Allergy & Immunology eJournal最新文献

筛选
英文 中文
Treatment of Periodontal Inflammation in Diabetic Rats with Injectable IL-1Ra Thermosensitive Hydrogel 注射IL-1Ra热敏水凝胶治疗糖尿病大鼠牙周炎症
Allergy & Immunology eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3943648
Yue Liu, Chang Liu, Chang Wang, Qian Zhang, Xingyuan Qu, Chen Liang, Lei Wang
{"title":"Treatment of Periodontal Inflammation in Diabetic Rats with Injectable IL-1Ra Thermosensitive Hydrogel","authors":"Yue Liu, Chang Liu, Chang Wang, Qian Zhang, Xingyuan Qu, Chen Liang, Lei Wang","doi":"10.2139/ssrn.3943648","DOIUrl":"https://doi.org/10.2139/ssrn.3943648","url":null,"abstract":"Periodontitis is a chronic inflammatory disease in which dental plaque plays a key role. Hyperglycemia can promote inflammatory cells to secrete various inflammatory factors, causing the destruction of periodontal tissues and leading to the sustained development of periodontitis and prolonged and unhealed periodontal tissues. IL-1β is an important prophase inflammatory factor, which participates in the pathophysiological process of periodontitis. Interleukin 1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1, can also reduce the levels of other cytokines, including TNF-α and IL-6, and the balance between IL-1Ra and IL-1β is one of the primary factors affecting chronic periodontitis(CP). In this experiment, a temperature-sensitive hydrogel loaded with IL-1Ra was prepared and characterized, and its anti-inflammatory properties were evaluated. The hydrogel could be injected locally, and the results showed that it had good morphology, was nontoxic both in vivo and in vitro, and could realize sustained drug release. Histological evaluation and micro-computed tomography (micro-CT) showed that IL-1Ra-loaded thermosensitive hydrogel could effectively inhibit periodontal inflammation in diabetic rats, and played a significant role in relieving hyperglycemia. Therefore, IL-1Ra-loaded thermosensitive hydrogel may be an effective method to treat periodontitis with diabetes. Funding: This work was supported by grants from the Science and Technology Research Project of Education Department of Jilin Province(JJKH20211218KJ),\"13th Five-Year plan\" science and technology project of Education Department of Jilin Province(JJKH20201115KJ). Declaration of Interests: The authors report no declarations of interest. Ethics Approval Statement: This experiment was approved by the Ethics Committee of the Hospital of Stomatology, Jilin University,China, and all animal experiments followed the National Institute of Health (NIH) guidelines on laboratory animal care and use (ARRIVE guidelines).","PeriodicalId":252984,"journal":{"name":"Allergy & Immunology eJournal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114340271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immune Microenvironment in Cartilage Injury, Repair and Regeneration 软骨损伤、修复和再生中的免疫微环境
Allergy & Immunology eJournal Pub Date : 1900-01-01 DOI: 10.2139/ssrn.3906848
Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Haojiang Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, X. Sui, Shuyun Liu, Zhiwei Chen, Q. Guo
{"title":"The Immune Microenvironment in Cartilage Injury, Repair and Regeneration","authors":"Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Haojiang Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, X. Sui, Shuyun Liu, Zhiwei Chen, Q. Guo","doi":"10.2139/ssrn.3906848","DOIUrl":"https://doi.org/10.2139/ssrn.3906848","url":null,"abstract":"Since articular cartilage lacks blood vessels, nerves, and lymph tissue, its ability to repair itself is limited. Once damaged, it can lead to joint swelling and pain, accelerating the progression of osteoarthritis. Complete regeneration of hyaline cartilage with good mechanical properties remains an elusive goal, despite the many technologies available today. The inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and the progression of cartilage injury to osteoarthritis. In the inflammatory microenvironment, MSCs undergo aberrant differentiation, and chondrocytes begin to convert or dedifferentiate into cells with a fibroblast phenotype, resulting in fibrocartilage with poor mechanical qualities. All of these suggest that inflammatory problems may be a major stumbling block to cartilage repair. To produce a milieu conducive to cartilage regeneration, multi-dimensional management of the joint inflammatory microenvironment in place and time is required. Therefore, it is of great significance to elucidate the immune microenvironment of cartilage repair and regeneration after injury. This review provides a brief overview of:(1)the pathogenesis of cartilage injury(2)immune cells in cartilage injury and repair(3)effects of inflammatory cytokines on cartilage repair;(4)clinical strategies for the treatment of cartilage defects(5)strategies for targeted immunoregulation in cartilage repair and regeneration.","PeriodicalId":252984,"journal":{"name":"Allergy & Immunology eJournal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116967264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信