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Synthesis of drimanyl indole fragments of drimentine alkaloids and their antibacterial activities drimanyl indole fragments of drimentine alkaloids and their antibacterial activities.
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-24 DOI: 10.1016/j.bmcl.2024.130040
Jili Feng , Nini Qu , Summia Kalsoom , Zunjun Zhou , Shiyi Zhang , Zhe Cui , Chongmin Zhong , Miaofeng Ma
{"title":"Synthesis of drimanyl indole fragments of drimentine alkaloids and their antibacterial activities","authors":"Jili Feng ,&nbsp;Nini Qu ,&nbsp;Summia Kalsoom ,&nbsp;Zunjun Zhou ,&nbsp;Shiyi Zhang ,&nbsp;Zhe Cui ,&nbsp;Chongmin Zhong ,&nbsp;Miaofeng Ma","doi":"10.1016/j.bmcl.2024.130040","DOIUrl":"10.1016/j.bmcl.2024.130040","url":null,"abstract":"<div><div>Two types of drimanyl indole fragments of drimentine alkaloids were synthesized and evaluated their <em>in vitro</em> antibacterial activities using minimum inhibitory concentration. Analysis of structure–activity relationship against <em>Ralstonia solanacearum</em> revealed that fragment I exhibited superior inhibitory activity compared to fragment II. Notably, free N<img>H of the indole motif was essential for antibacterial activity, while C<sup>12</sup><img>OH of the drimane skeleton was beneficial for enhancing the inhibitory effect. Compound <strong>2</strong>, possessing these structural features, showed the highest activity to <em>R</em>. <em>solanacearum</em> among all the tested compounds with a MIC value of 8 µg/mL, indicating its potential as a promising lead for the development of novel antibiotics.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130040"},"PeriodicalIF":2.5,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and biological evaluation of alginate oligosaccharide derivatives 海藻酸寡糖衍生物的设计、合成和生物学评价。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-23 DOI: 10.1016/j.bmcl.2024.130039
Wenkang Guo , Manchun Chen , Changjie Zou , Weizhi Liu , Weidong Wang , Heyong Gao
{"title":"Design, synthesis and biological evaluation of alginate oligosaccharide derivatives","authors":"Wenkang Guo ,&nbsp;Manchun Chen ,&nbsp;Changjie Zou ,&nbsp;Weizhi Liu ,&nbsp;Weidong Wang ,&nbsp;Heyong Gao","doi":"10.1016/j.bmcl.2024.130039","DOIUrl":"10.1016/j.bmcl.2024.130039","url":null,"abstract":"<div><div>To discover new potential drug for acute kidney injury (AKI), a series of novel alginate oligosaccharide derivatives were synthesized and characterized by the spectroscopic analysis. By using the controlled experimental method, the target compounds were evaluated preliminarily for therapeutic activity in AKI. The results demonstrated that compounds <strong>2a</strong>, <strong>2b</strong>, <strong>2c</strong> and <strong>3b</strong> exhibited notable inhibitory activity against the expression of related proteins at 250 μg/ml in vitro. Furthermore, the in vivo activity of <strong>2a</strong> and <strong>2b</strong> was found to be comparable to that of the trisaccharide (AOSC).</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130039"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances of selenized tubulin inhibitors in cancer therapy 硒化微管蛋白抑制剂在癌症治疗中的最新进展。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-22 DOI: 10.1016/j.bmcl.2024.130037
Yong-Chang Zhao , Liang-Qing Yan , Yuan Xu
{"title":"Recent advances of selenized tubulin inhibitors in cancer therapy","authors":"Yong-Chang Zhao ,&nbsp;Liang-Qing Yan ,&nbsp;Yuan Xu","doi":"10.1016/j.bmcl.2024.130037","DOIUrl":"10.1016/j.bmcl.2024.130037","url":null,"abstract":"<div><div>Cancer treatment always a huge challenge amidst the resistance and relapse caused by the various treatments. Inhibitors targeting mitosis have been considered as promising therapeutic drugs in clinic, of which tubulins play an important role. Selenium (Se) as an essential microelement in humans and animals, playing a crucial role in the formation of anti-oxidase (glutathione peroxidase) and selenoprotein, also attracted broad attention in cancer therapy. Because the introduction of Se atom could change the length and angle of chemical bond and alter their functional properties, regulating selenized chemotherapeutics has become one of the hot spots. However, little attention has been paid to studying the combination of Se and tubulin inhibitors. Herein, we review the latest research results of selenized tubulin inhibitors in cancer therapy, including its mechanisms, categories and biological activities, providing a theoretical basis for different selenized microtubules inhibitors therapies.