Research and Reports in Gynecology and Obstetrics最新文献

NaProTechnology: Healthcare women really need NaProTechnology:女性真正需要的医疗保健

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.35841/2591-7366-c3-007

Sr. Renée Mirkes

引用次数: 0

Preimplantation genetic testing for aneuploidy: New improvements with noninvasive liquid biopsy technique 非整倍体植入前基因检测:无创液体活检技术的新进展

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.35841/2591-7366-c3-009

J. Tesarik

{"title":"Preimplantation genetic testing for aneuploidy: New improvements with noninvasive liquid biopsy technique","authors":"J. Tesarik","doi":"10.35841/2591-7366-c3-009","DOIUrl":"https://doi.org/10.35841/2591-7366-c3-009","url":null,"abstract":"P genetic testing for aneuploidy (PGTA) was originally performed by analyzing the first and the second polar body. However, it has later been increasingly performed by sampling trophectoderm (TE) cells from blastocysts. Recently, there is increasing concern about the reliability of this technique which has actually never been tested sufficiently in animal models and human preclinical studies. The main problems of PGTA using TE biopsy can be resumed as follows: (1) The frequency of aneuploid TE cells does not necessarily reflect that in the inner cell mass (ICM) which will give rise to the future fetus, (2) the distribution of euploid and aneuploid TE cells is not random but rather clonal, making it impossible to obtain reliable information about the frequency of aneuploidy in the whole embryo, and (3) the removal of TE cells is inherently traumatic, can decrease embryo implantation potential and produce long-term effects on the offspring health. Since, in many cases, PGTA is performed in older women, with only few and relatively fragile embryos, the technique based on TE biopsy can lead to an irreparable damage due to accidental embryo destruction or voluntary destruction of viable embryos deemed aneuploid because of a false positive PGTA result. By contrast, PGTA using non-invasive liquid biopsy is based on analysis of cell-free DNA released both from TE and ICM cells to culture medium, thus allowing a more objective ploidy evaluation of the whole embryo. Here I present the latest data obtained by comparing ploidy evaluation results obtained from cell-free DNA analysis with those obtained by analysis of DNA obtained from whole embryos donated for research from consenting patients. These results show clearly the superiority of non-invasive PGTA based on liquid biopsy (cell-free DNA) from spent culture media over the conventional TE biopsy, with a considerable reduction of interpretation errors.","PeriodicalId":254211,"journal":{"name":"Research and Reports in Gynecology and Obstetrics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125794925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood based assay to predict delayed chemotherapy induced nausea 血液检测预测延迟化疗引起的恶心

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.4066/2591-7366-C1-002

M. Wallon

引用次数: 1

To determine risk of infertility index in female with Polycystic ovarian syndrome (WHO group 2 ovarian dysfunction) 测定多囊卵巢综合征(WHO 2组卵巢功能障碍)女性不孕风险指数

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.4066/2591-7366-c1-003

Munazzah Rafique

引用次数: 0

Oil blending for pain & symptom management: The use of medical Cannabis in palliative care 用于疼痛和症状管理的油调和:医用大麻在姑息治疗中的使用

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.4066/2591-7366-c1-001

D. Sine

引用次数: 0

A case of tubal schistosomiasis presenting as a ruptured ectopic gestation 一例输卵管血吸虫病表现为破裂异位妊娠

Research and Reports in Gynecology and Obstetrics Pub Date : 1900-01-01 DOI: 10.35841/2591-7366-c3-008

D. Gutierrez

{"title":"A case of tubal schistosomiasis presenting as a ruptured ectopic gestation","authors":"D. Gutierrez","doi":"10.35841/2591-7366-c3-008","DOIUrl":"https://doi.org/10.35841/2591-7366-c3-008","url":null,"abstract":"S chistosomiasis is a tropical disease caused by parasitic flatworms of the genus Schistosoma that enter the human body through the skin. The different species of these schistosomes have predilections for specific organs in the body, and signs and symptoms depend on which areas are affected. Cases of Schistosomiasis of the female reproductive tract are rare but have been seen in areas of the world where Schistosoma haematobium , in particular, is endemic. When Schistosomiasis involves the fallopian tubes, it produces fibrotic scars and tubal occlusion, leading to infertility and ectopic pregnancy. A thorough literature search has revealed no reported local case of tubal Schistosomiasis to date. Furthermore, the only Schistosoma species that has been found in the Philippines is Schistosoma japonicum , while the species most often isolated in tubal Schistosomiasis, in contrast, is Schistosoma haematobium . A case of a 32-year-old primigravid from Northern Samar, with amenorrhea of 8 weeks and 5 days, who presented with vaginal spotting and hypogastric pain is hereby reported. She underwent salpingostomy for ectopic pregnancy and was later, upon histopathological examination, found to have tubal infection by Schistosoma, which was treated with Praziquantel. This case is note-worthy because of the following reasons: a) no local case reports Schistosomiasis are currently based on literature search; b) Schistosoma , is not Philippines; the finding of","PeriodicalId":254211,"journal":{"name":"Research and Reports in Gynecology and Obstetrics","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132396054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0