Bioorganic & Medicinal Chemistry Letters最新文献

{"title":"Synthesis and antiproliferative activity of thiazole bioisosteres of goniofufurone and 7-epi-goniofufurone","authors":"Miloš Svirčev ,&nbsp;Mirjana Popsavin ,&nbsp;Bojan Levovnik ,&nbsp;Sanja Djokić ,&nbsp;Jelena Kesić ,&nbsp;Ivana Kovačević ,&nbsp;Goran Benedeković ,&nbsp;Bojana Srećo Zelenović ,&nbsp;Velimir Popsavin ,&nbsp;Vesna Kojić","doi":"10.1016/j.bmcl.2025.130218","DOIUrl":"10.1016/j.bmcl.2025.130218","url":null,"abstract":"<div><div>Several new goniofufurone (<strong>1</strong>) and 7-<em>epi</em>-goniofufurone (<strong>2</strong>) mimics in which the benzene ring has been replaced with a thiazole residue have been designed, synthesized and evaluated for their antiproliferative activity against a panel of human tumour cell lines. The key steps of the synthesis represent the initial condensation of suitably protected furanose urononitriles with cysteine ethyl ester hydrochloride, followed by the subsequent oxidation of resulting C-4′ epimeric thiazolines with BrCCl₃ and DBU, to build up the thiazole ring. Biological studies have shown that the HeLa cell line is most sensitive to the action of synthesized analogues with IC₅₀ values in the range of 0.01–7.67 μM. The most active compound in this cell culture was 7-<em>epi</em>-goniofufurone mimic <strong>28</strong>, with a thiazole-carboxamide function at C-7 and a benzyloxy group at the C-5 position. Compound <strong>28</strong> exhibited 89-fold higher antiproliferative potency in this cell line than lead <strong>2</strong> and was 7-fold more active than the commercial antitumour agent doxorubicin. A SAR study identified structural features responsible for the antiproliferative activity of synthesized analogues. The analogues <strong>3</strong>–<strong>28</strong> are completely inactive toward the normal MRC-5 cell line. Their selectivity indexes (SI) range from 4.1 to 17,470.7.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130218"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway","authors":"Chongyun Zhou ,&nbsp;Jiayun Wang ,&nbsp;Lili Zhou ,&nbsp;Hanxue Li ,&nbsp;Xing Liu ,&nbsp;Sen Wang ,&nbsp;Xingyu Zhang ,&nbsp;Xiaoqing Ye ,&nbsp;Hongyu Ren ,&nbsp;Kaile Zeng ,&nbsp;Xiuming Li ,&nbsp;Dan Wang ,&nbsp;Jing Ji","doi":"10.1016/j.bmcl.2025.130231","DOIUrl":"10.1016/j.bmcl.2025.130231","url":null,"abstract":"<div><div>The tumor suppressor protein p53 plays a crucial role in the pathogenesis of breast cancer; however, its function is often compromised due to MDM2 overexpression or mutations in the p53 gene, which occurs in approximately 30–35 % of breast cancer cases. Piperine, a natural bioactive compound, has shown potential in inhibiting breast cancer cell growth by upregulating p53 expression. However, its clinical application is hindered by poor bioavailability, potential toxicity, and the risk of undesirable drug interactions. In the present study, a novel derivative of Piperine, <strong>YL-1-9</strong>, was synthesized and evaluated for its anticancer activity against breast cancer. <strong>YL-1-9</strong>, a bicyclic amide derivative of Piperine, was evaluated for antitumor effects both in vitro and in vivo using MTT assays and the chick embryo chorioallantoic membrane (CAM) model. Further investigations into its effects on breast cancer cell clonogenicity, adhesion, invasion, and migration were conducted through colony formation assays, EdU assays, cell adhesion and invasion studies, and wound healing experiments. Western blot analysis was performed to elucidate the effects of <strong>YL-1-9</strong> on the cell cycle and apoptosis, which were further validated using YO-PRO-1 and propidium iodide dual staining. <strong>YL-1-9</strong> significantly inhibited breast cancer cell proliferation, adhesion, invasion, and migration, while inducing cell cycle arrest and promoting apoptosis. Mechanistically, <strong>YL-1-9</strong> downregulated critical proteins in the CDK4/6-cyclin D-Rb-E2F pathway and the Caspase 3/Bax/Bcl-2 apoptosis signaling pathway. These findings position <strong>YL-1-9</strong> as a promising candidate for breast cancer therapy; however, further clinical studies are necessary to fully assess its therapeutic potential.