOI: 10.33211/jnhpr.26

Pierre Betu Kasangana, Pierre S. Haddad, T. Stevanovic

{"title":"Partial Structural Characterization of Complex Polysaccharide Isolated from Sugar Maple (Acer saccharum Marsh) Bark and its Anti-Inflammatory Activity","authors":"Pierre Betu Kasangana, Pierre S. Haddad, T. Stevanovic","doi":"10.33211/jnhpr.26","DOIUrl":"https://doi.org/10.33211/jnhpr.26","url":null,"abstract":"The rationale of the present novel research was to report the properties of a major complex polysaccharide from an aqueous extract of sugar maple bark obtained after catalytic organosolv pulping of the maple bark, which impacted the chemical composition of residual liquor. By using such an aqueous extract of bark, a complex polysaccharide was obtained through ultrafiltration, followed by gel filtration on Sephadex G-50, which was named WSF-3, as the third eluted polysaccharide sub-fraction. Partial polymer and structural characterization revealed that WSF-3 had an average molecular weight of 21.5 kDa and consisted of a backbone of glucose residues (87.2%) linked together by α -(1 → 6) glycosidic bonds. The presence of galactose (9.8%) and rhamnose (3.1%) units may represent polysaccharide impurities as their structures have not been confirmed belonging to the glucan structure. If this was the case, WSF-3 could be similar to dextran, polysaccharide previously reported in sugar maple sap. An anti-inflammatory assay indicated that WSF-3 along with WE and its polysaccharide-rich fraction, all at 100 μg/mL, inhibited TNF-α production in LPS-stimulated RAW 264.7 cells. These results indicate that the concentrated WSF-3 was responsible, at least in part, for the anti-inflammatory effect of WE, suggest that WSF-3 could have therapeutic implications in the treatment of inflammation and inflammatory-related diseases.","PeriodicalId":258100,"journal":{"name":"Journal of Natural Health Product Research","volume":"278 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122712213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Favouring Responsible Publishing: Creating a Database of Researchers and Surveying Their Knowledge, Attitudes and Opinions towards Open Access Publishing and a New Field-Specific Journal 支持负责任的出版:创建一个研究人员数据库，调查他们对开放获取出版和一种新的特定领域期刊的知识、态度和意见

Journal of Natural Health Product Research Pub Date : 2022-11-24 DOI: 10.33211/jnhpr.27

J. Y. Ng, Halton Quach, Jeremy P. Steen, Ming Zheng, Tushar Dhawan, J. V. T. Dychiao, Aisha Hashmani, Bismah Jameel, Kirrthana Jegathesan, Abigal Leah Kogan, Xiao Wen (Vivian) Li, Natasha Reyes, Jill Shah, F. Ashbury, K. Cooley, Pierre S. Haddad

引用次数: 0

Abstracts of the 18th Annual Conference of the Natural Health Products Research Society of Canada: Food-derived NHPs in Health and Disease 加拿大天然保健品研究学会第18届年度会议摘要:健康和疾病中的食品衍生NHPs

Journal of Natural Health Product Research Pub Date : 2022-06-05 DOI: 10.33211/jnhpr.28

P. Haddad, A. Doyen, Kris Coventry, C. Ramassamy, G. Rousseau, D. St-Pierre, M. D. Saldaña

引用次数: 0

In Memoriam - Brian C. Foster, 1952-2021 纪念——布赖恩·c·福斯特，1952-2021

Journal of Natural Health Product Research Pub Date : 2022-01-12 DOI: 10.33211/jnhpr.23

J. Arnason, R. Marles, Cory Harris, Pierre S. Haddad

引用次数: 0

Research of Natural Health Products is Lacking – Right? 天然保健品的研究缺乏，对吗?

Journal of Natural Health Product Research Pub Date : 2021-11-11 DOI: 10.33211/jnhpr.22

Nigel A Pollard

引用次数: 0

In vitro Anticancer Activity of Aponogeton madagascariensis Anthocyanin Extracts 马达加斯加附藤花青素提取物的体外抗癌活性研究

Journal of Natural Health Product Research Pub Date : 2021-09-02 DOI: 10.33211/jnhpr.19

A. Gunawardena, Alice Rollini, Andrea Rasmussen, Adrian N. Dauphinee, Wasundara Fernando, S. Mackinnon, A. H. Wright, D. Hoskin

{"title":"In vitro Anticancer Activity of Aponogeton madagascariensis Anthocyanin Extracts","authors":"A. Gunawardena, Alice Rollini, Andrea Rasmussen, Adrian N. Dauphinee, Wasundara Fernando, S. Mackinnon, A. H. Wright, D. Hoskin","doi":"10.33211/jnhpr.19","DOIUrl":"https://doi.org/10.33211/jnhpr.19","url":null,"abstract":"INTRODUCTION: Aponogeton madagascariensis (lace plant) is a freshwater aquatic flowering plant belonging to the family Aponogetonaceae that forms leaf perforations via programmed cell death (PCD). The lace plant has emerged as a novel model system for studying PCD in planta due to the predictability and accessibility of this process. Anthocyanins, and the balance between ROS and antioxidants, play a central role in regulating PCD in lace plant leaves. Aponogetonaceae family members have shown medicinal properties, including antioxidant and anticancer activities; however, nothing is known about the lace plant’s potential for medicinal use. Therefore, this study evaluated the anticancer activities of lace plant anthocyanin extracts. METHODS: Cell line growth and viability were assessed following exposure to lace plant leaf anthocyanin extracts. This study utilized a triple-negative breast cancer cell line, MDA-MB-231, two human ovarian epithelial cancer cell lines, OVCAR-8 and SKOV-3, along with a normal mammary epithelial cell line, MCF-10A. Furthermore, crude anthocyanin extracts were fractionated into anthocyanin and non-anthocyanin containing fractions and tested only on MDA-MB-231 cells. RESULTS AND DISCUSSION: The crude anthocyanin extracts from lace plant leaves inhibited the growth of MDA-MB-231, OVCAR-8, and SKOV-3 cells in a concentration-dependent manner and had no effect on MCF-10A cells. Lace plant crude anthocyanin extracts appeared to induce apoptosis in MDA-MB-231 cells. Interestingly, treatment with anthocyanin and non-anthocyanin fractions decreased the growth of MDA-MB-231, similarly to crude anthocyanin extracts, suggesting the presence of other anticancer compounds in the lace plant extracts. CONCLUSIONS: Lace plant crude anthocyanin extracts and corresponding fractions have in vitro anticancer activities.","PeriodicalId":258100,"journal":{"name":"Journal of Natural Health Product Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117112415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Quercetin LipoMicel—A Novel Delivery System to Enhance Bioavailability of Quercetin 槲皮素脂质-一种提高槲皮素生物利用度的新型给药系统

Journal of Natural Health Product Research Pub Date : 2021-07-26 DOI: 10.33211/jnhpr.17

J. Solnier, Chuck Chang, Kyle Roh, Min Du, Yun Chai Kuo, Mary Hardy, Michael Lyon, R. Gahler

引用次数: 5