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130037"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7 发现新型环戊烷羧酸作为 NaV1.7 的强效选择性抑制剂。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-22 DOI: 10.1016/j.bmcl.2024.130033
Shaoyi Sun , Sultan Chowdhury , Ivan Hemeon , Abid Hasan , Michael S. Wilson , Phillipe Bergeron , Qi Jia , Alla Y. Zenova , Mike E. Grimwood , Wei Gong , Shannon M. Decker , Paul Bichler , Jean-Christophe Andrez , Thilo Focken , Theresa Ngyuen , Jiuxiang Zhu , Andrew D. White , Girish Bankar , Sarah Howard , Elaine Chang , Christoph M. Dehnhardt
{"title":"Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7","authors":"Shaoyi Sun ,&nbsp;Sultan Chowdhury ,&nbsp;Ivan Hemeon ,&nbsp;Abid Hasan ,&nbsp;Michael S. Wilson ,&nbsp;Phillipe Bergeron ,&nbsp;Qi Jia ,&nbsp;Alla Y. Zenova ,&nbsp;Mike E. Grimwood ,&nbsp;Wei Gong ,&nbsp;Shannon M. Decker ,&nbsp;Paul Bichler ,&nbsp;Jean-Christophe Andrez ,&nbsp;Thilo Focken ,&nbsp;Theresa Ngyuen ,&nbsp;Jiuxiang Zhu ,&nbsp;Andrew D. White ,&nbsp;Girish Bankar ,&nbsp;Sarah Howard ,&nbsp;Elaine Chang ,&nbsp;Christoph M. Dehnhardt","doi":"10.1016/j.bmcl.2024.130033","DOIUrl":"10.1016/j.bmcl.2024.130033","url":null,"abstract":"<div><div>Discovery efforts leading to the identification of cyclopentane carboxylic acid <strong>31</strong>, a potent inhibitor of Na<sub>V</sub>1.7 that showed high selectivity over Na<sub>V</sub>1.5 and exhibited robust analgesic effects in an inherited erythromelalgia (IEM) transgenic mouse assay, are described herein. Key design elements that culminated in the discovery of <strong>31</strong> include exploration of proline substituents, replacement of the proline warhead with cyclopentane carboxylic acid, that led to significantly boosted Na<sub>V</sub>1.7 potency, and replacement of the metabolically labile adamantane motif with the 2,6-dichlorobenzyl substituted piperidine system, that addressed metabolic instability and led to a significant improvement in PK.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130033"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and bioactivity evaluation of cinnamic acid derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury 肉桂酸衍生物的设计、合成和生物活性评估，作为抗 LPS 诱导的急性肺损伤的潜在抗炎剂。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-22 DOI: 10.1016/j.bmcl.2024.130036
Pengqin Chen , Pan Chen , Xiemin Wang
{"title":"Design, synthesis and bioactivity evaluation of cinnamic acid derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury","authors":"Pengqin Chen ,&nbsp;Pan Chen ,&nbsp;Xiemin Wang","doi":"10.1016/j.bmcl.2024.130036","DOIUrl":"10.1016/j.bmcl.2024.130036","url":null,"abstract":"<div><div>Acute lung injury (ALI), a common critical disease in clinical practice, has a mortality rate as high as 30–40 %, yet currently, no effective treatment methods are available. Research on ALI indicated that inhibition of overexpressed inflammatory factors might be a potential treatment for ALI. In this study, a series of cinnamic acid derivatives were obtained by introducing diverse aminothiazole fragments into the natural product cinnamic acid. Among these derivatives, compound <strong>22</strong> displayed excellent activity of inhibiting the release of IL-6 in J774A.1 cells. Moreover, it also ameliorated the LPS-induced ALI in mouse model by suppressing cytokine expression, reducing lung edema and macrophage infiltration. These findings indicated that compound <strong>22</strong> might provide a new lead structure for the development of drugs for ALI.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130036"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and evaluation of anti-Giardia activity of oseltamivir analogs 奥司他韦类似物的合成和抗贾第虫活性评估。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-21 DOI: 10.1016/j.bmcl.2024.130035