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130231"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of farnesoid X receptor antagonists from Salvia miltiorrhiza based on virtual screening and activity verification","authors":"Jiaojiao Tu ,&nbsp;Wa Cheng ,&nbsp;Zhenghu Ban,&nbsp;Jiayi Ning,&nbsp;Xiangduan Tan","doi":"10.1016/j.bmcl.2025.130222","DOIUrl":"10.1016/j.bmcl.2025.130222","url":null,"abstract":"<div><div>The farnesoid X receptor (FXR) is a promising therapeutic target for the treatment of non-alcoholic fatty liver disease (NAFLD). <em>Salvia miltiorrhiza</em>, a traditional Chinese medicine, has demonstrated significant efficacy in the prevention and treatment of liver diseases. Consequently, investigating the potential effects of <em>Salvia miltiorrhiza</em> on FXR could provide new insights for NAFLD treatment. This study explores whether active ingredients from <em>Salvia miltiorrhiza</em> can target FXR and serve as therapeutic agents for treating NAFLD. The findings revealed that cynaroside and lithospermic acid displayed strong FXR antagonistic activity, with IC₅₀ values of 5.41 ± 1.08 μM and 16.92 ± 2.68 μM, respectively. Salvianolic acid A also showed moderate activity (IC₅₀ = 56.35 ± 4.54 μM). MTT assays demonstrated that these three compounds were non-toxic to HepG2 and LO2 cells at a concentration of 200 μM. Molecular dynamics simulations were conducted to elucidate the interaction mechanisms of cynaroside and lithospermic acid with FXR. These results suggest that cynaroside and lithospermic acid from <em>Salvia miltiorrhiza</em> may be potential candidates for targeting FXR in treating NAFLD.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130222"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold","authors":"Junzhen Lin ,&nbsp;Fuling Xiao ,&nbsp;Sheng Han ,&nbsp;Youhong Hu ,&nbsp;Jianping Zuo ,&nbsp;Xiankun Tong ,&nbsp;Wuhong Chen","doi":"10.1016/j.bmcl.2025.130230","DOIUrl":"10.1016/j.bmcl.2025.130230","url":null,"abstract":"<div><div>Novel Ebola entry inhibitors were designed and synthesized based on decahydroisoquinolines by streamlining non-essential functional groups that do not compromise activity. All novel derivatives were evaluated for their anti-Ebola activities and cytotoxicitiies in a defective Ebola virus model. A novel tetrahydroisoquinoline Ebola virus entry inhibitor, <strong>Hu7</strong>, was readily available with antiviral activity comparable to previous findings, while demonstrating a marked reduction in toxicity. Such new compounds with simple and easy-to-synthesize structures could be potential leads for further optimizing the development of anti-Ebola drugs.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130230"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non‑zinc binding mode","authors":"Rainer E. Martin ,&nbsp;Alexander L. Satz ,&nbsp;Christoph Kuratli,&nbsp;Daniel Hunziker ,&nbsp;Patrizio Mattei ,&nbsp;Jérôme Hert ,&nbsp;Christoph Ullmer ,&nbsp;Markus G. Rudolph ,&nbsp;André M. Alker,&nbsp;Remo Hochstrasser,&nbsp;Andreas Marx,&nbsp;Martin Binder,&nbsp;Stephan Müller","doi":"10.1016/j.bmcl.2025.130221","DOIUrl":"10.1016/j.bmcl.2025.130221","url":null,"abstract":"<div><div>In recent years, lysophospholipase autotaxin (ATX) has emerged as an attractive target for treating a variety of human diseases, including inflammation, neurodegeneration, angiogenesis, cancer, ocular and fibrotic diseases, among others. Starting with the quinazolinone hit structure <strong>1,</strong> which emerged from a DNA-encoded library screen, the potent, non-Zn²⁺ binding ATX inhibitor <strong>31</strong> with good overall physicochemical properties has been developed. This compound demonstrated a sustained reduction of lysophosphatidic acid (LPA) in an <em>in vivo</em> rat experiment, qualifying it as a proof-of-concept compound for further mechanistic studies.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130221"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and synthesis of β-carboline-benzofuran based hybrids as antibacterial agents against Staphylococcus aureus","authors":"Mursalim Ali Khan ,&nbsp;Kishan Kumar Parida ,&nbsp;Dastari Sowmya ,&nbsp;Naveen Chand Rallabandi ,&nbsp;Nitin Pal Kalia ,&nbsp;Nagula Shankaraiah","doi":"10.1016/j.bmcl.2025.130220","DOIUrl":"10.1016/j.bmcl.2025.130220","url":null,"abstract":"<div><div>The significant threat posed by <em>Staphylococcus aureus</em> (MRSA) is attributed to various antibiotic resistance and its role in severe infections. As an approach to combat this, a series