Journal of Pathology Research Reviews & Reports最新文献

{"title":"Efficacy and Safety of Combination Treatment of Oral Terbinafine and Itraconazole in Patients with Extensive Superficial Dermatophytes","authors":"Mohammad Enamul Hoque, Suraiya Akhter, Wahida Rahman, Mohammad Mominul Hoque","doi":"10.47363/jpr/2024(6)165","DOIUrl":"https://doi.org/10.47363/jpr/2024(6)165","url":null,"abstract":"Background: Dermatophytosis, a prevalent fungal infection, is instigated by species like Trichophyton, Epidermophytonand Microsporum. The current approach for treating dermatophytosis involves a blend of systemic and topical antifungal therapies, applicable to all patients except those with localized, untreated Tinea. Notably, there is a growing incidence of inadequate response to the standard treatment regimen in recent times. Objective: To evaluate the efficacy andsafety of combination treatment of oralterbinafine anditraconazole in patients with extensive superficial dermatophytes. Materials and Methods: This research comprised a randomized clinical trial involving 50 individuals diagnosed with extensive superficial dermatophytosis. Study conducted at the Department of Dermatology and Venereology, Combined Military HospitalCumilla, the study spanned from July 2022 to June 2023. During the six-week duration, patients underwent treatment with terbinafine and itraconazole, with follow-up examinations every two weeks, including relevant investigations. Evaluation of treatment outcomes occurred at both four and six weeks. Statistical analysis was performed using version 25 of the Statistical Package for the Social Sciences (SPSS). Results: This study shows the majority of the participants within the age range of 16-30 years (56.0%) and the average age of the participants is 31.74±11.77 years. In terms of gender, the majority are male (78.0%). The most prevalent diagnosis is Tinea corporis (68.0%), followed by Tinea cruris (36.0%), Tinea faciei (28.0%), and Tinea incognito (12.0%). The majority of participants (85.0%) have had the disease for 12 months or less. The most common sites are the trunk (35.0%), whole body (26.0%), and crural area (24.0%). The majority of participants experience severe itching (56.0%), followed by moderate itching (34.0%), and a smaller percentage report mild itching (10.0%). The majority of participants showed improvement, with percentages increasing from 66.0% after 2 weeks to 84.0% after 4 weeks.The percentage of cured individuals also increased over time, reaching a substantial 90.0% after 6 weeks. Conclusion: The amalgamation of terbinafine and itraconazole demonstrates a superior clinical cure rate compared to use of single systemic antifungals. However, the observed clinical cure rate percentage is lower when juxtaposed with findings from previous studies. Notably, neither combination of systemic antifungals has exhibited efficacy against tinea infections previously treated with formulations containing topical steroids","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140410569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Analysis to Study the Histological and Immunohistochemical Profile of Diabetic and Non-Diabetic Human Pancreases in the Indian Population","authors":"Nithyakalyani Mohan, Anusha Sunder, Kandappa Himakar Reddy","doi":"10.47363/jpr/2024(6)164","DOIUrl":"https://doi.org/10.47363/jpr/2024(6)164","url":null,"abstract":"The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in pro-peptide processing and secretory function, along with the loss of these vital cells, is demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Due to ethical and practical difficulties, genomic or pathological data in Indian population are remarkably missing. Here we report the immunohistological observations for 21 pancreases. We analyzed the pathological differences between diabetic and non-diabetic samples along with pathological changes associated with beta cell density, expression, size, and diameter. This study provides an insight into the immunopathological and histochemical mechanisms that highlight a number of–inflammatory, immunoregulatory and regenerative pathways, some of which have received relatively little attention so far.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four-Eyed Fish (A. anableps) Fingerlings Demonstrated Multiple Birth Defects Suggestive of Nutritional Deficiencies","authors":"Schaftenaar W","doi":"10.47363/jpr/2024(6)166","DOIUrl":"https://doi.org/10.47363/jpr/2024(6)166","url":null,"abstract":"In a colony of four-eyed fishes (A. anableps) some females produced offspring demonstrating birth-defects. At external inspection, the ventral midline was open over variable lengths. In some cases, it was combined with lordosis, kyphosis, or scoliosis. Affected specimens also suffered from cataracts. Histopathology revealed widely scattered degeneration of myofibers. Sheath cells of the notochord had proliferated, resulting in asymmetric shape distortion of vertebrae and indentations in the spinal cord. The spinal cord revealed an extensive axonal degeneration. The liver appeared mottled due to focal fat infiltration. Cataracts of ocular lenses appeared as vacuolization of lens fibers. The multiple pathologies noted may have been due to nutritional imbalances because the colony received a carnivore-based diet. Feeding ecology of Anableps is one of omnivory with a predominance of herbivory. This may have resulted in lesions comparable to deficiencies in Vitamin E, Vitamin C, and Selenium.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Obesity and Diabetes Incidence: Histaminosis maybe Important","authors":"Doepp Manfred","doi":"10.47363/jpr/2023(5)162","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)162","url":null,"abstract":"Obesity and diabetes in children are rapidly increasing phenomena. Sugar, carbohydrates with a high glycemic index, industrially processed products and GMO products are one side of the coin, food allergies the other. One trigger for this is histaminosis, associated with leaky gut syndrome and insulin resistance. The normal breakfast in 1st and 2nd world countries is unhealthy and must be replaced, as must fast food and junk food. The switching of children's brains should be deswitched, the intestinal environment should be cleansed. An enzyme therapy for this purpose is shown.