Harrison W. VanKoten , Breanna C. Pence , James R. Klinkenberg , Siddhartha Das , Steven E. Patterson
{"title":"Synthesis and evaluation of anti-Giardia activity of oseltamivir analogs","authors":"Harrison W. VanKoten ,&nbsp;Breanna C. Pence ,&nbsp;James R. Klinkenberg ,&nbsp;Siddhartha Das ,&nbsp;Steven E. Patterson","doi":"10.1016/j.bmcl.2024.130035","DOIUrl":"10.1016/j.bmcl.2024.130035","url":null,"abstract":"<div><div>We reported earlier that oseltamivir (Osm, Tamiflu®), an anti-viral agent, inhibits the attachment of trophozoites to intestinal epithelial cells and cyst production in culture. Osm also disassembles lipid rafts (LRs) and the biogenesis of extracellular vesicles (EVs) by Giardia. In the current study, we synthesized forty-one Osm analogs with the derivatization of oseltamivir phosphate. These compounds were tested on giardial growth, and cyst production. Of these, four analogs, i.e., compounds <strong>3b</strong>, <strong>2c</strong>, <strong>11i</strong>, and <strong>11d</strong>, were found to have superior activities against trophozoites and cysts compared to the parent oseltamivir. Investigation of the mechanism(s) of action of these agents are in progress and will be reported in due course.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130035"},"PeriodicalIF":2.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Switching off cancer – An overview of G-quadruplex and i-motif functional role in oncogene expression 关闭癌症--G-四叠体和 i-motif 在癌基因表达中的功能作用概述。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-20 DOI: 10.1016/j.bmcl.2024.130038
Carolina Roxo, Anna Pasternak
{"title":"Switching off cancer – An overview of G-quadruplex and i-motif functional role in oncogene expression","authors":"Carolina Roxo,&nbsp;Anna Pasternak","doi":"10.1016/j.bmcl.2024.130038","DOIUrl":"10.1016/j.bmcl.2024.130038","url":null,"abstract":"<div><div>DNA can self-assemble into G-quadruplexes and i-motifs non-canonical secondary structures that are formed by guanine-rich sequences and the cytosine-rich sequences, respectively. G-quadruplexes and i-motifs have been closely linked to cancer development since they can regulate genes expression in various promoter regions. Moreover, these structures have gained attention as viable targets for anticancer treatments because of their physicochemical properties and gene-regulatory functions. As a result, they are attractive molecular targets for innovative cancer therapies. Herein, we review the G-quadruplex and i-motif structures, their dynamic relationship in biological systems, as well as their significance in cancer biology and the potential therapeutic approaches. Furthermore, we also address the simultaneous and mutually exclusive formation of G-quadruplex and i-motif structures in cellular environment.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"116 ","pages":"Article 130038"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor 在 AMD070 类似物上接枝发色团，用于 CXCR4 生物成像：化学合成和体外评估 CXCR4 受体的抑制特性。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-17 DOI: 10.1016/j.bmcl.2024.130027
Marie M. Le Roy , Cassandra Métivier , Latifa Rbah-Vidal , Patricia Le Saëc , Hela Bouhsine , Michel Chérel , Alain Faivre-Chauvet , Thibault Troadec , Raphaël Tripier