of novel β-carboline-benzofuran based molecular hybrids were designed, synthesized, and evaluated for their antibacterial activity against <em>Staphylococcus aureus</em> ATCC 29213. Among the series, the minimum inhibitory concentration (MIC) of key compounds <strong>13e</strong>, <strong>13</strong> <strong>h</strong>, and <strong>13q</strong> was determined to be 4 μg/mL, compared to ciprofloxacin 0.125 μg/mL. The docking results also supported the potent compounds' ability to inhibit DNA gyrase. These compounds demonstrated bacteriostatic effects at higher concentrations, with significant inhibition of biofilm formation (MBIC₅₀ ranging from 12.78 to 30.68 μg/mL). Additionally, the compounds displayed minimal cytotoxicity against HepG2 cells and inhibited DNA gyrase, which is proven by DNA supercoiling assays and molecular docking studies. In addition, ADMET predictions indicated favorable drug-like properties, adhering to Lipinski's rule of five. These findings suggest that the synthesized β-carboline-benzofuran hybrids possess significant potential as leads for developing new antibacterial agents against MRSA.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130220"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA binding studies of abietane diterpenes natural products using isothermal titration calorimetry, circular dichroism, fluorescence and gel assays","authors":"Ruel E. McKnight ,&nbsp;Gavin S. Gullickson ,&nbsp;Benjamin Kasper ,&nbsp;Kevin Siegenthaler ,&nbsp;Duanne A.C. Biggs ,&nbsp;Roy B. Porter","doi":"10.1016/j.bmcl.2025.130216","DOIUrl":"10.1016/j.bmcl.2025.130216","url":null,"abstract":"<div><div>A group of four structurally related abietane diterpenes (including royleanone and 7-acetoxy-horminone) were investigated for their DNA binding capabilities using isothermal titration calorimetry (ITC), circular dichroism (CD) and fluorescence displacement spectroscopy, and a topoisomerase DNA-unwinding assay. Both ITC and CD spectroscopy data indicate that the abietane diterpenes of this study exhibit strong binding to DNA, likely preferring a DNA-groove binding mode. Binding constants (<em>K</em>) were found to be in the order of 10^6–8 M⁻¹ and were strongly enthalpically driven. The binding of all compounds to DNA was accompanied by large negative enthalpy changes (more than −20 kcal/mol) and negative entropy changes. The substituent at the 7th position of the abietane ring system was important in determining both the magnitude of binding and the propensity to stack within their DNA binding sites, with derivatives 7-one/ene &gt; 7-OAc/H. This is significant given the reports that the identity of the substituent at position-7 is a strong determinant for bioactivity. Although the specific CD data observed was compound-dependent, most showed strong signal perturbations around one or both of the DNA signature wavelengths (245 and 280 nm). However, we do not attribute these perturbations to DNA intercalation. Compounds that were capable of self-stacking (i.e., 7-ene and 7-one) were also able to elicit very strong positively induced CD signal (ICD) around 330 nm, as well as perturbations at higher wavelengths. Additionally, topoisomerase DNA-unwinding and ethidium fluorescence displacement assays were used to corroborate the DNA binding mode, which was found to be consistent with the abietane diterpene compounds adopting a non-intercalative DNA binding mode.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130216"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of novel inhibitors for malate synthase of Mycobacterium Tuberculosis from natural products","authors":"Zhili Wu ,&nbsp;Yuchen Wu ,&nbsp;Yanhong Niu ,&nbsp;Qianfang Hu ,&nbsp;Qihua Jiang ,&nbsp;Lingbing Liao ,&nbsp;Guorong Qi ,&nbsp;Haoyang Lan ,&nbsp;Xiaolan Yang","doi":"10.1016/j.bmcl.2025.130217","DOIUrl":"10.1016/j.bmcl.2025.130217","url":null,"abstract":"<div><div>Tuberculosis (TB) caused by <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) remains a global public health threat, particularly due to dormant <em>Mtb</em>, which necessitates prolonged drug treatment. <em>Mycobacterium tuberculosis</em> malate synthase (<em>Mtb</em>MS) is a key rate-limiting enzyme in the glyoxylate shunt, essential for the survival of dormant <em>Mtb</em> but absent in the host. Using target-based virtual screening and biochemical approaches, we identified