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139132566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Pathologic Findings in the Heart of a Red-Eared Turtle (Trachemys Scripta Elegans)","authors":"Zwart P, Harshbarger C, Stumpel Jbg","doi":"10.47363/jpr/2023(5)161","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)161","url":null,"abstract":"The necropsy of a turtle (Trachemys scripta elegans), which was euthanized after rapid loss of vitality, revealed multiple unique abnormalities in the heart. We found areas of atrophy in the wall of the ventricle. These may be connected with aneurysmata at the same locations. A prominent hypertrophic, disc-like cartilago cordis was present. It may have disturbed the flow of blood leading to local atrophies. Gradually, the excessive size may have impeded the flow of blood by compression of large blood vessels at the heart base resulting in ischemia and acute cell death in the myocardium on one side of the ventricle. In one of the larger blood vessels there was an ulcus covered with a thrombus. Thrombi were found on various places and filled the larger part of the ventricular chamber. It can be assumed that these abnormalities were linked and fatal in the end.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139136568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher Toxoplasma Gondii Seropositivity in COVID-19 and Tuberculosis Patients: A Case-Control Study","authors":"Yan Yan, Yonghua Zhou","doi":"10.47363/jpr/2023(5)159","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)159","url":null,"abstract":"Using a case-control study, we compared the antibody-positive profiles for Toxoplasma gondii in patients infected with SARS-CoV-2, tuberculosis (TB), HBV, and HIV-1 in Wuxi of China. As an important pathogen, Toxoplasma gondii has higher co-infection and reactivation rates in patients with SARSCoV-2 and TB infection.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130095155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odontogenesis Tooth Development","authors":"Cristiane Shimazu","doi":"10.47363/jpr/2023(5)160","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)160","url":null,"abstract":"","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131936378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of Google Sheets for Specimen Tracking, Pathologists’ Requisitions, Quality Control and Data Retrieving for Statistics, Search and Research in Anatomical Pathology Laboratories in the Absence of Barcoding and/or Anatomical Pathology Laboratory Information System","authors":"Abdulbasit Andijany, Rehab Fadag","doi":"10.47363/jpr/2023(5)156","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)156","url":null,"abstract":"Background: Many Anatomical Pathology laboratories do not have a barcoding system or an anatomical pathology laboratory information system that allow for better workflow by tracking of specimens and orders, quality control documentation, statistics calculation, search and data retrieval for research purposes. Aim: This paper will show how Google sheet can be used as an alternative using the checkboxes, the electronic edit history and other features. Materials and Methods: Google accounts were created then Google sheets were designed with specific details and the daily quality log was designed to show compliances to national and international standards. Results: Descriptive templates allowed for tracking of specimens and pathologists’ requisitions, quality control documentation, statistics calculation, search and data retrieval for research purposes. Conclusion: Google sheet can be used in the absence of barcoding systems or an anatomical pathology laboratory information system for tracking, documentation, search, research and monitoring of all activities by the supervisor as required by some accreditation body.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124497933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Nitrous Oxide Poisoning: A Case Report","authors":"Nkouado Tchando Yannick","doi":"10.47363/jpr/2023(5)158","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)158","url":null,"abstract":"Background: Chronic nitrous oxide (N2O) poisoning induces irreversible inactivation of vitamin B12, affecting two biochemical reactions essential for the proper functioning of the body. The prognosis is excellent when adequately and quickly treated. We present the case of a 23-year-old Caucasian woman with symptoms caused by chronic N2O inhalation. Case Presentation: A 23-year-old Caucasian woman was admitted to the emergency department with complaints of confusion and gait disturbance. Following an in-depth history and laboratory tests, chronic N2O poisoning was confirmed, and vitamin B12 supplementation was initiated promptly. Conclusion: Our case demonstrated the clinical presentation and biological changes typical of N2O poisoning. The misuse of N2O is prevalent due to the easy accessibility of cylinders over-the-counter since a few years. Recreational misuse of N2O has been observed in young populations. It is important to raise awareness among emergency physicians and nursing staff regarding increases in their consumption. Treatment involved vitamin B12 supplementation and long-term addiction monitoring","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114419154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chédiak Higashi Syndrome -A hematological Diagnosis and Review of Literature","authors":"S. Raj, D. Aden","doi":"10.47363/jpr/2023(5)157","DOIUrl":"https://doi.org/10.47363/jpr/2023(5)157","url":null,"abstract":"Chediak Higashi Syndrome is a rare autosomal recessive disease come in picture early in age, mainly paediatric group and is fatal. In India, till the year 2000, only five cases have been reported. In this study ,we present all the cases reported in India, their clinical presentation, CBC ,PBS ,Bone marrow findings, skin biopsy or hair study (if performed) and their correlation to see the accelerated phase of the disease and approach to the management. Determined peripheral blood smear examination is the key to arrest the diagnosis of Chediak Higashi Syndrome in developing country like India, defining it is the most easiest, quickest, cheap, easily available investigation in our country.","PeriodicalId":253047,"journal":{"name":"Journal of Pathology Research Reviews & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129617714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}