{"title":"Supporting Diagnosis and Treatment","authors":"A. Jha, K. Mukhopadhaya","doi":"10.1007/978-3-030-56739-2_6","DOIUrl":"https://doi.org/10.1007/978-3-030-56739-2_6","url":null,"abstract":"","PeriodicalId":257365,"journal":{"name":"Alzheimer’s Disease","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125906671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzheimer’s DiseasePub Date : 2019-11-21DOI: 10.15586/alzheimersdisease.2019.ch10
E. Salobrar-García, R. Hoz, A. Ramírez, J. Salazar, P. Rojas, I. López-Cuenca, J. Fernández-Albarral, J. Ramírez
{"title":"Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia","authors":"E. Salobrar-García, R. Hoz, A. Ramírez, J. Salazar, P. Rojas, I. López-Cuenca, J. Fernández-Albarral, J. Ramírez","doi":"10.15586/alzheimersdisease.2019.ch10","DOIUrl":"https://doi.org/10.15586/alzheimersdisease.2019.ch10","url":null,"abstract":"ABSTRACT \u0000The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed up throughout the evolution of the disease. As opposed to other CNS structures, the eye is easily accessible for in vivo observation. Retinal organization allows for the identification of its different neurons, and in consequence, detection of minimal changes taking place during neurodegeneration is possible. Functional vision studies performed on AD patients in recent years have shown how visual acuity, contrast sensitivity, color vision, and visual integration vary with the progression of neurodegeneration. The development of optical coherence tomography in ophthalmology has meant a breakthrough in retinal exploratory techniques, allowing the obtention of high-resolution images using light. This technique enables retinal analysis in the earliest stages of AD, being considered as a biomarker of neuronal damage. Given AD’s high prevalence and its expected increase, it is important to perform easy tests that cause minimal discomfort to the patients at a low cost while offering abundant information on the stage of the disease.","PeriodicalId":257365,"journal":{"name":"Alzheimer’s Disease","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116763500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzheimer’s DiseasePub Date : 2019-11-21DOI: 10.15586/alzheimersdisease.2019.ch11
Israel Martínez-Nicolás, J. Carro, Thide E Llorente, J. J. Meilán
{"title":"The Deterioration of Semantic Networks in Alzheimer’s Disease","authors":"Israel Martínez-Nicolás, J. Carro, Thide E Llorente, J. J. Meilán","doi":"10.15586/alzheimersdisease.2019.ch11","DOIUrl":"https://doi.org/10.15586/alzheimersdisease.2019.ch11","url":null,"abstract":"ABSTRACTLanguage impairments in Alzheimer’s disease may appear at the prodromal stage. The most significant impairment is found at the lexical-semantic process level, which is explained either by a degradation of the areas that store the semantic network or by a failure at retrieving the information from that network. Regardless of the retrieval failure happening, there is evidence of the degradation of the semantic network at some levels. Several studies support the bottom-up breakdown, according to which the loss starts at the specific concept attribute level, along with the link with its coordinates, while superordinates are preserved. Some characteristics can affect this loss such as familiarity, age of acquisition, frequency, or affective features. While classic studies have focused on concrete neutral nouns, recent research is exploring the role of emotion. Since emotional processes strengthen the semantic relationship between concepts, it could be a relevant dimension for the preservation of the semantic network.","PeriodicalId":257365,"journal":{"name":"Alzheimer’s Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129358727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Drug Trials In Alzheimer’s Disease","authors":"L. Thal","doi":"10.1201/9780429260353-27","DOIUrl":"https://doi.org/10.1201/9780429260353-27","url":null,"abstract":"","PeriodicalId":257365,"journal":{"name":"Alzheimer’s Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129883204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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