{"title":"Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor","authors":"Marie M. Le Roy ,&nbsp;Cassandra Métivier ,&nbsp;Latifa Rbah-Vidal ,&nbsp;Patricia Le Saëc ,&nbsp;Hela Bouhsine ,&nbsp;Michel Chérel ,&nbsp;Alain Faivre-Chauvet ,&nbsp;Thibault Troadec ,&nbsp;Raphaël Tripier","doi":"10.1016/j.bmcl.2024.130027","DOIUrl":"10.1016/j.bmcl.2024.130027","url":null,"abstract":"<div><div>Thank to their particular pharmacokinetics, the use of small organic molecules can be a very promising alternative to macromolecular targeting biomolecules (<em>i.e.</em> antibodies, peptides…) for specific imaging of tumours. Herein, the potential of two AMD070-like inhibitors as CXCR4-targeting units for specific imaging of cancer cells, and the influence of chromophore-grafting on their recognition properties was investigated.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"115 ","pages":"Article 130027"},"PeriodicalIF":2.5,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and evaluation of novel N-substituent diphenylamine derivatives as tubulin colchicine binding site inhibitors 设计和评估新型 N-取代基二苯基胺衍生物作为管蛋白秋水仙碱结合位点抑制剂。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-16 DOI: 10.1016/j.bmcl.2024.130031
Zhong Chen , Da-Wei Geng , Tang-Bo Yuan , Chen Yu , Da-Wei Cai , Yong Yin , Qiang Shen
{"title":"Design and evaluation of novel N-substituent diphenylamine derivatives as tubulin colchicine binding site inhibitors","authors":"Zhong Chen ,&nbsp;Da-Wei Geng ,&nbsp;Tang-Bo Yuan ,&nbsp;Chen Yu ,&nbsp;Da-Wei Cai ,&nbsp;Yong Yin ,&nbsp;Qiang Shen","doi":"10.1016/j.bmcl.2024.130031","DOIUrl":"10.1016/j.bmcl.2024.130031","url":null,"abstract":"<div><div>Novel <em>N</em>-substituent diphenylamine derivatives as tubulin inhibitors targeting colchicine-binding site have been designed based on structural simplification and structural fusing strategy. Most designed compounds exhibited the moderate or potent antiproliferative activities against five cancer cell lines. Among them, compound <strong>4k</strong> displayed the significant selectivity for osteosarcoma cells MG-63 and U2OS with the IC<sub>50</sub> value of 0.08–0.14 μM. Further investigations verified <strong>4k</strong> could inhibit tubulin polymerization by targeting colchicine binding site. Meanwhile, compound <strong>4k</strong> not only effectively induced tumor cell cycle arrest at the G2/M phase, but also slightly induced cell apoptosis. These results indicated that N-substituent of diphenylamine derivatives are deserved for further development as tubulin colchicine binding site inhibitors.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"115 ","pages":"Article 130031"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell penetrable peptide nucleic acids targeting PDZK1IP1 with anti-inflammatory potential in human keratinocytes 靶向 PDZK1IP1 的可穿透细胞肽核酸具有在人类角质细胞中抗炎的潜力。
IF 2.5 4区 医学
Bioorganic & Medicinal Chemistry Letters Pub Date : 2024-11-16 DOI: 10.1016/j.bmcl.2024.130032
Daram Jung , Sun Hee Jin , Yeasel Jeon , Joonseo Kim , Sungjin Ahn , Minsoo Noh
{"title":"Cell penetrable peptide nucleic acids targeting PDZK1IP1 with anti-inflammatory potential in human keratinocytes","authors":"Daram Jung ,&nbsp;Sun Hee Jin ,&nbsp;Yeasel Jeon ,&nbsp;Joonseo Kim ,&nbsp;Sungjin Ahn ,&nbsp;Minsoo Noh","doi":"10.1016/j.bmcl.2024.130032","DOIUrl":"10.1016/j.bmcl.2024.130032","url":null,"abstract":"<div><div>PDZK1-interacting protein 1 (PDZK1IP1) has emerged as a potential therapeutic target for skin inflammatory diseases and epithelial tumors. This study investigates the modulation of PDZK1IP1 gene expression using peptide nucleic acids (PNAs), a class of oligonucleotide therapeutics known for their robust binding affinity to complementary nucleic acid sequences and their resistance to degradation by nucleases. To enhance water solubility and cellular permeability, modified PNA oligomers were synthesized by conjugating nucleobases with primary amine chains. A study using a fluorescein-labeled modified PNA oligomer demonstrated significantly enhanced cellular permeability in HaCaT cells compared to the unmodified PNA. These modified PNA oligomers effectively suppressed PDZK1IP1 gene expression and alleviated interferon γ (IFNγ)-induced inflammatory responses in normal human keratinocytes. These findings suggest the potential application of modified PNAs targeting PDZK1IP1 in the treatment of skin inflammatory diseases.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"115 ","pages":"Article 130032"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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