novel natural inhibitors of <em>Mtb</em>MS. Molecular docking by Schrödinger and subsequent manual selection identified 11 compounds as potential inhibitors. Molecular dynamics (MD) simulations and binding-free energy analysis (MM/GBSA) demonstrated high stability and binding affinity of <em>Mtb</em>MS with Nordihydroguaiaretic Acids (NDGA) and Meso-NDGA. NDGA and Meso-NDGA by inhibition experiment exhibited half-maximal inhibitory concentrations (IC₅₀) against <em>Mtb</em>MS at 1.10 ± 0.01 μM and 14.29 ± 0.95 μM and by Isothermal Titration Calorimetry (ITC) showed binding constants (<em>K</em>_d) of 5.66 μM and 34.90 μM, respectively. Their minimum inhibitory concentrations (MIC) against <em>Mtb</em> H37Rv were 60.47 μg/mL and 30.24 μg/mL, respectively. In conclusion, natural products NDGA and Meso-NDGA are potent inhibitors of <em>Mtb</em>MS and represent promising new scaffolds for combating dormant <em>Mtb</em>.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130217"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aptamer-modified GSH-degradable honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy","authors":"Chunhua Guo,&nbsp;Xiaowei Cheng,&nbsp;Yuxing Yang,&nbsp;Lijuan Wang,&nbsp;Wenfang Wang,&nbsp;Liping Shao","doi":"10.1016/j.bmcl.2025.130215","DOIUrl":"10.1016/j.bmcl.2025.130215","url":null,"abstract":"<div><div>Honokiol (HK) is a polyphenol isolated from the Magnolia genus, a component of traditional Chinese herbal medicine, which can effectively suppress the growth of various tumors, including ovarian cancer. However, its low water solubility and lack of tumor-targeting ability have greatly hindered the clinical application of HK. Herein, a glutathione (GSH)-sensitive HK polyprodrug was prepared using HK as the backbone. An EpCAM-specific aptamer and poly(ethylene glycol) (PEG) were then conjugated to the HK polyprodrug, and the resulting polyprodrug was assembled into nanoparticles (NPs) in water. The HK polyprodrug-formed NPs achieved high drug loading and GSH-responsive drug release. Moreover, after optimization, HK polyprodrug NPs (A/P-PHK NP40), formed by aptamer-modified and PEG-modified prodrug at a feed molar ratio of 2: 3, exhibited the highest ability to target EpCAM-overexpressing ovarian cancer cells. A/P-PHK NP40 also demonstrated a greater cell growth inhibition effect in ovarian cancer cells compared to free HK and control HK NPs. All in all, this work reported a novel strategy for HK delivery based on microenvironment responsiveness polyprodrug, which provided a potential method for ovarian cancer targeting therapy.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130215"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of novel pyridine skeleton derivatives as potent CLK2/3 inhibitors","authors":"Jie Wei ,&nbsp;Guochuang Zheng ,&nbsp;Tingting Yu ,&nbsp;Qi Liu ,&nbsp;Wenying Yu ,&nbsp;Cheng Jiang ,&nbsp;Xu Quan","doi":"10.1016/j.bmcl.2025.130212","DOIUrl":"10.1016/j.bmcl.2025.130212","url":null,"abstract":"<div><div>The CLK family plays a crucial role in regulating the transcript splicing, catalyzing the molecular mechanism of spliceosomes. It also regulates the activity or expression of non-spliced proteins by phosphorylating SR proteins. Hence, CLKs are promising therapeutic targets for a variety of diseases, especially in tumors. Several small molecule CLK2/3 inhibitors were under the clinical studies, while most of these molecule possessed N-containing bicyclic heteroaryl as the skeleton. The goal of this work was to introduce a novel skeleton as well as provide structure diversity to the development of CLK2/3 inhibitors. Herein, a series of pyridine derivatives (<strong>5a-5h</strong>, <strong>6a-6e</strong>, and <strong>7a-7g</strong>) were designed, synthesized and evaluated. Among them, compound <strong>7c</strong> was identified to have good inhibitory activities against both CLK2/3 and proliferation of SW480 tumor cell. Additionally, pharmacokinetic study in mice as well as the stability assay were performed to investigate the druggability of <strong>7c</strong>. The good in vitro activity and promising pharmacokinetic properties indicated that the <strong>7c</strong> was a reliable lead compound for further development.</div></div>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":"123 ","pages":"Article 130212"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}